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Protein

Tetratricopeptide repeat protein 23

Gene

TTC23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 23
Short name:
TPR repeat protein 23
Alternative name(s):
Cervical cancer proto-oncogene 8 protein
Short name:
HCC-8
Gene namesi
Name:TTC23
ORF Names:HCC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25730. TTC23.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103852.
PharmGKBiPA142670675.

Polymorphism and mutation databases

DMDMi74708246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895481 – 447Tetratricopeptide repeat protein 23Add BLAST447

Proteomic databases

EPDiQ5W5X9.
PaxDbiQ5W5X9.
PRIDEiQ5W5X9.

PTM databases

iPTMnetiQ5W5X9.
PhosphoSitePlusiQ5W5X9.

Expressioni

Gene expression databases

BgeeiENSG00000103852.
CleanExiHS_TTC23.
ExpressionAtlasiQ5W5X9. baseline and differential.
GenevisibleiQ5W5X9. HS.

Organism-specific databases

HPAiHPA039806.
HPA040369.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-6447954,EBI-3905054
BHLHE40O145033EBI-6447954,EBI-711810
CCNDBP1O952733EBI-6447954,EBI-748961
CNTROBQ8N1373EBI-6447954,EBI-947360
CREBZFQ9NS373EBI-6447954,EBI-632965
GOLGA2Q083793EBI-6447954,EBI-618309
KRT31Q153233EBI-6447954,EBI-948001
KRT40Q6A1623EBI-6447954,EBI-10171697
LDOC1O957513EBI-6447954,EBI-740738
LZTS2Q9BRK43EBI-6447954,EBI-741037
MAGED1Q9Y5V33EBI-6447954,EBI-716006
MDFIQ997503EBI-6447954,EBI-724076
PNMA5Q96PV43EBI-6447954,EBI-10171633
SPAG5Q96R063EBI-6447954,EBI-413317
SSX2IPQ9Y2D83EBI-6447954,EBI-2212028
TADA2AO754783EBI-6447954,EBI-742268
TRIM10Q9UDY63EBI-6447954,EBI-6427325
TRIM54Q9BYV23EBI-6447954,EBI-2130429

Protein-protein interaction databases

BioGridi122349. 22 interactors.
IntActiQ5W5X9. 57 interactors.
STRINGi9606.ENSP00000262074.

Structurei

3D structure databases

ProteinModelPortaliQ5W5X9.
SMRiQ5W5X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 78TPR 1Add BLAST34
Repeati137 – 170TPR 2Add BLAST34
Repeati186 – 219TPR 3Add BLAST34
Repeati356 – 389TPR 4Add BLAST34

Sequence similaritiesi

Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IJRU. Eukaryota.
ENOG410XVCY. LUCA.
GeneTreeiENSGT00530000063847.
HOGENOMiHOG000154704.
HOVERGENiHBG096816.
InParanoidiQ5W5X9.
OMAiWKLAEAH.
OrthoDBiEOG091G08RQ.
PhylomeDBiQ5W5X9.
TreeFamiTF332604.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W5X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQESQETHIS NHLDEVVAAV SITHRKKFQN KLLQTALFQP PREKLHLCEE
60 70 80 90 100
KAKSYSNSHE YKQAVHELVR CVALTRICYG DSHWKLAEAH VNLAQGYLQL
110 120 130 140 150
KGLSLQAKQH AEKARQILAN SIVPPYSENT DVFKFSIELF HTMGRALLSL
160 170 180 190 200
QKFKEAAENL TKAERLSKEL LQCGRIIKEE WIEIEARIRL SFAQVYQGQK
210 220 230 240 250
KSKEALSHYQ AALEYVEISK GETSRECVPI LRELAGVEQA LGLHDVSINH
260 270 280 290 300
FLQAHLIILS RSPSQVEAAD SAHIVAHAAV ASGRHEHHDV AEQYFQESMA
310 320 330 340 350
HLKDSEGMGR TKFLSIQDEF CHFLQMTGQK ERATSILRES LEAKVEAFGD
360 370 380 390 400
FSPEVAETYR LLGGADLAQG NHSGARKKLK KCLQIQTLLY GPQDKRTLAT
410 420 430 440
QQAMGMLSTA PKVASKPRQA SKAKVAFCTS IPQDTLLGKA RPGTTAD
Length:447
Mass (Da):50,009
Last modified:December 7, 2004 - v1
Checksum:i7548138692B33E57
GO
Isoform 2 (identifier: Q5W5X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-447: CLQIQTLLYG...GKARPGTTAD → VKLEPVLTRD

Show »
Length:391
Mass (Da):44,174
Checksum:i4D38FFBA005B3041
GO
Isoform 3 (identifier: Q5W5X9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-447: CLQIQTLLYG...GKARPGTTAD → GDLSFLLSATLP

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:393
Mass (Da):44,238
Checksum:iA7C4AAC73EAA15A5
GO

