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Protein

B box and SPRY domain-containing protein

Gene

BSPRY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate epithelial calcium transport by inhibiting TRPV5 activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 6549B box-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. calcium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B box and SPRY domain-containing protein
Gene namesi
Name:BSPRY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18232. BSPRY.

Subcellular locationi

Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cell leading edge Source: Ensembl
  2. cytoplasm Source: HPA
  3. focal adhesion Source: HPA
  4. membrane Source: UniProtKB-SubCell
  5. nucleoplasm Source: HPA
  6. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402B box and SPRY domain-containing proteinPRO_0000244257Add
BLAST

Proteomic databases

MaxQBiQ5W0U4.
PaxDbiQ5W0U4.
PRIDEiQ5W0U4.

PTM databases

PhosphoSiteiQ5W0U4.

Expressioni

Gene expression databases

BgeeiQ5W0U4.
CleanExiHS_BSPRY.
GenevestigatoriQ5W0U4.

Organism-specific databases

HPAiHPA042889.

Interactioni

Subunit structurei

Interacts with TRPV5 and TRPV6. Interacts with YWHAZ/14-3-3 protein zeta (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5W0U4. 1 interaction.
STRINGi9606.ENSP00000363298.

Structurei

3D structure databases

ProteinModelPortaliQ5W0U4.
SMRiQ5W0U4. Positions 231-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 402191B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 6549B box-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG264516.
GeneTreeiENSGT00780000121986.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ5W0U4.
OMAiAQELLFY.
OrthoDBiEOG7H1JKW.
PhylomeDBiQ5W0U4.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W0U4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEGAEPGP GSGSGPGPGP LCPEHGQALS WFCGSERRPV CAACAGLGGR
60 70 80 90 100
CRGHRIRRAE ERAEELRNKI VDQCERLQLQ SAAITKYVAD VLPGKNQRAV
110 120 130 140 150
SMASAARELV IQRLSLVRSL CESEEQRLLE QVHGEEERAH QSILTQRVHW
160 170 180 190 200
AEALQKLDTI RTGLVGMLTH LDDLQLIQKE QEIFERTEEA EGILDPQESE
210 220 230 240 250
MLNFNEKCTR SPLLTQLWAT AVLGSLSGTE DIRIDERTVS PFLQLSDDRK
260 270 280 290 300
TLTFSTKKSK ACADGPERFD HWPNALAATS FQNGLHAWMV NVQNSCAYKV
310 320 330 340 350
GVASGHLPRK GSGSDCRLGH NAFSWVFSRY DQEFRFSHNG QHEPLGLLRG
360 370 380 390 400
PAQLGVVLDL QVQELLFYEP ASGTVLCAHH VSFPGPLFPV FAVADQTISI

VR
Length:402
Mass (Da):44,381
Last modified:December 7, 2004 - v1
Checksum:iEEBBB95B0A9863F4
GO
Isoform 2 (identifier: Q5W0U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-193: TEEAEGI → HRGHTDR
     194-402: Missing.

Note: No experimental confirmation available.

Show »
Length:193
Mass (Da):21,413
Checksum:i39D43152A32707B0
GO

Sequence cautioni

The sequence BAA90980.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001V → E in BAA90980 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti261 – 2611A → P.
Corresponds to variant rs34089316 [ dbSNP | Ensembl ].
VAR_048397
Natural varianti293 – 2931Q → H.
Corresponds to variant rs818711 [ dbSNP | Ensembl ].
VAR_026882
Natural varianti374 – 3741T → I.2 Publications
Corresponds to variant rs3088235 [ dbSNP | Ensembl ].
VAR_026883

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 1937TEEAEGI → HRGHTDR in isoform 2. 1 PublicationVSP_019527
Alternative sequencei194 – 402209Missing in isoform 2. 1 PublicationVSP_019528Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276691 mRNA. Translation: CAC09324.1.
AL137066 Genomic DNA. Translation: CAH70097.1.
CH471090 Genomic DNA. Translation: EAW87374.1.
BC001477 mRNA. Translation: AAH01477.1.
AK000157 mRNA. Translation: BAA90980.1. Different initiation.
AK092607 mRNA. Translation: BAG52581.1.
CCDSiCCDS43868.1. [Q5W0U4-1]
RefSeqiNP_060158.2. NM_017688.2. [Q5W0U4-1]
XP_005252120.1. XM_005252063.2. [Q5W0U4-2]
UniGeneiHs.614517.

Genome annotation databases

EnsembliENST00000374183; ENSP00000363298; ENSG00000119411. [Q5W0U4-1]
GeneIDi54836.
KEGGihsa:54836.
UCSCiuc004bhg.4. human. [Q5W0U4-1]
uc010muw.3. human. [Q5W0U4-2]

Polymorphism databases

DMDMi74747982.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276691 mRNA. Translation: CAC09324.1.
AL137066 Genomic DNA. Translation: CAH70097.1.
CH471090 Genomic DNA. Translation: EAW87374.1.
BC001477 mRNA. Translation: AAH01477.1.
AK000157 mRNA. Translation: BAA90980.1. Different initiation.
AK092607 mRNA. Translation: BAG52581.1.
CCDSiCCDS43868.1. [Q5W0U4-1]
RefSeqiNP_060158.2. NM_017688.2. [Q5W0U4-1]
XP_005252120.1. XM_005252063.2. [Q5W0U4-2]
UniGeneiHs.614517.

3D structure databases

ProteinModelPortaliQ5W0U4.
SMRiQ5W0U4. Positions 231-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5W0U4. 1 interaction.
STRINGi9606.ENSP00000363298.

PTM databases

PhosphoSiteiQ5W0U4.

Polymorphism databases

DMDMi74747982.

Proteomic databases

MaxQBiQ5W0U4.
PaxDbiQ5W0U4.
PRIDEiQ5W0U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374183; ENSP00000363298; ENSG00000119411. [Q5W0U4-1]
GeneIDi54836.
KEGGihsa:54836.
UCSCiuc004bhg.4. human. [Q5W0U4-1]
uc010muw.3. human. [Q5W0U4-2]

Organism-specific databases

CTDi54836.
GeneCardsiGC09P116111.
HGNCiHGNC:18232. BSPRY.
HPAiHPA042889.
neXtProtiNX_Q5W0U4.
PharmGKBiPA134979106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264516.
GeneTreeiENSGT00780000121986.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ5W0U4.
OMAiAQELLFY.
OrthoDBiEOG7H1JKW.
PhylomeDBiQ5W0U4.
TreeFamiTF351014.

Miscellaneous databases

ChiTaRSiBSPRY. human.
GenomeRNAii54836.
NextBioi57630.
PROiQ5W0U4.

Gene expression databases

BgeeiQ5W0U4.
CleanExiHS_BSPRY.
GenevestigatoriQ5W0U4.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BSPRY, a novel protein of the Ro-Ret family."
    Schenker T., Trueb B.
    Biochim. Biophys. Acta 1493:255-258(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-374.
    Tissue: Placenta.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-374.
    Tissue: Colon and Prostate.

Entry informationi

Entry nameiBSPRY_HUMAN
AccessioniPrimary (citable) accession number: Q5W0U4
Secondary accession number(s): B3KS19
, Q96DJ2, Q9H4E4, Q9NXN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.