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Q5W0B7

- TM236_HUMAN

UniProt

Q5W0B7 - TM236_HUMAN

Protein

Transmembrane protein 236

Gene

TMEM236

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 236
    Gene namesi
    Name:TMEM236
    Synonyms:FAM23A, FAM23B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23473. TMEM236.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134931867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Transmembrane protein 236PRO_0000186716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5W0B7.
    PRIDEiQ5W0B7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5W0B7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5W0B7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM236 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG27561.
    HOVERGENiHBG080454.
    InParanoidiQ5W0B7.
    OMAiWLYPVYI.
    OrthoDBiEOG7N37D3.
    PhylomeDBiQ5W0B7.
    TreeFamiTF328759.

    Family and domain databases

    InterProiIPR020394. Uncharacterised_FAM23-like_TM.
    [Graphical view]
    ProDomiPD098445. Uncharacterised_FAM23-like_TM. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q5W0B7-1 [UniParc]FASTAAdd to Basket

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    MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI    50
    ISCSIAYVAL VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP 100
    CLTFSIAVTE VQKSINGSAD VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY 150
    PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR QSPENAASPQ ATNSTQVSQP 200
    SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW SFLLWSDTIE 250
    MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP 300
    FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP 350
    F 351
    Length:351
    Mass (Da):39,663
    Last modified:December 7, 2004 - v1
    Checksum:i9DE0E117BE24D76C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL139238 Genomic DNA. Translation: CAH70871.1.
    BC157856 mRNA. Translation: AAI57857.1.
    CCDSiCCDS41492.1.
    RefSeqiNP_001092314.1. NM_001098844.2.
    UniGeneiHs.564139.
    Hs.733272.

    Genome annotation databases

    EnsembliENST00000377495; ENSP00000366715; ENSG00000148483.
    GeneIDi653567.
    KEGGihsa:653567.
    UCSCiuc009xjx.4. human.

    Polymorphism databases

    DMDMi73620896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL139238 Genomic DNA. Translation: CAH70871.1 .
    BC157856 mRNA. Translation: AAI57857.1 .
    CCDSi CCDS41492.1.
    RefSeqi NP_001092314.1. NM_001098844.2.
    UniGenei Hs.564139.
    Hs.733272.

    3D structure databases

    ProteinModelPortali Q5W0B7.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 73620896.

    Proteomic databases

    PaxDbi Q5W0B7.
    PRIDEi Q5W0B7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377495 ; ENSP00000366715 ; ENSG00000148483 .
    GeneIDi 653567.
    KEGGi hsa:653567.
    UCSCi uc009xjx.4. human.

    Organism-specific databases

    CTDi 653567.
    GeneCardsi GC10P017796.
    HGNCi HGNC:23473. TMEM236.
    neXtProti NX_Q5W0B7.
    PharmGKBi PA134931867.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27561.
    HOVERGENi HBG080454.
    InParanoidi Q5W0B7.
    OMAi WLYPVYI.
    OrthoDBi EOG7N37D3.
    PhylomeDBi Q5W0B7.
    TreeFami TF328759.

    Miscellaneous databases

    GenomeRNAii 653567.
    NextBioi 123425.
    PROi Q5W0B7.

    Gene expression databases

    Genevestigatori Q5W0B7.

    Family and domain databases

    InterProi IPR020394. Uncharacterised_FAM23-like_TM.
    [Graphical view ]
    ProDomi PD098445. Uncharacterised_FAM23-like_TM. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTM236_HUMAN
    AccessioniPrimary (citable) accession number: Q5W0B7
    Secondary accession number(s): B2RXH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3