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Protein

Transmembrane protein 236

Gene

TMEM236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 236
Gene namesi
Name:TMEM236
Synonyms:FAM23A, FAM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23473. TMEM236.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Transmembrane protein 236PRO_0000186716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5W0B7.
PRIDEiQ5W0B7.

Expressioni

Gene expression databases

GenevestigatoriQ5W0B7.

Structurei

3D structure databases

ProteinModelPortaliQ5W0B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM236 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG27561.
GeneTreeiENSGT00390000015525.
HOVERGENiHBG080454.
InParanoidiQ5W0B7.
OMAiWLYPVYI.
OrthoDBiEOG7N37D3.
PhylomeDBiQ5W0B7.
TreeFamiTF328759.

Family and domain databases

InterProiIPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view]
ProDomiPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q5W0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI
60 70 80 90 100
ISCSIAYVAL VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP
110 120 130 140 150
CLTFSIAVTE VQKSINGSAD VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY
160 170 180 190 200
PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR QSPENAASPQ ATNSTQVSQP
210 220 230 240 250
SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW SFLLWSDTIE
260 270 280 290 300
MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP
310 320 330 340 350
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP

F
Length:351
Mass (Da):39,663
Last modified:December 7, 2004 - v1
Checksum:i9DE0E117BE24D76C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139238 Genomic DNA. Translation: CAH70871.1.
BC157856 mRNA. Translation: AAI57857.1.
CCDSiCCDS41492.1.
RefSeqiNP_001092314.1. NM_001098844.2.
UniGeneiHs.564139.
Hs.733272.

Genome annotation databases

EnsembliENST00000377495; ENSP00000366715; ENSG00000148483.
GeneIDi653567.
KEGGihsa:653567.
UCSCiuc009xjx.4. human.

Polymorphism databases

DMDMi73620896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139238 Genomic DNA. Translation: CAH70871.1.
BC157856 mRNA. Translation: AAI57857.1.
CCDSiCCDS41492.1.
RefSeqiNP_001092314.1. NM_001098844.2.
UniGeneiHs.564139.
Hs.733272.

3D structure databases

ProteinModelPortaliQ5W0B7.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi73620896.

Proteomic databases

PaxDbiQ5W0B7.
PRIDEiQ5W0B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377495; ENSP00000366715; ENSG00000148483.
GeneIDi653567.
KEGGihsa:653567.
UCSCiuc009xjx.4. human.

Organism-specific databases

CTDi653567.
GeneCardsiGC10P017796.
HGNCiHGNC:23473. TMEM236.
neXtProtiNX_Q5W0B7.
PharmGKBiPA134931867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG27561.
GeneTreeiENSGT00390000015525.
HOVERGENiHBG080454.
InParanoidiQ5W0B7.
OMAiWLYPVYI.
OrthoDBiEOG7N37D3.
PhylomeDBiQ5W0B7.
TreeFamiTF328759.

Miscellaneous databases

GenomeRNAii653567.
NextBioi123425.
PROiQ5W0B7.

Gene expression databases

GenevestigatoriQ5W0B7.

Family and domain databases

InterProiIPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view]
ProDomiPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTM236_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B7
Secondary accession number(s): B2RXH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.