ID Q5W0W2_HUMAN Unreviewed; 375 AA. AC Q5W0W2; DT 07-DEC-2004, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 4. DT 27-MAR-2024, entry version 123. DE SubName: Full=KN motif and ankyrin repeat domains 1 {ECO:0000313|Ensembl:ENSP00000371723.4}; GN Name=KANK1 {ECO:0000313|Ensembl:ENSP00000371723.4}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371723.4, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000371723.4, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000371723.4} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL136979; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL161725; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL392089; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; Q5W0W2; -. DR IntAct; Q5W0W2; 1. DR EPD; Q5W0W2; -. DR MassIVE; Q5W0W2; -. DR ProteomicsDB; 65783; -. DR Antibodypedia; 1018; 118 antibodies from 25 providers. DR Ensembl; ENST00000382286.3; ENSP00000371723.4; ENSG00000107104.21. DR UCSC; uc003zgt.2; human. DR HGNC; HGNC:19309; KANK1. DR VEuPathDB; HostDB:ENSG00000107104; -. DR GeneTree; ENSGT00940000154886; -. DR HOGENOM; CLU_049797_0_0_1; -. DR ChiTaRS; KANK1; human. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000107104; Expressed in blood vessel layer and 206 other cell types or tissues. DR ExpressionAtlas; Q5W0W2; baseline and differential. DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR047184; KANK1-4. DR PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1. DR PANTHER; PTHR24168:SF19; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF12796; Ank_2; 2. DR PRINTS; PR01415; ANKYRIN. DR SMART; SM00248; ANK; 5. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR PROSITE; PS50297; ANK_REP_REGION; 3. DR PROSITE; PS50088; ANK_REPEAT; 3. PE 1: Evidence at protein level; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Proteomics identification {ECO:0007829|EPD:Q5W0W2, KW ECO:0007829|MaxQB:Q5W0W2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REPEAT 184..206 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 256..288 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 289..310 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REGION 1..72 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 354..375 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12..37 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 38..66 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 375 AA; 40660 MW; C4B84D534F277A65 CRC64; MKKKDGNKDS NGAKKNLQFV GINGGYETTS SDDSSSDESS SSESDDECDV IEYPLEEEEE EEDEDTRGMA EGHHAVNIEG LKSARVEDEM QVQECEPEKV EIRERYELSE KMLSACNLLK NTINDPKALT SKDMRFCLNT LQHEWFRVSS QKSAIPAMVG DYIAAFEAIS PDVLRYVINL ADGNGNTALH YSVSHSNFEI VKLLLDADVC NVDHQNKAGY TPIMLAALAA VEAEKDMRIV EELFGCGDVN AKASQAGQTA LMLAVSHGRI DMVKGLLACG ADVNIQDDEG STALMCASEH GHVEIVKLLL AQPGCNGHLE DNDGSTALSI ALEAGHKDIA VLLYAHVNFA KAQSPGTPRL GRKTSPGPTH RGSFD //