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Q5W111

- SPRY7_HUMAN

UniProt

Q5W111 - SPRY7_HUMAN

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Protein

SPRY domain-containing protein 7

Gene
SPRYD7, C13orf1, CLLD6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 7
Alternative name(s):
Chronic lymphocytic leukemia deletion region gene 6 protein
Short name:
CLL deletion region gene 6 protein
Gene namesi
Name:SPRYD7
Synonyms:C13orf1, CLLD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:14297. SPRYD7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 196195SPRY domain-containing protein 7PRO_0000243925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ5W111.
PaxDbiQ5W111.
PRIDEiQ5W111.

PTM databases

PhosphoSiteiQ5W111.

Expressioni

Gene expression databases

BgeeiQ5W111.
CleanExiHS_C13orf1.
GenevestigatoriQ5W111.

Organism-specific databases

HPAiHPA043934.

Interactioni

Protein-protein interaction databases

BioGridi121451. 2 interactions.
STRINGi9606.ENSP00000354774.

Structurei

3D structure databases

ProteinModelPortaliQ5W111.
SMRiQ5W111. Positions 25-189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 184183B30.2/SPRYAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.

Phylogenomic databases

eggNOGiNOG291635.
HOVERGENiHBG056533.
InParanoidiQ5W111.
OMAiASAITHY.
OrthoDBiEOG7J447S.
PhylomeDBiQ5W111.
TreeFamiTF314996.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5W111-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG    50
TGGCLASAPL HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL 100
VMRNDGALYH NNEEKNRLPA NSLPQEGDVV GITYDHVELN VYLNGKNMHC 150
PASGIRGTVY PVVYVDDSAI LDCQFSEFYH TPPPGFEKIL FEQQIF 196
Length:196
Mass (Da):21,666
Last modified:June 27, 2006 - v2
Checksum:i3E6633F59C636174
GO
Isoform 2 (identifier: Q5W111-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-75: Missing.

Show »
Length:157
Mass (Da):17,487
Checksum:i0F3242D696565E41
GO

Sequence cautioni

The sequence AAC09363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 7539Missing in isoform 2. VSP_019498Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651V → D in AAH22519. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF334405 mRNA. Translation: AAK38371.1.
AF055016 mRNA. Translation: AAC09363.1. Different initiation.
AK290576 mRNA. Translation: BAF83265.1.
AL136123 Genomic DNA. Translation: CAH71578.1.
CH471075 Genomic DNA. Translation: EAX08843.1.
BC022519 mRNA. Translation: AAH22519.1.
CCDSiCCDS45046.1. [Q5W111-2]
CCDS9422.1. [Q5W111-1]
RefSeqiNP_001120954.1. NM_001127482.1. [Q5W111-2]
NP_065189.1. NM_020456.2. [Q5W111-1]
UniGeneiHs.44235.

Genome annotation databases

EnsembliENST00000361840; ENSP00000354774; ENSG00000123178. [Q5W111-1]
ENST00000378195; ENSP00000367437; ENSG00000123178. [Q5W111-2]
GeneIDi57213.
KEGGihsa:57213.
UCSCiuc001vdl.2. human. [Q5W111-1]
uc001vdm.2. human. [Q5W111-2]

Polymorphism databases

DMDMi109821809.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF334405 mRNA. Translation: AAK38371.1 .
AF055016 mRNA. Translation: AAC09363.1 . Different initiation.
AK290576 mRNA. Translation: BAF83265.1 .
AL136123 Genomic DNA. Translation: CAH71578.1 .
CH471075 Genomic DNA. Translation: EAX08843.1 .
BC022519 mRNA. Translation: AAH22519.1 .
CCDSi CCDS45046.1. [Q5W111-2 ]
CCDS9422.1. [Q5W111-1 ]
RefSeqi NP_001120954.1. NM_001127482.1. [Q5W111-2 ]
NP_065189.1. NM_020456.2. [Q5W111-1 ]
UniGenei Hs.44235.

3D structure databases

ProteinModelPortali Q5W111.
SMRi Q5W111. Positions 25-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121451. 2 interactions.
STRINGi 9606.ENSP00000354774.

PTM databases

PhosphoSitei Q5W111.

Polymorphism databases

DMDMi 109821809.

Proteomic databases

MaxQBi Q5W111.
PaxDbi Q5W111.
PRIDEi Q5W111.

Protocols and materials databases

DNASUi 57213.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361840 ; ENSP00000354774 ; ENSG00000123178 . [Q5W111-1 ]
ENST00000378195 ; ENSP00000367437 ; ENSG00000123178 . [Q5W111-2 ]
GeneIDi 57213.
KEGGi hsa:57213.
UCSCi uc001vdl.2. human. [Q5W111-1 ]
uc001vdm.2. human. [Q5W111-2 ]

Organism-specific databases

CTDi 57213.
GeneCardsi GC13M050487.
HGNCi HGNC:14297. SPRYD7.
HPAi HPA043934.
MIMi 607866. gene.
neXtProti NX_Q5W111.
PharmGKBi PA25511.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291635.
HOVERGENi HBG056533.
InParanoidi Q5W111.
OMAi ASAITHY.
OrthoDBi EOG7J447S.
PhylomeDBi Q5W111.
TreeFami TF314996.

Miscellaneous databases

GeneWikii C13orf1.
GenomeRNAii 57213.
NextBioi 63325.
PROi Q5W111.
SOURCEi Search...

Gene expression databases

Bgeei Q5W111.
CleanExi HS_C13orf1.
Genevestigatori Q5W111.

Family and domain databases

InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia."
    Mabuchi H., Fujii H., Calin G., Alder H., Negrini M., Rassenti L., Kipps T.J., Bullrich F., Croce C.M.
    Cancer Res. 61:2870-2877(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Yu W., Gibbs R.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPRY7_HUMAN
AccessioniPrimary (citable) accession number: Q5W111
Secondary accession number(s): A8K3G1
, O60648, Q8TBG8, Q96T69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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