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Q5W0U4

- BSPRY_HUMAN

UniProt

Q5W0U4 - BSPRY_HUMAN

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Protein

B box and SPRY domain-containing protein

Gene

BSPRY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May regulate epithelial calcium transport by inhibiting TRPV5 activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 6549B box-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. calcium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B box and SPRY domain-containing protein
Gene namesi
Name:BSPRY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18232. BSPRY.

Subcellular locationi

Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cell leading edge Source: Ensembl
  2. membrane Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402B box and SPRY domain-containing proteinPRO_0000244257Add
BLAST

Proteomic databases

MaxQBiQ5W0U4.
PaxDbiQ5W0U4.
PRIDEiQ5W0U4.

PTM databases

PhosphoSiteiQ5W0U4.

Expressioni

Gene expression databases

BgeeiQ5W0U4.
CleanExiHS_BSPRY.
GenevestigatoriQ5W0U4.

Organism-specific databases

HPAiHPA042889.

Interactioni

Subunit structurei

Interacts with TRPV5 and TRPV6. Interacts with YWHAZ/14-3-3 protein zeta (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5W0U4. 1 interaction.
STRINGi9606.ENSP00000363298.

Structurei

3D structure databases

ProteinModelPortaliQ5W0U4.
SMRiQ5W0U4. Positions 18-191, 231-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 402191B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 6549B box-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG264516.
GeneTreeiENSGT00760000119283.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ5W0U4.
OMAiAQELLFY.
OrthoDBiEOG7H1JKW.
PhylomeDBiQ5W0U4.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5W0U4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEGAEPGP GSGSGPGPGP LCPEHGQALS WFCGSERRPV CAACAGLGGR
60 70 80 90 100
CRGHRIRRAE ERAEELRNKI VDQCERLQLQ SAAITKYVAD VLPGKNQRAV
110 120 130 140 150
SMASAARELV IQRLSLVRSL CESEEQRLLE QVHGEEERAH QSILTQRVHW
160 170 180 190 200
AEALQKLDTI RTGLVGMLTH LDDLQLIQKE QEIFERTEEA EGILDPQESE
210 220 230 240 250
MLNFNEKCTR SPLLTQLWAT AVLGSLSGTE DIRIDERTVS PFLQLSDDRK
260 270 280 290 300
TLTFSTKKSK ACADGPERFD HWPNALAATS FQNGLHAWMV NVQNSCAYKV
310 320 330 340 350
GVASGHLPRK GSGSDCRLGH NAFSWVFSRY DQEFRFSHNG QHEPLGLLRG
360 370 380 390 400
PAQLGVVLDL QVQELLFYEP ASGTVLCAHH VSFPGPLFPV FAVADQTISI

VR
Length:402
Mass (Da):44,381
Last modified:December 7, 2004 - v1
Checksum:iEEBBB95B0A9863F4
GO
Isoform 2 (identifier: Q5W0U4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-193: TEEAEGI → HRGHTDR
     194-402: Missing.

Note: No experimental confirmation available.

Show »
Length:193
Mass (Da):21,413
Checksum:i39D43152A32707B0
GO

Sequence cautioni

The sequence BAA90980.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001V → E in BAA90980. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti261 – 2611A → P.
Corresponds to variant rs34089316 [ dbSNP | Ensembl ].
VAR_048397
Natural varianti293 – 2931Q → H.
Corresponds to variant rs818711 [ dbSNP | Ensembl ].
VAR_026882
Natural varianti374 – 3741T → I.2 Publications
Corresponds to variant rs3088235 [ dbSNP | Ensembl ].
VAR_026883

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 1937TEEAEGI → HRGHTDR in isoform 2. 1 PublicationVSP_019527
Alternative sequencei194 – 402209Missing in isoform 2. 1 PublicationVSP_019528Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276691 mRNA. Translation: CAC09324.1.
AL137066 Genomic DNA. Translation: CAH70097.1.
CH471090 Genomic DNA. Translation: EAW87374.1.
BC001477 mRNA. Translation: AAH01477.1.
AK000157 mRNA. Translation: BAA90980.1. Different initiation.
AK092607 mRNA. Translation: BAG52581.1.
CCDSiCCDS43868.1. [Q5W0U4-1]
RefSeqiNP_060158.2. NM_017688.2. [Q5W0U4-1]
XP_005252120.1. XM_005252063.2. [Q5W0U4-2]
UniGeneiHs.614517.

Genome annotation databases

EnsembliENST00000374183; ENSP00000363298; ENSG00000119411. [Q5W0U4-1]
GeneIDi54836.
KEGGihsa:54836.
UCSCiuc004bhg.4. human. [Q5W0U4-1]
uc010muw.3. human. [Q5W0U4-2]

Polymorphism databases

DMDMi74747982.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276691 mRNA. Translation: CAC09324.1 .
AL137066 Genomic DNA. Translation: CAH70097.1 .
CH471090 Genomic DNA. Translation: EAW87374.1 .
BC001477 mRNA. Translation: AAH01477.1 .
AK000157 mRNA. Translation: BAA90980.1 . Different initiation.
AK092607 mRNA. Translation: BAG52581.1 .
CCDSi CCDS43868.1. [Q5W0U4-1 ]
RefSeqi NP_060158.2. NM_017688.2. [Q5W0U4-1 ]
XP_005252120.1. XM_005252063.2. [Q5W0U4-2 ]
UniGenei Hs.614517.

3D structure databases

ProteinModelPortali Q5W0U4.
SMRi Q5W0U4. Positions 18-191, 231-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5W0U4. 1 interaction.
STRINGi 9606.ENSP00000363298.

PTM databases

PhosphoSitei Q5W0U4.

Polymorphism databases

DMDMi 74747982.

Proteomic databases

MaxQBi Q5W0U4.
PaxDbi Q5W0U4.
PRIDEi Q5W0U4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374183 ; ENSP00000363298 ; ENSG00000119411 . [Q5W0U4-1 ]
GeneIDi 54836.
KEGGi hsa:54836.
UCSCi uc004bhg.4. human. [Q5W0U4-1 ]
uc010muw.3. human. [Q5W0U4-2 ]

Organism-specific databases

CTDi 54836.
GeneCardsi GC09P116111.
HGNCi HGNC:18232. BSPRY.
HPAi HPA042889.
neXtProti NX_Q5W0U4.
PharmGKBi PA134979106.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264516.
GeneTreei ENSGT00760000119283.
HOGENOMi HOG000057290.
HOVERGENi HBG080574.
InParanoidi Q5W0U4.
OMAi AQELLFY.
OrthoDBi EOG7H1JKW.
PhylomeDBi Q5W0U4.
TreeFami TF351014.

Miscellaneous databases

ChiTaRSi BSPRY. human.
GenomeRNAii 54836.
NextBioi 57630.
PROi Q5W0U4.

Gene expression databases

Bgeei Q5W0U4.
CleanExi HS_BSPRY.
Genevestigatori Q5W0U4.

Family and domain databases

Gene3Di 4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00589. PRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BSPRY, a novel protein of the Ro-Ret family."
    Schenker T., Trueb B.
    Biochim. Biophys. Acta 1493:255-258(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-374.
    Tissue: Placenta.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-374.
    Tissue: Colon and Prostate.

Entry informationi

Entry nameiBSPRY_HUMAN
AccessioniPrimary (citable) accession number: Q5W0U4
Secondary accession number(s): B3KS19
, Q96DJ2, Q9H4E4, Q9NXN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3