Q5W9H1 (Q5W9H1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
KIAA0142 splice variant 1 EMBL BAD66826.1

Gene names

Name:

KIAA0142 EMBL BAD66826.1

Organism

Homo sapiens (Human) EMBL BAD66826.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	691 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS001331 Contains 1 PH domain. RuleBase RU003350 SAAS SAAS000219

Ontologies

Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD66826.1

Sequences

	Sequence		Length	Mass (Da)
	Q5W9H1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 79570CF1CA88AFEE	FASTA	691	77,790
	10 20 30 40 50 60 IPPSKPLRGS SLWGCWSRPK KTISDPEGFL QASLKDGVVL CRLLERLLPG TIEKVYPEPR 70 80 90 100 110 120 SESECLSNIR EFLRGCGASL RLETFDANDL YQGQNFNKVL SSLVTLNKVT ADIGLGSDSV 130 140 150 160 170 180 CARPSSHRIK SFDSLGSQSL HTRTSKLFQG QYRSLDMTDN SNNQLVVRAK FNFQQTNEDE 190 200 210 220 230 240 LSFSKGDVIH VTRVEEGGWW EGTLNGRTGW FPSNYVREVK ASEKPVSPKS GTLKSPPKGF 250 260 270 280 290 300 DTTAINKSYY NVVLQNILET ENEYSKELQT VLSTYLRPLQ TSEKLSSANI SYLMGNLEEI 310 320 330 340 350 360 CSFQQMLVQS LEECTKLPEA QQRVGGCFLN LMPQMKTLYL TYCANHPSAV NVLTEHSEEL 370 380 390 400 410 420 GEFMETKGAS SPGILVLTTG LSKPFMRLDK YPTLLKELER HMEDYHTDRQ DIQKSMAAFK 430 440 450 460 470 480 NLSAQCQEVR KRKELELQIL TEAIRNWEGD DIKTLGNVTY MSQVLIQCAG SEEKNERYLL 490 500 510 520 530 540 LFPNVLLMLS ASPRMSGFIY QGKLPTTGMT ITKLEDSENH RNAFEISGSM IERILVSCNN 550 560 570 580 590 600 QQDLQEWVEH LQKQTKVTSV GNPTIKPHSV PSHTLPSHPV TPSSKHADSK PAPLTPAYHT 610 620 630 640 650 660 LPHPSHHGTP HTTINWGPLE PPKTPKPWSL SCLRPAPPLR PSAALCYKED LSKSPKTMKK 670 680 690 LLPKRKPERK PSMRSSRPGK AQLLWKKMLR F

References

[1]	"Alternative splice variants encoding unstable protein domains exist in the human brain." Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K. J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD66826.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB177848 mRNA. Translation: BAD66826.1.
IPI	IPI00449909.
UniGene	Hs.508738.
3D structure databases
ProteinModelPortal	Q5W9H1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5W9H1.
Proteomic databases
PRIDE	Q5W9H1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
HUGE	Search...
Phylogenomic databases
HOGENOM	HOG000231381.
HOVERGEN	HBG050569.
Gene expression databases
ArrayExpress	Q5W9H1.
Bgee	Q5W9H1.
Family and domain databases
Gene3D	1.10.418.10. 1 hit. 1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00307. CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
SMART	SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF48065. DH-domain. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ARHGEF7. human.

Entry information

Entry name

Q5W9H1_HUMAN

Accession

Primary (citable) accession number: Q5W9H1

Entry history

Integrated into UniProtKB/TrEMBL:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	March 6, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.