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Q5VZK9

- LR16A_HUMAN

UniProt

Q5VZK9 - LR16A_HUMAN

Protein

Leucine-rich repeat-containing protein 16A

Gene

LRRC16A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization By similarity. May control actin dynamics in lamellipodia. Required for cell migration.By similarity2 Publications

    GO - Molecular functioni

    1. protein complex binding Source: UniProt

    GO - Biological processi

    1. actin filament organization Source: BHF-UCL
    2. barbed-end actin filament uncapping Source: UniProt
    3. blood coagulation Source: Reactome
    4. cell migration Source: BHF-UCL
    5. lamellipodium assembly Source: BHF-UCL
    6. negative regulation of barbed-end actin filament capping Source: UniProt
    7. positive regulation of actin filament polymerization Source: UniProt
    8. positive regulation of cell migration Source: UniProt
    9. positive regulation of lamellipodium organization Source: UniProt
    10. positive regulation of stress fiber assembly Source: UniProt
    11. positive regulation of substrate adhesion-dependent cell spreading Source: UniProt
    12. ruffle organization Source: BHF-UCL
    13. urate metabolic process Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat-containing protein 16A
    Alternative name(s):
    CARMIL homolog
    Gene namesi
    Name:LRRC16A
    Synonyms:CARMIL, CARMIL1a, LRRC16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21581. LRRC16A.

    Subcellular locationi

    Cell projectionlamellipodium 1 Publication. Cytoplasm 1 Publication
    Note: Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. filamentous actin Source: UniProt
    5. lamellipodium Source: BHF-UCL
    6. nucleus Source: HPA

    Keywords - Cellular componenti

    Cell projection, Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162394368.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13711371Leucine-rich repeat-containing protein 16APRO_0000325815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Cross-linki593 – 593Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei916 – 9161Phosphothreonine1 Publication
    Modified residuei968 – 9681Phosphoserine3 Publications
    Modified residuei1067 – 10671Phosphoserine1 Publication
    Modified residuei1288 – 12881Phosphoserine3 Publications
    Modified residuei1291 – 12911Phosphoserine1 Publication
    Modified residuei1315 – 13151Phosphoserine1 Publication
    Modified residuei1331 – 13311Phosphoserine3 Publications
    Modified residuei1360 – 13601Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ5VZK9.
    PaxDbiQ5VZK9.
    PeptideAtlasiQ5VZK9.
    PRIDEiQ5VZK9.

    PTM databases

    PhosphoSiteiQ5VZK9.

    Expressioni

    Tissue specificityi

    Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.1 Publication

    Gene expression databases

    BgeeiQ5VZK9.
    CleanExiHS_LRRC16A.
    GenevestigatoriQ5VZK9.

    Organism-specific databases

    HPAiHPA029038.
    HPA029039.

    Interactioni

    Subunit structurei

    Interacts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation By similarity. Homodimer.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi120745. 6 interactions.
    DIPiDIP-56920N.
    IntActiQ5VZK9. 1 interaction.
    MINTiMINT-5005073.
    STRINGi9606.ENSP00000331983.

    Structurei

    Secondary structure

    1
    1371
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi978 – 9803
    Helixi985 – 9884
    Beta strandi999 – 10024
    Helixi1026 – 10294

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LK2X-ray2.20T961-1012[»]
    3LK3X-ray2.68T964-1078[»]
    ProteinModelPortaliQ5VZK9.
    SMRiQ5VZK9. Positions 9-664, 961-1035.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5VZK9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati245 – 26925LRR 1Add
    BLAST
    Repeati275 – 29824LRR 2Add
    BLAST
    Repeati304 – 32724LRR 3Add
    BLAST
    Repeati336 – 36328LRR 4Add
    BLAST
    Repeati391 – 41828LRR 5Add
    BLAST
    Repeati423 – 44725LRR 6Add
    BLAST
    Repeati481 – 50626LRR 7Add
    BLAST
    Repeati543 – 56624LRR 8Add
    BLAST
    Repeati570 – 59324LRR 9Add
    BLAST
    Repeati654 – 67825LRR 10Add
    BLAST
    Repeati958 – 98124LRR 11Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni958 – 1082125Inhibits capping activity of CAPZA2By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili710 – 73425Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1243 – 12508Poly-Ser

    Sequence similaritiesi

    Belongs to the CARMIL family.Curated
    Contains 11 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Coiled coil, Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG239526.
    HOGENOMiHOG000230565.
    HOVERGENiHBG108094.
    InParanoidiQ5VZK9.
    OMAiTLIVWLS.
    OrthoDBiEOG72JWFD.
    PhylomeDBiQ5VZK9.
    TreeFamiTF316381.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VZK9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEESSDVPR ELIESIKDVI GRKIKISVKK KVKLEVKGDK VENKVLVLTS     50
    CRAFLVTARI PTKLELTFSY LEIHGVVCSK SAQMIVETEK CSISMKMASP 100
    EDVSEVLAHI GTCLRKIFPG LSPVRIMKKV SMEPSERLAS LQALWDSQTV 150
    AEQGPCGGFS QMYACVCDWL GFSYREEVQW DVDTIYLTQD TRELNLQDFS 200
    HLDHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR VVSRSNRLEE 250
    LVLENAGLRT DFAQKLASAL AHNPNSGLHT INLAGNPLED RGVSSLSIQF 300
    AKLPKGLKHL NLSKTSLSPK GVNSLSQSLS ANPLTASTLV HLDLSGNVLR 350
    GDDLSHMYNF LAQPNAIVHL DLSNTECSLD MVCGALLRGC LQYLAVLNLS 400
    RTVFSHRKGK EVPPSFKQFF SSSLALMHIN LSGTKLSPEP LKALLLGLAC 450
    NHNLKGVSLD LSNCELRSGG AQVLEGCIAE IHNITSLDIS DNGLESDLST 500
    LIVWLSKNRS IQHLALGKNF NNMKSKNLTP VLDNLVQMIQ DEESPLQSLS 550
    LADSKLKTEV TIIINALGSN TSLTKVDISG NGMGDMGAKM LAKALQINTK 600
    LRTVIWDKNN ITAQGFQDIA VAMEKNYTLR FMPIPMYDAS QALKTNPEKT 650
    EDALQKIENY LLRNHETRKY LQEQAYRLQQ GIVTSTTQQM IDRICVKVQD 700
    HLNSLRNCGG DAIQEDLKSA ERLMRDAKNS KTLLPNLYHV GGASWAGASG 750
    LLSSPIQETL ESMAGEVTRV VDEQLKALLE SMVDAAENLC PNVMKKAHIR 800
    QDLIHASTEK ISIPRTFVKN VLLEQSGIDI LNKISEVKLT VASFLSDRIV 850
    DEILDALSHC HHKLADHFSR RGKTLPQQES LEIELAEEKP VKRSIITVEE 900
    LTEIERLEDL DTCMMTPKSK RKSIHSRMLR PVSRAFEMEF DLDKALEEVP 950
    IHIEDPPFPS LRQEKRSSGF ISELPSEEGK KLEHFTKLRP KRNKKQQPTQ 1000
    AAVCAANIVS QDGEQNGLMG RVDEGVDEFF TKKVTKMDSK KWSTRGSESH 1050
    ELNEGGDEKK KRDSRKSSGF LNLIKSRSKS ERPPTILMTE EPSSPKGAVR 1100
    SPPVDCPRKD TKAAEHNGNS ERIEEIKTPD SFEESQGEEI GKVERSDSKS 1150
    SPQAGRRYGV QVMGSGLLAE MKAKQEKRAA CAQKKLGNDA VSQDSSSPAL 1200
    SGVERSDGGG AVPKLHPGLP ENRFGLGTPE KNTKAEPKAE AGSRSRSSSS 1250
    TPTSPKPLLQ SPKPSLAARP VIPQKPRTAS RPDDIPDSPS SPKVALLPPV 1300
    LKKVPSDKER DGQSSPQPSP RTFSQEVSRR SWGQQAQEYQ EQKQRSSSKD 1350
    GHQGSKSNDS GEEAEKEFIF V 1371
    Length:1,371
    Mass (Da):151,557
    Last modified:December 7, 2004 - v1
    Checksum:i6DECD6387FD73DCE
    GO
    Isoform 2 (identifier: Q5VZK9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1177-1221: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,326
    Mass (Da):147,088
    Checksum:iBC4881025483CA27
    GO
    Isoform 3 (identifier: Q5VZK9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         486-499: SLDISDNGLESDLS → QLGTRYRNAVLRVY
         500-1371: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:499
    Mass (Da):55,117
    Checksum:iA77D54FABEE374C8
    GO
    Isoform 4 (identifier: Q5VZK9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-161: Missing.
         292-337: GVSSLSIQFA...SLSANPLTAS → ETTTKIKRQN...NYYSDFSHDG
         338-1371: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:176
    Mass (Da):20,181
    Checksum:i806D8D31AAC2A04A
    GO

    Sequence cautioni

    The sequence BAA90912.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551N → D in BAC85701. (PubMed:14702039)Curated
    Sequence conflicti889 – 8891K → R in BAA90912. (PubMed:14702039)Curated
    Sequence conflicti1202 – 12021G → S in ACI49709. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771V → I.
    Corresponds to variant rs9358856 [ dbSNP | Ensembl ].
    VAR_039923
    Natural varianti545 – 5451P → L.
    Corresponds to variant rs12207840 [ dbSNP | Ensembl ].
    VAR_039924
    Natural varianti639 – 6391A → G.
    Corresponds to variant rs7454756 [ dbSNP | Ensembl ].
    VAR_039925
    Natural varianti1117 – 11171N → S.
    Corresponds to variant rs9885914 [ dbSNP | Ensembl ].
    VAR_039926

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 161161Missing in isoform 4. 1 PublicationVSP_032415Add
    BLAST
    Alternative sequencei292 – 33746GVSSL…PLTAS → ETTTKIKRQNVPTVLQTYLV VCPSDYQPCPLPLGKDNYYS DFSHDG in isoform 4. 1 PublicationVSP_032416Add
    BLAST
    Alternative sequencei338 – 13711034Missing in isoform 4. 1 PublicationVSP_032417Add
    BLAST
    Alternative sequencei486 – 49914SLDIS…ESDLS → QLGTRYRNAVLRVY in isoform 3. 1 PublicationVSP_032418Add
    BLAST
    Alternative sequencei500 – 1371872Missing in isoform 3. 1 PublicationVSP_032419Add
    BLAST
    Alternative sequencei1177 – 122145Missing in isoform 2. 1 PublicationVSP_032420Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ009082 mRNA. Translation: ACI49709.1.
    AK123817 mRNA. Translation: BAC85701.1.
    AK125696 mRNA. Translation: BAC86250.1.
    AK000055 mRNA. Translation: BAA90912.1. Different initiation.
    AL160037, AL022170, AL024509 Genomic DNA. Translation: CAH72024.1.
    AL022170, AL024509, AL160037 Genomic DNA. Translation: CAI21583.1.
    AL024509, AL022170, AL160037 Genomic DNA. Translation: CAI21665.1.
    CCDSiCCDS54973.1. [Q5VZK9-1]
    RefSeqiNP_060110.4. NM_017640.5. [Q5VZK9-1]
    UniGeneiHs.649550.

    Genome annotation databases

    EnsembliENST00000329474; ENSP00000331983; ENSG00000079691. [Q5VZK9-1]
    GeneIDi55604.
    KEGGihsa:55604.
    UCSCiuc011djw.2. human. [Q5VZK9-1]

    Polymorphism databases

    DMDMi74762279.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ009082 mRNA. Translation: ACI49709.1 .
    AK123817 mRNA. Translation: BAC85701.1 .
    AK125696 mRNA. Translation: BAC86250.1 .
    AK000055 mRNA. Translation: BAA90912.1 . Different initiation.
    AL160037 , AL022170 , AL024509 Genomic DNA. Translation: CAH72024.1 .
    AL022170 , AL024509 , AL160037 Genomic DNA. Translation: CAI21583.1 .
    AL024509 , AL022170 , AL160037 Genomic DNA. Translation: CAI21665.1 .
    CCDSi CCDS54973.1. [Q5VZK9-1 ]
    RefSeqi NP_060110.4. NM_017640.5. [Q5VZK9-1 ]
    UniGenei Hs.649550.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LK2 X-ray 2.20 T 961-1012 [» ]
    3LK3 X-ray 2.68 T 964-1078 [» ]
    ProteinModelPortali Q5VZK9.
    SMRi Q5VZK9. Positions 9-664, 961-1035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120745. 6 interactions.
    DIPi DIP-56920N.
    IntActi Q5VZK9. 1 interaction.
    MINTi MINT-5005073.
    STRINGi 9606.ENSP00000331983.

    PTM databases

    PhosphoSitei Q5VZK9.

    Polymorphism databases

    DMDMi 74762279.

    Proteomic databases

    MaxQBi Q5VZK9.
    PaxDbi Q5VZK9.
    PeptideAtlasi Q5VZK9.
    PRIDEi Q5VZK9.

    Protocols and materials databases

    DNASUi 55604.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329474 ; ENSP00000331983 ; ENSG00000079691 . [Q5VZK9-1 ]
    GeneIDi 55604.
    KEGGi hsa:55604.
    UCSCi uc011djw.2. human. [Q5VZK9-1 ]

    Organism-specific databases

    CTDi 55604.
    GeneCardsi GC06P025279.
    H-InvDB HIX0005632.
    HGNCi HGNC:21581. LRRC16A.
    HPAi HPA029038.
    HPA029039.
    MIMi 609593. gene.
    neXtProti NX_Q5VZK9.
    PharmGKBi PA162394368.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239526.
    HOGENOMi HOG000230565.
    HOVERGENi HBG108094.
    InParanoidi Q5VZK9.
    OMAi TLIVWLS.
    OrthoDBi EOG72JWFD.
    PhylomeDBi Q5VZK9.
    TreeFami TF316381.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi LRRC16A. human.
    EvolutionaryTracei Q5VZK9.
    GeneWikii LRRC16A.
    GenomeRNAii 55604.
    NextBioi 35481565.
    PROi Q5VZK9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VZK9.
    CleanExi HS_LRRC16A.
    Genevestigatori Q5VZK9.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1371 (ISOFORM 2).
      Tissue: Colon, Esophageal carcinoma and Teratocarcinoma.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
    4. "Mammalian CARMIL inhibits actin filament capping by capping protein."
      Yang C., Pring M., Wear M.A., Huang M., Cooper J.A., Svitkina T.M., Zigmond S.H.
      Dev. Cell 9:209-221(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-593.
      Tissue: Mammary cancer.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-916; SER-968; SER-1288; SER-1291 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067; SER-1288 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968; SER-1288; SER-1315; SER-1331 AND SER-1360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLR16A_HUMAN
    AccessioniPrimary (citable) accession number: Q5VZK9
    Secondary accession number(s): B8X1J0
    , Q6ZUH5, Q6ZW07, Q9NXU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3