Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cystatin-9

Gene

CST9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation (PubMed:12535658). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-9
Alternative name(s):
Cystatin-like molecule
Gene namesi
Name:CST9
Synonyms:CLM1 Publication, CTES7A1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13261. CST9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898267.

Polymorphism and mutation databases

BioMutaiCST9.
DMDMi74748036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 159131Cystatin-9PRO_0000314693Add
BLAST

Proteomic databases

PaxDbiQ5W186.
PRIDEiQ5W186.

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung, liver, skeletal muscle and pancreas (PubMed:12535658). Not expressed in brain (PubMed:12535658). Expressed in epididymis, kidney, testis, spinal cord, and thymus with a strong expression in epididymis and kidney and a weak expression in the spinal cord and thymus (PubMed:20565543).2 Publications

Inductioni

Up-regulated by bacterial lipopolysaccharides (LPS), in some cancer cells such as promyelocytic leukemia cells (HL-60) or myelomonocytic leukemia cells (U-937).1 Publication

Gene expression databases

BgeeiQ5W186.
CleanExiHS_CST9.
GenevisibleiQ5W186. HS.

Organism-specific databases

HPAiHPA029190.

Interactioni

Protein-protein interaction databases

BioGridi126160. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5W186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1WW. Eukaryota.
ENOG4111DUC. LUCA.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ5W186.
KOiK13905.
OMAiKAIPRDK.
OrthoDBiEOG7M98J9.
PhylomeDBiQ5W186.

Family and domain databases

InterProiIPR027214. Cystatin.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5W186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPQRRKAM PWALSLLLMG FQLLVTYAWC SEEEMGGNNK IVQDPMFLAT
60 70 80 90 100
VEFALNTFNV QSKEEHAYRL LRVLSSWRED SMDRKWRGKM VFSMNLQLRQ
110 120 130 140 150
TVCRKFEDDI DNCPFQESLE LNNVRQGISF PQVHSCGCCM GCGVGTGAAD

KAIPRDKGK
Length:159
Mass (Da):18,135
Last modified:December 7, 2004 - v1
Checksum:i89280B27DB7A3C0A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481L → F.1 Publication
Corresponds to variant rs2983640 [ dbSNP | Ensembl ].
VAR_038045

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494536 mRNA. Translation: AAM18055.1.
AL121894 Genomic DNA. Translation: CAH71437.1.
BC137302 mRNA. Translation: AAI37303.1.
BC137303 mRNA. Translation: AAI37304.1.
CCDSiCCDS33450.1.
RefSeqiNP_001008693.2. NM_001008693.2.
UniGeneiHs.698020.

Genome annotation databases

EnsembliENST00000376971; ENSP00000366170; ENSG00000173335.
GeneIDi128822.
KEGGihsa:128822.
UCSCiuc002wtl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494536 mRNA. Translation: AAM18055.1.
AL121894 Genomic DNA. Translation: CAH71437.1.
BC137302 mRNA. Translation: AAI37303.1.
BC137303 mRNA. Translation: AAI37304.1.
CCDSiCCDS33450.1.
RefSeqiNP_001008693.2. NM_001008693.2.
UniGeneiHs.698020.

3D structure databases

ProteinModelPortaliQ5W186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126160. 5 interactions.

Polymorphism and mutation databases

BioMutaiCST9.
DMDMi74748036.

Proteomic databases

PaxDbiQ5W186.
PRIDEiQ5W186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376971; ENSP00000366170; ENSG00000173335.
GeneIDi128822.
KEGGihsa:128822.
UCSCiuc002wtl.4. human.

Organism-specific databases

CTDi128822.
GeneCardsiCST9.
H-InvDBHIX0040530.
HGNCiHGNC:13261. CST9.
HPAiHPA029190.
MIMi616543. gene.
neXtProtiNX_Q5W186.
PharmGKBiPA134898267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1WW. Eukaryota.
ENOG4111DUC. LUCA.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ5W186.
KOiK13905.
OMAiKAIPRDK.
OrthoDBiEOG7M98J9.
PhylomeDBiQ5W186.

Miscellaneous databases

GenomeRNAii128822.
PROiQ5W186.
SOURCEiSearch...

Gene expression databases

BgeeiQ5W186.
CleanExiHS_CST9.
GenevisibleiQ5W186. HS.

Family and domain databases

InterProiIPR027214. Cystatin.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells."
    Sun H., Li N., Wang X., Liu S., Chen T., Zhang L., Wan T., Cao X.
    Biochem. Biophys. Res. Commun. 301:176-182(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION BY LPS, VARIANT PHE-48.
    Tissue: Bone marrow stroma.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins."
    Frygelius J., Arvestad L., Wedell A., Toehoenen V.
    Evol. Dev. 12:329-342(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiCST9_HUMAN
AccessioniPrimary (citable) accession number: Q5W186
Secondary accession number(s): B2RP76, Q8TD53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.