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Reviewed, UniProtKB/Swiss-Prot Q5WAV8 (MURB_BACSK)

Last modified November 3, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase
    EC=1.1.1.158
Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase
Gene names
Name: murB
Ordered Locus Names: ABC3971
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the murB family.

Contains 1 FAD-binding PCMH-type domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_0000224658

Regions

Domain34 – 198165FAD-binding PCMH-type

Sites

Active site1771 By similarity
Active site2271Proton donor By similarity
Active site2971 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5WAV8-1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 970FC3354348F1FB

FASTA31134,121
        10         20         30         40         50         60 
MKRYIEICKP LWTLLPEGTI HEDERLCKHT YTQMGGAADL FITPQSYEET QTVLKFAHEH 

        70         80         90        100        110        120 
RVPVTLLGNG SNVIVKDGGI RGITLSLKKL NTITCTGVEL VAQTGATIIE ASRRARDAEL 

       130        140        150        160        170        180 
TGLEFACGIP GTVGGAFYMN AGAYGGQIAD VLESVLVLTE QGEFKTLSKE EFDFDYRKSV 

       190        200        210        220        230        240 
FSAKRYIALE GTFRLQKGDM AQIQAKMDEL TIARETKQPL EYPSCGSVFK RPPGMFAGKL 

       250        260        270        280        290        300 
IQDSGLQGTR IGGAEVSKKH AGFIVNVDNA TATEYMSLVR HVQQTVKDKF GVELETEVIT 

       310 
IGEDIEEPVS D

« Hide

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References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AP006627 Genomic DNA. Translation: BAD66502.1.
RefSeqYP_177463.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WAV8.

Genome annotation databases

GeneID3204493.
GenomeReviewsGene locus ABC3971 in contig AP006627_GR.
KEGGbcl:ABC3971.
NMPDRfig|66692.3.peg.3946.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ5WAV8.
OMAQPIREKT.

Enzyme and pathway databases

BioCycBCLA66692:ABC3971-MON.

Family and domain databases

HAMAPMF_00037.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMURB_BACSK
AccessionPrimary (citable) accession number: Q5WAV8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents