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Q5W041 (ARMC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Armadillo repeat-containing protein 3
Alternative name(s):
Beta-catenin-like protein
Cancer/testis antigen 81
Short name=CT81
KU-CT-1
Gene names
Name:ARMC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length872 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Isoform 2is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines. Ref.1 Ref.5

Sequence similarities

Contains 12 ARM repeats.

Sequence caution

The sequence BAC05389.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5W041-2)

Also known as: ARMC3_Nu1; KU-CT-1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3 (identifier: Q5W041-3)

Also known as: ARMC3_Nu2;

The sequence of this isoform differs from the canonical sequence as follows:
     682-688: RKSKGKK → SSLPTSR
     689-872: Missing.
Isoform 4 (identifier: Q5W041-4)

The sequence of this isoform differs from the canonical sequence as follows:
     643-650: KKNSYHFS → N
Note: No experimental confirmation available.
Isoform 5 (identifier: Q5W041-5)

Also known as: KU-CT-1;

The sequence of this isoform differs from the canonical sequence as follows:
     392-397: NAAAEA → KEMEHE
     398-872: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 872872Armadillo repeat-containing protein 3
PRO_0000284403

Regions

Repeat15 – 5440ARM 1
Repeat57 – 9640ARM 2
Repeat98 – 13841ARM 3
Repeat140 – 17940ARM 4
Repeat181 – 22040ARM 5
Repeat222 – 26241ARM 6
Repeat264 – 30441ARM 7
Repeat306 – 34540ARM 8
Repeat346 – 38540ARM 9
Repeat388 – 42740ARM 10
Repeat429 – 46840ARM 11
Repeat470 – 50940ARM 12
Compositional bias627 – 6337Poly-Ser
Compositional bias695 – 6984Poly-Glu

Natural variations

Alternative sequence392 – 3976NAAAEA → KEMEHE in isoform 5.
VSP_028551
Alternative sequence398 – 872475Missing in isoform 5.
VSP_028552
Alternative sequence643 – 6508KKNSYHFS → N in isoform 4.
VSP_024498
Alternative sequence682 – 6887RKSKGKK → SSLPTSR in isoform 3.
VSP_024500
Alternative sequence689 – 872184Missing in isoform 3.
VSP_024501
Natural variant3451E → G.
Corresponds to variant rs16922864 [ dbSNP | Ensembl ].
VAR_050669
Natural variant6081S → P.
Corresponds to variant rs11013233 [ dbSNP | Ensembl ].
VAR_050670
Natural variant6261R → Q. Ref.4
Corresponds to variant rs10828395 [ dbSNP | Ensembl ].
VAR_050671

Experimental info

Sequence conflict5861P → S in BAB71463. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ARMC3_Nu1) (KU-CT-1L) [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 02ED1C432D961857

FASTA87296,405
        10         20         30         40         50         60 
MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK 

        70         80         90        100        110        120 
TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE 

       130        140        150        160        170        180 
EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD 

       190        200        210        220        230        240 
FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI 

       250        260        270        280        290        300 
LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT 

       310        320        330        340        350        360 
KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ 

       370        380        390        400        410        420 
LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI DPLINLLSSK RDGAIANAAT 

       430        440        450        460        470        480 
VLTNMAMQEP LRLNIQNHDI MHAIISPLRS ANTVVQSKAA LAVTATACDV EARTELRNSG 

       490        500        510        520        530        540 
GLEPLVELLR SKNDEVRKHA SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS 

       550        560        570        580        590        600 
EAAYNKLLNN NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA 

       610        620        630        640        650        660 
VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS AGFGSPIEDK 

       670        680        690        700        710        720 
SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM VVPKFVGEGS SDKEWCPPSD 

       730        740        750        760        770        780 
PDFSMYVYEV TKSILPITNI KEQIEDLAKY VAEKMGGKIP KEKLPDFSWE LHISELKFQL 

       790        800        810        820        830        840 
KSNVIPIGHV KKGIFYHRAL LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG 

       850        860        870 
LPAPEMYVID LMFHPGGLMK LRSREADLYR FI 

« Hide

Isoform 3 (ARMC3_Nu2) [UniParc].

Checksum: 3C1459C84491B9BD
Show »

FASTA68875,318
Isoform 4 [UniParc].

Checksum: AA4B1CE46CBA3498
Show »

FASTA86595,527
Isoform 5 (KU-CT-1) [UniParc].

Checksum: 37CF353D598D7531
Show »

FASTA39743,985

References

« Hide 'large scale' references
[1]"Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene."
Li X., Liu B., Ji C.N., Kang Y., Mao Y.
Genetika 42:999-1003(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 459-875 (ISOFORM 1).
Tissue: Testis.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-626.
Tissue: Testis.
[5]"A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers."
Okada T., Akada M., Fujita T., Iwata T., Goto Y., Kido K., Okada T., Matsuzaki Y., Kobayashi K., Matsuno S., Sunamura M., Kawakami Y.
Clin. Cancer Res. 12:191-197(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY436643 mRNA. Translation: AAR99738.1.
AK057389 mRNA. Translation: BAB71463.1.
AK098711 mRNA. Translation: BAC05389.1. Different initiation.
AL139815, AC079269 Genomic DNA. Translation: CAX14862.1.
AL139815, AC079269 Genomic DNA. Translation: CAX14863.1.
AK302985 mRNA. Translation: BAG64125.1.
AL139815, AC079269 Genomic DNA. Translation: CAH72189.2.
BC039312 mRNA. Translation: AAH39312.1.
RefSeqNP_001269674.1. NM_001282745.1.
NP_001269675.1. NM_001282746.1.
NP_001269676.1. NM_001282747.1.
NP_775104.2. NM_173081.4.
UniGeneHs.659807.
Hs.722481.

3D structure databases

ProteinModelPortalQ5W041.
SMRQ5W041. Positions 3-532.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5W041.

Polymorphism databases

DMDM215273946.

Proteomic databases

PaxDbQ5W041.
PRIDEQ5W041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298032; ENSP00000298032; ENSG00000165309. [Q5W041-2]
ENST00000409049; ENSP00000387288; ENSG00000165309. [Q5W041-3]
ENST00000409983; ENSP00000386943; ENSG00000165309. [Q5W041-4]
GeneID219681.
KEGGhsa:219681.
UCSCuc001irm.4. human. [Q5W041-2]
uc010qcv.2. human. [Q5W041-4]

Organism-specific databases

CTD219681.
GeneCardsGC10P023256.
H-InvDBHIX0023076.
HGNCHGNC:30964. ARMC3.
HPAHPA037823.
HPA037824.
MIM611226. gene.
neXtProtNX_Q5W041.
PharmGKBPA134917281.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG265712.
HOVERGENHBG059366.
InParanoidQ5W041.
OMARRNATMI.
OrthoDBEOG7W6WK2.
PhylomeDBQ5W041.
TreeFamTF329738.

Enzyme and pathway databases

SignaLinkQ5W041.

Gene expression databases

ArrayExpressQ5W041.
BgeeQ5W041.
CleanExHS_ARMC3.
GenevestigatorQ5W041.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamPF00514. Arm. 3 hits.
[Graphical view]
SMARTSM00185. ARM. 10 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
PROSITEPS50176. ARM_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi219681.
NextBio90715.
PROQ5W041.
SOURCESearch...

Entry information

Entry nameARMC3_HUMAN
AccessionPrimary (citable) accession number: Q5W041
Secondary accession number(s): A0PG76 expand/collapse secondary AC list , A6NH64, B4DZL3, B7ZBN6, B7ZBN7, Q8IXS5, Q8N7B0, Q96M49
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: March 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM