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Q5W0B7

- TM236_HUMAN

UniProt

Q5W0B7 - TM236_HUMAN

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Protein
Transmembrane protein 236
Gene
TMEM236, FAM23A, FAM23B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 236
Gene namesi
Name:TMEM236
Synonyms:FAM23A, FAM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23473. TMEM236.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei49 – 6921Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Reviewed prediction
Add
BLAST
Transmembranei301 – 32121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Transmembrane protein 236
PRO_0000186716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi193 – 1931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5W0B7.
PRIDEiQ5W0B7.

Expressioni

Gene expression databases

GenevestigatoriQ5W0B7.

Structurei

3D structure databases

ProteinModelPortaliQ5W0B7.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM236 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG27561.
HOVERGENiHBG080454.
InParanoidiQ5W0B7.
OMAiWLYPVYI.
OrthoDBiEOG7N37D3.
PhylomeDBiQ5W0B7.
TreeFamiTF328759.

Family and domain databases

InterProiIPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view]
ProDomiPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q5W0B7-1 [UniParc]FASTAAdd to Basket

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MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI    50
ISCSIAYVAL VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP 100
CLTFSIAVTE VQKSINGSAD VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY 150
PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR QSPENAASPQ ATNSTQVSQP 200
SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW SFLLWSDTIE 250
MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP 300
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP 350
F 351
Length:351
Mass (Da):39,663
Last modified:December 7, 2004 - v1
Checksum:i9DE0E117BE24D76C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL139238 Genomic DNA. Translation: CAH70871.1.
BC157856 mRNA. Translation: AAI57857.1.
CCDSiCCDS41492.1.
RefSeqiNP_001092314.1. NM_001098844.2.
UniGeneiHs.564139.
Hs.733272.

Genome annotation databases

EnsembliENST00000338221; ENSP00000348463; ENSG00000148483.
ENST00000377495; ENSP00000366715; ENSG00000148483.
ENST00000569785; ENSP00000457455; ENSG00000260324.
GeneIDi653567.
KEGGihsa:653567.
UCSCiuc009xjx.4. human.

Polymorphism databases

DMDMi73620896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL139238 Genomic DNA. Translation: CAH70871.1 .
BC157856 mRNA. Translation: AAI57857.1 .
CCDSi CCDS41492.1.
RefSeqi NP_001092314.1. NM_001098844.2.
UniGenei Hs.564139.
Hs.733272.

3D structure databases

ProteinModelPortali Q5W0B7.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 73620896.

Proteomic databases

PaxDbi Q5W0B7.
PRIDEi Q5W0B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338221 ; ENSP00000348463 ; ENSG00000148483 .
ENST00000377495 ; ENSP00000366715 ; ENSG00000148483 .
ENST00000569785 ; ENSP00000457455 ; ENSG00000260324 .
GeneIDi 653567.
KEGGi hsa:653567.
UCSCi uc009xjx.4. human.

Organism-specific databases

CTDi 653567.
GeneCardsi GC10P017796.
HGNCi HGNC:23473. TMEM236.
neXtProti NX_Q5W0B7.
PharmGKBi PA134931867.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27561.
HOVERGENi HBG080454.
InParanoidi Q5W0B7.
OMAi WLYPVYI.
OrthoDBi EOG7N37D3.
PhylomeDBi Q5W0B7.
TreeFami TF328759.

Miscellaneous databases

GenomeRNAii 653567.
NextBioi 123425.
PROi Q5W0B7.

Gene expression databases

Genevestigatori Q5W0B7.

Family and domain databases

InterProi IPR020394. Uncharacterised_FAM23-like_TM.
[Graphical view ]
ProDomi PD098445. Uncharacterised_FAM23-like_TM. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTM236_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B7
Secondary accession number(s): B2RXH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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