Reviewed, UniProtKB/Swiss-Prot Q5W041 (ARMC3_HUMAN)

Names and origin

Protein names

Recommended name:
    Armadillo repeat-containing protein 3
Alternative name(s):
    Beta-catenin-like protein
    KU-CT-1
    Cancer/testis antigen 81
      Short name=CT81

Gene names

Name:

ARMC3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	872 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Isoform 2 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines. Ref.1 Ref.5
Sequence similarities	Contains 12 ARM repeats.
Sequence caution	The sequence CAH72189.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5W041-2)

Also known as: ARMC3_Nu1; KU-CT-1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q5W041-3)

Also known as: ARMC3_Nu2;

The sequence of this isoform differs from the canonical sequence as follows:
     682-688: RKSKGKK → SSLPTSR
     689-872: Missing.

Isoform 4 (identifier: Q5W041-4)

The sequence of this isoform differs from the canonical sequence as follows:
     643-650: KKNSYHFS → N

Note: No experimental confirmation available.

Isoform 5 (identifier: Q5W041-5)

Also known as: KU-CT-1;

The sequence of this isoform differs from the canonical sequence as follows:
     392-397: NAAAEA → KEMEHE
     398-872: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 872	872	Armadillo repeat-containing protein 3		PRO_0000284403
Regions
	Repeat	15 – 54	40	ARM 1
	Repeat	57 – 96	40	ARM 2
	Repeat	98 – 138	41	ARM 3
	Repeat	140 – 179	40	ARM 4
	Repeat	181 – 220	40	ARM 5
	Repeat	222 – 262	41	ARM 6
	Repeat	264 – 304	41	ARM 7
	Repeat	306 – 345	40	ARM 8
	Repeat	346 – 385	40	ARM 9
	Repeat	388 – 427	40	ARM 10
	Repeat	429 – 468	40	ARM 11
	Repeat	470 – 509	40	ARM 12
	Compositional bias	627 – 633	7	Poly-Ser
	Compositional bias	695 – 698	4	Poly-Glu
Natural variations
	Alternative sequence	392 – 397	6	NAAAEA → KEMEHE in isoform 5.		VSP_028551
	Alternative sequence	398 – 872	475	Missing in isoform 5.		VSP_028552
	Alternative sequence	643 – 650	8	KKNSYHFS → N in isoform 4.		VSP_024498
	Alternative sequence	682 – 688	7	RKSKGKK → SSLPTSR in isoform 3.		VSP_024500
	Alternative sequence	689 – 872	184	Missing in isoform 3.		VSP_024501
	Natural variant	345	1	E → G: dbSNP rs16922864.		VAR_050669
	Natural variant	608	1	S → P: dbSNP rs11013233.		VAR_050670
	Natural variant	626	1	R → Q: dbSNP rs10828395. Ref.4		VAR_050671
Experimental info
	Sequence conflict	586	1	P → S in BAB71463. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ARMC3_Nu1) (KU-CT-1L) [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 02ED1C432D961857	FASTA	872	96,405
	10 20 30 40 50 60 MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK 70 80 90 100 110 120 TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE 130 140 150 160 170 180 EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD 190 200 210 220 230 240 FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI 250 260 270 280 290 300 LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT 310 320 330 340 350 360 KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ 370 380 390 400 410 420 LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI DPLINLLSSK RDGAIANAAT 430 440 450 460 470 480 VLTNMAMQEP LRLNIQNHDI MHAIISPLRS ANTVVQSKAA LAVTATACDV EARTELRNSG 490 500 510 520 530 540 GLEPLVELLR SKNDEVRKHA SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS 550 560 570 580 590 600 EAAYNKLLNN NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA 610 620 630 640 650 660 VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS AGFGSPIEDK 670 680 690 700 710 720 SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM VVPKFVGEGS SDKEWCPPSD 730 740 750 760 770 780 PDFSMYVYEV TKSILPITNI KEQIEDLAKY VAEKMGGKIP KEKLPDFSWE LHISELKFQL 790 800 810 820 830 840 KSNVIPIGHV KKGIFYHRAL LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG 850 860 870 LPAPEMYVID LMFHPGGLMK LRSREADLYR FI
	Isoform 3 (ARMC3_Nu2). Checksum: 3C1459C84491B9BD	FASTA	688	75,318
	10 20 30 40 50 60 MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK 70 80 90 100 110 120 TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE 130 140 150 160 170 180 EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD 190 200 210 220 230 240 FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI 250 260 270 280 290 300 LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT 310 320 330 340 350 360 KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ 370 380 390 400 410 420 LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI DPLINLLSSK RDGAIANAAT 430 440 450 460 470 480 VLTNMAMQEP LRLNIQNHDI MHAIISPLRS ANTVVQSKAA LAVTATACDV EARTELRNSG 490 500 510 520 530 540 GLEPLVELLR SKNDEVRKHA SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS 550 560 570 580 590 600 EAAYNKLLNN NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA 610 620 630 640 650 660 VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS AGFGSPIEDK 670 680 SEPASGRNTV LSKSATKEKG WSSLPTSR
