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Protein

Tetratricopeptide repeat protein 23

Gene

TTC23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 23
Short name:
TPR repeat protein 23
Alternative name(s):
Cervical cancer proto-oncogene 8 protein
Short name:
HCC-8
Gene namesi
Name:TTC23
ORF Names:HCC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103852.12
HGNCiHGNC:25730 TTC23
neXtProtiNX_Q5W5X9

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103852
PharmGKBiPA142670675

Polymorphism and mutation databases

DMDMi74708246

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895481 – 447Tetratricopeptide repeat protein 23Add BLAST447

Proteomic databases

EPDiQ5W5X9
PaxDbiQ5W5X9
PeptideAtlasiQ5W5X9
PRIDEiQ5W5X9
ProteomicsDBi65810
65811 [Q5W5X9-2]
65812 [Q5W5X9-3]

PTM databases

iPTMnetiQ5W5X9
PhosphoSitePlusiQ5W5X9

Expressioni

Gene expression databases

BgeeiENSG00000103852
CleanExiHS_TTC23
ExpressionAtlasiQ5W5X9 baseline and differential
GenevisibleiQ5W5X9 HS

Organism-specific databases

HPAiHPA039806
HPA040369

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122349, 22 interactors
IntActiQ5W5X9, 70 interactors
MINTiQ5W5X9

Structurei

3D structure databases

ProteinModelPortaliQ5W5X9
SMRiQ5W5X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 78TPR 1Add BLAST34
Repeati137 – 170TPR 2Add BLAST34
Repeati186 – 219TPR 3Add BLAST34
Repeati356 – 389TPR 4Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IJRU Eukaryota
ENOG410XVCY LUCA
GeneTreeiENSGT00530000063847
HOGENOMiHOG000154704
HOVERGENiHBG096816
InParanoidiQ5W5X9
OMAiHWKLAEA
OrthoDBiEOG091G08RQ
PhylomeDBiQ5W5X9
TreeFamiTF332604

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W5X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQESQETHIS NHLDEVVAAV SITHRKKFQN KLLQTALFQP PREKLHLCEE
60 70 80 90 100
KAKSYSNSHE YKQAVHELVR CVALTRICYG DSHWKLAEAH VNLAQGYLQL
110 120 130 140 150
KGLSLQAKQH AEKARQILAN SIVPPYSENT DVFKFSIELF HTMGRALLSL
160 170 180 190 200
QKFKEAAENL TKAERLSKEL LQCGRIIKEE WIEIEARIRL SFAQVYQGQK
210 220 230 240 250
KSKEALSHYQ AALEYVEISK GETSRECVPI LRELAGVEQA LGLHDVSINH
260 270 280 290 300
FLQAHLIILS RSPSQVEAAD SAHIVAHAAV ASGRHEHHDV AEQYFQESMA
310 320 330 340 350
HLKDSEGMGR TKFLSIQDEF CHFLQMTGQK ERATSILRES LEAKVEAFGD
360 370 380 390 400
FSPEVAETYR LLGGADLAQG NHSGARKKLK KCLQIQTLLY GPQDKRTLAT
410 420 430 440
QQAMGMLSTA PKVASKPRQA SKAKVAFCTS IPQDTLLGKA RPGTTAD
Length:447
Mass (Da):50,009
Last modified:December 7, 2004 - v1
Checksum:i7548138692B33E57
GO
Isoform 2 (identifier: Q5W5X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-447: CLQIQTLLYG...GKARPGTTAD → VKLEPVLTRD

Show »
Length:391
Mass (Da):44,174
Checksum:i4D38FFBA005B3041
GO
Isoform 3 (identifier: Q5W5X9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-447: CLQIQTLLYG...GKARPGTTAD → GDLSFLLSATLP

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:393
Mass (Da):44,238
Checksum:iA7C4AAC73EAA15A5
GO

Sequence cautioni

The sequence BAB14144 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374G → E in BAD96300 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026017382 – 447CLQIQ…GTTAD → VKLEPVLTRD in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_026018382 – 447CLQIQ…GTTAD → GDLSFLLSATLP in isoform 3. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411456 mRNA Translation: AAQ03215.1
AK022634 mRNA Translation: BAB14144.1 Different initiation.
AK023230 mRNA Translation: BAB14480.1
AK222580 mRNA Translation: BAD96300.1
AK291690 mRNA Translation: BAF84379.1
BC015728 mRNA Translation: AAH15728.1
CCDSiCCDS10379.2 [Q5W5X9-1]
RefSeqiNP_001275544.1, NM_001288615.1 [Q5W5X9-1]
NP_001275545.1, NM_001288616.1 [Q5W5X9-1]
XP_016878001.1, XM_017022512.1 [Q5W5X9-1]
XP_016878002.1, XM_017022513.1 [Q5W5X9-1]
XP_016878003.1, XM_017022514.1 [Q5W5X9-1]
XP_016878004.1, XM_017022515.1 [Q5W5X9-1]
XP_016878005.1, XM_017022516.1 [Q5W5X9-1]
XP_016878006.1, XM_017022517.1 [Q5W5X9-1]
XP_016878007.1, XM_017022518.1 [Q5W5X9-1]
UniGeneiHs.513195
Hs.621260
Hs.737076

Genome annotation databases

EnsembliENST00000262074; ENSP00000262074; ENSG00000103852 [Q5W5X9-3]
ENST00000394129; ENSP00000457901; ENSG00000103852 [Q5W5X9-2]
ENST00000394132; ENSP00000377690; ENSG00000103852 [Q5W5X9-1]
ENST00000394135; ENSP00000377692; ENSG00000103852 [Q5W5X9-1]
ENST00000459771; ENSP00000433162; ENSG00000103852 [Q5W5X9-3]
ENST00000558663; ENSP00000452923; ENSG00000103852 [Q5W5X9-1]
GeneIDi64927
KEGGihsa:64927
UCSCiuc002buy.5 human [Q5W5X9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTTC23_HUMAN
AccessioniPrimary (citable) accession number: Q5W5X9
Secondary accession number(s): A8K6M5
, Q53HK0, Q96BC9, Q9H8W9, Q9H9S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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