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Protein

Lipase member J

Gene

LIPJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141NucleophileBy similarity1
Active sitei312Charge relay systemPROSITE-ProRule annotation1
Active sitei341Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-LIPJ. Acidic_Lipase.
MEROPSiS33.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member J (EC:3.1.1.-)
Alternative name(s):
Lipase-like abhydrolase domain-containing protein 1
Gene namesi
Name:LIPJ
Synonyms:LIPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21773. LIPJ.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204022.
PharmGKBiPA162394099.

Polymorphism and mutation databases

BioMutaiLIPJ.
DMDMi317373431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889701 – 366Lipase member JAdd BLAST366

Proteomic databases

PaxDbiQ5W064.
PeptideAtlasiQ5W064.
PRIDEiQ5W064.

PTM databases

iPTMnetiQ5W064.
PhosphoSitePlusiQ5W064.

Expressioni

Gene expression databases

BgeeiENSG00000204022.
CleanExiHS_LIPJ.
ExpressionAtlasiQ5W064. baseline and differential.
GenevisibleiQ5W064. HS.

Organism-specific databases

HPAiHPA048594.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361007.

Structurei

3D structure databases

ProteinModelPortaliQ5W064.
SMRiQ5W064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiQ5W064.
OMAiQEEIFYV.
OrthoDBiEOG091G09AX.
PhylomeDBiQ5W064.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF04083. Abhydro_lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5W064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISQIISYW GYPDEEYDIV TEDGYILGLY RIPYWRTDNN KNLAQRVVVY
60 70 80 90 100
LQHGLLTSAS SWISNLPNNS LGFILADAGY DVWMGNSRGN TWSRKHLYLE
110 120 130 140 150
TSSKEFWAFS FDEMAKYDLP ASIDFTVKQT RQEEIFYVGH SQGTTIGFIT
160 170 180 190 200
FSTISKIAER IKIFFALAPV FSTKYLKSPL IRMTYKWKSI VMAFSGNKDF
210 220 230 240 250
LPKTSFKKFI GSKLCPLQIF DKICLNILFM MFGYDPKNLN MSRLDVYFSH
260 270 280 290 300
NPAGTSVQNM LHWSQLLNST HLKAYDWGSP DLNLVHYNQT TSPLYNMTNM
310 320 330 340 350
NVATAIWNGK SDLLADPEDV NILHSEITNH IYYKTISYYN HIDSLFGLDV
360
YDQVYHEIID IIQDNL
Length:366
Mass (Da):42,388
Last modified:January 11, 2011 - v3
Checksum:i0019AE513B75DD7A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032543210I → V.1 PublicationCorresponds to variant rs1409136dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139406 Genomic DNA. Translation: CAH73713.1.
BC031219 mRNA. Translation: AAH31219.1.
CCDSiCCDS31240.1.
RefSeqiNP_001010939.2. NM_001010939.2.
XP_006717698.1. XM_006717635.2.
XP_011537616.1. XM_011539314.2.
XP_011537617.1. XM_011539315.2.
UniGeneiHs.440959.
Hs.601660.

Genome annotation databases

EnsembliENST00000371939; ENSP00000361007; ENSG00000204022.
GeneIDi142910.
KEGGihsa:142910.
UCSCiuc001kff.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139406 Genomic DNA. Translation: CAH73713.1.
BC031219 mRNA. Translation: AAH31219.1.
CCDSiCCDS31240.1.
RefSeqiNP_001010939.2. NM_001010939.2.
XP_006717698.1. XM_006717635.2.
XP_011537616.1. XM_011539314.2.
XP_011537617.1. XM_011539315.2.
UniGeneiHs.440959.
Hs.601660.

3D structure databases

ProteinModelPortaliQ5W064.
SMRiQ5W064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361007.

Protein family/group databases

ESTHERihuman-LIPJ. Acidic_Lipase.
MEROPSiS33.020.

PTM databases

iPTMnetiQ5W064.
PhosphoSitePlusiQ5W064.

Polymorphism and mutation databases

BioMutaiLIPJ.
DMDMi317373431.

Proteomic databases

PaxDbiQ5W064.
PeptideAtlasiQ5W064.
PRIDEiQ5W064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371939; ENSP00000361007; ENSG00000204022.
GeneIDi142910.
KEGGihsa:142910.
UCSCiuc001kff.3. human.

Organism-specific databases

CTDi142910.
GeneCardsiLIPJ.
HGNCiHGNC:21773. LIPJ.
HPAiHPA048594.
MIMi613921. gene.
neXtProtiNX_Q5W064.
OpenTargetsiENSG00000204022.
PharmGKBiPA162394099.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiQ5W064.
OMAiQEEIFYV.
OrthoDBiEOG091G09AX.
PhylomeDBiQ5W064.
TreeFamiTF315485.

Enzyme and pathway databases

ReactomeiR-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

GenomeRNAii142910.
PROiQ5W064.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204022.
CleanExiHS_LIPJ.
ExpressionAtlasiQ5W064. baseline and differential.
GenevisibleiQ5W064. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF04083. Abhydro_lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPJ_HUMAN
AccessioniPrimary (citable) accession number: Q5W064
Secondary accession number(s): A8MT98, Q0P671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.