Reviewed, UniProtKB/Swiss-Prot Q5W111 (CLLD6_HUMAN)

Names and origin

Protein names

Recommended name:
    Chronic lymphocytic leukemia deletion region gene 6 protein
      Short name=CLL deletion region gene 6 protein

Gene names

Name:	CLLD6
Synonyms:	C13orf1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 B30.2/SPRY domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5W111-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5W111-2)

The sequence of this isoform differs from the canonical sequence as follows:
     37-75: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Chronic lymphocytic leukemia deletion region gene 6 protein		PRO_0000243925
Regions
	Domain	1 – 184	184	B30.2/SPRY
Natural variations
	Alternative sequence	37 – 75	39	Missing in isoform 2.		VSP_019498
Experimental info
	Sequence conflict	165	1	V → D in AAH22519. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 3E6633F59C636174	FASTA	196	21,666
	10 20 30 40 50 60 MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG TGGCLASAPL 70 80 90 100 110 120 HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL VMRNDGALYH NNEEKNRLPA 130 140 150 160 170 180 NSLPQEGDVV GITYDHVELN VYLNGKNMHC PASGIRGTVY PVVYVDDSAI LDCQFSEFYH 190 TPPPGFEKIL FEQQIF
	Isoform 2. Checksum: 0F3242D696565E41	FASTA	157	17,487
	10 20 30 40 50 60 MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGIWGI GVATQKVNLN QIPLGRDMHS 70 80 90 100 110 120 LVMRNDGALY HNNEEKNRLP ANSLPQEGDV VGITYDHVEL NVYLNGKNMH CPASGIRGTV 130 140 150 YPVVYVDDSA ILDCQFSEFY HTPPPGFEKI LFEQQIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia." Mabuchi H., Fujii H., Calin G., Alder H., Negrini M., Rassenti L., Kipps T.J., Bullrich F., Croce C.M. Cancer Res. 61:2870-2877(2001) [PubMed: 11306461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Yu W., Gibbs R.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF334405 mRNA. Translation: AAK38371.1. AF055016 mRNA. Translation: AAC09363.1. Different initiation. AK290576 mRNA. Translation: BAF83265.1. AL136123 Genomic DNA. Translation: CAH71578.1. CH471075 Genomic DNA. Translation: EAX08843.1. BC022519 mRNA. Translation: AAH22519.1.
IPI	IPI00290764. IPI00411705.
RefSeq	NP_001120954.1. NP_065189.1.
UniGene	Hs.44235
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5W111.
Proteomic databases
PRIDE	Q5W111.
Genome annotation databases
Ensembl	ENST00000361840; ENSP00000354774; ENSG00000123178; Homo sapiens. [Genome view]
GeneID	57213.
KEGG	hsa:57213.
UCSC	uc001vdl.2. human. uc001vdm.2. human.
Organism-specific databases
CTD	57213.
GeneCards	GC13M049384.
HGNC	HGNC:14297. C13orf1.
MIM	607866. gene.
PharmGKB	PA25511.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG315944.
HOVERGEN	Q5W111.
InParanoid	Q5W111.
OMA	PIVQNKA.
OrthoDB	EOG9PCDBX.
Gene expression databases
ArrayExpress	Q5W111.
Bgee	Q5W111.
CleanEx	HS_C13orf1.
Genevestigator	Q5W111.
GermOnline	ENSG00000123178. Homo sapiens.
Family and domain databases
InterPro	IPR001870. B302. IPR018355. SPla/RYanodine_receptor_sg. IPR003877. SPRY_rcpt. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. [Graphical view]
SMART	SM00449. SPRY. 1 hit. [Graphical view]
PROSITE	PS50188. B302_SPRY. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	63325.
SOURCE	Search...

Entry information

Entry name

CLLD6_HUMAN

Accession

Primary (citable) accession number: Q5W111
Secondary accession number(s): A8K3G1 , O60648, Q8TBG8, Q96T69

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	December 15, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.