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Q5W041

- ARMC3_HUMAN

UniProt

Q5W041 - ARMC3_HUMAN

Protein

Armadillo repeat-containing protein 3

Gene

ARMC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ5W041.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo repeat-containing protein 3
    Alternative name(s):
    Beta-catenin-like protein
    Cancer/testis antigen 81
    Short name:
    CT81
    KU-CT-1
    Gene namesi
    Name:ARMC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:30964. ARMC3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134917281.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 872872Armadillo repeat-containing protein 3PRO_0000284403Add
    BLAST

    Proteomic databases

    PaxDbiQ5W041.
    PRIDEiQ5W041.

    PTM databases

    PhosphoSiteiQ5W041.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines.2 Publications

    Gene expression databases

    ArrayExpressiQ5W041.
    BgeeiQ5W041.
    CleanExiHS_ARMC3.
    GenevestigatoriQ5W041.

    Organism-specific databases

    HPAiHPA037823.
    HPA037824.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5W041.
    SMRiQ5W041. Positions 3-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati15 – 5440ARM 1Add
    BLAST
    Repeati57 – 9640ARM 2Add
    BLAST
    Repeati98 – 13841ARM 3Add
    BLAST
    Repeati140 – 17940ARM 4Add
    BLAST
    Repeati181 – 22040ARM 5Add
    BLAST
    Repeati222 – 26241ARM 6Add
    BLAST
    Repeati264 – 30441ARM 7Add
    BLAST
    Repeati306 – 34540ARM 8Add
    BLAST
    Repeati346 – 38540ARM 9Add
    BLAST
    Repeati388 – 42740ARM 10Add
    BLAST
    Repeati429 – 46840ARM 11Add
    BLAST
    Repeati470 – 50940ARM 12Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi627 – 6337Poly-Ser
    Compositional biasi695 – 6984Poly-Glu

    Sequence similaritiesi

    Contains 12 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG265712.
    HOVERGENiHBG059366.
    InParanoidiQ5W041.
    OMAiRRNATMI.
    OrthoDBiEOG7W6WK2.
    PhylomeDBiQ5W041.
    TreeFamiTF329738.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view]
    PfamiPF00514. Arm. 3 hits.
    [Graphical view]
    SMARTiSM00185. ARM. 10 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50176. ARM_REPEAT. 4 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5W041-2) [UniParc]FASTAAdd to Basket

    Also known as: ARMC3_Nu1, KU-CT-1L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY    50
    KFALKGEENK TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV 100
    KKLLRELDVM NSVIAQLAPE EEVVIHEFAS LCLANMSAEY TSKVQIFEHG 150
    GLEPLIRLLS SPDPDVKKNS MECIYNLVQD FQCRAKLQEL NAIPPILDLL 200
    KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI LETKELNDLH 250
    IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT 300
    KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK 350
    DFFNNQGIPQ LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI 400
    DPLINLLSSK RDGAIANAAT VLTNMAMQEP LRLNIQNHDI MHAIISPLRS 450
    ANTVVQSKAA LAVTATACDV EARTELRNSG GLEPLVELLR SKNDEVRKHA 500
    SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS EAAYNKLLNN 550
    NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA 600
    VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS 650
    AGFGSPIEDK SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM 700
    VVPKFVGEGS SDKEWCPPSD PDFSMYVYEV TKSILPITNI KEQIEDLAKY 750
    VAEKMGGKIP KEKLPDFSWE LHISELKFQL KSNVIPIGHV KKGIFYHRAL 800
    LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG LPAPEMYVID 850
    LMFHPGGLMK LRSREADLYR FI 872
    Length:872
    Mass (Da):96,405
    Last modified:November 25, 2008 - v2
    Checksum:i02ED1C432D961857
    GO
    Isoform 3 (identifier: Q5W041-3) [UniParc]FASTAAdd to Basket

    Also known as: ARMC3_Nu2

    The sequence of this isoform differs from the canonical sequence as follows:
         682-688: RKSKGKK → SSLPTSR
         689-872: Missing.

    Show »
    Length:688
    Mass (Da):75,318
    Checksum:i3C1459C84491B9BD
    GO
    Isoform 4 (identifier: Q5W041-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         643-650: KKNSYHFS → N

    Note: No experimental confirmation available.

    Show »
    Length:865
    Mass (Da):95,527
    Checksum:iAA4B1CE46CBA3498
    GO
    Isoform 5 (identifier: Q5W041-5) [UniParc]FASTAAdd to Basket

    Also known as: KU-CT-1

    The sequence of this isoform differs from the canonical sequence as follows:
         392-397: NAAAEA → KEMEHE
         398-872: Missing.

    Show »
    Length:397
    Mass (Da):43,985
    Checksum:i37CF353D598D7531
    GO

    Sequence cautioni

    The sequence BAC05389.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti586 – 5861P → S in BAB71463. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti345 – 3451E → G.
    Corresponds to variant rs16922864 [ dbSNP | Ensembl ].
    VAR_050669
    Natural varianti608 – 6081S → P.
    Corresponds to variant rs11013233 [ dbSNP | Ensembl ].
    VAR_050670
    Natural varianti626 – 6261R → Q.1 Publication
    Corresponds to variant rs10828395 [ dbSNP | Ensembl ].
    VAR_050671

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei392 – 3976NAAAEA → KEMEHE in isoform 5. 1 PublicationVSP_028551
    Alternative sequencei398 – 872475Missing in isoform 5. 1 PublicationVSP_028552Add
    BLAST
    Alternative sequencei643 – 6508KKNSYHFS → N in isoform 4. 1 PublicationVSP_024498
    Alternative sequencei682 – 6887RKSKGKK → SSLPTSR in isoform 3. 1 PublicationVSP_024500
    Alternative sequencei689 – 872184Missing in isoform 3. 1 PublicationVSP_024501Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY436643 mRNA. Translation: AAR99738.1.
    AK057389 mRNA. Translation: BAB71463.1.
    AK098711 mRNA. Translation: BAC05389.1. Different initiation.
    AL139815, AC079269 Genomic DNA. Translation: CAX14862.1.
    AL139815, AC079269 Genomic DNA. Translation: CAX14863.1.
    AK302985 mRNA. Translation: BAG64125.1.
    AL139815, AC079269 Genomic DNA. Translation: CAH72189.2.
    BC039312 mRNA. Translation: AAH39312.1.
    CCDSiCCDS60499.1. [Q5W041-3]
    CCDS60500.1. [Q5W041-4]
    CCDS7142.1. [Q5W041-2]
    RefSeqiNP_001269674.1. NM_001282745.1. [Q5W041-4]
    NP_001269675.1. NM_001282746.1. [Q5W041-3]
    NP_001269676.1. NM_001282747.1.
    NP_775104.2. NM_173081.4. [Q5W041-2]
    UniGeneiHs.659807.
    Hs.722481.

    Genome annotation databases

    EnsembliENST00000298032; ENSP00000298032; ENSG00000165309. [Q5W041-2]
    ENST00000409049; ENSP00000387288; ENSG00000165309. [Q5W041-3]
    ENST00000409983; ENSP00000386943; ENSG00000165309. [Q5W041-4]
    GeneIDi219681.
    KEGGihsa:219681.
    UCSCiuc001irm.4. human. [Q5W041-2]
    uc010qcv.2. human. [Q5W041-4]

    Polymorphism databases

    DMDMi215273946.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY436643 mRNA. Translation: AAR99738.1 .
    AK057389 mRNA. Translation: BAB71463.1 .
    AK098711 mRNA. Translation: BAC05389.1 . Different initiation.
    AL139815 , AC079269 Genomic DNA. Translation: CAX14862.1 .
    AL139815 , AC079269 Genomic DNA. Translation: CAX14863.1 .
    AK302985 mRNA. Translation: BAG64125.1 .
    AL139815 , AC079269 Genomic DNA. Translation: CAH72189.2 .
    BC039312 mRNA. Translation: AAH39312.1 .
    CCDSi CCDS60499.1. [Q5W041-3 ]
    CCDS60500.1. [Q5W041-4 ]
    CCDS7142.1. [Q5W041-2 ]
    RefSeqi NP_001269674.1. NM_001282745.1. [Q5W041-4 ]
    NP_001269675.1. NM_001282746.1. [Q5W041-3 ]
    NP_001269676.1. NM_001282747.1.
    NP_775104.2. NM_173081.4. [Q5W041-2 ]
    UniGenei Hs.659807.
    Hs.722481.

    3D structure databases

    ProteinModelPortali Q5W041.
    SMRi Q5W041. Positions 3-532.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5W041.

    Polymorphism databases

    DMDMi 215273946.

    Proteomic databases

    PaxDbi Q5W041.
    PRIDEi Q5W041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298032 ; ENSP00000298032 ; ENSG00000165309 . [Q5W041-2 ]
    ENST00000409049 ; ENSP00000387288 ; ENSG00000165309 . [Q5W041-3 ]
    ENST00000409983 ; ENSP00000386943 ; ENSG00000165309 . [Q5W041-4 ]
    GeneIDi 219681.
    KEGGi hsa:219681.
    UCSCi uc001irm.4. human. [Q5W041-2 ]
    uc010qcv.2. human. [Q5W041-4 ]

    Organism-specific databases

    CTDi 219681.
    GeneCardsi GC10P023256.
    H-InvDB HIX0023076.
    HGNCi HGNC:30964. ARMC3.
    HPAi HPA037823.
    HPA037824.
    MIMi 611226. gene.
    neXtProti NX_Q5W041.
    PharmGKBi PA134917281.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265712.
    HOVERGENi HBG059366.
    InParanoidi Q5W041.
    OMAi RRNATMI.
    OrthoDBi EOG7W6WK2.
    PhylomeDBi Q5W041.
    TreeFami TF329738.

    Enzyme and pathway databases

    SignaLinki Q5W041.

    Miscellaneous databases

    GenomeRNAii 219681.
    NextBioi 90715.
    PROi Q5W041.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5W041.
    Bgeei Q5W041.
    CleanExi HS_ARMC3.
    Genevestigatori Q5W041.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view ]
    Pfami PF00514. Arm. 3 hits.
    [Graphical view ]
    SMARTi SM00185. ARM. 10 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50176. ARM_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene."
      Li X., Liu B., Ji C.N., Kang Y., Mao Y.
      Genetika 42:999-1003(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 459-875 (ISOFORM 1).
      Tissue: Testis.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-626.
      Tissue: Testis.
    5. "A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers."
      Okada T., Akada M., Fujita T., Iwata T., Goto Y., Kido K., Okada T., Matsuzaki Y., Kobayashi K., Matsuno S., Sunamura M., Kawakami Y.
      Clin. Cancer Res. 12:191-197(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
      Tissue: Testis.

    Entry informationi

    Entry nameiARMC3_HUMAN
    AccessioniPrimary (citable) accession number: Q5W041
    Secondary accession number(s): A0PG76
    , A6NH64, B4DZL3, B7ZBN6, B7ZBN7, Q8IXS5, Q8N7B0, Q96M49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3