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Q5VZK9

- LR16A_HUMAN

UniProt

Q5VZK9 - LR16A_HUMAN

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Protein

Leucine-rich repeat-containing protein 16A

Gene

LRRC16A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration.By similarity2 Publications

GO - Molecular functioni

  1. protein complex binding Source: UniProt

GO - Biological processi

  1. actin filament organization Source: BHF-UCL
  2. barbed-end actin filament uncapping Source: UniProt
  3. blood coagulation Source: Reactome
  4. cell migration Source: BHF-UCL
  5. lamellipodium assembly Source: BHF-UCL
  6. negative regulation of barbed-end actin filament capping Source: UniProt
  7. positive regulation of actin filament polymerization Source: UniProt
  8. positive regulation of cell migration Source: UniProt
  9. positive regulation of lamellipodium organization Source: UniProt
  10. positive regulation of stress fiber assembly Source: UniProt
  11. positive regulation of substrate adhesion-dependent cell spreading Source: UniProt
  12. ruffle organization Source: BHF-UCL
  13. urate metabolic process Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 16A
Alternative name(s):
CARMIL homolog
Gene namesi
Name:LRRC16A
Synonyms:CARMIL, CARMIL1a, LRRC16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21581. LRRC16A.

Subcellular locationi

Cell projectionlamellipodium 1 Publication. Cytoplasm 1 Publication
Note: Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. filamentous actin Source: UniProt
  5. lamellipodium Source: BHF-UCL
  6. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13711371Leucine-rich repeat-containing protein 16APRO_0000325815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Cross-linki593 – 593Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei916 – 9161Phosphothreonine1 Publication
Modified residuei968 – 9681Phosphoserine3 Publications
Modified residuei1067 – 10671Phosphoserine1 Publication
Modified residuei1288 – 12881Phosphoserine3 Publications
Modified residuei1291 – 12911Phosphoserine1 Publication
Modified residuei1315 – 13151Phosphoserine1 Publication
Modified residuei1331 – 13311Phosphoserine3 Publications
Modified residuei1360 – 13601Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ5VZK9.
PaxDbiQ5VZK9.
PeptideAtlasiQ5VZK9.
PRIDEiQ5VZK9.

PTM databases

PhosphoSiteiQ5VZK9.

Expressioni

Tissue specificityi

Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.1 Publication

Gene expression databases

BgeeiQ5VZK9.
CleanExiHS_LRRC16A.
GenevestigatoriQ5VZK9.

Organism-specific databases

HPAiHPA029038.
HPA029039.

Interactioni

Subunit structurei

Interacts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation (By similarity). Homodimer.By similarity1 Publication

Protein-protein interaction databases

BioGridi120745. 8 interactions.
DIPiDIP-56920N.
IntActiQ5VZK9. 1 interaction.
MINTiMINT-5005073.
STRINGi9606.ENSP00000331983.

Structurei

Secondary structure

1
1371
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi978 – 9803Combined sources
Helixi985 – 9884Combined sources
Beta strandi999 – 10024Combined sources
Helixi1026 – 10294Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LK2X-ray2.20T961-1012[»]
3LK3X-ray2.68T964-1078[»]
ProteinModelPortaliQ5VZK9.
SMRiQ5VZK9. Positions 9-664, 961-1035.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5VZK9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati245 – 26925LRR 1Add
BLAST
Repeati275 – 29824LRR 2Add
BLAST
Repeati304 – 32724LRR 3Add
BLAST
Repeati336 – 36328LRR 4Add
BLAST
Repeati391 – 41828LRR 5Add
BLAST
Repeati423 – 44725LRR 6Add
BLAST
Repeati481 – 50626LRR 7Add
BLAST
Repeati543 – 56624LRR 8Add
BLAST
Repeati570 – 59324LRR 9Add
BLAST
Repeati654 – 67825LRR 10Add
BLAST
Repeati958 – 98124LRR 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni958 – 1082125Inhibits capping activity of CAPZA2By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili710 – 73425Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1243 – 12508Poly-Ser

Sequence similaritiesi

Belongs to the CARMIL family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG239526.
GeneTreeiENSGT00390000014487.
HOGENOMiHOG000230565.
HOVERGENiHBG108094.
InParanoidiQ5VZK9.
OMAiTLIVWLS.
OrthoDBiEOG72JWFD.
PhylomeDBiQ5VZK9.
TreeFamiTF316381.

Family and domain databases

InterProiIPR029764. CARMIL1.
[Graphical view]
PANTHERiPTHR24112:SF39. PTHR24112:SF39. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VZK9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEESSDVPR ELIESIKDVI GRKIKISVKK KVKLEVKGDK VENKVLVLTS
60 70 80 90 100
CRAFLVTARI PTKLELTFSY LEIHGVVCSK SAQMIVETEK CSISMKMASP
110 120 130 140 150
EDVSEVLAHI GTCLRKIFPG LSPVRIMKKV SMEPSERLAS LQALWDSQTV
160 170 180 190 200
AEQGPCGGFS QMYACVCDWL GFSYREEVQW DVDTIYLTQD TRELNLQDFS
210 220 230 240 250
HLDHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR VVSRSNRLEE
260 270 280 290 300
LVLENAGLRT DFAQKLASAL AHNPNSGLHT INLAGNPLED RGVSSLSIQF
310 320 330 340 350
AKLPKGLKHL NLSKTSLSPK GVNSLSQSLS ANPLTASTLV HLDLSGNVLR
360 370 380 390 400
GDDLSHMYNF LAQPNAIVHL DLSNTECSLD MVCGALLRGC LQYLAVLNLS
410 420 430 440 450
RTVFSHRKGK EVPPSFKQFF SSSLALMHIN LSGTKLSPEP LKALLLGLAC
460 470 480 490 500
NHNLKGVSLD LSNCELRSGG AQVLEGCIAE IHNITSLDIS DNGLESDLST
510 520 530 540 550
LIVWLSKNRS IQHLALGKNF NNMKSKNLTP VLDNLVQMIQ DEESPLQSLS
560 570 580 590 600
LADSKLKTEV TIIINALGSN TSLTKVDISG NGMGDMGAKM LAKALQINTK
610 620 630 640 650
LRTVIWDKNN ITAQGFQDIA VAMEKNYTLR FMPIPMYDAS QALKTNPEKT
660 670 680 690 700
EDALQKIENY LLRNHETRKY LQEQAYRLQQ GIVTSTTQQM IDRICVKVQD
710 720 730 740 750
HLNSLRNCGG DAIQEDLKSA ERLMRDAKNS KTLLPNLYHV GGASWAGASG
760 770 780 790 800
LLSSPIQETL ESMAGEVTRV VDEQLKALLE SMVDAAENLC PNVMKKAHIR
810 820 830 840 850
QDLIHASTEK ISIPRTFVKN VLLEQSGIDI LNKISEVKLT VASFLSDRIV
860 870 880 890 900
DEILDALSHC HHKLADHFSR RGKTLPQQES LEIELAEEKP VKRSIITVEE
910 920 930 940 950
LTEIERLEDL DTCMMTPKSK RKSIHSRMLR PVSRAFEMEF DLDKALEEVP
960 970 980 990 1000
IHIEDPPFPS LRQEKRSSGF ISELPSEEGK KLEHFTKLRP KRNKKQQPTQ
1010 1020 1030 1040 1050
AAVCAANIVS QDGEQNGLMG RVDEGVDEFF TKKVTKMDSK KWSTRGSESH
1060 1070 1080 1090 1100
ELNEGGDEKK KRDSRKSSGF LNLIKSRSKS ERPPTILMTE EPSSPKGAVR
1110 1120 1130 1140 1150
SPPVDCPRKD TKAAEHNGNS ERIEEIKTPD SFEESQGEEI GKVERSDSKS
1160 1170 1180 1190 1200
SPQAGRRYGV QVMGSGLLAE MKAKQEKRAA CAQKKLGNDA VSQDSSSPAL
1210 1220 1230 1240 1250
SGVERSDGGG AVPKLHPGLP ENRFGLGTPE KNTKAEPKAE AGSRSRSSSS
1260 1270 1280 1290 1300
TPTSPKPLLQ SPKPSLAARP VIPQKPRTAS RPDDIPDSPS SPKVALLPPV
1310 1320 1330 1340 1350
LKKVPSDKER DGQSSPQPSP RTFSQEVSRR SWGQQAQEYQ EQKQRSSSKD
1360 1370
GHQGSKSNDS GEEAEKEFIF V
Length:1,371
Mass (Da):151,557
Last modified:December 7, 2004 - v1
Checksum:i6DECD6387FD73DCE
GO
Isoform 2 (identifier: Q5VZK9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1221: Missing.

Note: No experimental confirmation available.

Show »
Length:1,326
Mass (Da):147,088
Checksum:iBC4881025483CA27
GO
Isoform 3 (identifier: Q5VZK9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     486-499: SLDISDNGLESDLS → QLGTRYRNAVLRVY
     500-1371: Missing.

Note: No experimental confirmation available.

Show »
Length:499
Mass (Da):55,117
Checksum:iA77D54FABEE374C8
GO
Isoform 4 (identifier: Q5VZK9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     292-337: GVSSLSIQFA...SLSANPLTAS → ETTTKIKRQN...NYYSDFSHDG
     338-1371: Missing.

Note: No experimental confirmation available.

Show »
Length:176
Mass (Da):20,181
Checksum:i806D8D31AAC2A04A
GO

Sequence cautioni

The sequence BAA90912.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551N → D in BAC85701. (PubMed:14702039)Curated
Sequence conflicti889 – 8891K → R in BAA90912. (PubMed:14702039)Curated
Sequence conflicti1202 – 12021G → S in ACI49709. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771V → I.
Corresponds to variant rs9358856 [ dbSNP | Ensembl ].
VAR_039923
Natural varianti545 – 5451P → L.
Corresponds to variant rs12207840 [ dbSNP | Ensembl ].
VAR_039924
Natural varianti639 – 6391A → G.
Corresponds to variant rs7454756 [ dbSNP | Ensembl ].
VAR_039925
Natural varianti1117 – 11171N → S.
Corresponds to variant rs9885914 [ dbSNP | Ensembl ].
VAR_039926

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 161161Missing in isoform 4. 1 PublicationVSP_032415Add
BLAST
Alternative sequencei292 – 33746GVSSL…PLTAS → ETTTKIKRQNVPTVLQTYLV VCPSDYQPCPLPLGKDNYYS DFSHDG in isoform 4. 1 PublicationVSP_032416Add
BLAST
Alternative sequencei338 – 13711034Missing in isoform 4. 1 PublicationVSP_032417Add
BLAST
Alternative sequencei486 – 49914SLDIS…ESDLS → QLGTRYRNAVLRVY in isoform 3. 1 PublicationVSP_032418Add
BLAST
Alternative sequencei500 – 1371872Missing in isoform 3. 1 PublicationVSP_032419Add
BLAST
Alternative sequencei1177 – 122145Missing in isoform 2. 1 PublicationVSP_032420Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ009082 mRNA. Translation: ACI49709.1.
AK123817 mRNA. Translation: BAC85701.1.
AK125696 mRNA. Translation: BAC86250.1.
AK000055 mRNA. Translation: BAA90912.1. Different initiation.
AL160037, AL022170, AL024509 Genomic DNA. Translation: CAH72024.1.
AL022170, AL024509, AL160037 Genomic DNA. Translation: CAI21583.1.
AL024509, AL022170, AL160037 Genomic DNA. Translation: CAI21665.1.
CCDSiCCDS54973.1. [Q5VZK9-1]
RefSeqiNP_060110.4. NM_017640.5. [Q5VZK9-1]
UniGeneiHs.649550.

Genome annotation databases

EnsembliENST00000329474; ENSP00000331983; ENSG00000079691. [Q5VZK9-1]
GeneIDi55604.
KEGGihsa:55604.
UCSCiuc011djw.2. human. [Q5VZK9-1]

Polymorphism databases

DMDMi74762279.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ009082 mRNA. Translation: ACI49709.1 .
AK123817 mRNA. Translation: BAC85701.1 .
AK125696 mRNA. Translation: BAC86250.1 .
AK000055 mRNA. Translation: BAA90912.1 . Different initiation.
AL160037 , AL022170 , AL024509 Genomic DNA. Translation: CAH72024.1 .
AL022170 , AL024509 , AL160037 Genomic DNA. Translation: CAI21583.1 .
AL024509 , AL022170 , AL160037 Genomic DNA. Translation: CAI21665.1 .
CCDSi CCDS54973.1. [Q5VZK9-1 ]
RefSeqi NP_060110.4. NM_017640.5. [Q5VZK9-1 ]
UniGenei Hs.649550.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LK2 X-ray 2.20 T 961-1012 [» ]
3LK3 X-ray 2.68 T 964-1078 [» ]
ProteinModelPortali Q5VZK9.
SMRi Q5VZK9. Positions 9-664, 961-1035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120745. 8 interactions.
DIPi DIP-56920N.
IntActi Q5VZK9. 1 interaction.
MINTi MINT-5005073.
STRINGi 9606.ENSP00000331983.

PTM databases

PhosphoSitei Q5VZK9.

Polymorphism databases

DMDMi 74762279.

Proteomic databases

MaxQBi Q5VZK9.
PaxDbi Q5VZK9.
PeptideAtlasi Q5VZK9.
PRIDEi Q5VZK9.

Protocols and materials databases

DNASUi 55604.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329474 ; ENSP00000331983 ; ENSG00000079691 . [Q5VZK9-1 ]
GeneIDi 55604.
KEGGi hsa:55604.
UCSCi uc011djw.2. human. [Q5VZK9-1 ]

Organism-specific databases

CTDi 55604.
GeneCardsi GC06P025279.
H-InvDB HIX0005632.
HGNCi HGNC:21581. LRRC16A.
HPAi HPA029038.
HPA029039.
MIMi 609593. gene.
neXtProti NX_Q5VZK9.
PharmGKBi PA162394368.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239526.
GeneTreei ENSGT00390000014487.
HOGENOMi HOG000230565.
HOVERGENi HBG108094.
InParanoidi Q5VZK9.
OMAi TLIVWLS.
OrthoDBi EOG72JWFD.
PhylomeDBi Q5VZK9.
TreeFami TF316381.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi LRRC16A. human.
EvolutionaryTracei Q5VZK9.
GeneWikii LRRC16A.
GenomeRNAii 55604.
NextBioi 35481565.
PROi Q5VZK9.
SOURCEi Search...

Gene expression databases

Bgeei Q5VZK9.
CleanExi HS_LRRC16A.
Genevestigatori Q5VZK9.

Family and domain databases

InterProi IPR029764. CARMIL1.
[Graphical view ]
PANTHERi PTHR24112:SF39. PTHR24112:SF39. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1371 (ISOFORM 2).
    Tissue: Colon, Esophageal carcinoma and Teratocarcinoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
  4. "Mammalian CARMIL inhibits actin filament capping by capping protein."
    Yang C., Pring M., Wear M.A., Huang M., Cooper J.A., Svitkina T.M., Zigmond S.H.
    Dev. Cell 9:209-221(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-593.
    Tissue: Mammary cancer.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-916; SER-968; SER-1288; SER-1291 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067; SER-1288 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968; SER-1288; SER-1315; SER-1331 AND SER-1360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLR16A_HUMAN
AccessioniPrimary (citable) accession number: Q5VZK9
Secondary accession number(s): B8X1J0
, Q6ZUH5, Q6ZW07, Q9NXU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3