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Q5WA72 (PDI15_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide isomerase-like 1-5

Short name=OsPDIL1-5
EC=5.3.4.1
Alternative name(s):
Protein disulfide isomerase-like 3-1
Short name=OsPDIL3-1
Gene names
Name:PDIL1-5
Synonyms:PDIL3-1
Ordered Locus Names:Os06g0163400, LOC_Os06g06790
ORF Names:P0681F10.44
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis By similarity.

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen Probable.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRedox-active center
Repeat
Signal
   Molecular functionIsomerase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein disulfide isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 533511Protein disulfide isomerase-like 1-5
PRO_0000400032

Regions

Domain51 – 196146Thioredoxin 1
Domain387 – 516130Thioredoxin 2
Motif530 – 5334Prevents secretion from ER By similarity

Sites

Active site971Nucleophile By similarity
Active site4361Nucleophile By similarity
Active site4391Nucleophile By similarity

Amino acid modifications

Glycosylation1511N-linked (GlcNAc...) Potential
Disulfide bond436 ↔ 439Redox-active By similarity

Experimental info

Sequence conflict2081A → T in AK073970. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5WA72 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: F435D08CE96793B7

FASTA53359,032
        10         20         30         40         50         60 
MRARRVVAAA AVLLLFAVVA VARLDLDDDG DDSEVLDELL AVDEEEERGE LGGGGEAAAA 

        70         80         90        100        110        120 
EAVRRAQSMV LVLDNDNARR AVEENAEVLL LGYAPWCERS AQLMPRFAEA AAALRAMGSA 

       130        140        150        160        170        180 
VAFAKLDGER YPKAASAVGV KGFPTVLLFV NGTEHQFTGL HTKDAIVTWV RKKTGAPASR 

       190        200        210        220        230        240 
IQSKDSAEEF LKKDQTFAVG LFKNFEGAEY EEFVKAATSE NEVQFVETND RNVAKILFPG 

       250        260        270        280        290        300 
IASEEQFLGL VKSEPEKFEK FNGAFEEKEI IQFVELNKFP LITVFTDLNS GKVYGSPIKL 

       310        320        330        340        350        360 
QVFTFAEAYD FEDLESMIQE VARGFKTKIM LIYVDTAEEK LAKPFLTLYG LEPEKPTVTA 

       370        380        390        400        410        420 
FDTSKGTKYL MEAEINAKNL QDFCLSLLEG TLPPYFRSEP VPEEKGPIEK VVGRTFDSSV 

       430        440        450        460        470        480 
LESPQNVFLE VHAPWCVDCE AISKNVEKLA KHFNDLGQTN LKFARIDASV NEHPKLQINN 

       490        500        510        520        530 
YPTLLLYPAQ DKSNPIKLSK KSNLKDMAKF VKEKLQIADV ETVAAGDIVK DEL 

« Hide

References

« Hide 'large scale' references
[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[3]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.
[4]"Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026295 Genomic DNA. Translation: BAD67648.1.
AP008212 Genomic DNA. Translation: BAF18810.1.
AK073970 mRNA. No translation available.
RefSeqNP_001056896.1. NM_001063431.1.
UniGeneOs.4371.

3D structure databases

ProteinModelPortalQ5WA72.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS06T0163400-01; OS06T0163400-01; OS06G0163400.
GeneID4340223.
KEGGosa:4340223.

Organism-specific databases

GrameneQ5WA72.

Phylogenomic databases

eggNOGCOG0526.
KOK09580.
OMANEIQFVE.
ProtClustDBCLSN2680753.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 4 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDI15_ORYSJ
AccessionPrimary (citable) accession number: Q5WA72
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations