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Q5W041

- ARMC3_HUMAN

UniProt

Q5W041 - ARMC3_HUMAN

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Protein

Armadillo repeat-containing protein 3

Gene

ARMC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ5W041.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 3
Alternative name(s):
Beta-catenin-like protein
Cancer/testis antigen 81
Short name:
CT81
KU-CT-1
Gene namesi
Name:ARMC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30964. ARMC3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 872872Armadillo repeat-containing protein 3PRO_0000284403Add
BLAST

Proteomic databases

MaxQBiQ5W041.
PaxDbiQ5W041.
PRIDEiQ5W041.

PTM databases

PhosphoSiteiQ5W041.

Expressioni

Tissue specificityi

Isoform 2 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines.2 Publications

Gene expression databases

BgeeiQ5W041.
CleanExiHS_ARMC3.
ExpressionAtlasiQ5W041. baseline and differential.
GenevestigatoriQ5W041.

Organism-specific databases

HPAiHPA037823.
HPA037824.

Structurei

3D structure databases

ProteinModelPortaliQ5W041.
SMRiQ5W041. Positions 3-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 5440ARM 1Add
BLAST
Repeati57 – 9640ARM 2Add
BLAST
Repeati98 – 13841ARM 3Add
BLAST
Repeati140 – 17940ARM 4Add
BLAST
Repeati181 – 22040ARM 5Add
BLAST
Repeati222 – 26241ARM 6Add
BLAST
Repeati264 – 30441ARM 7Add
BLAST
Repeati306 – 34540ARM 8Add
BLAST
Repeati346 – 38540ARM 9Add
BLAST
Repeati388 – 42740ARM 10Add
BLAST
Repeati429 – 46840ARM 11Add
BLAST
Repeati470 – 50940ARM 12Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 6337Poly-Ser
Compositional biasi695 – 6984Poly-Glu

Sequence similaritiesi

Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG265712.
GeneTreeiENSGT00730000110852.
HOVERGENiHBG059366.
InParanoidiQ5W041.
OMAiRRNATMI.
OrthoDBiEOG7W6WK2.
PhylomeDBiQ5W041.
TreeFamiTF329738.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 10 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5W041-2) [UniParc]FASTAAdd to Basket

Also known as: ARMC3_Nu1, KU-CT-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY
60 70 80 90 100
KFALKGEENK TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV
110 120 130 140 150
KKLLRELDVM NSVIAQLAPE EEVVIHEFAS LCLANMSAEY TSKVQIFEHG
160 170 180 190 200
GLEPLIRLLS SPDPDVKKNS MECIYNLVQD FQCRAKLQEL NAIPPILDLL
210 220 230 240 250
KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI LETKELNDLH
260 270 280 290 300
IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT
310 320 330 340 350
KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK
360 370 380 390 400
DFFNNQGIPQ LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI
410 420 430 440 450
DPLINLLSSK RDGAIANAAT VLTNMAMQEP LRLNIQNHDI MHAIISPLRS
460 470 480 490 500
ANTVVQSKAA LAVTATACDV EARTELRNSG GLEPLVELLR SKNDEVRKHA
510 520 530 540 550
SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS EAAYNKLLNN
560 570 580 590 600
NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA
610 620 630 640 650
VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS
660 670 680 690 700
AGFGSPIEDK SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM
710 720 730 740 750
VVPKFVGEGS SDKEWCPPSD PDFSMYVYEV TKSILPITNI KEQIEDLAKY
760 770 780 790 800
VAEKMGGKIP KEKLPDFSWE LHISELKFQL KSNVIPIGHV KKGIFYHRAL
810 820 830 840 850
LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG LPAPEMYVID
860 870
LMFHPGGLMK LRSREADLYR FI
Length:872
Mass (Da):96,405
Last modified:November 25, 2008 - v2
Checksum:i02ED1C432D961857
GO
Isoform 3 (identifier: Q5W041-3) [UniParc]FASTAAdd to Basket

Also known as: ARMC3_Nu2

The sequence of this isoform differs from the canonical sequence as follows:
     682-688: RKSKGKK → SSLPTSR
     689-872: Missing.

Show »
Length:688
Mass (Da):75,318
Checksum:i3C1459C84491B9BD
GO
Isoform 4 (identifier: Q5W041-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-650: KKNSYHFS → N

Note: No experimental confirmation available.

Show »
Length:865
Mass (Da):95,527
Checksum:iAA4B1CE46CBA3498
GO
Isoform 5 (identifier: Q5W041-5) [UniParc]FASTAAdd to Basket

Also known as: KU-CT-1

The sequence of this isoform differs from the canonical sequence as follows:
     392-397: NAAAEA → KEMEHE
     398-872: Missing.

Show »
Length:397
Mass (Da):43,985
Checksum:i37CF353D598D7531
GO

Sequence cautioni

The sequence BAC05389.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti586 – 5861P → S in BAB71463. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti345 – 3451E → G.
Corresponds to variant rs16922864 [ dbSNP | Ensembl ].
VAR_050669
Natural varianti608 – 6081S → P.
Corresponds to variant rs11013233 [ dbSNP | Ensembl ].
VAR_050670
Natural varianti626 – 6261R → Q.1 Publication
Corresponds to variant rs10828395 [ dbSNP | Ensembl ].
VAR_050671

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei392 – 3976NAAAEA → KEMEHE in isoform 5. 1 PublicationVSP_028551
Alternative sequencei398 – 872475Missing in isoform 5. 1 PublicationVSP_028552Add
BLAST
Alternative sequencei643 – 6508KKNSYHFS → N in isoform 4. 1 PublicationVSP_024498
Alternative sequencei682 – 6887RKSKGKK → SSLPTSR in isoform 3. 1 PublicationVSP_024500
Alternative sequencei689 – 872184Missing in isoform 3. 1 PublicationVSP_024501Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436643 mRNA. Translation: AAR99738.1.
AK057389 mRNA. Translation: BAB71463.1.
AK098711 mRNA. Translation: BAC05389.1. Different initiation.
AL139815, AC079269 Genomic DNA. Translation: CAX14862.1.
AL139815, AC079269 Genomic DNA. Translation: CAX14863.1.
AK302985 mRNA. Translation: BAG64125.1.
AL139815, AC079269 Genomic DNA. Translation: CAH72189.2.
BC039312 mRNA. Translation: AAH39312.1.
CCDSiCCDS60499.1. [Q5W041-3]
CCDS60500.1. [Q5W041-4]
CCDS7142.1. [Q5W041-2]
RefSeqiNP_001269674.1. NM_001282745.1. [Q5W041-4]
NP_001269675.1. NM_001282746.1. [Q5W041-3]
NP_001269676.1. NM_001282747.1.
NP_775104.2. NM_173081.4. [Q5W041-2]
UniGeneiHs.659807.
Hs.722481.

Genome annotation databases

EnsembliENST00000298032; ENSP00000298032; ENSG00000165309. [Q5W041-2]
ENST00000409049; ENSP00000387288; ENSG00000165309. [Q5W041-3]
ENST00000409983; ENSP00000386943; ENSG00000165309. [Q5W041-4]
GeneIDi219681.
KEGGihsa:219681.
UCSCiuc001irm.4. human. [Q5W041-2]
uc010qcv.2. human. [Q5W041-4]

Polymorphism databases

DMDMi215273946.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436643 mRNA. Translation: AAR99738.1 .
AK057389 mRNA. Translation: BAB71463.1 .
AK098711 mRNA. Translation: BAC05389.1 . Different initiation.
AL139815 , AC079269 Genomic DNA. Translation: CAX14862.1 .
AL139815 , AC079269 Genomic DNA. Translation: CAX14863.1 .
AK302985 mRNA. Translation: BAG64125.1 .
AL139815 , AC079269 Genomic DNA. Translation: CAH72189.2 .
BC039312 mRNA. Translation: AAH39312.1 .
CCDSi CCDS60499.1. [Q5W041-3 ]
CCDS60500.1. [Q5W041-4 ]
CCDS7142.1. [Q5W041-2 ]
RefSeqi NP_001269674.1. NM_001282745.1. [Q5W041-4 ]
NP_001269675.1. NM_001282746.1. [Q5W041-3 ]
NP_001269676.1. NM_001282747.1.
NP_775104.2. NM_173081.4. [Q5W041-2 ]
UniGenei Hs.659807.
Hs.722481.

3D structure databases

ProteinModelPortali Q5W041.
SMRi Q5W041. Positions 3-538.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5W041.

Polymorphism databases

DMDMi 215273946.

Proteomic databases

MaxQBi Q5W041.
PaxDbi Q5W041.
PRIDEi Q5W041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298032 ; ENSP00000298032 ; ENSG00000165309 . [Q5W041-2 ]
ENST00000409049 ; ENSP00000387288 ; ENSG00000165309 . [Q5W041-3 ]
ENST00000409983 ; ENSP00000386943 ; ENSG00000165309 . [Q5W041-4 ]
GeneIDi 219681.
KEGGi hsa:219681.
UCSCi uc001irm.4. human. [Q5W041-2 ]
uc010qcv.2. human. [Q5W041-4 ]

Organism-specific databases

CTDi 219681.
GeneCardsi GC10P023256.
H-InvDB HIX0023076.
HGNCi HGNC:30964. ARMC3.
HPAi HPA037823.
HPA037824.
MIMi 611226. gene.
neXtProti NX_Q5W041.
PharmGKBi PA134917281.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265712.
GeneTreei ENSGT00730000110852.
HOVERGENi HBG059366.
InParanoidi Q5W041.
OMAi RRNATMI.
OrthoDBi EOG7W6WK2.
PhylomeDBi Q5W041.
TreeFami TF329738.

Enzyme and pathway databases

SignaLinki Q5W041.

Miscellaneous databases

GenomeRNAii 219681.
NextBioi 90715.
PROi Q5W041.
SOURCEi Search...

Gene expression databases

Bgeei Q5W041.
CleanExi HS_ARMC3.
ExpressionAtlasi Q5W041. baseline and differential.
Genevestigatori Q5W041.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view ]
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
SMARTi SM00185. ARM. 10 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50176. ARM_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene."
    Li X., Liu B., Ji C.N., Kang Y., Mao Y.
    Genetika 42:999-1003(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 459-875 (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-626.
    Tissue: Testis.
  5. "A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers."
    Okada T., Akada M., Fujita T., Iwata T., Goto Y., Kido K., Okada T., Matsuzaki Y., Kobayashi K., Matsuno S., Sunamura M., Kawakami Y.
    Clin. Cancer Res. 12:191-197(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
    Tissue: Testis.

Entry informationi

Entry nameiARMC3_HUMAN
AccessioniPrimary (citable) accession number: Q5W041
Secondary accession number(s): A0PG76
, A6NH64, B4DZL3, B7ZBN6, B7ZBN7, Q8IXS5, Q8N7B0, Q96M49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3