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Protein
Submitted name:

KIAA1149 splice variant 1

Gene

KIAA1149

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
KIAA1149 splice variant 1Imported
Gene namesi
Name:KIAA1149Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ5W9H2.
PeptideAtlasiQ5W9H2.

Expressioni

Gene expression databases

GenevisibleiQ5W9H2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000292095.

Structurei

3D structure databases

ProteinModelPortaliQ5W9H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 311Peptidase A1InterPro annotationAdd BLAST311

Sequence similaritiesi

Belongs to the peptidase A1 family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOVERGENiHBG059578.

Family and domain databases

CDDicd05473. beta_secretase_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR009119. BACE.
IPR009120. BACE1.
IPR033874. Memapsin-like.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF245. PTHR13683:SF245. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR01816. BACE1.
PR01815. BACEFAMILY.
PR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5W9H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YLQAHFTLCS GWSSTYRDLR KGVYVPYTQG KWEGELGTDL VSIPHGPNVT
60 70 80 90 100
VRANIAAITE SDKFFINGSN WEGILGLAYA EIARPDDSLE PFFDSLVKQT
110 120 130 140 150
HVPNLFSLQL CGAGFPLNQS EVLASVGGSM IIGGIDHSLY TGSLWYTPIR
160 170 180 190 200
REWYYEVIIV RVEINGQDLK MDCKEYNYDK SIVDSGTTNL RLPKKVFEAA
210 220 230 240 250
VKSIKAASST EKFPDGFWLG EQLVCWQAGT TPWNIFPVIS LYLMGEVTNQ
260 270 280 290 300
SFRITILPQQ YLRPVEDVAT SQDDCYKFAI SQSSTGTVMG AVIMEGFYVV
310 320 330 340 350
FDRARKRIGF AVSACHVHDE FRTAAVEGPF VTLDMEDCGY NIPQTDESTL
360 370 380 390
MTIAYVMAAI CALFMLPLCL MVCQWRCLRC LRQQHDDFAD DISLLK
Length:396
Mass (Da):44,429
Last modified:December 7, 2004 - v1
Checksum:iA2CBCD52DCC089E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177847 mRNA. Translation: BAD66825.1.
RefSeqiNP_001193977.1. NM_001207048.1.
UniGeneiHs.504003.

Genome annotation databases

GeneIDi23621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177847 mRNA. Translation: BAD66825.1.
RefSeqiNP_001193977.1. NM_001207048.1.
UniGeneiHs.504003.

3D structure databases

ProteinModelPortaliQ5W9H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000292095.

Proteomic databases

PaxDbiQ5W9H2.
PeptideAtlasiQ5W9H2.

Protocols and materials databases

DNASUi23621.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23621.

Organism-specific databases

CTDi23621.
HUGEiSearch...

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOVERGENiHBG059578.

Miscellaneous databases

GenomeRNAii23621.

Gene expression databases

GenevisibleiQ5W9H2. HS.

Family and domain databases

CDDicd05473. beta_secretase_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR009119. BACE.
IPR009120. BACE1.
IPR033874. Memapsin-like.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF245. PTHR13683:SF245. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR01816. BACE1.
PR01815. BACEFAMILY.
PR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5W9H2_HUMAN
AccessioniPrimary (citable) accession number: Q5W9H2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.