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Protein

Putative uncharacterized protein C10orf113

Gene

C10orf113

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uncharacterized protein C10orf113
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:31447. C10orf113.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950749.

Polymorphism and mutation databases

BioMutaiC10orf113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Putative uncharacterized protein C10orf113PRO_0000254039Add
BLAST

Proteomic databases

PaxDbiQ5VZT2.
PRIDEiQ5VZT2.

PTM databases

iPTMnetiQ5VZT2.
PhosphoSiteiQ5VZT2.

Expressioni

Gene expression databases

BgeeiQ5VZT2.
CleanExiHS_C10orf113.

Organism-specific databases

HPAiHPA037013.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J2MX. Eukaryota.
ENOG41115PV. LUCA.
GeneTreeiENSGT00410000028701.
HOGENOMiHOG000111707.
InParanoidiQ5VZT2.
OMAiPNELFRE.
OrthoDBiEOG7XSTG7.
PhylomeDBiQ5VZT2.
TreeFamiTF353304.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VZT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSERRIYS MESMAPEISE DIGCPLAYMR ESVCALLINQ SFFSCVAEMY
60 70 80 90 100
IPDMNRPGKA ERRAEKGLRP PRKLVGETRR LQSWPTLARW LRRVSFSLYK
110 120 130 140 150
PPIQAAPEPD PGNWAKSPRL SLGPEGITKG KHGFKFQGIK EKFNVSKKVL

KMTFL
Length:155
Mass (Da):17,689
Last modified:June 28, 2011 - v2
Checksum:i71E5D38A3FA07109
GO
Isoform 2 (identifier: Q5VZT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-79: PGKAERRAEKGLRPPRKLVGETR → LEERTAALYPIGLVRQNGEPRRA
     80-155: Missing.

Note: No experimental confirmation available.
Show »
Length:79
Mass (Da):9,021
Checksum:i4932F1B405B985AF
GO

Sequence cautioni

The sequence AAI40745.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH70812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721R → G.
Corresponds to variant rs11591355 [ dbSNP | Ensembl ].
VAR_050858
Natural varianti110 – 1101D → H.1 Publication
Corresponds to variant rs625223 [ dbSNP | Ensembl ].
VAR_028801

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei57 – 7923PGKAE…VGETR → LEERTAALYPIGLVRQNGEP RRA in isoform 2. 1 PublicationVSP_044974Add
BLAST
Alternative sequencei80 – 15576Missing in isoform 2. 1 PublicationVSP_044975Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158160 Genomic DNA. Translation: CAH70812.1. Different initiation.
BC140744 mRNA. Translation: AAI40745.1. Different initiation.
BC144447 mRNA. No translation available.
CCDSiCCDS31162.2. [Q5VZT2-1]
CCDS53496.1. [Q5VZT2-2]
RefSeqiNP_001010896.2. NM_001010896.2. [Q5VZT2-1]
NP_001170954.1. NM_001177483.1. [Q5VZT2-2]
UniGeneiHs.664110.

Genome annotation databases

EnsembliENST00000529198; ENSP00000434089; ENSG00000204683. [Q5VZT2-2]
ENST00000534331; ENSP00000433646; ENSG00000204683. [Q5VZT2-1]
GeneIDi387638.
KEGGihsa:387638.
UCSCiuc001iqm.3. human. [Q5VZT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158160 Genomic DNA. Translation: CAH70812.1. Different initiation.
BC140744 mRNA. Translation: AAI40745.1. Different initiation.
BC144447 mRNA. No translation available.
CCDSiCCDS31162.2. [Q5VZT2-1]
CCDS53496.1. [Q5VZT2-2]
RefSeqiNP_001010896.2. NM_001010896.2. [Q5VZT2-1]
NP_001170954.1. NM_001177483.1. [Q5VZT2-2]
UniGeneiHs.664110.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5VZT2.
PhosphoSiteiQ5VZT2.

Polymorphism and mutation databases

BioMutaiC10orf113.

Proteomic databases

PaxDbiQ5VZT2.
PRIDEiQ5VZT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529198; ENSP00000434089; ENSG00000204683. [Q5VZT2-2]
ENST00000534331; ENSP00000433646; ENSG00000204683. [Q5VZT2-1]
GeneIDi387638.
KEGGihsa:387638.
UCSCiuc001iqm.3. human. [Q5VZT2-1]

Organism-specific databases

CTDi387638.
GeneCardsiC10orf113.
HGNCiHGNC:31447. C10orf113.
HPAiHPA037013.
neXtProtiNX_Q5VZT2.
PharmGKBiPA134950749.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2MX. Eukaryota.
ENOG41115PV. LUCA.
GeneTreeiENSGT00410000028701.
HOGENOMiHOG000111707.
InParanoidiQ5VZT2.
OMAiPNELFRE.
OrthoDBiEOG7XSTG7.
PhylomeDBiQ5VZT2.
TreeFamiTF353304.

Miscellaneous databases

GenomeRNAii387638.
NextBioi101466.
PROiQ5VZT2.

Gene expression databases

BgeeiQ5VZT2.
CleanExiHS_C10orf113.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-110.

Entry informationi

Entry nameiCJ113_HUMAN
AccessioniPrimary (citable) accession number: Q5VZT2
Secondary accession number(s): B9EIM9, E9PRX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 28, 2011
Last modified: January 20, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Encoded in intron of the NEBL gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.