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Protein

Protein FAM160B1

Gene

FAM160B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM160B1
Gene namesi
Name:FAM160B1
Synonyms:KIAA1600
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29320. FAM160B1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386798.

Polymorphism and mutation databases

BioMutaiFAM160B1.
DMDMi74747988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Protein FAM160B1PRO_0000284648Add
BLAST

Proteomic databases

EPDiQ5W0V3.
MaxQBiQ5W0V3.
PaxDbiQ5W0V3.
PeptideAtlasiQ5W0V3.
PRIDEiQ5W0V3.

PTM databases

iPTMnetiQ5W0V3.
PhosphoSiteiQ5W0V3.

Expressioni

Gene expression databases

BgeeiENSG00000151553.
CleanExiHS_FAM160B1.
ExpressionAtlasiQ5W0V3. baseline and differential.
GenevisibleiQ5W0V3. HS.

Organism-specific databases

HPAiHPA043624.

Interactioni

Protein-protein interaction databases

BioGridi121725. 6 interactions.
IntActiQ5W0V3. 2 interactions.
MINTiMINT-8201763.
STRINGi9606.ENSP00000358251.

Structurei

3D structure databases

ProteinModelPortaliQ5W0V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0518 family.Curated

Phylogenomic databases

eggNOGiENOG410IN31. Eukaryota.
ENOG410XTDG. LUCA.
GeneTreeiENSGT00760000119270.
HOGENOMiHOG000006896.
HOVERGENiHBG107875.
InParanoidiQ5W0V3.
OMAiEPAAAKC.
OrthoDBiEOG091G04PO.
PhylomeDBiQ5W0V3.
TreeFamiTF313941.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W0V3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSKFTSILQ HAVEALAPSL PLQEDFVYHW KAITHYYIET SDDKAPVTDT
60 70 80 90 100
NIPSHLEQML DILVQEENER ESGETGPCME YLLHHKILET LYTLGKADCP
110 120 130 140 150
PGMKQQVLVF YTKLLGRIRQ PLLPHINVHR PVQKLIRLCG EVLATPTENE
160 170 180 190 200
EIQFLCIVCA KLKQDPYLVN FFLENKMKSL ASKGVPNVIS EDTLKGQDSL
210 220 230 240 250
STDTGQSRQP EELSGATGME QTELEDEPPH QMDHLSTSLD NLSVTSLPEA
260 270 280 290 300
SVVCPNQDYN LVNSLLNLTR SPDGRIAVKA CEGLMLLVSL PEPAAAKCLT
310 320 330 340 350
QSTCLCELLT DRLASLYKAL PQSVDPLDIE TVEAINWGLD SYSHKEDASA
360 370 380 390 400
FPGKRALISF LSWFDYCDQL IKEAQKTAAV ALAKAVHERF FIGVMEPQLM
410 420 430 440 450
QTSEMGILTS TALLHRIVRQ VTSDVLLQEM VFFILGEQRE PETLAEISRH
460 470 480 490 500
PLRHRLIEHC DHISDEISIM TLRMFEHLLQ KPNEHILYNL VLRNLEERNY
510 520 530 540 550
TEYKPLCPED KDVVENGLIA GAVDLEEDPL FTDISPENTL PNQEWLSSSP
560 570 580 590 600
PATPDHPKND GKTEVHKIVN SFLCLVPDDA KSSYHVEGTG YDTYLRDAHR
610 620 630 640 650
QFRDYCAICL RWEWPGSPKA LEKCNLEAAF FEGHFLKVLF DRMGRILDQP
660 670 680 690 700
YDVNLQVTSV LSRLSLFPHP HIHEYLLDPY VNLAPGCRSL FSVIVRVVGD
710 720 730 740 750
LMLRIQRIQD FTPKLLLVRK RLLGLEPEGP IIDHITLLEG VIVLEEFCKE
760
LAAIAFVKYH ASSTP
Length:765
Mass (Da):86,558
Last modified:December 7, 2004 - v1
Checksum:i3F65615B0DE5CED3
GO
Isoform 2 (identifier: Q5W0V3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-738: IIDHITLL → MQTLPSWW
     739-765: Missing.

Show »
Length:738
Mass (Da):83,735
Checksum:iEE36F52D44ADB43B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391E → G in CAI45992 (PubMed:17974005).Curated
Sequence conflicti120 – 1201Q → R in CAI45992 (PubMed:17974005).Curated
Sequence conflicti600 – 6001R → G in CAI45992 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti408 – 4081L → I.1 Publication
Corresponds to variant rs17853717 [ dbSNP | Ensembl ].
VAR_031793
Natural varianti631 – 6311F → L.
Corresponds to variant rs3180654 [ dbSNP | Ensembl ].
VAR_031794

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei731 – 7388IIDHITLL → MQTLPSWW in isoform 2. 1 PublicationVSP_024590
Alternative sequencei739 – 76527Missing in isoform 2. 1 PublicationVSP_024591Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR933692 mRNA. Translation: CAI45992.1.
AL137025 Genomic DNA. Translation: CAH69999.1.
AL137025 Genomic DNA. Translation: CAH70000.1.
BC037207 mRNA. Translation: AAH37207.1.
AB046820 mRNA. Translation: BAB13426.2.
CCDSiCCDS31290.1. [Q5W0V3-1]
CCDS44480.1. [Q5W0V3-2]
RefSeqiNP_001128523.1. NM_001135051.1. [Q5W0V3-2]
NP_065991.3. NM_020940.3. [Q5W0V3-1]
UniGeneiHs.192619.

Genome annotation databases

EnsembliENST00000369248; ENSP00000358251; ENSG00000151553. [Q5W0V3-1]
ENST00000369250; ENSP00000358253; ENSG00000151553. [Q5W0V3-2]
GeneIDi57700.
KEGGihsa:57700.
UCSCiuc001lcb.4. human. [Q5W0V3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR933692 mRNA. Translation: CAI45992.1.
AL137025 Genomic DNA. Translation: CAH69999.1.
AL137025 Genomic DNA. Translation: CAH70000.1.
BC037207 mRNA. Translation: AAH37207.1.
AB046820 mRNA. Translation: BAB13426.2.
CCDSiCCDS31290.1. [Q5W0V3-1]
CCDS44480.1. [Q5W0V3-2]
RefSeqiNP_001128523.1. NM_001135051.1. [Q5W0V3-2]
NP_065991.3. NM_020940.3. [Q5W0V3-1]
UniGeneiHs.192619.

3D structure databases

ProteinModelPortaliQ5W0V3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121725. 6 interactions.
IntActiQ5W0V3. 2 interactions.
MINTiMINT-8201763.
STRINGi9606.ENSP00000358251.

PTM databases

iPTMnetiQ5W0V3.
PhosphoSiteiQ5W0V3.

Polymorphism and mutation databases

BioMutaiFAM160B1.
DMDMi74747988.

Proteomic databases

EPDiQ5W0V3.
MaxQBiQ5W0V3.
PaxDbiQ5W0V3.
PeptideAtlasiQ5W0V3.
PRIDEiQ5W0V3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369248; ENSP00000358251; ENSG00000151553. [Q5W0V3-1]
ENST00000369250; ENSP00000358253; ENSG00000151553. [Q5W0V3-2]
GeneIDi57700.
KEGGihsa:57700.
UCSCiuc001lcb.4. human. [Q5W0V3-1]

Organism-specific databases

CTDi57700.
GeneCardsiFAM160B1.
H-InvDBHIX0009230.
HGNCiHGNC:29320. FAM160B1.
HPAiHPA043624.
neXtProtiNX_Q5W0V3.
PharmGKBiPA162386798.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN31. Eukaryota.
ENOG410XTDG. LUCA.
GeneTreeiENSGT00760000119270.
HOGENOMiHOG000006896.
HOVERGENiHBG107875.
InParanoidiQ5W0V3.
OMAiEPAAAKC.
OrthoDBiEOG091G04PO.
PhylomeDBiQ5W0V3.
TreeFamiTF313941.

Miscellaneous databases

ChiTaRSiFAM160B1. human.
GenomeRNAii57700.
PROiQ5W0V3.

Gene expression databases

BgeeiENSG00000151553.
CleanExiHS_FAM160B1.
ExpressionAtlasiQ5W0V3. baseline and differential.
GenevisibleiQ5W0V3. HS.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16B1_HUMAN
AccessioniPrimary (citable) accession number: Q5W0V3
Secondary accession number(s): Q5H9P7
, Q5W0V2, Q8IY76, Q9HCH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.