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Protein

SPRY domain-containing protein 7

Gene

SPRYD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 7
Alternative name(s):
Chronic lymphocytic leukemia deletion region gene 6 protein
Short name:
CLL deletion region gene 6 protein
Gene namesi
Name:SPRYD7
Synonyms:C13orf1, CLLD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000123178.14.
HGNCiHGNC:14297. SPRYD7.

Pathology & Biotechi

Organism-specific databases

DisGeNETi57213.
OpenTargetsiENSG00000123178.
PharmGKBiPA25511.

Polymorphism and mutation databases

BioMutaiSPRYD7.
DMDMi109821809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002439252 – 196SPRY domain-containing protein 7Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5W111.
MaxQBiQ5W111.
PaxDbiQ5W111.
PeptideAtlasiQ5W111.
PRIDEiQ5W111.

PTM databases

iPTMnetiQ5W111.
PhosphoSitePlusiQ5W111.
SwissPalmiQ5W111.

Expressioni

Gene expression databases

BgeeiENSG00000123178.
CleanExiHS_C13orf1.
ExpressionAtlasiQ5W111. baseline and differential.
GenevisibleiQ5W111. HS.

Organism-specific databases

HPAiHPA043934.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121451. 17 interactors.
IntActiQ5W111. 5 interactors.
STRINGi9606.ENSP00000354774.

Structurei

3D structure databases

ProteinModelPortaliQ5W111.
SMRiQ5W111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 184B30.2/SPRYPROSITE-ProRule annotationAdd BLAST183

Phylogenomic databases

eggNOGiKOG4030. Eukaryota.
ENOG410XNNE. LUCA.
GeneTreeiENSGT00390000011048.
HOVERGENiHBG056533.
InParanoidiQ5W111.
OMAiDRESWCL.
OrthoDBiEOG091G0KM6.
PhylomeDBiQ5W111.
TreeFamiTF314996.

Family and domain databases

InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
PfamiView protein in Pfam
PF00622. SPRY. 1 hit.
SMARTiView protein in SMART
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W111-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG
60 70 80 90 100
TGGCLASAPL HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL
110 120 130 140 150
VMRNDGALYH NNEEKNRLPA NSLPQEGDVV GITYDHVELN VYLNGKNMHC
160 170 180 190
PASGIRGTVY PVVYVDDSAI LDCQFSEFYH TPPPGFEKIL FEQQIF
Length:196
Mass (Da):21,666
Last modified:June 27, 2006 - v2
Checksum:i3E6633F59C636174
GO
Isoform 2 (identifier: Q5W111-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-75: Missing.

Show »
Length:157
Mass (Da):17,487
Checksum:i0F3242D696565E41
GO

Sequence cautioni

The sequence AAC09363 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165V → D in AAH22519 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01949837 – 75Missing in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334405 mRNA. Translation: AAK38371.1.
AF055016 mRNA. Translation: AAC09363.1. Different initiation.
AK290576 mRNA. Translation: BAF83265.1.
AL136123 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08843.1.
BC022519 mRNA. Translation: AAH22519.1.
CCDSiCCDS45046.1. [Q5W111-2]
CCDS9422.1. [Q5W111-1]
RefSeqiNP_001120954.1. NM_001127482.2. [Q5W111-2]
NP_065189.1. NM_020456.3. [Q5W111-1]
UniGeneiHs.44235.

Genome annotation databases

EnsembliENST00000361840; ENSP00000354774; ENSG00000123178. [Q5W111-1]
ENST00000378195; ENSP00000367437; ENSG00000123178. [Q5W111-2]
ENST00000613924; ENSP00000484495; ENSG00000123178. [Q5W111-2]
GeneIDi57213.
KEGGihsa:57213.
UCSCiuc001vdl.3. human. [Q5W111-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSPRY7_HUMAN
AccessioniPrimary (citable) accession number: Q5W111
Secondary accession number(s): A8K3G1
, O60648, Q8TBG8, Q96T69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 27, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot