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Q5VZ66 (JKIP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Janus kinase and microtubule-interacting protein 3
Alternative name(s):
Neuroendocrine long coiled-coil protein 2
Gene names
Name:JAKMIP3
Synonyms:C10orf14, C10orf39, JAMIP3, NECC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length844 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Golgi apparatus By similarity.

Tissue specificity

Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate. Ref.4

Sequence similarities

Belongs to the JAKMIP family.

Sequence caution

The sequence BAC86766.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH10388.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAH10388.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
   Cellular componentGolgi apparatus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VZ66-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q5VZ66-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     829-844: FLFLFLFFSLAFILWS → LSFSGHSPSW...KIFRNNRGLA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 844844Janus kinase and microtubule-interacting protein 3
PRO_0000323011

Regions

Coiled coil8 – 258251 Potential
Coiled coil289 – 421133 Potential
Coiled coil493 – 621129 Potential
Coiled coil683 – 834152 Potential

Natural variations

Alternative sequence1 – 563563Missing in isoform 2.
VSP_031998
Alternative sequence829 – 84416FLFLF…FILWS → LSFSGHSPSWHPDVPHIESD PFPPVGPESRDKMGRRVSIL KTQGDLVSARPSRGGRVRRG SVWGVELPSTWDVPELELAL PTSRGLLRDRPGLGCWTLGP FSRTAAPIPFPGMCSIPCQA GVRTASVQKHQPRVPSSLLV LTVAATGVWRKIFRNNRGLA in isoform 2.
VSP_031999
Natural variant4931M → V.
Corresponds to variant rs11592585 [ dbSNP | Ensembl ].
VAR_054016
Natural variant7951R → G in a breast cancer sample; somatic mutation. Ref.5
VAR_039473

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: CBB47F31B3E5BD27

FASTA84498,529
        10         20         30         40         50         60 
MSKRGMSSRA KGDKAEALAA LQAANEDLRA KLTDIQIELQ QEKSKVSKVE REKNQELRQV 

        70         80         90        100        110        120 
REHEQHKTAV LLTELKTKLH EEKMKELQAV RETLLRQHEA ELLRVIKIKD NENQRLQALL 

       130        140        150        160        170        180 
SALRDGGPEK VKTVLLSEAK EEAKKGFEVE KVKMQQEISE LKGAKRQVEE ALTLVIQADK 

       190        200        210        220        230        240 
IKAAEIRSVY HLHQEEITRI KKECEREIRR LMEEIKFKDR AVFVLERELG VQAGHAQRLQ 

       250        260        270        280        290        300 
LQKEALDEQL SQVREADRHP GSPRRELPHA AGAGDASDHS GSPEQQLDEK DARRFQLKIA 

       310        320        330        340        350        360 
ELSAIIRKLE DRNALLSEER NELLKRVREA ESQYKPLLDK NKRLSRKNED LSHALRRMEN 

       370        380        390        400        410        420 
KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREVDFL KLQIVEQQNL IDELSKTLET 

       430        440        450        460        470        480 
AGYVKSVLER DKLLRFRKQR KKMAKLPKPV VVETFFGYDE EASLESDGSS VSYQTDRTDQ 

       490        500        510        520        530        540 
TPCTPDDDLE EGMAKEETEL RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ 

       550        560        570        580        590        600 
AEVQRAQARI EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLRHEVQD 

       610        620        630        640        650        660 
ARDQNELLEF RILELEERER KSPAISFHHT PFVDGKSPLQ VYCEAEGVTD IVVAELMKKL 

       670        680        690        700        710        720 
DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQQIEETEAA LQRKMVDLES EKELFSKQKG 

       730        740        750        760        770        780 
YLDEELDYRK QALDQANKHI LELEAMLYDA LQQEAGAKVA ELLSEEEREK LKVAVEQWKR 

       790        800        810        820        830        840 
QVMSELRERD AQILRERMEL LQLAQQRIKE LEERIEAQKR QIKELEEKFL FLFLFFSLAF 


ILWS 

« Hide

Isoform 2 [UniParc].

Checksum: 33E46BCEA9B72992
Show »

FASTA42548,807

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-844 (ISOFORM 1).
Tissue: Brain.
[4]"Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins."
Cruz-Garcia D., Vazquez-Martinez R., Peinado J.R., Anouar Y., Tonon M.C., Vaudry H., Castano J.P., Malagon M.M.
FEBS Lett. 581:3149-3156(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-795.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL832756 mRNA. Translation: CAH10388.1. Sequence problems.
AL512622 Genomic DNA. No translation available.
AL162274 Genomic DNA. No translation available.
AK126964 mRNA. Translation: BAC86766.1. Different initiation.
CCDSCCDS44494.1. [Q5VZ66-1]
RefSeqNP_001098991.1. NM_001105521.2. [Q5VZ66-1]
XP_006717843.1. XM_006717780.1. [Q5VZ66-1]
UniGeneHs.106254.

3D structure databases

ProteinModelPortalQ5VZ66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298622.

PTM databases

PhosphoSiteQ5VZ66.

Polymorphism databases

DMDM172045962.

Proteomic databases

MaxQBQ5VZ66.
PaxDbQ5VZ66.
PRIDEQ5VZ66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298622; ENSP00000298622; ENSG00000188385. [Q5VZ66-1]
GeneID282973.
KEGGhsa:282973.
UCSCuc001lkx.4. human. [Q5VZ66-1]
uc009yba.1. human. [Q5VZ66-2]

Organism-specific databases

CTD282973.
GeneCardsGC10P133918.
HGNCHGNC:23523. JAKMIP3.
HPAHPA022872.
MIM611198. gene.
neXtProtNX_Q5VZ66.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG127074.
HOGENOMHOG000060161.
HOVERGENHBG054249.
InParanoidQ5VZ66.
OMAEGQKRQI.
OrthoDBEOG7HHWRJ.
PhylomeDBQ5VZ66.
TreeFamTF331900.

Gene expression databases

BgeeQ5VZ66.
CleanExHS_JAKMIP3.
GenevestigatorQ5VZ66.

Family and domain databases

InterProIPR024836. JAKMIP.
[Graphical view]
PANTHERPTHR18935. PTHR18935. 1 hit.
ProtoNetSearch...

Other

ChiTaRSJAKMIP3. human.
GenomeRNAi282973.
PROQ5VZ66.
SOURCESearch...

Entry information

Entry nameJKIP3_HUMAN
AccessionPrimary (citable) accession number: Q5VZ66
Secondary accession number(s): A6PW00, Q69YM6, Q6ZT29
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM