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Protein

RING finger protein 219

Gene

RNF219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 219
Gene namesi
Name:RNF219
Synonyms:C13orf7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000152193.7
HGNCiHGNC:20308 RNF219
neXtProtiNX_Q5W0B1

Pathology & Biotechi

Organism-specific databases

DisGeNETi79596
OpenTargetsiENSG00000152193
PharmGKBiPA162401869

Polymorphism and mutation databases

BioMutaiRNF219
DMDMi73917812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558761 – 726RING finger protein 219Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei553PhosphoserineBy similarity1
Modified residuei561PhosphoserineCombined sources1
Modified residuei568PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei719PhosphoserineCombined sources1
Modified residuei721PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5W0B1
MaxQBiQ5W0B1
PaxDbiQ5W0B1
PeptideAtlasiQ5W0B1
PRIDEiQ5W0B1
ProteomicsDBi65758

PTM databases

iPTMnetiQ5W0B1
PhosphoSitePlusiQ5W0B1

Expressioni

Gene expression databases

BgeeiENSG00000152193
CleanExiHS_RNF219
GenevisibleiQ5W0B1 HS

Organism-specific databases

HPAiHPA034785
HPA034786

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEANCQ8N8B73EBI-2562035,EBI-954696

Protein-protein interaction databases

BioGridi122736, 36 interactors
IntActiQ5W0B1, 21 interactors
MINTiQ5W0B1
STRINGi9606.ENSP00000282003

Structurei

3D structure databases

ProteinModelPortaliQ5W0B1
SMRiQ5W0B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 129Sequence analysisAdd BLAST43
Coiled coili155 – 270Sequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 310Poly-Ser7
Compositional biasi434 – 721Ser-richAdd BLAST288

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IG50 Eukaryota
ENOG4111GZ3 LUCA
GeneTreeiENSGT00390000013512
HOGENOMiHOG000008702
HOVERGENiHBG054043
InParanoidiQ5W0B1
OMAiSMMSESD
OrthoDBiEOG091G0DH8
PhylomeDBiQ5W0B1
TreeFamiTF329331

Family and domain databases

CDDicd16562 RING-HC_RNF219, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035691 RNF219_RING-HC
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5W0B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS
60 70 80 90 100
QCPACRVPIT PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE
110 120 130 140 150
DEIDCLQKEV EELKSKNLSL ESQIKTILDP LTLVQGNQNE DKHLVTDNPS
160 170 180 190 200
KINPETVAEW KKKLRTANEI YEKVKDDVDK LKEANKKLKL ENGGLVRENL
210 220 230 240 250
RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL ERSDKYIEEL
260 270 280 290 300
ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK
310 320 330 340 350
QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE
360 370 380 390 400
VMLDVTDTSM DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL
410 420 430 440 450
STPENRESSV VQAGGSKKHS NHLRKLVFDD FCDSSNVSNK DSSEDDISRS
460 470 480 490 500
ENEKKSECFS SPKTGFWDCC STSYAQNLDF ESSEGNTIAN SVGEISSKLS
510 520 530 540 550
EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE LDSMMSESDN
560 570 580 590 600
SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ
610 620 630 640 650
LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF
660 670 680 690 700
SQGILLSSSH RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN
710 720
KNVNQSTKRK IQSSLSSASP SKATKS
Length:726
Mass (Da):81,116
Last modified:December 7, 2004 - v1
Checksum:i2ADD8EAE5282A1CF
GO

Sequence cautioni

The sequence BAB14594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC028586 differs from that shown. Reason: Frameshift at position 614.Curated
The sequence CAB66586 differs from that shown. Reason: Frameshift at position 614.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126T → A in CAB66586 (PubMed:11230166).Curated1
Sequence conflicti386L → F in CAB66586 (PubMed:11230166).Curated1
Sequence conflicti462P → T in CAB66586 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136651 mRNA Translation: CAB66586.3 Sequence problems.
AL139319 Genomic DNA No translation available.
AL445209 Genomic DNA No translation available.
BC028586 mRNA No translation available.
CH471093 Genomic DNA Translation: EAW80586.1
BC136764 mRNA Translation: AAI36765.1
BC136765 mRNA Translation: AAI36766.1
AK023511 mRNA Translation: BAB14594.1 Different initiation.
CCDSiCCDS31997.1
RefSeqiNP_078822.3, NM_024546.3
UniGeneiHs.567576

Genome annotation databases

EnsembliENST00000282003; ENSP00000282003; ENSG00000152193
GeneIDi79596
KEGGihsa:79596
UCSCiuc001vkw.2 human

Similar proteinsi

Entry informationi

Entry nameiRN219_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B1
Secondary accession number(s): B2RN99
, Q8TBY2, Q9H0T2, Q9H8M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM

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