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Protein

RING finger protein 219

Gene

RNF219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5639RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 219
Gene namesi
Name:RNF219
Synonyms:C13orf7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20308. RNF219.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401869.

Polymorphism and mutation databases

BioMutaiRNF219.
DMDMi73917812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726RING finger protein 219PRO_0000055876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei553 – 5531PhosphoserineBy similarity
Modified residuei568 – 5681PhosphoserineBy similarity
Modified residuei570 – 5701PhosphoserineBy similarity
Modified residuei719 – 7191PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5W0B1.
MaxQBiQ5W0B1.
PaxDbiQ5W0B1.
PRIDEiQ5W0B1.

PTM databases

iPTMnetiQ5W0B1.
PhosphoSiteiQ5W0B1.

Expressioni

Gene expression databases

BgeeiQ5W0B1.
CleanExiHS_RNF219.
GenevisibleiQ5W0B1. HS.

Organism-specific databases

HPAiHPA034785.
HPA034786.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEANCQ8N8B73EBI-2562035,EBI-954696

Protein-protein interaction databases

BioGridi122736. 29 interactions.
IntActiQ5W0B1. 17 interactions.
MINTiMINT-4716514.
STRINGi9606.ENSP00000282003.

Structurei

3D structure databases

ProteinModelPortaliQ5W0B1.
SMRiQ5W0B1. Positions 15-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 12943Sequence analysisAdd
BLAST
Coiled coili155 – 270116Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi304 – 3107Poly-Ser
Compositional biasi434 – 721288Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5639RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IG50. Eukaryota.
ENOG4111GZ3. LUCA.
GeneTreeiENSGT00390000013512.
HOGENOMiHOG000008702.
HOVERGENiHBG054043.
InParanoidiQ5W0B1.
OMAiSMMSESD.
OrthoDBiEOG7QNVMW.
PhylomeDBiQ5W0B1.
TreeFamiTF329331.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5W0B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS
60 70 80 90 100
QCPACRVPIT PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE
110 120 130 140 150
DEIDCLQKEV EELKSKNLSL ESQIKTILDP LTLVQGNQNE DKHLVTDNPS
160 170 180 190 200
KINPETVAEW KKKLRTANEI YEKVKDDVDK LKEANKKLKL ENGGLVRENL
210 220 230 240 250
RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL ERSDKYIEEL
260 270 280 290 300
ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK
310 320 330 340 350
QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE
360 370 380 390 400
VMLDVTDTSM DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL
410 420 430 440 450
STPENRESSV VQAGGSKKHS NHLRKLVFDD FCDSSNVSNK DSSEDDISRS
460 470 480 490 500
ENEKKSECFS SPKTGFWDCC STSYAQNLDF ESSEGNTIAN SVGEISSKLS
510 520 530 540 550
EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE LDSMMSESDN
560 570 580 590 600
SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ
610 620 630 640 650
LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF
660 670 680 690 700
SQGILLSSSH RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN
710 720
KNVNQSTKRK IQSSLSSASP SKATKS
Length:726
Mass (Da):81,116
Last modified:December 7, 2004 - v1
Checksum:i2ADD8EAE5282A1CF
GO

Sequence cautioni

The sequence BAB14594.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BC028586 differs from that shown. Reason: Frameshift at position 614. Curated
The sequence CAB66586.3 differs from that shown. Reason: Frameshift at position 614. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261T → A in CAB66586 (PubMed:11230166).Curated
Sequence conflicti386 – 3861L → F in CAB66586 (PubMed:11230166).Curated
Sequence conflicti462 – 4621P → T in CAB66586 (PubMed:11230166).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136651 mRNA. Translation: CAB66586.3. Sequence problems.
AL139319, AL445209 Genomic DNA. Translation: CAH70397.1.
AL445209, AL139319 Genomic DNA. Translation: CAI15183.1.
BC028586 mRNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80586.1.
BC136764 mRNA. Translation: AAI36765.1.
BC136765 mRNA. Translation: AAI36766.1.
AK023511 mRNA. Translation: BAB14594.1. Different initiation.
CCDSiCCDS31997.1.
RefSeqiNP_078822.3. NM_024546.3.
UniGeneiHs.567576.

Genome annotation databases

EnsembliENST00000282003; ENSP00000282003; ENSG00000152193.
GeneIDi79596.
KEGGihsa:79596.
UCSCiuc001vkw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136651 mRNA. Translation: CAB66586.3. Sequence problems.
AL139319, AL445209 Genomic DNA. Translation: CAH70397.1.
AL445209, AL139319 Genomic DNA. Translation: CAI15183.1.
BC028586 mRNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80586.1.
BC136764 mRNA. Translation: AAI36765.1.
BC136765 mRNA. Translation: AAI36766.1.
AK023511 mRNA. Translation: BAB14594.1. Different initiation.
CCDSiCCDS31997.1.
RefSeqiNP_078822.3. NM_024546.3.
UniGeneiHs.567576.

3D structure databases

ProteinModelPortaliQ5W0B1.
SMRiQ5W0B1. Positions 15-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122736. 29 interactions.
IntActiQ5W0B1. 17 interactions.
MINTiMINT-4716514.
STRINGi9606.ENSP00000282003.

PTM databases

iPTMnetiQ5W0B1.
PhosphoSiteiQ5W0B1.

Polymorphism and mutation databases

BioMutaiRNF219.
DMDMi73917812.

Proteomic databases

EPDiQ5W0B1.
MaxQBiQ5W0B1.
PaxDbiQ5W0B1.
PRIDEiQ5W0B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282003; ENSP00000282003; ENSG00000152193.
GeneIDi79596.
KEGGihsa:79596.
UCSCiuc001vkw.2. human.

Organism-specific databases

CTDi79596.
GeneCardsiRNF219.
H-InvDBHIX0011388.
HGNCiHGNC:20308. RNF219.
HPAiHPA034785.
HPA034786.
neXtProtiNX_Q5W0B1.
PharmGKBiPA162401869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG50. Eukaryota.
ENOG4111GZ3. LUCA.
GeneTreeiENSGT00390000013512.
HOGENOMiHOG000008702.
HOVERGENiHBG054043.
InParanoidiQ5W0B1.
OMAiSMMSESD.
OrthoDBiEOG7QNVMW.
PhylomeDBiQ5W0B1.
TreeFamiTF329331.

Miscellaneous databases

GenomeRNAii79596.
NextBioi68618.
PROiQ5W0B1.

Gene expression databases

BgeeiQ5W0B1.
CleanExiHS_RNF219.
GenevisibleiQ5W0B1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-726.
    Tissue: Placenta.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-719, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRN219_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B1
Secondary accession number(s): B2RN99
, Q8TBY2, Q9H0T2, Q9H8M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.