ID   ERI6B_HUMAN             Reviewed;         696 AA.
AC   Q5W0A0; Q96MB5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   24-JAN-2024, entry version 119.
DE   RecName: Full=Glutamate-rich protein 6B;
DE   AltName: Full=Protein FAM194B;
GN   Name=ERICH6B; Synonyms=FAM194B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT LYS-178.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5W0A0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5W0A0-2; Sequence=VSP_032523;
CC   -!- SIMILARITY: Belongs to the ERICH6 family. {ECO:0000305}.
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DR   EMBL; AK057244; BAB71393.1; -; mRNA.
DR   EMBL; AL139326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45045.1; -. [Q5W0A0-1]
DR   RefSeq; NP_872348.2; NM_182542.2. [Q5W0A0-1]
DR   RefSeq; XP_016875907.1; XM_017020418.1. [Q5W0A0-1]
DR   AlphaFoldDB; Q5W0A0; -.
DR   BioGRID; 128626; 4.
DR   IntAct; Q5W0A0; 2.
DR   MINT; Q5W0A0; -.
DR   STRING; 9606.ENSP00000298738; -.
DR   iPTMnet; Q5W0A0; -.
DR   PhosphoSitePlus; Q5W0A0; -.
DR   BioMuta; ERICH6B; -.
DR   DMDM; 74747903; -.
DR   EPD; Q5W0A0; -.
DR   MassIVE; Q5W0A0; -.
DR   PaxDb; 9606-ENSP00000298738; -.
DR   PeptideAtlas; Q5W0A0; -.
DR   ProteomicsDB; 65755; -. [Q5W0A0-1]
DR   ProteomicsDB; 65756; -. [Q5W0A0-2]
DR   Antibodypedia; 57850; 21 antibodies from 9 providers.
DR   DNASU; 220081; -.
DR   Ensembl; ENST00000298738.3; ENSP00000298738.2; ENSG00000165837.12. [Q5W0A0-1]
DR   GeneID; 220081; -.
DR   KEGG; hsa:220081; -.
DR   MANE-Select; ENST00000298738.3; ENSP00000298738.2; NM_182542.3; NP_872348.2.
DR   UCSC; uc001val.2; human. [Q5W0A0-1]
DR   AGR; HGNC:26523; -.
DR   CTD; 220081; -.
DR   DisGeNET; 220081; -.
DR   GeneCards; ERICH6B; -.
DR   HGNC; HGNC:26523; ERICH6B.
DR   HPA; ENSG00000165837; Tissue enriched (testis).
DR   neXtProt; NX_Q5W0A0; -.
DR   PharmGKB; PA165505094; -.
DR   VEuPathDB; HostDB:ENSG00000165837; -.
DR   eggNOG; ENOG502S2BR; Eukaryota.
DR   GeneTree; ENSGT00940000153655; -.
DR   HOGENOM; CLU_025846_0_0_1; -.
DR   InParanoid; Q5W0A0; -.
DR   OMA; NVMEFAS; -.
DR   OrthoDB; 5305866at2759; -.
DR   PhylomeDB; Q5W0A0; -.
DR   TreeFam; TF350393; -.
DR   PathwayCommons; Q5W0A0; -.
DR   SignaLink; Q5W0A0; -.
DR   BioGRID-ORCS; 220081; 49 hits in 1140 CRISPR screens.
DR   ChiTaRS; ERICH6B; human.
DR   GenomeRNAi; 220081; -.
DR   Pharos; Q5W0A0; Tdark.
DR   PRO; PR:Q5W0A0; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q5W0A0; Protein.
DR   Bgee; ENSG00000165837; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 93 other cell types or tissues.
DR   InterPro; IPR029281; FAM194_C.
DR   PANTHER; PTHR23093:SF17; GLUTAMATE-RICH PROTEIN 6B; 1.
DR   PANTHER; PTHR23093; SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20; 1.
DR   Pfam; PF14977; FAM194; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..696
FT                   /note="Glutamate-rich protein 6B"
FT                   /id="PRO_0000326050"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..73
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         134..139
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_032523"
FT   VARIANT         63
FT                   /note="E -> D (in dbSNP:rs12020217)"
FT                   /id="VAR_039969"
FT   VARIANT         99
FT                   /note="E -> G (in dbSNP:rs12020731)"
FT                   /id="VAR_039970"
FT   VARIANT         174
FT                   /note="S -> T (in dbSNP:rs17066954)"
FT                   /id="VAR_039971"
FT   VARIANT         178
FT                   /note="E -> K (in dbSNP:rs3014939)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_039972"
FT   VARIANT         303
FT                   /note="L -> P (in dbSNP:rs11618506)"
FT                   /id="VAR_039973"
FT   VARIANT         427
FT                   /note="T -> I (in dbSNP:rs749071)"
FT                   /id="VAR_039974"
FT   VARIANT         439
FT                   /note="P -> R (in dbSNP:rs12429125)"
FT                   /id="VAR_039975"
FT   VARIANT         453
FT                   /note="H -> R (in dbSNP:rs17066902)"
FT                   /id="VAR_039976"
FT   VARIANT         565
FT                   /note="R -> C (in dbSNP:rs7327901)"
FT                   /id="VAR_039977"
FT   VARIANT         653
FT                   /note="V -> F (in dbSNP:rs1536207)"
FT                   /id="VAR_039978"
FT   CONFLICT        101
FT                   /note="A -> V (in Ref. 1; BAB71393)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   696 AA;  81686 MW;  E82E8019FB58C9A9 CRC64;
     MSAENNQLSG ASPPHPPTTP QYSTQNLPSE KEDTEVELDE ESLQDESPFS PEGESLEDKE
     YLEEEEDLEE EEYLGKEEYL KEEEYLGKEE HLEEEEYLEK AGYLEEEEYI EEEEYLGKEG
     YLEEEEYLGK EEHLEEEEYL GKEGYLEKED YIEEVDYLGK KAYLEEEEYL GKKSYLEEEK
     ALEKEENLEE EEALEKEENL DGKENLYKKY LKEPKASYSS QTMLLRDARS PDAGPSQVTT
     FLTVPLTFAT PSPVSESATE SSELLLTLYR RSQASQTDWC YDRTAVKSLK SKSETEQETT
     TKLAPEEHVN TKVQQKKEEN VLEFASKENF WDGITDESID KLEVEDLDEN FLNSSYQTVF
     KTIIKEMAAH NELEEDFDIP LTKLLESENR WKLVIMLKKN YEKFKETILR IKRRREAQKL
     TEMTSFTFHL MSKPTPEKPE TEEIQKPQRV VHHRKKLERD KEWIQKKTVV HQGDGKLILY
     PNKNVYQILF PDGTGQIHYP SGNLAMLILY AKMKKFTYII LEDSLEGRIR ALINNSGNAT
     FYDENSDIWL NLSSNLGYYF PKDKRQKAWN WWNLNIHVHA PPVQPISLKI NEYIQVQIRS
     QDKIIFCFTY EQKQICLNLG TRYKFVIPEV LSEMKKKTIL EAEPGPTAQK IRVLLGKMNR
     LLNYATTPDL ENFIEAVSIS LMDNKYLKKM LSKLWF
//