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Q5W111

- SPRY7_HUMAN

UniProt

Q5W111 - SPRY7_HUMAN

Protein

SPRY domain-containing protein 7

Gene

SPRYD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SPRY domain-containing protein 7
    Alternative name(s):
    Chronic lymphocytic leukemia deletion region gene 6 protein
    Short name:
    CLL deletion region gene 6 protein
    Gene namesi
    Name:SPRYD7
    Synonyms:C13orf1, CLLD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:14297. SPRYD7.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25511.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 196195SPRY domain-containing protein 7PRO_0000243925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ5W111.
    PaxDbiQ5W111.
    PRIDEiQ5W111.

    PTM databases

    PhosphoSiteiQ5W111.

    Expressioni

    Gene expression databases

    BgeeiQ5W111.
    CleanExiHS_C13orf1.
    GenevestigatoriQ5W111.

    Organism-specific databases

    HPAiHPA043934.

    Interactioni

    Protein-protein interaction databases

    BioGridi121451. 2 interactions.
    STRINGi9606.ENSP00000354774.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5W111.
    SMRiQ5W111. Positions 25-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 184183B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291635.
    HOVERGENiHBG056533.
    InParanoidiQ5W111.
    OMAiASAITHY.
    OrthoDBiEOG7J447S.
    PhylomeDBiQ5W111.
    TreeFamiTF314996.

    Family and domain databases

    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5W111-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG    50
    TGGCLASAPL HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL 100
    VMRNDGALYH NNEEKNRLPA NSLPQEGDVV GITYDHVELN VYLNGKNMHC 150
    PASGIRGTVY PVVYVDDSAI LDCQFSEFYH TPPPGFEKIL FEQQIF 196
    Length:196
    Mass (Da):21,666
    Last modified:June 27, 2006 - v2
    Checksum:i3E6633F59C636174
    GO
    Isoform 2 (identifier: Q5W111-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         37-75: Missing.

    Show »
    Length:157
    Mass (Da):17,487
    Checksum:i0F3242D696565E41
    GO

    Sequence cautioni

    The sequence AAC09363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651V → D in AAH22519. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei37 – 7539Missing in isoform 2. 2 PublicationsVSP_019498Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF334405 mRNA. Translation: AAK38371.1.
    AF055016 mRNA. Translation: AAC09363.1. Different initiation.
    AK290576 mRNA. Translation: BAF83265.1.
    AL136123 Genomic DNA. Translation: CAH71578.1.
    CH471075 Genomic DNA. Translation: EAX08843.1.
    BC022519 mRNA. Translation: AAH22519.1.
    CCDSiCCDS45046.1. [Q5W111-2]
    CCDS9422.1. [Q5W111-1]
    RefSeqiNP_001120954.1. NM_001127482.1. [Q5W111-2]
    NP_065189.1. NM_020456.2. [Q5W111-1]
    UniGeneiHs.44235.

    Genome annotation databases

    EnsembliENST00000361840; ENSP00000354774; ENSG00000123178. [Q5W111-1]
    ENST00000378195; ENSP00000367437; ENSG00000123178. [Q5W111-2]
    GeneIDi57213.
    KEGGihsa:57213.
    UCSCiuc001vdl.2. human. [Q5W111-1]
    uc001vdm.2. human. [Q5W111-2]

    Polymorphism databases

    DMDMi109821809.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF334405 mRNA. Translation: AAK38371.1 .
    AF055016 mRNA. Translation: AAC09363.1 . Different initiation.
    AK290576 mRNA. Translation: BAF83265.1 .
    AL136123 Genomic DNA. Translation: CAH71578.1 .
    CH471075 Genomic DNA. Translation: EAX08843.1 .
    BC022519 mRNA. Translation: AAH22519.1 .
    CCDSi CCDS45046.1. [Q5W111-2 ]
    CCDS9422.1. [Q5W111-1 ]
    RefSeqi NP_001120954.1. NM_001127482.1. [Q5W111-2 ]
    NP_065189.1. NM_020456.2. [Q5W111-1 ]
    UniGenei Hs.44235.

    3D structure databases

    ProteinModelPortali Q5W111.
    SMRi Q5W111. Positions 25-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121451. 2 interactions.
    STRINGi 9606.ENSP00000354774.

    PTM databases

    PhosphoSitei Q5W111.

    Polymorphism databases

    DMDMi 109821809.

    Proteomic databases

    MaxQBi Q5W111.
    PaxDbi Q5W111.
    PRIDEi Q5W111.

    Protocols and materials databases

    DNASUi 57213.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361840 ; ENSP00000354774 ; ENSG00000123178 . [Q5W111-1 ]
    ENST00000378195 ; ENSP00000367437 ; ENSG00000123178 . [Q5W111-2 ]
    GeneIDi 57213.
    KEGGi hsa:57213.
    UCSCi uc001vdl.2. human. [Q5W111-1 ]
    uc001vdm.2. human. [Q5W111-2 ]

    Organism-specific databases

    CTDi 57213.
    GeneCardsi GC13M050487.
    HGNCi HGNC:14297. SPRYD7.
    HPAi HPA043934.
    MIMi 607866. gene.
    neXtProti NX_Q5W111.
    PharmGKBi PA25511.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291635.
    HOVERGENi HBG056533.
    InParanoidi Q5W111.
    OMAi ASAITHY.
    OrthoDBi EOG7J447S.
    PhylomeDBi Q5W111.
    TreeFami TF314996.

    Miscellaneous databases

    GeneWikii C13orf1.
    GenomeRNAii 57213.
    NextBioi 63325.
    PROi Q5W111.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5W111.
    CleanExi HS_C13orf1.
    Genevestigatori Q5W111.

    Family and domain databases

    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia."
      Mabuchi H., Fujii H., Calin G., Alder H., Negrini M., Rassenti L., Kipps T.J., Bullrich F., Croce C.M.
      Cancer Res. 61:2870-2877(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Yu W., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPRY7_HUMAN
    AccessioniPrimary (citable) accession number: Q5W111
    Secondary accession number(s): A8K3G1
    , O60648, Q8TBG8, Q96T69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3