	Isoform 4. Checksum: AA4B1CE46CBA3498	FASTA	865	95,527
	10 20 30 40 50 60 MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK 70 80 90 100 110 120 TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE 130 140 150 160 170 180 EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD 190 200 210 220 230 240 FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI 250 260 270 280 290 300 LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT 310 320 330 340 350 360 KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ 370 380 390 400 410 420 LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI DPLINLLSSK RDGAIANAAT 430 440 450 460 470 480 VLTNMAMQEP LRLNIQNHDI MHAIISPLRS ANTVVQSKAA LAVTATACDV EARTELRNSG 490 500 510 520 530 540 GLEPLVELLR SKNDEVRKHA SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS 550 560 570 580 590 600 EAAYNKLLNN NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA 610 620 630 640 650 660 VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNNAGFGSPI EDKSEPASGR 670 680 690 700 710 720 NTVLSKSATK EKGWRKSKGK KEEEKVKEEE EVMVVPKFVG EGSSDKEWCP PSDPDFSMYV 730 740 750 760 770 780 YEVTKSILPI TNIKEQIEDL AKYVAEKMGG KIPKEKLPDF SWELHISELK FQLKSNVIPI 790 800 810 820 830 840 GHVKKGIFYH RALLFKALAD RIGIGCSLVR GEYGRAWNEV MLQNDSRKGV IGGLPAPEMY 850 860 VIDLMFHPGG LMKLRSREAD LYRFI
	Isoform 5 (KU-CT-1). Checksum: 37CF353D598D7531	FASTA	397	43,985
	10 20 30 40 50 60 MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK 70 80 90 100 110 120 TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE 130 140 150 160 170 180 EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD 190 200 210 220 230 240 FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI 250 260 270 280 290 300 LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT 310 320 330 340 350 360 KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ 370 380 390 LIQLLKSDNE EVREAAALAL ANLTTCNPAN AKEMEHE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene." Li X., Liu B., Ji C.N., Kang Y., Mao Y. Genetika 42:999-1003(2006) [PubMed: 16915934] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 459-875 (ISOFORM 1). Tissue: Testis.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-626. Tissue: Testis.
[5]	"A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers." Okada T., Akada M., Fujita T., Iwata T., Goto Y., Kido K., Okada T., Matsuzaki Y., Kobayashi K., Matsuno S., Sunamura M., Kawakami Y. Clin. Cancer Res. 12:191-197(2006) [PubMed: 16397042] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY436643 mRNA. Translation: AAR99738.1. AK057389 mRNA. Translation: BAB71463.1. AK098711 mRNA. Translation: BAC05389.1. Different initiation. AK302985 mRNA. Translation: BAG64125.1. AL139815, AC079269 Genomic DNA. Translation: CAH72189.1. Sequence problems. BC039312 mRNA. Translation: AAH39312.1.
IPI	IPI00217612. IPI00743000. IPI00844025. IPI00867686.
RefSeq	NP_775104.2.
UniGene	Hs.659807
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5W041.
Proteomic databases
PRIDE	Q5W041.
Genome annotation databases
Ensembl	ENSG00000165309. Homo sapiens. [Contig view]
GeneID	219681.
KEGG	hsa:219681.
Organism-specific databases
GeneCards	GC10P023256.
HGNC	HGNC:30964. ARMC3.
MIM	611226. gene.
PharmGKB	PA134917281.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5W041.
Gene expression databases
ArrayExpress	Q5W041.
Bgee	Q5W041.
CleanEx	HS_ARMC3.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR000225. Armadillo. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 2 hits.
Pfam	PF00514. Arm. 6 hits. [Graphical view]
SMART	SM00185. ARM. 10 hits. [Graphical view]
PROSITE	PS50176. ARM_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	90715.
SOURCE	Search...

Entry information

Entry name

ARMC3_HUMAN

Accession

Primary (citable) accession number: Q5W041
Secondary accession number(s): A0PG76 , A6NH64, B4DZL3, Q8IXS5, Q8N7B0, Q96M49

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	November 25, 2008
Last modified:	March 24, 2009
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)