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Q5W0U4

- BSPRY_HUMAN

UniProt

Q5W0U4 - BSPRY_HUMAN

Protein

B box and SPRY domain-containing protein

Gene

BSPRY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    May regulate epithelial calcium transport by inhibiting TRPV5 activity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri17 – 6549B box-typeAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B box and SPRY domain-containing protein
    Gene namesi
    Name:BSPRY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18232. BSPRY.

    Subcellular locationi

    Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cell leading edge Source: Ensembl
    2. membrane Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134979106.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402B box and SPRY domain-containing proteinPRO_0000244257Add
    BLAST

    Proteomic databases

    MaxQBiQ5W0U4.
    PaxDbiQ5W0U4.
    PRIDEiQ5W0U4.

    PTM databases

    PhosphoSiteiQ5W0U4.

    Expressioni

    Gene expression databases

    BgeeiQ5W0U4.
    CleanExiHS_BSPRY.
    GenevestigatoriQ5W0U4.

    Organism-specific databases

    HPAiHPA042889.

    Interactioni

    Subunit structurei

    Interacts with TRPV5 and TRPV6. Interacts with YWHAZ/14-3-3 protein zeta By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ5W0U4. 1 interaction.
    STRINGi9606.ENSP00000363298.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5W0U4.
    SMRiQ5W0U4. Positions 232-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini212 – 402191B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B box-type zinc finger.Curated
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri17 – 6549B box-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG264516.
    HOGENOMiHOG000057290.
    HOVERGENiHBG080574.
    InParanoidiQ5W0U4.
    OMAiAQELLFY.
    OrthoDBiEOG7H1JKW.
    PhylomeDBiQ5W0U4.
    TreeFamiTF351014.

    Family and domain databases

    Gene3Di4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00589. PRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5W0U4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAEGAEPGP GSGSGPGPGP LCPEHGQALS WFCGSERRPV CAACAGLGGR    50
    CRGHRIRRAE ERAEELRNKI VDQCERLQLQ SAAITKYVAD VLPGKNQRAV 100
    SMASAARELV IQRLSLVRSL CESEEQRLLE QVHGEEERAH QSILTQRVHW 150
    AEALQKLDTI RTGLVGMLTH LDDLQLIQKE QEIFERTEEA EGILDPQESE 200
    MLNFNEKCTR SPLLTQLWAT AVLGSLSGTE DIRIDERTVS PFLQLSDDRK 250
    TLTFSTKKSK ACADGPERFD HWPNALAATS FQNGLHAWMV NVQNSCAYKV 300
    GVASGHLPRK GSGSDCRLGH NAFSWVFSRY DQEFRFSHNG QHEPLGLLRG 350
    PAQLGVVLDL QVQELLFYEP ASGTVLCAHH VSFPGPLFPV FAVADQTISI 400
    VR 402
    Length:402
    Mass (Da):44,381
    Last modified:December 7, 2004 - v1
    Checksum:iEEBBB95B0A9863F4
    GO
    Isoform 2 (identifier: Q5W0U4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         187-193: TEEAEGI → HRGHTDR
         194-402: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:193
    Mass (Da):21,413
    Checksum:i39D43152A32707B0
    GO

    Sequence cautioni

    The sequence BAA90980.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001V → E in BAA90980. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti261 – 2611A → P.
    Corresponds to variant rs34089316 [ dbSNP | Ensembl ].
    VAR_048397
    Natural varianti293 – 2931Q → H.
    Corresponds to variant rs818711 [ dbSNP | Ensembl ].
    VAR_026882
    Natural varianti374 – 3741T → I.2 Publications
    Corresponds to variant rs3088235 [ dbSNP | Ensembl ].
    VAR_026883