Sequence cautioni

The sequence BAB14144 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374G → E in BAD96300 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026017382 – 447CLQIQ…GTTAD → VKLEPVLTRD in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_026018382 – 447CLQIQ…GTTAD → GDLSFLLSATLP in isoform 3. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411456 mRNA. Translation: AAQ03215.1.
AK022634 mRNA. Translation: BAB14144.1. Different initiation.
AK023230 mRNA. Translation: BAB14480.1.
AK222580 mRNA. Translation: BAD96300.1.
AK291690 mRNA. Translation: BAF84379.1.
BC015728 mRNA. Translation: AAH15728.1.
CCDSiCCDS10379.2. [Q5W5X9-1]
RefSeqiNP_001275544.1. NM_001288615.1. [Q5W5X9-1]
NP_001275545.1. NM_001288616.1. [Q5W5X9-1]
XP_016878001.1. XM_017022512.1. [Q5W5X9-1]
XP_016878002.1. XM_017022513.1. [Q5W5X9-1]
XP_016878003.1. XM_017022514.1. [Q5W5X9-1]
XP_016878004.1. XM_017022515.1. [Q5W5X9-1]
XP_016878005.1. XM_017022516.1. [Q5W5X9-1]
XP_016878006.1. XM_017022517.1. [Q5W5X9-1]
XP_016878007.1. XM_017022518.1. [Q5W5X9-1]
UniGeneiHs.513195.
Hs.621260.
Hs.737076.

Genome annotation databases

EnsembliENST00000262074; ENSP00000262074; ENSG00000103852. [Q5W5X9-3]
ENST00000394129; ENSP00000457901; ENSG00000103852. [Q5W5X9-2]
ENST00000394132; ENSP00000377690; ENSG00000103852. [Q5W5X9-1]
ENST00000394135; ENSP00000377692; ENSG00000103852. [Q5W5X9-1]
ENST00000459771; ENSP00000433162; ENSG00000103852. [Q5W5X9-3]
ENST00000558663; ENSP00000452923; ENSG00000103852. [Q5W5X9-1]
GeneIDi64927.
KEGGihsa:64927.
UCSCiuc002buy.5. human. [Q5W5X9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411456 mRNA. Translation: AAQ03215.1.
AK022634 mRNA. Translation: BAB14144.1. Different initiation.
AK023230 mRNA. Translation: BAB14480.1.
AK222580 mRNA. Translation: BAD96300.1.
AK291690 mRNA. Translation: BAF84379.1.
BC015728 mRNA. Translation: AAH15728.1.
CCDSiCCDS10379.2. [Q5W5X9-1]
RefSeqiNP_001275544.1. NM_001288615.1. [Q5W5X9-1]
NP_001275545.1. NM_001288616.1. [Q5W5X9-1]
XP_016878001.1. XM_017022512.1. [Q5W5X9-1]
XP_016878002.1. XM_017022513.1. [Q5W5X9-1]
XP_016878003.1. XM_017022514.1. [Q5W5X9-1]
XP_016878004.1. XM_017022515.1. [Q5W5X9-1]
XP_016878005.1. XM_017022516.1. [Q5W5X9-1]
XP_016878006.1. XM_017022517.1. [Q5W5X9-1]
XP_016878007.1. XM_017022518.1. [Q5W5X9-1]
UniGeneiHs.513195.
Hs.621260.
Hs.737076.

3D structure databases

ProteinModelPortaliQ5W5X9.
SMRiQ5W5X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122349. 22 interactors.
IntActiQ5W5X9. 57 interactors.
STRINGi9606.ENSP00000262074.

PTM databases

iPTMnetiQ5W5X9.
PhosphoSitePlusiQ5W5X9.

Polymorphism and mutation databases

DMDMi74708246.

Proteomic databases

EPDiQ5W5X9.
PaxDbiQ5W5X9.
PRIDEiQ5W5X9.

Protocols and materials databases

DNASUi64927.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262074; ENSP00000262074; ENSG00000103852. [Q5W5X9-3]
ENST00000394129; ENSP00000457901; ENSG00000103852. [Q5W5X9-2]
ENST00000394132; ENSP00000377690; ENSG00000103852. [Q5W5X9-1]
ENST00000394135; ENSP00000377692; ENSG00000103852. [Q5W5X9-1]
ENST00000459771; ENSP00000433162; ENSG00000103852. [Q5W5X9-3]
ENST00000558663; ENSP00000452923; ENSG00000103852. [Q5W5X9-1]
GeneIDi64927.
KEGGihsa:64927.
UCSCiuc002buy.5. human. [Q5W5X9-1]

Organism-specific databases

CTDi64927.
GeneCardsiTTC23.
HGNCiHGNC:25730. TTC23.
HPAiHPA039806.
HPA040369.
neXtProtiNX_Q5W5X9.
OpenTargetsiENSG00000103852.
PharmGKBiPA142670675.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJRU. Eukaryota.
ENOG410XVCY. LUCA.
GeneTreeiENSGT00530000063847.
HOGENOMiHOG000154704.
HOVERGENiHBG096816.
InParanoidiQ5W5X9.
OMAiWKLAEAH.
OrthoDBiEOG091G08RQ.
PhylomeDBiQ5W5X9.
TreeFamiTF332604.

Miscellaneous databases

ChiTaRSiTTC23. human.
GenomeRNAii64927.
PROiQ5W5X9.

Gene expression databases

BgeeiENSG00000103852.
CleanExiHS_TTC23.
ExpressionAtlasiQ5W5X9. baseline and differential.
GenevisibleiQ5W5X9. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTTC23_HUMAN
AccessioniPrimary (citable) accession number: Q5W5X9
Secondary accession number(s): A8K6M5
, Q53HK0, Q96BC9, Q9H8W9, Q9H9S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.