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Q5VZK9

- LR16A_HUMAN

UniProt

Q5VZK9 - LR16A_HUMAN

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Protein
Leucine-rich repeat-containing protein 16A
Gene
LRRC16A, CARMIL, CARMIL1a, LRRC16
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization By similarity. May control actin dynamics in lamellipodia. Required for cell migration.2 Publications

GO - Molecular functioni

  1. protein complex binding Source: UniProt

GO - Biological processi

  1. actin filament organization Source: BHF-UCL
  2. barbed-end actin filament uncapping Source: UniProt
  3. blood coagulation Source: Reactome
  4. cell migration Source: BHF-UCL
  5. lamellipodium assembly Source: BHF-UCL
  6. negative regulation of barbed-end actin filament capping Source: UniProt
  7. positive regulation of actin filament polymerization Source: UniProt
  8. positive regulation of cell migration Source: UniProt
  9. positive regulation of lamellipodium organization Source: UniProt
  10. positive regulation of stress fiber assembly Source: UniProt
  11. positive regulation of substrate adhesion-dependent cell spreading Source: UniProt
  12. ruffle organization Source: BHF-UCL
  13. urate metabolic process Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 16A
Alternative name(s):
CARMIL homolog
Gene namesi
Name:LRRC16A
Synonyms:CARMIL, CARMIL1a, LRRC16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21581. LRRC16A.

Subcellular locationi

Cell projectionlamellipodium. Cytoplasm
Note: Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. filamentous actin Source: UniProt
  5. lamellipodium Source: BHF-UCL
  6. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13711371Leucine-rich repeat-containing protein 16A
PRO_0000325815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Cross-linki593 – 593Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei916 – 9161Phosphothreonine1 Publication
Modified residuei968 – 9681Phosphoserine3 Publications
Modified residuei1067 – 10671Phosphoserine1 Publication
Modified residuei1288 – 12881Phosphoserine3 Publications
Modified residuei1291 – 12911Phosphoserine1 Publication
Modified residuei1315 – 13151Phosphoserine1 Publication
Modified residuei1331 – 13311Phosphoserine3 Publications
Modified residuei1360 – 13601Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ5VZK9.
PaxDbiQ5VZK9.
PeptideAtlasiQ5VZK9.
PRIDEiQ5VZK9.

PTM databases

PhosphoSiteiQ5VZK9.

Expressioni

Tissue specificityi

Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.1 Publication

Gene expression databases

BgeeiQ5VZK9.
CleanExiHS_LRRC16A.
GenevestigatoriQ5VZK9.

Organism-specific databases

HPAiHPA029038.
HPA029039.

Interactioni

Subunit structurei

Interacts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation By similarity. Homodimer.1 Publication

Protein-protein interaction databases

BioGridi120745. 6 interactions.
DIPiDIP-56920N.
IntActiQ5VZK9. 1 interaction.
MINTiMINT-5005073.
STRINGi9606.ENSP00000331983.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi978 – 9803
Helixi985 – 9884
Beta strandi999 – 10024
Helixi1026 – 10294

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LK2X-ray2.20T961-1012[»]
3LK3X-ray2.68T964-1078[»]
ProteinModelPortaliQ5VZK9.
SMRiQ5VZK9. Positions 9-664, 961-1035.

Miscellaneous databases

EvolutionaryTraceiQ5VZK9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati245 – 26925LRR 1
Add
BLAST
Repeati275 – 29824LRR 2
Add
BLAST
Repeati304 – 32724LRR 3
Add
BLAST
Repeati336 – 36328LRR 4
Add
BLAST
Repeati391 – 41828LRR 5
Add
BLAST
Repeati423 – 44725LRR 6
Add
BLAST
Repeati481 – 50626LRR 7
Add
BLAST
Repeati543 – 56624LRR 8
Add
BLAST
Repeati570 – 59324LRR 9
Add
BLAST
Repeati654 – 67825LRR 10
Add
BLAST
Repeati958 – 98124LRR 11
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni958 – 1082125Inhibits capping activity of CAPZA2 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili710 – 73425 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1243 – 12508Poly-Ser

Sequence similaritiesi

Belongs to the CARMIL family.

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG239526.
HOGENOMiHOG000230565.
HOVERGENiHBG108094.
InParanoidiQ5VZK9.
OMAiTLIVWLS.
OrthoDBiEOG72JWFD.
PhylomeDBiQ5VZK9.
TreeFamiTF316381.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VZK9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTEESSDVPR ELIESIKDVI GRKIKISVKK KVKLEVKGDK VENKVLVLTS     50
CRAFLVTARI PTKLELTFSY LEIHGVVCSK SAQMIVETEK CSISMKMASP 100
EDVSEVLAHI GTCLRKIFPG LSPVRIMKKV SMEPSERLAS LQALWDSQTV 150
AEQGPCGGFS QMYACVCDWL GFSYREEVQW DVDTIYLTQD TRELNLQDFS 200
HLDHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR VVSRSNRLEE 250
LVLENAGLRT DFAQKLASAL AHNPNSGLHT INLAGNPLED RGVSSLSIQF 300
AKLPKGLKHL NLSKTSLSPK GVNSLSQSLS ANPLTASTLV HLDLSGNVLR 350
GDDLSHMYNF LAQPNAIVHL DLSNTECSLD MVCGALLRGC LQYLAVLNLS 400
RTVFSHRKGK EVPPSFKQFF SSSLALMHIN LSGTKLSPEP LKALLLGLAC 450
NHNLKGVSLD LSNCELRSGG AQVLEGCIAE IHNITSLDIS DNGLESDLST 500
LIVWLSKNRS IQHLALGKNF NNMKSKNLTP VLDNLVQMIQ DEESPLQSLS 550
LADSKLKTEV TIIINALGSN TSLTKVDISG NGMGDMGAKM LAKALQINTK 600
LRTVIWDKNN ITAQGFQDIA VAMEKNYTLR FMPIPMYDAS QALKTNPEKT 650
EDALQKIENY LLRNHETRKY LQEQAYRLQQ GIVTSTTQQM IDRICVKVQD 700
HLNSLRNCGG DAIQEDLKSA ERLMRDAKNS KTLLPNLYHV GGASWAGASG 750
LLSSPIQETL ESMAGEVTRV VDEQLKALLE SMVDAAENLC PNVMKKAHIR 800
QDLIHASTEK ISIPRTFVKN VLLEQSGIDI LNKISEVKLT VASFLSDRIV 850
DEILDALSHC HHKLADHFSR RGKTLPQQES LEIELAEEKP VKRSIITVEE 900
LTEIERLEDL DTCMMTPKSK RKSIHSRMLR PVSRAFEMEF DLDKALEEVP 950
IHIEDPPFPS LRQEKRSSGF ISELPSEEGK KLEHFTKLRP KRNKKQQPTQ 1000
AAVCAANIVS QDGEQNGLMG RVDEGVDEFF TKKVTKMDSK KWSTRGSESH 1050
ELNEGGDEKK KRDSRKSSGF LNLIKSRSKS ERPPTILMTE EPSSPKGAVR 1100
SPPVDCPRKD TKAAEHNGNS ERIEEIKTPD SFEESQGEEI GKVERSDSKS 1150
SPQAGRRYGV QVMGSGLLAE MKAKQEKRAA CAQKKLGNDA VSQDSSSPAL 1200
SGVERSDGGG AVPKLHPGLP ENRFGLGTPE KNTKAEPKAE AGSRSRSSSS 1250
TPTSPKPLLQ SPKPSLAARP VIPQKPRTAS RPDDIPDSPS SPKVALLPPV 1300
LKKVPSDKER DGQSSPQPSP RTFSQEVSRR SWGQQAQEYQ EQKQRSSSKD 1350
GHQGSKSNDS GEEAEKEFIF V 1371
Length:1,371
Mass (Da):151,557
Last modified:December 7, 2004 - v1
Checksum:i6DECD6387FD73DCE
GO
Isoform 2 (identifier: Q5VZK9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1221: Missing.

Note: No experimental confirmation available.

Show »
Length:1,326
Mass (Da):147,088
Checksum:iBC4881025483CA27
GO
Isoform 3 (identifier: Q5VZK9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     486-499: SLDISDNGLESDLS → QLGTRYRNAVLRVY
     500-1371: Missing.

Note: No experimental confirmation available.

Show »
Length:499
Mass (Da):55,117
Checksum:iA77D54FABEE374C8
GO
Isoform 4 (identifier: Q5VZK9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     292-337: GVSSLSIQFA...SLSANPLTAS → ETTTKIKRQN...NYYSDFSHDG
     338-1371: Missing.

Note: No experimental confirmation available.

Show »
Length:176
Mass (Da):20,181
Checksum:i806D8D31AAC2A04A
GO

Sequence cautioni

The sequence BAA90912.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771V → I.
Corresponds to variant rs9358856 [ dbSNP | Ensembl ].
VAR_039923
Natural varianti545 – 5451P → L.
Corresponds to variant rs12207840 [ dbSNP | Ensembl ].
VAR_039924
Natural varianti639 – 6391A → G.
Corresponds to variant rs7454756 [ dbSNP | Ensembl ].
VAR_039925
Natural varianti1117 – 11171N → S.
Corresponds to variant rs9885914 [ dbSNP | Ensembl ].
VAR_039926

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 161161Missing in isoform 4.
VSP_032415Add
BLAST
Alternative sequencei292 – 33746GVSSL…PLTAS → ETTTKIKRQNVPTVLQTYLV VCPSDYQPCPLPLGKDNYYS DFSHDG in isoform 4.
VSP_032416Add
BLAST
Alternative sequencei338 – 13711034Missing in isoform 4.
VSP_032417Add
BLAST
Alternative sequencei486 – 49914SLDIS…ESDLS → QLGTRYRNAVLRVY in isoform 3.
VSP_032418Add
BLAST
Alternative sequencei500 – 1371872Missing in isoform 3.
VSP_032419Add
BLAST
Alternative sequencei1177 – 122145Missing in isoform 2.
VSP_032420Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551N → D in BAC85701. 1 Publication
Sequence conflicti889 – 8891K → R in BAA90912. 1 Publication
Sequence conflicti1202 – 12021G → S in ACI49709. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ009082 mRNA. Translation: ACI49709.1.
AK123817 mRNA. Translation: BAC85701.1.
AK125696 mRNA. Translation: BAC86250.1.
AK000055 mRNA. Translation: BAA90912.1. Different initiation.
AL160037, AL022170, AL024509 Genomic DNA. Translation: CAH72024.1.
AL022170, AL024509, AL160037 Genomic DNA. Translation: CAI21583.1.
AL024509, AL022170, AL160037 Genomic DNA. Translation: CAI21665.1.
CCDSiCCDS54973.1. [Q5VZK9-1]
RefSeqiNP_060110.4. NM_017640.5. [Q5VZK9-1]
UniGeneiHs.649550.

Genome annotation databases

EnsembliENST00000329474; ENSP00000331983; ENSG00000079691. [Q5VZK9-1]
ENST00000377969; ENSP00000367206; ENSG00000079691. [Q5VZK9-4]
GeneIDi55604.
KEGGihsa:55604.
UCSCiuc011djw.2. human. [Q5VZK9-1]

Polymorphism databases

DMDMi74762279.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ009082 mRNA. Translation: ACI49709.1 .
AK123817 mRNA. Translation: BAC85701.1 .
AK125696 mRNA. Translation: BAC86250.1 .
AK000055 mRNA. Translation: BAA90912.1 . Different initiation.
AL160037 , AL022170 , AL024509 Genomic DNA. Translation: CAH72024.1 .
AL022170 , AL024509 , AL160037 Genomic DNA. Translation: CAI21583.1 .
AL024509 , AL022170 , AL160037 Genomic DNA. Translation: CAI21665.1 .
CCDSi CCDS54973.1. [Q5VZK9-1 ]
RefSeqi NP_060110.4. NM_017640.5. [Q5VZK9-1 ]
UniGenei Hs.649550.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LK2 X-ray 2.20 T 961-1012 [» ]
3LK3 X-ray 2.68 T 964-1078 [» ]
ProteinModelPortali Q5VZK9.
SMRi Q5VZK9. Positions 9-664, 961-1035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120745. 6 interactions.
DIPi DIP-56920N.
IntActi Q5VZK9. 1 interaction.
MINTi MINT-5005073.
STRINGi 9606.ENSP00000331983.

PTM databases

PhosphoSitei Q5VZK9.

Polymorphism databases

DMDMi 74762279.

Proteomic databases

MaxQBi Q5VZK9.
PaxDbi Q5VZK9.
PeptideAtlasi Q5VZK9.
PRIDEi Q5VZK9.

Protocols and materials databases

DNASUi 55604.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329474 ; ENSP00000331983 ; ENSG00000079691 . [Q5VZK9-1 ]
ENST00000377969 ; ENSP00000367206 ; ENSG00000079691 . [Q5VZK9-4 ]
GeneIDi 55604.
KEGGi hsa:55604.
UCSCi uc011djw.2. human. [Q5VZK9-1 ]

Organism-specific databases

CTDi 55604.
GeneCardsi GC06P025279.
H-InvDB HIX0005632.
HGNCi HGNC:21581. LRRC16A.
HPAi HPA029038.
HPA029039.
MIMi 609593. gene.
neXtProti NX_Q5VZK9.
PharmGKBi PA162394368.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239526.
HOGENOMi HOG000230565.
HOVERGENi HBG108094.
InParanoidi Q5VZK9.
OMAi TLIVWLS.
OrthoDBi EOG72JWFD.
PhylomeDBi Q5VZK9.
TreeFami TF316381.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi LRRC16A. human.
EvolutionaryTracei Q5VZK9.
GeneWikii LRRC16A.
GenomeRNAii 55604.
NextBioi 35481565.
PROi Q5VZK9.
SOURCEi Search...

Gene expression databases

Bgeei Q5VZK9.
CleanExi HS_LRRC16A.
Genevestigatori Q5VZK9.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1371 (ISOFORM 2).
    Tissue: Colon, Esophageal carcinoma and Teratocarcinoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
  4. "Mammalian CARMIL inhibits actin filament capping by capping protein."
    Yang C., Pring M., Wear M.A., Huang M., Cooper J.A., Svitkina T.M., Zigmond S.H.
    Dev. Cell 9:209-221(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-593.
    Tissue: Mammary cancer.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-916; SER-968; SER-1288; SER-1291 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067; SER-1288 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968; SER-1288; SER-1315; SER-1331 AND SER-1360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLR16A_HUMAN
AccessioniPrimary (citable) accession number: Q5VZK9
Secondary accession number(s): B8X1J0
, Q6ZUH5, Q6ZW07, Q9NXU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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