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei187 – 1937TEEAEGI → HRGHTDR in isoform 2. 1 PublicationVSP_019527
    Alternative sequencei194 – 402209Missing in isoform 2. 1 PublicationVSP_019528Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ276691 mRNA. Translation: CAC09324.1.
    AL137066 Genomic DNA. Translation: CAH70097.1.
    CH471090 Genomic DNA. Translation: EAW87374.1.
    BC001477 mRNA. Translation: AAH01477.1.
    AK000157 mRNA. Translation: BAA90980.1. Different initiation.
    AK092607 mRNA. Translation: BAG52581.1.
    CCDSiCCDS43868.1. [Q5W0U4-1]
    RefSeqiNP_060158.2. NM_017688.2. [Q5W0U4-1]
    XP_005252120.1. XM_005252063.2. [Q5W0U4-2]
    UniGeneiHs.614517.

    Genome annotation databases

    EnsembliENST00000374183; ENSP00000363298; ENSG00000119411. [Q5W0U4-1]
    GeneIDi54836.
    KEGGihsa:54836.
    UCSCiuc004bhg.4. human. [Q5W0U4-1]
    uc010muw.3. human. [Q5W0U4-2]

    Polymorphism databases

    DMDMi74747982.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ276691 mRNA. Translation: CAC09324.1 .
    AL137066 Genomic DNA. Translation: CAH70097.1 .
    CH471090 Genomic DNA. Translation: EAW87374.1 .
    BC001477 mRNA. Translation: AAH01477.1 .
    AK000157 mRNA. Translation: BAA90980.1 . Different initiation.
    AK092607 mRNA. Translation: BAG52581.1 .
    CCDSi CCDS43868.1. [Q5W0U4-1 ]
    RefSeqi NP_060158.2. NM_017688.2. [Q5W0U4-1 ]
    XP_005252120.1. XM_005252063.2. [Q5W0U4-2 ]
    UniGenei Hs.614517.

    3D structure databases

    ProteinModelPortali Q5W0U4.
    SMRi Q5W0U4. Positions 232-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5W0U4. 1 interaction.
    STRINGi 9606.ENSP00000363298.

    PTM databases

    PhosphoSitei Q5W0U4.

    Polymorphism databases

    DMDMi 74747982.

    Proteomic databases

    MaxQBi Q5W0U4.
    PaxDbi Q5W0U4.
    PRIDEi Q5W0U4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374183 ; ENSP00000363298 ; ENSG00000119411 . [Q5W0U4-1 ]
    GeneIDi 54836.
    KEGGi hsa:54836.
    UCSCi uc004bhg.4. human. [Q5W0U4-1 ]
    uc010muw.3. human. [Q5W0U4-2 ]

    Organism-specific databases

    CTDi 54836.
    GeneCardsi GC09P116111.
    HGNCi HGNC:18232. BSPRY.
    HPAi HPA042889.
    neXtProti NX_Q5W0U4.
    PharmGKBi PA134979106.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264516.
    HOGENOMi HOG000057290.
    HOVERGENi HBG080574.
    InParanoidi Q5W0U4.
    OMAi AQELLFY.
    OrthoDBi EOG7H1JKW.
    PhylomeDBi Q5W0U4.
    TreeFami TF351014.

    Miscellaneous databases

    ChiTaRSi BSPRY. human.
    GenomeRNAii 54836.
    NextBioi 57630.
    PROi Q5W0U4.

    Gene expression databases

    Bgeei Q5W0U4.
    CleanExi HS_BSPRY.
    Genevestigatori Q5W0U4.

    Family and domain databases

    Gene3Di 4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00589. PRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BSPRY, a novel protein of the Ro-Ret family."
      Schenker T., Trueb B.
      Biochim. Biophys. Acta 1493:255-258(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-374.
      Tissue: Placenta.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-374.
      Tissue: Colon and Prostate.

    Entry informationi

    Entry nameiBSPRY_HUMAN
    AccessioniPrimary (citable) accession number: Q5W0U4
    Secondary accession number(s): B3KS19
    , Q96DJ2, Q9H4E4, Q9NXN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3