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Q5VZ66

- JKIP3_HUMAN

UniProt

Q5VZ66 - JKIP3_HUMAN

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Protein

Janus kinase and microtubule-interacting protein 3

Gene

JAKMIP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 3
Alternative name(s):
Neuroendocrine long coiled-coil protein 2
Gene namesi
Name:JAKMIP3
Synonyms:C10orf14, C10orf39, JAMIP3, NECC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23523. JAKMIP3.

Subcellular locationi

Golgi apparatus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Janus kinase and microtubule-interacting protein 3PRO_0000323011Add
BLAST

Proteomic databases

MaxQBiQ5VZ66.
PaxDbiQ5VZ66.
PRIDEiQ5VZ66.

PTM databases

PhosphoSiteiQ5VZ66.

Expressioni

Tissue specificityi

Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate.1 Publication

Gene expression databases

BgeeiQ5VZ66.
CleanExiHS_JAKMIP3.
GenevestigatoriQ5VZ66.

Organism-specific databases

HPAiHPA022872.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298622.

Structurei

3D structure databases

ProteinModelPortaliQ5VZ66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 258251Sequence AnalysisAdd
BLAST
Coiled coili289 – 421133Sequence AnalysisAdd
BLAST
Coiled coili493 – 621129Sequence AnalysisAdd
BLAST
Coiled coili683 – 834152Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG127074.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ5VZ66.
OMAiEGQKRQI.
OrthoDBiEOG7HHWRJ.
PhylomeDBiQ5VZ66.
TreeFamiTF331900.

Family and domain databases

InterProiIPR024836. JAKMIP.
[Graphical view]
PANTHERiPTHR18935. PTHR18935. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VZ66-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKRGMSSRA KGDKAEALAA LQAANEDLRA KLTDIQIELQ QEKSKVSKVE
60 70 80 90 100
REKNQELRQV REHEQHKTAV LLTELKTKLH EEKMKELQAV RETLLRQHEA
110 120 130 140 150
ELLRVIKIKD NENQRLQALL SALRDGGPEK VKTVLLSEAK EEAKKGFEVE
160 170 180 190 200
KVKMQQEISE LKGAKRQVEE ALTLVIQADK IKAAEIRSVY HLHQEEITRI
210 220 230 240 250
KKECEREIRR LMEEIKFKDR AVFVLERELG VQAGHAQRLQ LQKEALDEQL
260 270 280 290 300
SQVREADRHP GSPRRELPHA AGAGDASDHS GSPEQQLDEK DARRFQLKIA
310 320 330 340 350
ELSAIIRKLE DRNALLSEER NELLKRVREA ESQYKPLLDK NKRLSRKNED
360 370 380 390 400
LSHALRRMEN KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREVDFL
410 420 430 440 450
KLQIVEQQNL IDELSKTLET AGYVKSVLER DKLLRFRKQR KKMAKLPKPV
460 470 480 490 500
VVETFFGYDE EASLESDGSS VSYQTDRTDQ TPCTPDDDLE EGMAKEETEL
510 520 530 540 550
RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ AEVQRAQARI
560 570 580 590 600
EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLRHEVQD
610 620 630 640 650
ARDQNELLEF RILELEERER KSPAISFHHT PFVDGKSPLQ VYCEAEGVTD
660 670 680 690 700
IVVAELMKKL DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQQIEETEAA
710 720 730 740 750
LQRKMVDLES EKELFSKQKG YLDEELDYRK QALDQANKHI LELEAMLYDA
760 770 780 790 800
LQQEAGAKVA ELLSEEEREK LKVAVEQWKR QVMSELRERD AQILRERMEL
810 820 830 840
LQLAQQRIKE LEERIEAQKR QIKELEEKFL FLFLFFSLAF ILWS

Note: No experimental confirmation available.

Length:844
Mass (Da):98,529
Last modified:August 21, 2007 - v2
Checksum:iCBB47F31B3E5BD27
GO
Isoform 2 (identifier: Q5VZ66-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     829-844: FLFLFLFFSLAFILWS → LSFSGHSPSW...KIFRNNRGLA

Note: No experimental confirmation available.

Show »
Length:425
Mass (Da):48,807
Checksum:i33E46BCEA9B72992
GO

Sequence cautioni

The sequence BAC86766.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH10388.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti493 – 4931M → V.
Corresponds to variant rs11592585 [ dbSNP | Ensembl ].
VAR_054016
Natural varianti795 – 7951R → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_039473

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 563563Missing in isoform 2. 1 PublicationVSP_031998Add
BLAST
Alternative sequencei829 – 84416FLFLF…FILWS → LSFSGHSPSWHPDVPHIESD PFPPVGPESRDKMGRRVSIL KTQGDLVSARPSRGGRVRRG SVWGVELPSTWDVPELELAL PTSRGLLRDRPGLGCWTLGP FSRTAAPIPFPGMCSIPCQA GVRTASVQKHQPRVPSSLLV LTVAATGVWRKIFRNNRGLA in isoform 2. 1 PublicationVSP_031999Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832756 mRNA. Translation: CAH10388.1. Sequence problems.
AL512622 Genomic DNA. No translation available.
AL162274 Genomic DNA. No translation available.
AK126964 mRNA. Translation: BAC86766.1. Different initiation.
CCDSiCCDS44494.1. [Q5VZ66-1]
RefSeqiNP_001098991.1. NM_001105521.2. [Q5VZ66-1]
XP_006717843.1. XM_006717780.1. [Q5VZ66-1]
UniGeneiHs.106254.

Genome annotation databases

EnsembliENST00000298622; ENSP00000298622; ENSG00000188385. [Q5VZ66-1]
GeneIDi282973.
KEGGihsa:282973.
UCSCiuc001lkx.4. human. [Q5VZ66-1]
uc009yba.1. human. [Q5VZ66-2]

Polymorphism databases

DMDMi172045962.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832756 mRNA. Translation: CAH10388.1 . Sequence problems.
AL512622 Genomic DNA. No translation available.
AL162274 Genomic DNA. No translation available.
AK126964 mRNA. Translation: BAC86766.1 . Different initiation.
CCDSi CCDS44494.1. [Q5VZ66-1 ]
RefSeqi NP_001098991.1. NM_001105521.2. [Q5VZ66-1 ]
XP_006717843.1. XM_006717780.1. [Q5VZ66-1 ]
UniGenei Hs.106254.

3D structure databases

ProteinModelPortali Q5VZ66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000298622.

PTM databases

PhosphoSitei Q5VZ66.

Polymorphism databases

DMDMi 172045962.

Proteomic databases

MaxQBi Q5VZ66.
PaxDbi Q5VZ66.
PRIDEi Q5VZ66.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298622 ; ENSP00000298622 ; ENSG00000188385 . [Q5VZ66-1 ]
GeneIDi 282973.
KEGGi hsa:282973.
UCSCi uc001lkx.4. human. [Q5VZ66-1 ]
uc009yba.1. human. [Q5VZ66-2 ]

Organism-specific databases

CTDi 282973.
GeneCardsi GC10P133918.
HGNCi HGNC:23523. JAKMIP3.
HPAi HPA022872.
MIMi 611198. gene.
neXtProti NX_Q5VZ66.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG127074.
GeneTreei ENSGT00390000002812.
HOGENOMi HOG000060161.
HOVERGENi HBG054249.
InParanoidi Q5VZ66.
OMAi EGQKRQI.
OrthoDBi EOG7HHWRJ.
PhylomeDBi Q5VZ66.
TreeFami TF331900.

Miscellaneous databases

ChiTaRSi JAKMIP3. human.
GenomeRNAii 282973.
PROi Q5VZ66.
SOURCEi Search...

Gene expression databases

Bgeei Q5VZ66.
CleanExi HS_JAKMIP3.
Genevestigatori Q5VZ66.

Family and domain databases

InterProi IPR024836. JAKMIP.
[Graphical view ]
PANTHERi PTHR18935. PTHR18935. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-844 (ISOFORM 1).
    Tissue: Brain.
  4. "Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins."
    Cruz-Garcia D., Vazquez-Martinez R., Peinado J.R., Anouar Y., Tonon M.C., Vaudry H., Castano J.P., Malagon M.M.
    FEBS Lett. 581:3149-3156(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-795.

Entry informationi

Entry nameiJKIP3_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ66
Secondary accession number(s): A6PW00, Q69YM6, Q6ZT29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3