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Protein
Submitted name:

Interleukin 2 receptor, alpha, isoform CRA_b

Gene

IL2RA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 2 receptor, alpha, isoform CRA_bImported
Submitted name:
Interleukin-2 receptor subunit alphaImported
Gene namesi
Name:IL2RAImported
ORF Names:hCG_23482Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6008. IL2RA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 189HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500971272822 – 200Sequence analysisAdd BLAST179

Expressioni

Gene expression databases

BgeeiENSG00000134460.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 79Sushi (CCP/SCR)InterPro annotationAdd BLAST54

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000018872.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.

Family and domain databases

InterProiView protein in InterPro
IPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiView protein in Pfam
PF00084. Sushi. 1 hit.
SUPFAMiSSF57535. SSF57535. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5W005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SPMQPVDQAS LPGEEKPQAS PEGRPESETS CLVTTTDFQI
160 170 180 190 200
QTEMAATMET SIFTTEYQVA VAGCVFLLIS VLLLSGLTWQ RRQRKSRRTI
Length:200
Mass (Da):22,454
Last modified:December 7, 2004 - v1
Checksum:i7793254ABA60CEB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. No translation available.
AL157395 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86413.1.
RefSeqiNP_001295171.1. NM_001308242.1.
UniGeneiHs.231367.

Genome annotation databases

EnsembliENST00000379954; ENSP00000369287; ENSG00000134460.
GeneIDi3559.
UCSCiuc009xih.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. No translation available.
AL157395 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86413.1.
RefSeqiNP_001295171.1. NM_001308242.1.
UniGeneiHs.231367.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379954; ENSP00000369287; ENSG00000134460.
GeneIDi3559.
UCSCiuc009xih.3. human.

Organism-specific databases

CTDi3559.
HGNCiHGNC:6008. IL2RA.
OpenTargetsiENSG00000134460.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000018872.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.

Miscellaneous databases

GenomeRNAii3559.

Gene expression databases

BgeeiENSG00000134460.

Family and domain databases

InterProiView protein in InterPro
IPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiView protein in Pfam
PF00084. Sushi. 1 hit.
SUPFAMiSSF57535. SSF57535. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5W005_HUMAN
AccessioniPrimary (citable) accession number: Q5W005
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 15, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.