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Protein

Armadillo repeat-containing protein 3

Gene

ARMC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Enzyme and pathway databases

SignaLinkiQ5W041

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 3
Alternative name(s):
Beta-catenin-like protein
Cancer/testis antigen 81
Short name:
CT81
KU-CT-1
Gene namesi
Name:ARMC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165309.13
HGNCiHGNC:30964 ARMC3
MIMi611226 gene
neXtProtiNX_Q5W041

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi219681
OpenTargetsiENSG00000165309
PharmGKBiPA134917281

Polymorphism and mutation databases

BioMutaiARMC3
DMDMi215273946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844031 – 872Armadillo repeat-containing protein 3Add BLAST872

Proteomic databases

EPDiQ5W041
PaxDbiQ5W041
PeptideAtlasiQ5W041
PRIDEiQ5W041

PTM databases

iPTMnetiQ5W041
PhosphoSitePlusiQ5W041

Expressioni

Tissue specificityi

Isoform 1 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines.2 Publications

Gene expression databases

BgeeiENSG00000165309
CleanExiHS_ARMC3
ExpressionAtlasiQ5W041 baseline and differential
GenevisibleiQ5W041 HS

Organism-specific databases

HPAiHPA037823
HPA037824

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298032

Structurei

3D structure databases

ProteinModelPortaliQ5W041
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 54ARM 1Add BLAST40
Repeati57 – 96ARM 2Add BLAST40
Repeati98 – 138ARM 3Add BLAST41
Repeati140 – 179ARM 4Add BLAST40
Repeati181 – 220ARM 5Add BLAST40
Repeati222 – 262ARM 6Add BLAST41
Repeati264 – 304ARM 7Add BLAST41
Repeati306 – 345ARM 8Add BLAST40
Repeati346 – 385ARM 9Add BLAST40
Repeati388 – 427ARM 10Add BLAST40
Repeati429 – 468ARM 11Add BLAST40
Repeati470 – 509ARM 12Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi627 – 633Poly-Ser7
Compositional biasi695 – 698Poly-Glu4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITMR Eukaryota
ENOG410XPHA LUCA
GeneTreeiENSGT00730000110852
HOVERGENiHBG059366
InParanoidiQ5W041
OMAiLKYSQTG
OrthoDBiEOG091G02KO
PhylomeDBiQ5W041
TreeFamiTF329738

Family and domain databases

Gene3Di1.25.10.102 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 10 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 4 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W041-2) [UniParc]FASTAAdd to basket
Also known as: ARMC3_Nu1, KU-CT-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY
60 70 80 90 100
KFALKGEENK TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV
110 120 130 140 150
KKLLRELDVM NSVIAQLAPE EEVVIHEFAS LCLANMSAEY TSKVQIFEHG
160 170 180 190 200
GLEPLIRLLS SPDPDVKKNS MECIYNLVQD FQCRAKLQEL NAIPPILDLL
210 220 230 240 250
KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI LETKELNDLH
260 270 280 290 300
IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT
310 320 330 340 350
KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK
360 370 380 390 400
DFFNNQGIPQ LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI
410 420 430 440 450
DPLINLLSSK RDGAIANAAT VLTNMAMQEP LRLNIQNHDI MHAIISPLRS
460 470 480 490 500
ANTVVQSKAA LAVTATACDV EARTELRNSG GLEPLVELLR SKNDEVRKHA
510 520 530 540 550
SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS EAAYNKLLNN
560 570 580 590 600
NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA
610 620 630 640 650
VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS
660 670 680 690 700
AGFGSPIEDK SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM
710 720 730 740 750
VVPKFVGEGS SDKEWCPPSD PDFSMYVYEV TKSILPITNI KEQIEDLAKY
760 770 780 790 800
VAEKMGGKIP KEKLPDFSWE LHISELKFQL KSNVIPIGHV KKGIFYHRAL
810 820 830 840 850
LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG LPAPEMYVID
860 870
LMFHPGGLMK LRSREADLYR FI
Length:872
Mass (Da):96,405
Last modified:November 25, 2008 - v2
Checksum:i02ED1C432D961857
GO
Isoform 3 (identifier: Q5W041-3) [UniParc]FASTAAdd to basket
Also known as: ARMC3_Nu2

The sequence of this isoform differs from the canonical sequence as follows:
     682-688: RKSKGKK → SSLPTSR
     689-872: Missing.

Show »
Length:688
Mass (Da):75,318
Checksum:i3C1459C84491B9BD
GO
Isoform 4 (identifier: Q5W041-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-650: KKNSYHFS → N

Note: No experimental confirmation available.
Show »
Length:865
Mass (Da):95,527
Checksum:iAA4B1CE46CBA3498
GO
Isoform 5 (identifier: Q5W041-5) [UniParc]FASTAAdd to basket
Also known as: KU-CT-1

The sequence of this isoform differs from the canonical sequence as follows:
     392-397: NAAAEA → KEMEHE
     398-872: Missing.

Show »
Length:397
Mass (Da):43,985
Checksum:i37CF353D598D7531
GO

Sequence cautioni

The sequence BAC05389 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti586P → S in BAB71463 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050669345E → G. Corresponds to variant dbSNP:rs16922864Ensembl.1
Natural variantiVAR_050670608S → P. Corresponds to variant dbSNP:rs11013233Ensembl.1
Natural variantiVAR_050671626R → Q1 PublicationCorresponds to variant dbSNP:rs10828395Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028551392 – 397NAAAEA → KEMEHE in isoform 5. 1 Publication6
Alternative sequenceiVSP_028552398 – 872Missing in isoform 5. 1 PublicationAdd BLAST475
Alternative sequenceiVSP_024498643 – 650KKNSYHFS → N in isoform 4. 1 Publication8
Alternative sequenceiVSP_024500682 – 688RKSKGKK → SSLPTSR in isoform 3. 1 Publication7
Alternative sequenceiVSP_024501689 – 872Missing in isoform 3. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436643 mRNA Translation: AAR99738.1
AK057389 mRNA Translation: BAB71463.1
AK098711 mRNA Translation: BAC05389.1 Different initiation.
AL139815, AC079269 Genomic DNA Translation: CAX14862.1
AL139815, AC079269 Genomic DNA Translation: CAX14863.1
AK302985 mRNA Translation: BAG64125.1
AL139815, AC079269 Genomic DNA Translation: CAH72189.2
BC039312 mRNA Translation: AAH39312.1
CCDSiCCDS60499.1 [Q5W041-3]
CCDS60500.1 [Q5W041-4]
CCDS7142.1 [Q5W041-2]
RefSeqiNP_001269674.1, NM_001282745.1 [Q5W041-4]
NP_001269675.1, NM_001282746.1 [Q5W041-3]
NP_001269676.1, NM_001282747.1
NP_775104.2, NM_173081.4 [Q5W041-2]
UniGeneiHs.659807
Hs.722481

Genome annotation databases

EnsembliENST00000298032; ENSP00000298032; ENSG00000165309 [Q5W041-2]
ENST00000409049; ENSP00000387288; ENSG00000165309 [Q5W041-3]
ENST00000409983; ENSP00000386943; ENSG00000165309 [Q5W041-4]
GeneIDi219681
KEGGihsa:219681
UCSCiuc001irm.6 human [Q5W041-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARMC3_HUMAN
AccessioniPrimary (citable) accession number: Q5W041
Secondary accession number(s): A0PG76
, A6NH64, B4DZL3, B7ZBN6, B7ZBN7, Q8IXS5, Q8N7B0, Q96M49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome