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Protein

RING finger protein 219

Gene

RNF219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 219
Gene namesi
Name:RNF219
Synonyms:C13orf7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000152193.7.
HGNCiHGNC:20308. RNF219.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79596.
OpenTargetsiENSG00000152193.
PharmGKBiPA162401869.

Polymorphism and mutation databases

BioMutaiRNF219.
DMDMi73917812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558761 – 726RING finger protein 219Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei553PhosphoserineBy similarity1
Modified residuei561PhosphoserineCombined sources1
Modified residuei568PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei719PhosphoserineCombined sources1
Modified residuei721PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5W0B1.
MaxQBiQ5W0B1.
PaxDbiQ5W0B1.
PeptideAtlasiQ5W0B1.
PRIDEiQ5W0B1.

PTM databases

iPTMnetiQ5W0B1.
PhosphoSitePlusiQ5W0B1.

Expressioni

Gene expression databases

BgeeiENSG00000152193.
CleanExiHS_RNF219.
GenevisibleiQ5W0B1. HS.

Organism-specific databases

HPAiHPA034785.
HPA034786.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEANCQ8N8B73EBI-2562035,EBI-954696

Protein-protein interaction databases

BioGridi122736. 36 interactors.
IntActiQ5W0B1. 21 interactors.
MINTiMINT-4716514.
STRINGi9606.ENSP00000282003.

Structurei

3D structure databases

ProteinModelPortaliQ5W0B1.
SMRiQ5W0B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 129Sequence analysisAdd BLAST43
Coiled coili155 – 270Sequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 310Poly-Ser7
Compositional biasi434 – 721Ser-richAdd BLAST288

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IG50. Eukaryota.
ENOG4111GZ3. LUCA.
GeneTreeiENSGT00390000013512.
HOGENOMiHOG000008702.
HOVERGENiHBG054043.
InParanoidiQ5W0B1.
OMAiSMMSESD.
OrthoDBiEOG091G0DH8.
PhylomeDBiQ5W0B1.
TreeFamiTF329331.

Family and domain databases

CDDicd16562. RING-HC_RNF219. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR035691. RNF219_RING-HC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5W0B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS
60 70 80 90 100
QCPACRVPIT PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE
110 120 130 140 150
DEIDCLQKEV EELKSKNLSL ESQIKTILDP LTLVQGNQNE DKHLVTDNPS
160 170 180 190 200
KINPETVAEW KKKLRTANEI YEKVKDDVDK LKEANKKLKL ENGGLVRENL
210 220 230 240 250
RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL ERSDKYIEEL
260 270 280 290 300
ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK
310 320 330 340 350
QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE
360 370 380 390 400
VMLDVTDTSM DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL
410 420 430 440 450
STPENRESSV VQAGGSKKHS NHLRKLVFDD FCDSSNVSNK DSSEDDISRS
460 470 480 490 500
ENEKKSECFS SPKTGFWDCC STSYAQNLDF ESSEGNTIAN SVGEISSKLS
510 520 530 540 550
EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE LDSMMSESDN
560 570 580 590 600
SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ
610 620 630 640 650
LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF
660 670 680 690 700
SQGILLSSSH RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN
710 720
KNVNQSTKRK IQSSLSSASP SKATKS
Length:726
Mass (Da):81,116
Last modified:December 7, 2004 - v1
Checksum:i2ADD8EAE5282A1CF
GO

Sequence cautioni

The sequence BAB14594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC028586 differs from that shown. Reason: Frameshift at position 614.Curated
The sequence CAB66586 differs from that shown. Reason: Frameshift at position 614.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126T → A in CAB66586 (PubMed:11230166).Curated1
Sequence conflicti386L → F in CAB66586 (PubMed:11230166).Curated1
Sequence conflicti462P → T in CAB66586 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136651 mRNA. Translation: CAB66586.3. Sequence problems.
AL139319 Genomic DNA. No translation available.
AL445209 Genomic DNA. No translation available.
BC028586 mRNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80586.1.
BC136764 mRNA. Translation: AAI36765.1.
BC136765 mRNA. Translation: AAI36766.1.
AK023511 mRNA. Translation: BAB14594.1. Different initiation.
CCDSiCCDS31997.1.
RefSeqiNP_078822.3. NM_024546.3.
UniGeneiHs.567576.

Genome annotation databases

EnsembliENST00000282003; ENSP00000282003; ENSG00000152193.
GeneIDi79596.
KEGGihsa:79596.
UCSCiuc001vkw.2. human.

Similar proteinsi

Entry informationi

Entry nameiRN219_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B1
Secondary accession number(s): B2RN99
, Q8TBY2, Q9H0T2, Q9H8M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: November 22, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM