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Protein

DENN domain-containing protein 4C

Gene

DENND4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.1 Publication

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
DENN domain-containing protein 4C
Gene namesi
Name:DENND4C
Synonyms:C9orf55, C9orf55B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 9, Unplaced

Organism-specific databases

HGNCiHGNC:26079. DENND4C.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137145.
PharmGKBiPA134939495.

Polymorphism and mutation databases

DMDMi158937337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896971 – 1909DENN domain-containing protein 4CAdd BLAST1909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1046PhosphoserineBy similarity1
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1325PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VZ89.
MaxQBiQ5VZ89.
PaxDbiQ5VZ89.
PeptideAtlasiQ5VZ89.
PRIDEiQ5VZ89.

PTM databases

iPTMnetiQ5VZ89.
PhosphoSitePlusiQ5VZ89.

Expressioni

Gene expression databases

BgeeiENSG00000137145.
CleanExiHS_DENND4C.
ExpressionAtlasiR4GN35. baseline and differential.

Organism-specific databases

HPAiHPA014917.
HPA015096.

Interactioni

Protein-protein interaction databases

BioGridi120799. 10 interactors.
IntActiQ5VZ89. 10 interactors.
STRINGi9606.ENSP00000369802.

Structurei

3D structure databases

ProteinModelPortaliQ5VZ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 199MABPPROSITE-ProRule annotationAdd BLAST160
Domaini202 – 276uDENNPROSITE-ProRule annotationAdd BLAST75
Domaini308 – 492DENNPROSITE-ProRule annotationAdd BLAST185
Domaini558 – 632dDENNPROSITE-ProRule annotationAdd BLAST75
Repeati821 – 855PPRAdd BLAST35

Phylogenomic databases

eggNOGiKOG2127. Eukaryota.
ENOG410XQMX. LUCA.
GeneTreeiENSGT00760000118819.
HOVERGENiHBG058313.
InParanoidiQ5VZ89.
KOiK20163.
OMAiQHSLHMI.
OrthoDBiEOG091G00CV.
PhylomeDBiQ5VZ89.
TreeFamiTF313237.

Family and domain databases

InterProiView protein in InterPro
IPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
PfamiView protein in Pfam
PF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
SMARTiView protein in SMART
SM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
PROSITEiView protein in PROSITE
PS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS51498. MABP. 1 hit.
PS50946. UDENN. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VZ89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RLDTKSTGPK APITDIAIII
60 70 80 90 100
KSAGETVPEG YTCVEATPSA LQANLNYGSL KSPELFLCYK RGRDKPPLTD
110 120 130 140 150
IGVLYEGKER LIPGCEVILA TPYGRCANVN NSSTTSQRIF ITYRRAPPVR
160 170 180 190 200
PQNSLAVTDI CVIVTSKGET PPHTFCKVDK NLNCGMWGSS VFLCYKKSVP
210 220 230 240 250
ASNAIAYKAG LIFRYPEEDY ESFPLSESDV PLFCLPMGAT IECWDPETKY
260 270 280 290 300
PLPVFSTFVL TGSSAKKVYG AAIQFYEPYS RELLSEKQLM HLGLLTPVER
310 320 330 340 350
KMVSKSINTN KCICLLSHWP FFEAFRKFLM FIYKLSVSGP HPLPIEKHIS
360 370 380 390 400
HFMQNIPFPS PQRPRILVQL SVHDALILSQ PVSTPLPLSG ANFSTLLMNL
410 420 430 440 450
GPENCATLLL FVLLESKILL HSLRPAVLTG VAEAVVAMIF PFQWQCPYIP
460 470 480 490 500
LCPLSLAAVL SAPLPFIVGV DSRYFDLHDP PQDVVCIDLD TNMLYVSDEK
510 520 530 540 550
KNMNWKQLPK KPCKNLLSTL KKLYPQLSSV HQKTQEGSAI DMTPIEADFS
560 570 580 590 600
WQKKMTQLEM EIQEAFLRFM ASILKGYRTY LRPITEAPSN KATAADSLFD
610 620 630 640 650
RQGFLKSRDR AYAKFYTLLS KTQIFIRFIE ECSFVSDKDT GLAFFDDCIE
660 670 680 690 700
KLFPDKGTEK TDKVDFDSAE DTRLIELDDS QKSEHTVFIM PPEPPPDDGK
710 720 730 740 750
DLSPKYSYKY FPRLDLKLFD RPQELKLCFS RHPTGNSITK SPPLMAKRTK
760 770 780 790 800
QEIKTAHKLA KRCYTNPPQW AKCLFSHCYS LWFICLPAYV RVSHPKVRAL
810 820 830 840 850
QQAYDVLIKM RKTDVDPLDE VCYRVVMQLC GLWGHPVLAV RVLFEMKTAR
860 870 880 890 900
IKPNAITYGY YNKVVLESPW PSSTRSGIFL WTKVRNVVRG LAQFRQPLKK
910 920 930 940 950
TVQRSQVSSI SGGQSDQGYG SKDELIKDDA EIHVPEEQAA RELITKTKMQ
960 970 980 990 1000
TEEVCDASAI VAKHSQPSPE PHSPTEPPAW GSSIVKVPSG IFDVNSRKSS
1010 1020 1030 1040 1050
TGSISNVLFS TQDPVEDAVF GEATNLKKNG DRGEKRQKHF PERSCSFSSE
1060 1070 1080 1090 1100
SRAGMLLKKS SLDSNSSEMA IMMGADAKIL TAALTCPKTS LLHIARTHSF
1110 1120 1130 1140 1150
ENVSCHLPDS RTCMSESTWN PEHRSSPVPE MLEESQELLE PVVDDVPKTT
1160 1170 1180 1190 1200
ATVDTYESLL SDSNSNQSRD LKTVSKDLRN KRSSLYGIAK VVQREDVETG
1210 1220 1230 1240 1250
LDPLSLLATE CTGGKTPDSE DKLFSPVIAR NLADEIESYM NLKSPLGSKS
1260 1270 1280 1290 1300
SSMELHREEN RESGMTTAFI HALERRSSLP LDHGSPAQEN PESEKSSPAV
1310 1320 1330 1340 1350
SRSKTFTGRF KQQTPSRTHK ERSTSLSALV RSSPHGSLGS VVNSLSGLKL
1360 1370 1380 1390 1400
DNILSGPKID VLKSGMKQAA TVASKMWVAV ASAYSYSDDE EETNRDYSFP
1410 1420 1430 1440 1450
AGLEDHILGE NISPNTSISG LVPSELTQSN TSLGSSSSSG DVGKLHYPTG
1460 1470 1480 1490 1500
EVPFPRGMKG QDFEKSDHGS SQNTSMSSIY QNCAMEVLMS SCSQCRACGA
1510 1520 1530 1540 1550
LVYDEEIMAG WTADDSNLNT ACPFCKSNFL PLLNIEFKDL RGSASFFLKP
1560 1570 1580 1590 1600
STSGDSLQSG SIPLANESLE HKPVSSLAEP DLINFMDFPK HNQIITEETG
1610 1620 1630 1640 1650
SAVEPSDEIK RASGDVQTMK ISSVPNSLSK RNVSLTRSHS VGGPLQNIDF
1660 1670 1680 1690 1700
TQRPFHGIST VSLPNSLQEV VDPLGKRPNP PPVSVPYLSP LVLRKELESL
1710 1720 1730 1740 1750
LENEGDQVIH TSSFINQHPI IFWNLVWYFR RLDLPSNLPG LILTSEHCNE
1760 1770 1780 1790 1800
GVQLPLSSLS QDSKLVYIQL LWDNINLHQE PREPLYVSWR NFNSEKKSSL
1810 1820 1830 1840 1850
LSEEQQETST LVETIRQSIQ HNNVLKPINL LSQQMKPGMK RQRSLYREIL
1860 1870 1880 1890 1900
FLSLVSLGRE NIDIEAFDNE YGIAYNSLSS EILERLQKID APPSASVEWC

RKCFGAPLI
Length:1,909
Mass (Da):212,711
Last modified:June 7, 2017 - v3
Checksum:i3AB522323299D990
GO
Isoform 3 (identifier: Q5VZ89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1844-1845: SL → GI
     1846-1909: Missing.

Show »
Length:1,845
Mass (Da):205,433
Checksum:iB901F629D17DAE00
GO
Isoform 5 (identifier: Q5VZ89-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1623: SDEIKRASGDVQTMKISS → RYQRVQRPLYVVINGVPL
     1624-1909: Missing.

Show »
Length:1,623
Mass (Da):180,333
Checksum:iFB5FBDACEA776B2D
GO
Isoform 2 (identifier: Q5VZ89-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     911-911: S → SALQNVTGGSDGDTVSHGSVDSSNDANNGEHTVFVRDLIRLESIDNHSST

