Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate-rich protein 6B

Gene

ERICH6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich protein 6B
Alternative name(s):
Protein FAM194B
Gene namesi
Name:ERICH6B
Synonyms:FAM194B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000165837.11
HGNCiHGNC:26523 ERICH6B
neXtProtiNX_Q5W0A0

Pathology & Biotechi

Organism-specific databases

DisGeNETi220081
PharmGKBiPA165505094

Polymorphism and mutation databases

BioMutaiFAM194B
DMDMi74747903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260501 – 696Glutamate-rich protein 6BAdd BLAST696

Proteomic databases

EPDiQ5W0A0
PaxDbiQ5W0A0
PeptideAtlasiQ5W0A0
PRIDEiQ5W0A0
ProteomicsDBi65755
65756 [Q5W0A0-2]

PTM databases

iPTMnetiQ5W0A0
PhosphoSitePlusiQ5W0A0

Expressioni

Gene expression databases

BgeeiENSG00000165837

Organism-specific databases

HPAiHPA043559

Interactioni

Protein-protein interaction databases

IntActiQ5W0A0, 1 interactor
MINTiQ5W0A0

Structurei

3D structure databases

ProteinModelPortaliQ5W0A0
SMRiQ5W0A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 198Glu-richAdd BLAST169

Sequence similaritiesi

Belongs to the ERICH6 family.Curated

Phylogenomic databases

eggNOGiENOG410IJPV Eukaryota
ENOG4111TGA LUCA
GeneTreeiENSGT00530000064027
HOGENOMiHOG000155621
InParanoidiQ5W0A0
OMAiMSAENNQ
OrthoDBiEOG091G0M7X
PhylomeDBiQ5W0A0
TreeFamiTF350393

Family and domain databases

InterProiView protein in InterPro
IPR029281 FAM194
PfamiView protein in Pfam
PF14977 FAM194, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W0A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAENNQLSG ASPPHPPTTP QYSTQNLPSE KEDTEVELDE ESLQDESPFS
60 70 80 90 100
PEGESLEDKE YLEEEEDLEE EEYLGKEEYL KEEEYLGKEE HLEEEEYLEK
110 120 130 140 150
AGYLEEEEYI EEEEYLGKEG YLEEEEYLGK EEHLEEEEYL GKEGYLEKED
160 170 180 190 200
YIEEVDYLGK KAYLEEEEYL GKKSYLEEEK ALEKEENLEE EEALEKEENL
210 220 230 240 250
DGKENLYKKY LKEPKASYSS QTMLLRDARS PDAGPSQVTT FLTVPLTFAT
260 270 280 290 300
PSPVSESATE SSELLLTLYR RSQASQTDWC YDRTAVKSLK SKSETEQETT
310 320 330 340 350
TKLAPEEHVN TKVQQKKEEN VLEFASKENF WDGITDESID KLEVEDLDEN
360 370 380 390 400
FLNSSYQTVF KTIIKEMAAH NELEEDFDIP LTKLLESENR WKLVIMLKKN
410 420 430 440 450
YEKFKETILR IKRRREAQKL TEMTSFTFHL MSKPTPEKPE TEEIQKPQRV
460 470 480 490 500
VHHRKKLERD KEWIQKKTVV HQGDGKLILY PNKNVYQILF PDGTGQIHYP
510 520 530 540 550
SGNLAMLILY AKMKKFTYII LEDSLEGRIR ALINNSGNAT FYDENSDIWL
560 570 580 590 600
NLSSNLGYYF PKDKRQKAWN WWNLNIHVHA PPVQPISLKI NEYIQVQIRS
610 620 630 640 650
QDKIIFCFTY EQKQICLNLG TRYKFVIPEV LSEMKKKTIL EAEPGPTAQK
660 670 680 690
IRVLLGKMNR LLNYATTPDL ENFIEAVSIS LMDNKYLKKM LSKLWF
Length:696
Mass (Da):81,686
Last modified:December 7, 2004 - v1
Checksum:iE82E8019FB58C9A9
GO
Isoform 2 (identifier: Q5W0A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-139: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):80,893
Checksum:i3BB417340E8E5E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101A → V in BAB71393 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03996963E → D. Corresponds to variant dbSNP:rs12020217Ensembl.1
Natural variantiVAR_03997099E → G. Corresponds to variant dbSNP:rs12020731Ensembl.1
Natural variantiVAR_039971174S → T. Corresponds to variant dbSNP:rs17066954Ensembl.1
Natural variantiVAR_039972178E → K1 PublicationCorresponds to variant dbSNP:rs3014939Ensembl.1
Natural variantiVAR_039973303L → P. Corresponds to variant dbSNP:rs11618506Ensembl.1
Natural variantiVAR_039974427T → I. Corresponds to variant dbSNP:rs749071Ensembl.1
Natural variantiVAR_039975439P → R. Corresponds to variant dbSNP:rs12429125Ensembl.1
Natural variantiVAR_039976453H → R. Corresponds to variant dbSNP:rs17066902Ensembl.1
Natural variantiVAR_039977565R → C. Corresponds to variant dbSNP:rs7327901Ensembl.1
Natural variantiVAR_039978653V → F. Corresponds to variant dbSNP:rs1536207Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032523134 – 139Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057244 mRNA Translation: BAB71393.1
AL139326 Genomic DNA No translation available.
CCDSiCCDS45045.1 [Q5W0A0-1]
RefSeqiNP_872348.2, NM_182542.2 [Q5W0A0-1]
XP_016875907.1, XM_017020418.1 [Q5W0A0-1]
UniGeneiHs.668747

Genome annotation databases

EnsembliENST00000298738; ENSP00000298738; ENSG00000165837 [Q5W0A0-1]
GeneIDi220081
KEGGihsa:220081
UCSCiuc001val.2 human [Q5W0A0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiERI6B_HUMAN
AccessioniPrimary (citable) accession number: Q5W0A0
Secondary accession number(s): Q96MB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health