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Protein

Protein-lysine methyltransferase METTL21C

Gene

METTL21C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein-lysine methyltransferase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei141S-adenosyl-L-methionine1 Publication1
Binding sitei172S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei193S-adenosyl-L-homocysteine; via carbonyl oxygen1 Publication1

GO - Molecular functioni

  • protein-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • protein methylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine methyltransferase METTL21C (EC:2.1.1.-)
Alternative name(s):
Methyltransferase-like protein 21C
Gene namesi
Name:METTL21C
Synonyms:C13orf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:33717. METTL21C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141D → A: Abolishes methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNETi196541.
OpenTargetsiENSG00000139780.
PharmGKBiPA162378126.

Polymorphism and mutation databases

DMDMi74757117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195901 – 264Protein-lysine methyltransferase METTL21CAdd BLAST264

Proteomic databases

MaxQBiQ5VZV1.
PaxDbiQ5VZV1.
PRIDEiQ5VZV1.

PTM databases

iPTMnetiQ5VZV1.
PhosphoSitePlusiQ5VZV1.

Expressioni

Gene expression databases

BgeeiENSG00000139780.
CleanExiHS_C13orf39.
GenevisibleiQ5VZV1. HS.

Organism-specific databases

HPAiHPA040083.

Interactioni

Subunit structurei

Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEB1Q153693EBI-10236049,EBI-301231

Protein-protein interaction databases

BioGridi128220. 17 interactors.
IntActiQ5VZV1. 1 interactor.
STRINGi9606.ENSP00000267273.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 56Combined sources5
Beta strandi67 – 73Combined sources7
Beta strandi76 – 82Combined sources7
Helixi87 – 89Combined sources3
Helixi93 – 109Combined sources17
Beta strandi115 – 120Combined sources6
Helixi125 – 132Combined sources8
Beta strandi136 – 141Combined sources6
Turni143 – 145Combined sources3
Helixi146 – 157Combined sources12
Turni158 – 160Combined sources3
Beta strandi161 – 163Combined sources3
Beta strandi166 – 169Combined sources4
Helixi176 – 179Combined sources4
Turni182 – 184Combined sources3
Beta strandi188 – 194Combined sources7
Beta strandi197 – 199Combined sources3
Helixi202 – 212Combined sources11
Beta strandi218 – 224Combined sources7
Helixi228 – 240Combined sources13
Beta strandi241 – 249Combined sources9
Turni250 – 253Combined sources4
Beta strandi254 – 261Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MTLX-ray1.65A/B22-264[»]
ProteinModelPortaliQ5VZV1.
SMRiQ5VZV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 122S-adenosyl-L-methionine binding1 Publication3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2793. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00550000074572.
HOVERGENiHBG107723.
InParanoidiQ5VZV1.
OMAiTMVYLSQ.
OrthoDBiEOG091G0NXA.
PhylomeDBiQ5VZV1.
TreeFamiTF354267.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VZV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVCLSSAQQ PGRRGEGLSS PGGWLEAEKK GAPQKDSTGG VLEESNKIEP
60 70 80 90 100
SLHSLQKFVP TDYASYTQEH YRFAGKEIVI QESIESYGAV VWPGAMALCQ
110 120 130 140 150
YLEEHAEELN FQDAKILEIG AGPGLVSIVA SILGAQVTAT DLPDVLGNLQ
160 170 180 190 200
YNLLKNTLQC TAHLPEVKEL VWGEDLDKNF PKSAFYYDYV LASDVVYHHY
210 220 230 240 250
FLDKLLTTMV YLSQPGTVLL WANKFRFSTD YEFLDKFKQV FDTTLLAEYP
260
ESSVKLFKGI LKWD
Length:264
Mass (Da):29,565
Last modified:December 7, 2004 - v1
Checksum:i239B4B24D62DC1D0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06222915G → R.Corresponds to variant rs45462291dbSNPEnsembl.1
Natural variantiVAR_03901346N → S.Corresponds to variant rs16960383dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158063 Genomic DNA. Translation: CAH72181.1.
BC132748 mRNA. Translation: AAI32749.1.
BC132750 mRNA. Translation: AAI32751.1.
CCDSiCCDS32003.1.
RefSeqiNP_001010977.1. NM_001010977.2.
XP_016875896.1. XM_017020407.1.
XP_016875897.1. XM_017020408.1.
UniGeneiHs.508623.

Genome annotation databases

EnsembliENST00000267273; ENSP00000267273; ENSG00000139780.
GeneIDi196541.
KEGGihsa:196541.
UCSCiuc001vpj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158063 Genomic DNA. Translation: CAH72181.1.
BC132748 mRNA. Translation: AAI32749.1.
BC132750 mRNA. Translation: AAI32751.1.
CCDSiCCDS32003.1.
RefSeqiNP_001010977.1. NM_001010977.2.
XP_016875896.1. XM_017020407.1.
XP_016875897.1. XM_017020408.1.
UniGeneiHs.508623.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MTLX-ray1.65A/B22-264[»]
ProteinModelPortaliQ5VZV1.
SMRiQ5VZV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128220. 17 interactors.
IntActiQ5VZV1. 1 interactor.
STRINGi9606.ENSP00000267273.

PTM databases

iPTMnetiQ5VZV1.
PhosphoSitePlusiQ5VZV1.

Polymorphism and mutation databases

DMDMi74757117.

Proteomic databases

MaxQBiQ5VZV1.
PaxDbiQ5VZV1.
PRIDEiQ5VZV1.

Protocols and materials databases

DNASUi196541.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267273; ENSP00000267273; ENSG00000139780.
GeneIDi196541.
KEGGihsa:196541.
UCSCiuc001vpj.5. human.

Organism-specific databases

CTDi196541.
DisGeNETi196541.
GeneCardsiMETTL21C.
HGNCiHGNC:33717. METTL21C.
HPAiHPA040083.
MIMi615259. gene.
neXtProtiNX_Q5VZV1.
OpenTargetsiENSG00000139780.
PharmGKBiPA162378126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2793. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00550000074572.
HOVERGENiHBG107723.
InParanoidiQ5VZV1.
OMAiTMVYLSQ.
OrthoDBiEOG091G0NXA.
PhylomeDBiQ5VZV1.
TreeFamiTF354267.

Miscellaneous databases

GenomeRNAii196541.
PROiQ5VZV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139780.
CleanExiHS_C13orf39.
GenevisibleiQ5VZV1. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMT21C_HUMAN
AccessioniPrimary (citable) accession number: Q5VZV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.