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Protein
Submitted name:

Tripeptidyl-peptidase 2

Gene

TPP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiQ5VZU9.

Names & Taxonomyi

Protein namesi
Submitted name:
Tripeptidyl-peptidase 2Imported
Gene namesi
Name:TPP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000134900.11.
HGNCiHGNC:12016. TPP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134900.

PTM / Processingi

Proteomic databases

EPDiQ5VZU9.
MaxQBiQ5VZU9.
PaxDbiQ5VZU9.
PeptideAtlasiQ5VZU9.
PRIDEiQ5VZU9.

Expressioni

Gene expression databases

BgeeiENSG00000134900.
ExpressionAtlasiQ5VZU9. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-4999515.

Structurei

3D structure databases

ProteinModelPortaliQ5VZU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 500Peptidase S8InterPro annotationAdd BLAST466
Domaini777 – 963TPPIIInterPro annotationAdd BLAST187

Phylogenomic databases

eggNOGiKOG1114. Eukaryota.
COG1404. LUCA.
GeneTreeiENSGT00390000014623.
HOGENOMiHOG000008178.
HOVERGENiHBG017992.
OMAiRIDVINM.
OrthoDBiEOG091G00P0.
PhylomeDBiQ5VZU9.

Family and domain databases

CDDicd04857. Peptidases_S8_Tripeptidyl_Amin. 1 hit.
Gene3Di3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022229. Peptidase_S8A_TPPII.
IPR034051. TPP_II_domain.
PfamiView protein in Pfam
PF00082. Peptidase_S8. 1 hit.
PF12580. TPPII. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
PROSITEiView protein in PROSITE
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VZU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG
60 70 80 90 100
APGMQVTTDG KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP
110 120 130 140 150
ASWTNPSGKY HIGIKNGYDF YPKALKERIQ KERKEKIWDP VHRVALAEAC
160 170 180 190 200
RKQEEFDVAN NGSSQANKLI KEELQSQVEL LNSFEKKYSD PGPVYDCLVW
210 220 230 240 250
HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE MLNYSVNIYD
260 270 280 290 300
DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR
310 320 330 340 350
LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW
360 370 380 390 400
KHNIIYVSSA GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE
410 420 430 440 450
KLPANQYTWS SRGPSADGAL GVSISAPGGA IASVPNWTLR GTQLMNGTSM
460 470 480 490 500
SSPNACGGIA LILSGLKANN IDYTVHSVRR ALENTAVKAD NIEVFAQGHG
510 520 530 540 550
IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ VAAPSDHGVG
560 570 580 590 600
IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD
610 620 630 640 650
PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT
660 670 680 690 700
DVHFKPGQIR RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA
710 720 730 740 750
YRSHEFYKFC SLPEKGTLTE AFPVLGGKAI EFCIARWWAS LSDVNIDYTI
760 770 780 790 800
SFHGIVCTAP QLNIHASEGI NRFDVQSSLK YEDLAPCITL KNWVQTLRPV
810 820 830 840 850
SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC PLLCELLYES
860 870 880 890 900
EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL
910 920 930 940 950
ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF
960 970 980 990 1000
VTSLPDDKIP KGAGPGCYLA GSLTLSKTEL GKKAGQSAAK RQGKFKKDVI
1010 1020 1030 1040 1050
PVHYYLIPPP TKTKNGSKDK EKDSEKEKDL KEEFTEALRD LKIQWMTKLD
1060 1070 1080 1090 1100
SSDIYNELKE TYPNYLPLYV ARLHQLDAEK ERMKRLNEIV DAANAVISHI
1110 1120 1130 1140 1150
DQTALAVYIA MKTDPRPDAA TIKNDMDKQK STLVDALCRK GCALADHLLH
1160 1170 1180 1190 1200
TQAQDGAIST DAEGKEEEGE SPLDSLAETF WETTKWTDLF DNKVLTFAYK
1210 1220 1230 1240 1250
HALVNKMYGR GLKFATKLVE EKPTKENWKN CIQLMKLLGW THCASFTENW
1260
LPIMYPPDYC VF
Length:1,262
Mass (Da):139,766
Last modified:December 7, 2004 - v1
Checksum:iFD7528A15433F987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158063 Genomic DNA. No translation available.
RefSeqiNP_001317517.1. NM_001330588.1.
UniGeneiHs.432424.
Hs.733961.

Genome annotation databases

EnsembliENST00000376052; ENSP00000365220; ENSG00000134900.
GeneIDi7174.
UCSCiuc058ybz.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ5VZU9_HUMAN
AccessioniPrimary (citable) accession number: Q5VZU9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported