Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5VZ66

- JKIP3_HUMAN

UniProt

Q5VZ66 - JKIP3_HUMAN

Protein

Janus kinase and microtubule-interacting protein 3

Gene

JAKMIP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Janus kinase and microtubule-interacting protein 3
    Alternative name(s):
    Neuroendocrine long coiled-coil protein 2
    Gene namesi
    Name:JAKMIP3
    Synonyms:C10orf14, C10orf39, JAMIP3, NECC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23523. JAKMIP3.

    Subcellular locationi

    Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 844844Janus kinase and microtubule-interacting protein 3PRO_0000323011Add
    BLAST

    Proteomic databases

    MaxQBiQ5VZ66.
    PaxDbiQ5VZ66.
    PRIDEiQ5VZ66.

    PTM databases

    PhosphoSiteiQ5VZ66.

    Expressioni

    Tissue specificityi

    Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate.1 Publication

    Gene expression databases

    BgeeiQ5VZ66.
    CleanExiHS_JAKMIP3.
    GenevestigatoriQ5VZ66.

    Organism-specific databases

    HPAiHPA022872.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000298622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VZ66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili8 – 258251Sequence AnalysisAdd
    BLAST
    Coiled coili289 – 421133Sequence AnalysisAdd
    BLAST
    Coiled coili493 – 621129Sequence AnalysisAdd
    BLAST
    Coiled coili683 – 834152Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the JAKMIP family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG127074.
    HOGENOMiHOG000060161.
    HOVERGENiHBG054249.
    InParanoidiQ5VZ66.
    OMAiEGQKRQI.
    OrthoDBiEOG7HHWRJ.
    PhylomeDBiQ5VZ66.
    TreeFamiTF331900.

    Family and domain databases

    InterProiIPR024836. JAKMIP.
    [Graphical view]
    PANTHERiPTHR18935. PTHR18935. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VZ66-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKRGMSSRA KGDKAEALAA LQAANEDLRA KLTDIQIELQ QEKSKVSKVE    50
    REKNQELRQV REHEQHKTAV LLTELKTKLH EEKMKELQAV RETLLRQHEA 100
    ELLRVIKIKD NENQRLQALL SALRDGGPEK VKTVLLSEAK EEAKKGFEVE 150
    KVKMQQEISE LKGAKRQVEE ALTLVIQADK IKAAEIRSVY HLHQEEITRI 200
    KKECEREIRR LMEEIKFKDR AVFVLERELG VQAGHAQRLQ LQKEALDEQL 250
    SQVREADRHP GSPRRELPHA AGAGDASDHS GSPEQQLDEK DARRFQLKIA 300
    ELSAIIRKLE DRNALLSEER NELLKRVREA ESQYKPLLDK NKRLSRKNED 350
    LSHALRRMEN KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREVDFL 400
    KLQIVEQQNL IDELSKTLET AGYVKSVLER DKLLRFRKQR KKMAKLPKPV 450
    VVETFFGYDE EASLESDGSS VSYQTDRTDQ TPCTPDDDLE EGMAKEETEL 500
    RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ AEVQRAQARI 550
    EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLRHEVQD 600
    ARDQNELLEF RILELEERER KSPAISFHHT PFVDGKSPLQ VYCEAEGVTD 650
    IVVAELMKKL DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQQIEETEAA 700
    LQRKMVDLES EKELFSKQKG YLDEELDYRK QALDQANKHI LELEAMLYDA 750
    LQQEAGAKVA ELLSEEEREK LKVAVEQWKR QVMSELRERD AQILRERMEL 800
    LQLAQQRIKE LEERIEAQKR QIKELEEKFL FLFLFFSLAF ILWS 844

    Note: No experimental confirmation available.

    Length:844
    Mass (Da):98,529
    Last modified:August 21, 2007 - v2
    Checksum:iCBB47F31B3E5BD27
    GO
    Isoform 2 (identifier: Q5VZ66-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-563: Missing.
         829-844: FLFLFLFFSLAFILWS → LSFSGHSPSW...KIFRNNRGLA

    Note: No experimental confirmation available.

    Show »
    Length:425
    Mass (Da):48,807
    Checksum:i33E46BCEA9B72992
    GO

    Sequence cautioni

    The sequence BAC86766.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAH10388.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti493 – 4931M → V.
    Corresponds to variant rs11592585 [ dbSNP | Ensembl ].
    VAR_054016
    Natural varianti795 – 7951R → G in a breast cancer sample; somatic mutation. 1 Publication
    VAR_039473

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 563563Missing in isoform 2. 1 PublicationVSP_031998Add
    BLAST
    Alternative sequencei829 – 84416FLFLF…FILWS → LSFSGHSPSWHPDVPHIESD PFPPVGPESRDKMGRRVSIL KTQGDLVSARPSRGGRVRRG SVWGVELPSTWDVPELELAL PTSRGLLRDRPGLGCWTLGP FSRTAAPIPFPGMCSIPCQA GVRTASVQKHQPRVPSSLLV LTVAATGVWRKIFRNNRGLA in isoform 2. 1 PublicationVSP_031999Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832756 mRNA. Translation: CAH10388.1. Sequence problems.
    AL512622 Genomic DNA. No translation available.
    AL162274 Genomic DNA. No translation available.
    AK126964 mRNA. Translation: BAC86766.1. Different initiation.
    CCDSiCCDS44494.1. [Q5VZ66-1]
    RefSeqiNP_001098991.1. NM_001105521.2. [Q5VZ66-1]
    XP_006717843.1. XM_006717780.1. [Q5VZ66-1]
    UniGeneiHs.106254.

    Genome annotation databases

    EnsembliENST00000298622; ENSP00000298622; ENSG00000188385. [Q5VZ66-1]
    GeneIDi282973.
    KEGGihsa:282973.
    UCSCiuc001lkx.4. human. [Q5VZ66-1]
    uc009yba.1. human. [Q5VZ66-2]

    Polymorphism databases

    DMDMi172045962.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832756 mRNA. Translation: CAH10388.1 . Sequence problems.
    AL512622 Genomic DNA. No translation available.
    AL162274 Genomic DNA. No translation available.
    AK126964 mRNA. Translation: BAC86766.1 . Different initiation.
    CCDSi CCDS44494.1. [Q5VZ66-1 ]
    RefSeqi NP_001098991.1. NM_001105521.2. [Q5VZ66-1 ]
    XP_006717843.1. XM_006717780.1. [Q5VZ66-1 ]
    UniGenei Hs.106254.

    3D structure databases

    ProteinModelPortali Q5VZ66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000298622.

    PTM databases

    PhosphoSitei Q5VZ66.

    Polymorphism databases

    DMDMi 172045962.

    Proteomic databases

    MaxQBi Q5VZ66.
    PaxDbi Q5VZ66.
    PRIDEi Q5VZ66.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298622 ; ENSP00000298622 ; ENSG00000188385 . [Q5VZ66-1 ]
    GeneIDi 282973.
    KEGGi hsa:282973.
    UCSCi uc001lkx.4. human. [Q5VZ66-1 ]
    uc009yba.1. human. [Q5VZ66-2 ]

    Organism-specific databases

    CTDi 282973.
    GeneCardsi GC10P133918.
    HGNCi HGNC:23523. JAKMIP3.
    HPAi HPA022872.
    MIMi 611198. gene.
    neXtProti NX_Q5VZ66.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG127074.
    HOGENOMi HOG000060161.
    HOVERGENi HBG054249.
    InParanoidi Q5VZ66.
    OMAi EGQKRQI.
    OrthoDBi EOG7HHWRJ.
    PhylomeDBi Q5VZ66.
    TreeFami TF331900.

    Miscellaneous databases

    ChiTaRSi JAKMIP3. human.
    GenomeRNAii 282973.
    PROi Q5VZ66.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VZ66.
    CleanExi HS_JAKMIP3.
    Genevestigatori Q5VZ66.

    Family and domain databases

    InterProi IPR024836. JAKMIP.
    [Graphical view ]
    PANTHERi PTHR18935. PTHR18935. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-844 (ISOFORM 1).
      Tissue: Brain.
    4. "Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins."
      Cruz-Garcia D., Vazquez-Martinez R., Peinado J.R., Anouar Y., Tonon M.C., Vaudry H., Castano J.P., Malagon M.M.
      FEBS Lett. 581:3149-3156(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-795.

    Entry informationi

    Entry nameiJKIP3_HUMAN
    AccessioniPrimary (citable) accession number: Q5VZ66
    Secondary accession number(s): A6PW00, Q69YM6, Q6ZT29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3