Show »
Length:1,958
Mass (Da):217,819
Checksum:iD8BDDDCA43A36BEC
GO

Sequence cautioni

The sequence BAA91294 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86313 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH10466 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti683S → G in BAC86313 (PubMed:14702039).Curated1
Sequence conflicti1297S → P in BAA91294 (PubMed:14702039).Curated1
Sequence conflicti1656H → R in BAA91478 (PubMed:14702039).Curated1
Sequence conflicti1769Q → H in BAA92039 (PubMed:14702039).Curated1
Sequence conflicti1862I → V in CAH10466 (PubMed:17974005).Curated1
Sequence conflicti1868D → G in CAH10466 (PubMed:17974005).Curated1
Sequence conflicti1893P → A in CAD39177 (PubMed:17974005).Curated1
Sequence conflicti1897V → A in CAH10466 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0616401227V → G. Corresponds to variant dbSNP:rs34267952Ensembl.1
Natural variantiVAR_0228911266T → A. Corresponds to variant dbSNP:rs17818730Ensembl.1
Natural variantiVAR_0228921343N → H. Corresponds to variant dbSNP:rs6475322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027379911S → SALQNVTGGSDGDTVSHGSV DSSNDANNGEHTVFVRDLIR LESIDNHSST in isoform 2. Curated1
Alternative sequenceiVSP_0273821606 – 1623SDEIK…MKISS → RYQRVQRPLYVVINGVPL in isoform 5. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0273831624 – 1909Missing in isoform 5. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_0273841844 – 1845SL → GI in isoform 3. 1 Publication2
Alternative sequenceiVSP_0273861846 – 1909Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161909 Genomic DNA. No translation available.
AL391834 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58645.1.
AK000627 mRNA. Translation: BAA91294.1. Different initiation.
AK001046 mRNA. Translation: BAA91478.1. Different initiation.
AK002020 mRNA. Translation: BAA92039.1. Different initiation.
AK025705 mRNA. Translation: BAB15221.1. Different initiation.
AK125842 mRNA. Translation: BAC86313.1. Different initiation.
AL834521 mRNA. Translation: CAD39177.1.
CR627367 mRNA. Translation: CAH10466.1. Sequence problems.
RefSeqiNP_060395.5. NM_017925.6.
UniGeneiHs.249591.

Genome annotation databases

EnsembliENST00000380432; ENSP00000369797; ENSG00000137145.
GeneIDi55667.
KEGGihsa:55667.
UCSCiuc031tcw.2. human.
uc064shn.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161909 Genomic DNA. No translation available.
AL391834 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58645.1.
AK000627 mRNA. Translation: BAA91294.1. Different initiation.
AK001046 mRNA. Translation: BAA91478.1. Different initiation.
AK002020 mRNA. Translation: BAA92039.1. Different initiation.
AK025705 mRNA. Translation: BAB15221.1. Different initiation.
AK125842 mRNA. Translation: BAC86313.1. Different initiation.
AL834521 mRNA. Translation: CAD39177.1.
CR627367 mRNA. Translation: CAH10466.1. Sequence problems.
RefSeqiNP_060395.5. NM_017925.6.
UniGeneiHs.249591.

3D structure databases

ProteinModelPortaliQ5VZ89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120799. 10 interactors.
IntActiQ5VZ89. 10 interactors.
STRINGi9606.ENSP00000369802.

PTM databases

iPTMnetiQ5VZ89.
PhosphoSitePlusiQ5VZ89.

Polymorphism and mutation databases

DMDMi158937337.

Proteomic databases

EPDiQ5VZ89.
MaxQBiQ5VZ89.
PaxDbiQ5VZ89.
PeptideAtlasiQ5VZ89.
PRIDEiQ5VZ89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380432; ENSP00000369797; ENSG00000137145.
GeneIDi55667.
KEGGihsa:55667.
UCSCiuc031tcw.2. human.
uc064shn.1. human.

Organism-specific databases

CTDi55667.
GeneCardsiDENND4C.
H-InvDBiHIX0007946.
HGNCiHGNC:26079. DENND4C.
HPAiHPA014917.
HPA015096.
neXtProtiNX_Q5VZ89.
OpenTargetsiENSG00000137145.
PharmGKBiPA134939495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2127. Eukaryota.
ENOG410XQMX. LUCA.
GeneTreeiENSGT00760000118819.
HOVERGENiHBG058313.
InParanoidiQ5VZ89.
KOiK20163.
OMAiQHSLHMI.
OrthoDBiEOG091G00CV.
PhylomeDBiQ5VZ89.
TreeFamiTF313237.

Enzyme and pathway databases

ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiDENND4C. human.
GenomeRNAii55667.
PROiPR:Q5VZ89.

Gene expression databases

BgeeiENSG00000137145.
CleanExiHS_DENND4C.
ExpressionAtlasiR4GN35. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
PfamiView protein in Pfam
PF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
SMARTiView protein in SMART
SM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
PROSITEiView protein in PROSITE
PS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS51498. MABP. 1 hit.
PS50946. UDENN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEN4C_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ89
Secondary accession number(s): A2A3R1
, A2A3R2, A2A3R3, A2A3R9, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 7, 2017
Last modified: June 7, 2017
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.