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Q5W0B7 (TM236_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 236
Gene names
Name:TMEM236
Synonyms:FAM23A, FAM23B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM236 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Transmembrane protein 236
PRO_0000186716

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane301 – 32121Helical; Potential

Amino acid modifications

Glycosylation1931N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5W0B7 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 9DE0E117BE24D76C

FASTA35139,663
        10         20         30         40         50         60 
MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI ISCSIAYVAL 

        70         80         90        100        110        120 
VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP CLTFSIAVTE VQKSINGSAD 

       130        140        150        160        170        180 
VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR 

       190        200        210        220        230        240 
QSPENAASPQ ATNSTQVSQP SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW 

       250        260        270        280        290        300 
SFLLWSDTIE MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP 

       310        320        330        340        350 
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP F 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL139238 Genomic DNA. Translation: CAH70871.1.
BC157856 mRNA. Translation: AAI57857.1.
CCDSCCDS41492.1.
RefSeqNP_001092314.1. NM_001098844.2.
UniGeneHs.564139.
Hs.733272.

3D structure databases

ProteinModelPortalQ5W0B7.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM73620896.

Proteomic databases

PaxDbQ5W0B7.
PRIDEQ5W0B7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338221; ENSP00000348463; ENSG00000148483.
ENST00000377495; ENSP00000366715; ENSG00000148483.
ENST00000569785; ENSP00000457455; ENSG00000260324.
GeneID653567.
KEGGhsa:653567.
UCSCuc009xjx.4. human.

Organism-specific databases

CTD653567.
GeneCardsGC10P017796.
HGNCHGNC:23473. TMEM236.
neXtProtNX_Q5W0B7.
PharmGKBPA134931867.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG27561.
HOVERGENHBG080454.
InParanoidQ5W0B7.
OMAWLYPVYI.
OrthoDBEOG7N37D3.
PhylomeDBQ5W0B7.
TreeFamTF328759.

Gene expression databases

GenevestigatorQ5W0B7.

Family and domain databases

InterProIPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view]
ProDomPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GenomeRNAi653567.
NextBio123425.
PROQ5W0B7.

Entry information

Entry nameTM236_HUMAN
AccessionPrimary (citable) accession number: Q5W0B7
Secondary accession number(s): B2RXH7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM