ID Q5VZY9_HUMAN Unreviewed; 363 AA. AC Q5VZY9; DT 07-DEC-2004, integrated into UniProtKB/TrEMBL. DT 07-DEC-2004, sequence version 1. DT 27-MAR-2024, entry version 137. DE SubName: Full=Doublecortin like kinase 1 {ECO:0000313|Ensembl:ENSP00000369222.4}; GN Name=DCLK1 {ECO:0000313|Ensembl:ENSP00000369222.4}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000369222.4, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000369222.4, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., RA Frankish A.G., Frankland J., French L., Garner P., Garnett J., RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., RA Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R., RA Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000369222.4} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL139083; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL157694; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL157760; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL160392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL390029; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_016876337.1; XM_017020848.1. DR AlphaFoldDB; Q5VZY9; -. DR SMR; Q5VZY9; -. DR iPTMnet; Q5VZY9; -. DR MassIVE; Q5VZY9; -. DR MaxQB; Q5VZY9; -. DR PeptideAtlas; Q5VZY9; -. DR ProteomicsDB; 65738; -. DR Antibodypedia; 23046; 500 antibodies from 39 providers. DR DNASU; 9201; -. DR Ensembl; ENST00000379892.4; ENSP00000369222.4; ENSG00000133083.15. DR GeneID; 9201; -. DR UCSC; uc058wkm.1; human. DR CTD; 9201; -. DR HGNC; HGNC:2700; DCLK1. DR VEuPathDB; HostDB:ENSG00000133083; -. DR GeneTree; ENSGT00940000154956; -. DR HOGENOM; CLU_035041_1_1_1; -. DR OrthoDB; 2956627at2759; -. DR BioGRID-ORCS; 9201; 13 hits in 1181 CRISPR screens. DR ChiTaRS; DCLK1; human. DR GenomeRNAi; 9201; -. DR Proteomes; UP000005640; Chromosome 13. DR Bgee; ENSG00000133083; Expressed in endothelial cell and 188 other cell types or tissues. DR ExpressionAtlas; Q5VZY9; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0043005; C:neuron projection; IEA:InterPro. DR GO; GO:0008017; F:microtubule binding; IEA:InterPro. DR GO; GO:0035082; P:axoneme assembly; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0001764; P:neuron migration; IEA:InterPro. DR GO; GO:0060041; P:retina development in camera-type eye; IEA:InterPro. DR CDD; cd17140; DCX1_DCLK1; 1. DR CDD; cd17069; DCX2; 1. DR Gene3D; 3.10.20.230; Doublecortin domain; 2. DR InterPro; IPR049626; DCX/DCDC2-like. DR InterPro; IPR017302; DCX_chordates. DR InterPro; IPR003533; Doublecortin_dom. DR InterPro; IPR036572; Doublecortin_dom_sf. DR PANTHER; PTHR23004; DOUBLECORTIN DOMAIN CONTAINING 2; 1. DR PANTHER; PTHR23004:SF11; PROTEIN RPI-1; 1. DR Pfam; PF03607; DCX; 2. DR PIRSF; PIRSF037870; Doublin; 1. DR SMART; SM00537; DCX; 2. DR SUPFAM; SSF89837; Doublecortin (DC); 2. DR PROSITE; PS50309; DC; 2. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:Q5VZY9, KW ECO:0007829|MaxQB:Q5VZY9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 57..143 FT /note="Doublecortin" FT /evidence="ECO:0000259|PROSITE:PS50309" FT DOMAIN 186..269 FT /note="Doublecortin" FT /evidence="ECO:0000259|PROSITE:PS50309" FT REGION 287..363 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 287..341 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 363 AA; 40457 MW; DE6323CEF652839A CRC64; MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRDLYRP LSSDDLDSVG DSV //