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Protein

Transmembrane protein 236

Gene

TMEM236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30792-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 236
Gene namesi
Name:TMEM236
Synonyms:FAM23A, FAM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23473. TMEM236.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148483.
PharmGKBiPA134931867.

Polymorphism and mutation databases

DMDMi73620896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001867161 – 351Transmembrane protein 236Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5W0B7.
PeptideAtlasiQ5W0B7.
PRIDEiQ5W0B7.

PTM databases

iPTMnetiQ5W0B7.
PhosphoSitePlusiQ5W0B7.

Interactioni

Protein-protein interaction databases

BioGridi575888. 1 interactor.
STRINGi9606.ENSP00000414144.

Structurei

3D structure databases

ProteinModelPortaliQ5W0B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM236 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGEQ. Eukaryota.
ENOG410YD0S. LUCA.
GeneTreeiENSGT00390000015525.
HOVERGENiHBG080454.
InParanoidiQ5W0B7.
OMAiGWLYPVY.
OrthoDBiEOG091G0DFD.
PhylomeDBiQ5W0B7.
TreeFamiTF328759.

Family and domain databases

InterProiIPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view]
ProDomiPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q5W0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI
60 70 80 90 100
ISCSIAYVAL VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP
110 120 130 140 150
CLTFSIAVTE VQKSINGSAD VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY
160 170 180 190 200
PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR QSPENAASPQ ATNSTQVSQP
210 220 230 240 250
SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW SFLLWSDTIE
260 270 280 290 300
MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP
310 320 330 340 350
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP

F
Length:351
Mass (Da):39,663
Last modified:December 7, 2004 - v1
Checksum:i9DE0E117BE24D76C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139238 Genomic DNA. Translation: CAH70871.1.
BC157856 mRNA. Translation: AAI57857.1.
CCDSiCCDS41492.1.
RefSeqiNP_001092314.1. NM_001098844.2.
UniGeneiHs.564139.
Hs.733272.

Genome annotation databases

EnsembliENST00000377495; ENSP00000366715; ENSG00000148483.
GeneIDi653567.
KEGGihsa:653567.
UCSCiuc009xjx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139238 Genomic DNA. Translation: CAH70871.1.
BC157856 mRNA. Translation: AAI57857.1.
CCDSiCCDS41492.1.
RefSeqiNP_001092314.1. NM_001098844.2.
UniGeneiHs.564139.
Hs.733272.

3D structure databases

ProteinModelPortaliQ5W0B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575888. 1 interactor.
STRINGi9606.ENSP00000414144.

PTM databases

iPTMnetiQ5W0B7.
PhosphoSitePlusiQ5W0B7.

Polymorphism and mutation databases

DMDMi73620896.

Proteomic databases

PaxDbiQ5W0B7.
PeptideAtlasiQ5W0B7.
PRIDEiQ5W0B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377495; ENSP00000366715; ENSG00000148483.
GeneIDi653567.
KEGGihsa:653567.
UCSCiuc009xjx.5. human.

Organism-specific databases

CTDi653567.
GeneCardsiTMEM236.
HGNCiHGNC:23473. TMEM236.
neXtProtiNX_Q5W0B7.
OpenTargetsiENSG00000148483.
PharmGKBiPA134931867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGEQ. Eukaryota.
ENOG410YD0S. LUCA.
GeneTreeiENSGT00390000015525.
HOVERGENiHBG080454.
InParanoidiQ5W0B7.
OMAiGWLYPVY.
OrthoDBiEOG091G0DFD.
PhylomeDBiQ5W0B7.
TreeFamiTF328759.

Enzyme and pathway databases

BioCyciZFISH:G66-30792-MONOMER.

Miscellaneous databases

GenomeRNAii653567.
PROiQ5W0B7.

Family and domain databases

InterProiIPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view]
ProDomiPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiTM236_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B7
Secondary accession number(s): B2RXH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.