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Protein

Glutamate-rich protein 6B

Gene

ERICH6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich protein 6B
Alternative name(s):
Protein FAM194B
Gene namesi
Name:ERICH6B
Synonyms:FAM194B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:26523. ERICH6B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi220081.
OpenTargetsiENSG00000165837.
PharmGKBiPA165505094.

Polymorphism and mutation databases

BioMutaiFAM194B.
DMDMi74747903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260501 – 696Glutamate-rich protein 6BAdd BLAST696

Proteomic databases

EPDiQ5W0A0.
PaxDbiQ5W0A0.
PRIDEiQ5W0A0.

PTM databases

iPTMnetiQ5W0A0.
PhosphoSitePlusiQ5W0A0.

Expressioni

Gene expression databases

BgeeiENSG00000165837.

Organism-specific databases

HPAiCAB034242.
HPA040358.
HPA043559.

Interactioni

Protein-protein interaction databases

IntActiQ5W0A0. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ5W0A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 198Glu-richAdd BLAST169

Sequence similaritiesi

Belongs to the ERICH6 family.Curated

Phylogenomic databases

eggNOGiENOG410IJPV. Eukaryota.
ENOG4111TGA. LUCA.
GeneTreeiENSGT00530000064027.
HOGENOMiHOG000155621.
InParanoidiQ5W0A0.
OMAiMSAENNQ.
OrthoDBiEOG091G0M7X.
PhylomeDBiQ5W0A0.
TreeFamiTF350393.

Family and domain databases

InterProiIPR029281. FAM194.
[Graphical view]
PfamiPF14977. FAM194. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W0A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAENNQLSG ASPPHPPTTP QYSTQNLPSE KEDTEVELDE ESLQDESPFS
60 70 80 90 100
PEGESLEDKE YLEEEEDLEE EEYLGKEEYL KEEEYLGKEE HLEEEEYLEK
110 120 130 140 150
AGYLEEEEYI EEEEYLGKEG YLEEEEYLGK EEHLEEEEYL GKEGYLEKED
160 170 180 190 200
YIEEVDYLGK KAYLEEEEYL GKKSYLEEEK ALEKEENLEE EEALEKEENL
210 220 230 240 250
DGKENLYKKY LKEPKASYSS QTMLLRDARS PDAGPSQVTT FLTVPLTFAT
260 270 280 290 300
PSPVSESATE SSELLLTLYR RSQASQTDWC YDRTAVKSLK SKSETEQETT
310 320 330 340 350
TKLAPEEHVN TKVQQKKEEN VLEFASKENF WDGITDESID KLEVEDLDEN
360 370 380 390 400
FLNSSYQTVF KTIIKEMAAH NELEEDFDIP LTKLLESENR WKLVIMLKKN
410 420 430 440 450
YEKFKETILR IKRRREAQKL TEMTSFTFHL MSKPTPEKPE TEEIQKPQRV
460 470 480 490 500
VHHRKKLERD KEWIQKKTVV HQGDGKLILY PNKNVYQILF PDGTGQIHYP
510 520 530 540 550
SGNLAMLILY AKMKKFTYII LEDSLEGRIR ALINNSGNAT FYDENSDIWL
560 570 580 590 600
NLSSNLGYYF PKDKRQKAWN WWNLNIHVHA PPVQPISLKI NEYIQVQIRS
610 620 630 640 650
QDKIIFCFTY EQKQICLNLG TRYKFVIPEV LSEMKKKTIL EAEPGPTAQK
660 670 680 690
IRVLLGKMNR LLNYATTPDL ENFIEAVSIS LMDNKYLKKM LSKLWF
Length:696
Mass (Da):81,686
Last modified:December 7, 2004 - v1
Checksum:iE82E8019FB58C9A9
GO
Isoform 2 (identifier: Q5W0A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-139: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):80,893
Checksum:i3BB417340E8E5E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101A → V in BAB71393 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03996963E → D.Corresponds to variant rs12020217dbSNPEnsembl.1
Natural variantiVAR_03997099E → G.Corresponds to variant rs12020731dbSNPEnsembl.1
Natural variantiVAR_039971174S → T.Corresponds to variant rs17066954dbSNPEnsembl.1
Natural variantiVAR_039972178E → K.1 PublicationCorresponds to variant rs3014939dbSNPEnsembl.1
Natural variantiVAR_039973303L → P.Corresponds to variant rs11618506dbSNPEnsembl.1
Natural variantiVAR_039974427T → I.Corresponds to variant rs749071dbSNPEnsembl.1
Natural variantiVAR_039975439P → R.Corresponds to variant rs12429125dbSNPEnsembl.1
Natural variantiVAR_039976453H → R.Corresponds to variant rs17066902dbSNPEnsembl.1
Natural variantiVAR_039977565R → C.Corresponds to variant rs7327901dbSNPEnsembl.1
Natural variantiVAR_039978653V → F.Corresponds to variant rs1536207dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032523134 – 139Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057244 mRNA. Translation: BAB71393.1.
AL139326 Genomic DNA. Translation: CAH72890.1.
CCDSiCCDS45045.1. [Q5W0A0-1]
RefSeqiNP_872348.2. NM_182542.2. [Q5W0A0-1]
XP_016875907.1. XM_017020418.1. [Q5W0A0-1]
UniGeneiHs.668747.

Genome annotation databases

EnsembliENST00000298738; ENSP00000298738; ENSG00000165837. [Q5W0A0-1]
GeneIDi220081.
KEGGihsa:220081.
UCSCiuc001val.2. human. [Q5W0A0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057244 mRNA. Translation: BAB71393.1.
AL139326 Genomic DNA. Translation: CAH72890.1.
CCDSiCCDS45045.1. [Q5W0A0-1]
RefSeqiNP_872348.2. NM_182542.2. [Q5W0A0-1]
XP_016875907.1. XM_017020418.1. [Q5W0A0-1]
UniGeneiHs.668747.

3D structure databases

ProteinModelPortaliQ5W0A0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5W0A0. 1 interactor.

PTM databases

iPTMnetiQ5W0A0.
PhosphoSitePlusiQ5W0A0.

Polymorphism and mutation databases

BioMutaiFAM194B.
DMDMi74747903.

Proteomic databases

EPDiQ5W0A0.
PaxDbiQ5W0A0.
PRIDEiQ5W0A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298738; ENSP00000298738; ENSG00000165837. [Q5W0A0-1]
GeneIDi220081.
KEGGihsa:220081.
UCSCiuc001val.2. human. [Q5W0A0-1]

Organism-specific databases

CTDi220081.
DisGeNETi220081.
GeneCardsiERICH6B.
HGNCiHGNC:26523. ERICH6B.
HPAiCAB034242.
HPA040358.
HPA043559.
neXtProtiNX_Q5W0A0.
OpenTargetsiENSG00000165837.
PharmGKBiPA165505094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJPV. Eukaryota.
ENOG4111TGA. LUCA.
GeneTreeiENSGT00530000064027.
HOGENOMiHOG000155621.
InParanoidiQ5W0A0.
OMAiMSAENNQ.
OrthoDBiEOG091G0M7X.
PhylomeDBiQ5W0A0.
TreeFamiTF350393.

Enzyme and pathway databases

BioCyciZFISH:G66-33103-MONOMER.

Miscellaneous databases

GenomeRNAii220081.
PROiQ5W0A0.

Gene expression databases

BgeeiENSG00000165837.

Family and domain databases

InterProiIPR029281. FAM194.
[Graphical view]
PfamiPF14977. FAM194. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERI6B_HUMAN
AccessioniPrimary (citable) accession number: Q5W0A0
Secondary accession number(s): Q96MB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.