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Protein

Armadillo repeat-containing protein 3

Gene

ARMC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ5W041.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 3
Alternative name(s):
Beta-catenin-like protein
Cancer/testis antigen 81
Short name:
CT81
KU-CT-1
Gene namesi
Name:ARMC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:30964. ARMC3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi219681.
OpenTargetsiENSG00000165309.
PharmGKBiPA134917281.

Polymorphism and mutation databases

BioMutaiARMC3.
DMDMi215273946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844031 – 872Armadillo repeat-containing protein 3Add BLAST872

Proteomic databases

EPDiQ5W041.
PaxDbiQ5W041.
PeptideAtlasiQ5W041.
PRIDEiQ5W041.

PTM databases

iPTMnetiQ5W041.
PhosphoSitePlusiQ5W041.

Expressioni

Tissue specificityi

Isoform 1 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines.2 Publications

Gene expression databases

BgeeiENSG00000165309.
CleanExiHS_ARMC3.
ExpressionAtlasiQ5W041. baseline and differential.
GenevisibleiQ5W041. HS.

Organism-specific databases

HPAiHPA037823.
HPA037824.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298032.

Structurei

3D structure databases

ProteinModelPortaliQ5W041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 54ARM 1Add BLAST40
Repeati57 – 96ARM 2Add BLAST40
Repeati98 – 138ARM 3Add BLAST41
Repeati140 – 179ARM 4Add BLAST40
Repeati181 – 220ARM 5Add BLAST40
Repeati222 – 262ARM 6Add BLAST41
Repeati264 – 304ARM 7Add BLAST41
Repeati306 – 345ARM 8Add BLAST40
Repeati346 – 385ARM 9Add BLAST40
Repeati388 – 427ARM 10Add BLAST40
Repeati429 – 468ARM 11Add BLAST40
Repeati470 – 509ARM 12Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi627 – 633Poly-Ser7
Compositional biasi695 – 698Poly-Glu4

Sequence similaritiesi

Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITMR. Eukaryota.
ENOG410XPHA. LUCA.
GeneTreeiENSGT00730000110852.
HOVERGENiHBG059366.
InParanoidiQ5W041.
OMAiLKYSQTG.
OrthoDBiEOG091G02KO.
PhylomeDBiQ5W041.
TreeFamiTF329738.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 10 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5W041-2) [UniParc]FASTAAdd to basket
Also known as: ARMC3_Nu1, KU-CT-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY
60 70 80 90 100
KFALKGEENK TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV
110 120 130 140 150
KKLLRELDVM NSVIAQLAPE EEVVIHEFAS LCLANMSAEY TSKVQIFEHG
160 170 180 190 200
GLEPLIRLLS SPDPDVKKNS MECIYNLVQD FQCRAKLQEL NAIPPILDLL
210 220 230 240 250
KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI LETKELNDLH
260 270 280 290 300
IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT
310 320 330 340 350
KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK
360 370 380 390 400
DFFNNQGIPQ LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI
410 420 430 440 450
DPLINLLSSK RDGAIANAAT VLTNMAMQEP LRLNIQNHDI MHAIISPLRS
460 470 480 490 500
ANTVVQSKAA LAVTATACDV EARTELRNSG GLEPLVELLR SKNDEVRKHA
510 520 530 540 550
SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS EAAYNKLLNN
560 570 580 590 600
NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA
610 620 630 640 650
VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS
660 670 680 690 700
AGFGSPIEDK SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM
710 720 730 740 750
VVPKFVGEGS SDKEWCPPSD PDFSMYVYEV TKSILPITNI KEQIEDLAKY
760 770 780 790 800
VAEKMGGKIP KEKLPDFSWE LHISELKFQL KSNVIPIGHV KKGIFYHRAL
810 820 830 840 850
LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG LPAPEMYVID
860 870
LMFHPGGLMK LRSREADLYR FI
Length:872
Mass (Da):96,405
Last modified:November 25, 2008 - v2
Checksum:i02ED1C432D961857
GO
Isoform 3 (identifier: Q5W041-3) [UniParc]FASTAAdd to basket
Also known as: ARMC3_Nu2

The sequence of this isoform differs from the canonical sequence as follows:
     682-688: RKSKGKK → SSLPTSR
     689-872: Missing.

Show »
Length:688
Mass (Da):75,318
Checksum:i3C1459C84491B9BD
GO
Isoform 4 (identifier: Q5W041-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-650: KKNSYHFS → N

Note: No experimental confirmation available.
Show »
Length:865
Mass (Da):95,527
Checksum:iAA4B1CE46CBA3498
GO
Isoform 5 (identifier: Q5W041-5) [UniParc]FASTAAdd to basket
Also known as: KU-CT-1

The sequence of this isoform differs from the canonical sequence as follows:
     392-397: NAAAEA → KEMEHE
     398-872: Missing.

Show »
Length:397
Mass (Da):43,985
Checksum:i37CF353D598D7531
GO

Sequence cautioni

The sequence BAC05389 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti586P → S in BAB71463 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050669345E → G.Corresponds to variant rs16922864dbSNPEnsembl.1
Natural variantiVAR_050670608S → P.Corresponds to variant rs11013233dbSNPEnsembl.1
Natural variantiVAR_050671626R → Q.1 PublicationCorresponds to variant rs10828395dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028551392 – 397NAAAEA → KEMEHE in isoform 5. 1 Publication6
Alternative sequenceiVSP_028552398 – 872Missing in isoform 5. 1 PublicationAdd BLAST475
Alternative sequenceiVSP_024498643 – 650KKNSYHFS → N in isoform 4. 1 Publication8
Alternative sequenceiVSP_024500682 – 688RKSKGKK → SSLPTSR in isoform 3. 1 Publication7
Alternative sequenceiVSP_024501689 – 872Missing in isoform 3. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436643 mRNA. Translation: AAR99738.1.
AK057389 mRNA. Translation: BAB71463.1.
AK098711 mRNA. Translation: BAC05389.1. Different initiation.
AL139815, AC079269 Genomic DNA. Translation: CAX14862.1.
AL139815, AC079269 Genomic DNA. Translation: CAX14863.1.
AK302985 mRNA. Translation: BAG64125.1.
AL139815, AC079269 Genomic DNA. Translation: CAH72189.2.
BC039312 mRNA. Translation: AAH39312.1.
CCDSiCCDS60499.1. [Q5W041-3]
CCDS60500.1. [Q5W041-4]
CCDS7142.1. [Q5W041-2]
RefSeqiNP_001269674.1. NM_001282745.1. [Q5W041-4]
NP_001269675.1. NM_001282746.1. [Q5W041-3]
NP_001269676.1. NM_001282747.1.
NP_775104.2. NM_173081.4. [Q5W041-2]
UniGeneiHs.659807.
Hs.722481.

Genome annotation databases

EnsembliENST00000298032; ENSP00000298032; ENSG00000165309. [Q5W041-2]
ENST00000409049; ENSP00000387288; ENSG00000165309. [Q5W041-3]
ENST00000409983; ENSP00000386943; ENSG00000165309. [Q5W041-4]
GeneIDi219681.
KEGGihsa:219681.
UCSCiuc001irm.6. human. [Q5W041-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436643 mRNA. Translation: AAR99738.1.
AK057389 mRNA. Translation: BAB71463.1.
AK098711 mRNA. Translation: BAC05389.1. Different initiation.
AL139815, AC079269 Genomic DNA. Translation: CAX14862.1.
AL139815, AC079269 Genomic DNA. Translation: CAX14863.1.
AK302985 mRNA. Translation: BAG64125.1.
AL139815, AC079269 Genomic DNA. Translation: CAH72189.2.
BC039312 mRNA. Translation: AAH39312.1.
CCDSiCCDS60499.1. [Q5W041-3]
CCDS60500.1. [Q5W041-4]
CCDS7142.1. [Q5W041-2]
RefSeqiNP_001269674.1. NM_001282745.1. [Q5W041-4]
NP_001269675.1. NM_001282746.1. [Q5W041-3]
NP_001269676.1. NM_001282747.1.
NP_775104.2. NM_173081.4. [Q5W041-2]
UniGeneiHs.659807.
Hs.722481.

3D structure databases

ProteinModelPortaliQ5W041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298032.

PTM databases

iPTMnetiQ5W041.
PhosphoSitePlusiQ5W041.

Polymorphism and mutation databases

BioMutaiARMC3.
DMDMi215273946.

Proteomic databases

EPDiQ5W041.
PaxDbiQ5W041.
PeptideAtlasiQ5W041.
PRIDEiQ5W041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298032; ENSP00000298032; ENSG00000165309. [Q5W041-2]
ENST00000409049; ENSP00000387288; ENSG00000165309. [Q5W041-3]
ENST00000409983; ENSP00000386943; ENSG00000165309. [Q5W041-4]
GeneIDi219681.
KEGGihsa:219681.
UCSCiuc001irm.6. human. [Q5W041-2]

Organism-specific databases

CTDi219681.
DisGeNETi219681.
GeneCardsiARMC3.
H-InvDBHIX0023076.
HGNCiHGNC:30964. ARMC3.
HPAiHPA037823.
HPA037824.
MIMi611226. gene.
neXtProtiNX_Q5W041.
OpenTargetsiENSG00000165309.
PharmGKBiPA134917281.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITMR. Eukaryota.
ENOG410XPHA. LUCA.
GeneTreeiENSGT00730000110852.
HOVERGENiHBG059366.
InParanoidiQ5W041.
OMAiLKYSQTG.
OrthoDBiEOG091G02KO.
PhylomeDBiQ5W041.
TreeFamiTF329738.

Enzyme and pathway databases

SignaLinkiQ5W041.

Miscellaneous databases

GenomeRNAii219681.
PROiQ5W041.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165309.
CleanExiHS_ARMC3.
ExpressionAtlasiQ5W041. baseline and differential.
GenevisibleiQ5W041. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 10 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARMC3_HUMAN
AccessioniPrimary (citable) accession number: Q5W041
Secondary accession number(s): A0PG76
, A6NH64, B4DZL3, B7ZBN6, B7ZBN7, Q8IXS5, Q8N7B0, Q96M49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.