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Protein
Submitted name:

KIAA0142 splice variant 1

Gene

KIAA0142

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
KIAA0142 splice variant 1Imported
Gene namesi
Name:KIAA0142Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiQ5W9H1.

Expressioni

Gene expression databases

BgeeiQ5W9H1.

Structurei

3D structure databases

ProteinModelPortaliQ5W9H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000231381.
HOVERGENiHBG050569.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5W9H1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IPPSKPLRGS SLWGCWSRPK KTISDPEGFL QASLKDGVVL CRLLERLLPG
60 70 80 90 100
TIEKVYPEPR SESECLSNIR EFLRGCGASL RLETFDANDL YQGQNFNKVL
110 120 130 140 150
SSLVTLNKVT ADIGLGSDSV CARPSSHRIK SFDSLGSQSL HTRTSKLFQG
160 170 180 190 200
QYRSLDMTDN SNNQLVVRAK FNFQQTNEDE LSFSKGDVIH VTRVEEGGWW
210 220 230 240 250
EGTLNGRTGW FPSNYVREVK ASEKPVSPKS GTLKSPPKGF DTTAINKSYY
260 270 280 290 300
NVVLQNILET ENEYSKELQT VLSTYLRPLQ TSEKLSSANI SYLMGNLEEI
310 320 330 340 350
CSFQQMLVQS LEECTKLPEA QQRVGGCFLN LMPQMKTLYL TYCANHPSAV
360 370 380 390 400
NVLTEHSEEL GEFMETKGAS SPGILVLTTG LSKPFMRLDK YPTLLKELER
410 420 430 440 450
HMEDYHTDRQ DIQKSMAAFK NLSAQCQEVR KRKELELQIL TEAIRNWEGD
460 470 480 490 500
DIKTLGNVTY MSQVLIQCAG SEEKNERYLL LFPNVLLMLS ASPRMSGFIY
510 520 530 540 550
QGKLPTTGMT ITKLEDSENH RNAFEISGSM IERILVSCNN QQDLQEWVEH
560 570 580 590 600
LQKQTKVTSV GNPTIKPHSV PSHTLPSHPV TPSSKHADSK PAPLTPAYHT
610 620 630 640 650
LPHPSHHGTP HTTINWGPLE PPKTPKPWSL SCLRPAPPLR PSAALCYKED
660 670 680 690
LSKSPKTMKK LLPKRKPERK PSMRSSRPGK AQLLWKKMLR F
Length:691
Mass (Da):77,790
Last modified:December 7, 2004 - v1
Checksum:i79570CF1CA88AFEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177848 mRNA. Translation: BAD66826.1.
UniGeneiHs.508738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177848 mRNA. Translation: BAD66826.1.
UniGeneiHs.508738.

3D structure databases

ProteinModelPortaliQ5W9H1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5W9H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

HUGEiSearch...

Phylogenomic databases

HOGENOMiHOG000231381.
HOVERGENiHBG050569.

Miscellaneous databases

ChiTaRSiARHGEF7. human.

Gene expression databases

BgeeiQ5W9H1.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alternative splice variants encoding unstable protein domains exist in the human brain."
    Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
    J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ5W9H1_HUMAN
AccessioniPrimary (citable) accession number: Q5W9H1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.