Q5VZ66 (JKIP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Janus kinase and microtubule-interacting protein 3

Alternative name(s):
Neuroendocrine long coiled-coil protein 2

Gene names

Name:	JAKMIP3
Synonyms:	C10orf14, C10orf39, JAMIP3, NECC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	844 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Golgi apparatus By similarity.
Tissue specificity	Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate. Ref.4
Sequence similarities	Belongs to the JAKMIP family.
Sequence caution	The sequence BAC86766.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH10388.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAH10388.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Cellular component	Golgi apparatus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VZ66-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q5VZ66-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     829-844: FLFLFLFFSLAFILWS → LSFSGHSPSW...KIFRNNRGLA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 844	844	Janus kinase and microtubule-interacting protein 3		PRO_0000323011
Regions
	Coiled coil	8 – 258	251	Potential
	Coiled coil	289 – 421	133	Potential
	Coiled coil	493 – 621	129	Potential
	Coiled coil	683 – 834	152	Potential
Natural variations
	Alternative sequence	1 – 563	563	Missing in isoform 2.		VSP_031998
	Alternative sequence	829 – 844	16	FLFLF…FILWS → LSFSGHSPSWHPDVPHIESD PFPPVGPESRDKMGRRVSIL KTQGDLVSARPSRGGRVRRG SVWGVELPSTWDVPELELAL PTSRGLLRDRPGLGCWTLGP FSRTAAPIPFPGMCSIPCQA GVRTASVQKHQPRVPSSLLV LTVAATGVWRKIFRNNRGLA in isoform 2.		VSP_031999
	Natural variant	493	1	M → V. Corresponds to variant rs11592585 [ dbSNP | Ensembl ].		VAR_054016
	Natural variant	795	1	R → G in a breast cancer sample; somatic mutation. Ref.5		VAR_039473

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: CBB47F31B3E5BD27	FASTA	844	98,529
	10 20 30 40 50 60 MSKRGMSSRA KGDKAEALAA LQAANEDLRA KLTDIQIELQ QEKSKVSKVE REKNQELRQV 70 80 90 100 110 120 REHEQHKTAV LLTELKTKLH EEKMKELQAV RETLLRQHEA ELLRVIKIKD NENQRLQALL 130 140 150 160 170 180 SALRDGGPEK VKTVLLSEAK EEAKKGFEVE KVKMQQEISE LKGAKRQVEE ALTLVIQADK 190 200 210 220 230 240 IKAAEIRSVY HLHQEEITRI KKECEREIRR LMEEIKFKDR AVFVLERELG VQAGHAQRLQ 250 260 270 280 290 300 LQKEALDEQL SQVREADRHP GSPRRELPHA AGAGDASDHS GSPEQQLDEK DARRFQLKIA 310 320 330 340 350 360 ELSAIIRKLE DRNALLSEER NELLKRVREA ESQYKPLLDK NKRLSRKNED LSHALRRMEN 370 380 390 400 410 420 KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREVDFL KLQIVEQQNL IDELSKTLET 430 440 450 460 470 480 AGYVKSVLER DKLLRFRKQR KKMAKLPKPV VVETFFGYDE EASLESDGSS VSYQTDRTDQ 490 500 510 520 530 540 TPCTPDDDLE EGMAKEETEL RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ 550 560 570 580 590 600 AEVQRAQARI EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLRHEVQD 610 620 630 640 650 660 ARDQNELLEF RILELEERER KSPAISFHHT PFVDGKSPLQ VYCEAEGVTD IVVAELMKKL 670 680 690 700 710 720 DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQQIEETEAA LQRKMVDLES EKELFSKQKG 730 740 750 760 770 780 YLDEELDYRK QALDQANKHI LELEAMLYDA LQQEAGAKVA ELLSEEEREK LKVAVEQWKR 790 800 810 820 830 840 QVMSELRERD AQILRERMEL LQLAQQRIKE LEERIEAQKR QIKELEEKFL FLFLFFSLAF ILWS
	Isoform 2 [UniParc]. Checksum: 33E46BCEA9B72992	FASTA	425	48,807
	10 20 30 40 50 60 MKWIEEKQAL YRRNQELVEK IKQMETEEAR LRHEVQDARD QNELLEFRIL ELEERERKSP 70 80 90 100 110 120 AISFHHTPFV DGKSPLQVYC EAEGVTDIVV AELMKKLDIL GDNANLTNEE QVVVIQARTV 130 140 150 160 170 180 LTLAEKWLQQ IEETEAALQR KMVDLESEKE LFSKQKGYLD EELDYRKQAL DQANKHILEL 190 200 210 220 230 240 EAMLYDALQQ EAGAKVAELL SEEEREKLKV AVEQWKRQVM SELRERDAQI LRERMELLQL 250 260 270 280 290 300 AQQRIKELEE RIEAQKRQIK ELEEKLSFSG HSPSWHPDVP HIESDPFPPV GPESRDKMGR 310 320 330 340 350 360 RVSILKTQGD LVSARPSRGG RVRRGSVWGV ELPSTWDVPE LELALPTSRG LLRDRPGLGC 370 380 390 400 410 420 WTLGPFSRTA APIPFPGMCS IPCQAGVRTA SVQKHQPRVP SSLLVLTVAA TGVWRKIFRN NRGLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-844 (ISOFORM 1). Tissue: Brain.
[4]	"Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins." Cruz-Garcia D., Vazquez-Martinez R., Peinado J.R., Anouar Y., Tonon M.C., Vaudry H., Castano J.P., Malagon M.M. FEBS Lett. 581:3149-3156(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-795.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL832756 mRNA. Translation: CAH10388.1. Sequence problems. AL512622 Genomic DNA. No translation available. AL162274 Genomic DNA. No translation available. AK126964 mRNA. Translation: BAC86766.1. Different initiation.
IPI	IPI00375609. IPI00641749.
RefSeq	NP_001098991.1. NM_001105521.2.
UniGene	Hs.106254.
3D structure databases
ProteinModelPortal	Q5VZ66.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298622.
PTM databases
PhosphoSite	Q5VZ66.
Polymorphism databases
DMDM	172045962.
Proteomic databases
PaxDb	Q5VZ66.
PRIDE	Q5VZ66.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298622; ENSP00000298622; ENSG00000188385.
GeneID	282973.
KEGG	hsa:282973.
UCSC	uc001lkx.4. human. uc009yba.1. human.
Organism-specific databases
CTD	282973.
GeneCards	GC10P133918.
HGNC	HGNC:23523. JAKMIP3.
HPA	HPA022872.
MIM	611198. gene.
neXtProt	NX_Q5VZ66.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG127074.
HOGENOM	HOG000060161.
HOVERGEN	HBG054249.
InParanoid	Q5VZ66.
OMA	EGQKRQI.
OrthoDB	EOG4Z62N2.
Gene expression databases
Bgee	Q5VZ66.
CleanEx	HS_JAKMIP3.
Genevestigator	Q5VZ66.
Family and domain databases
InterPro	IPR024836. JAKMIP. [Graphical view]
PANTHER	PTHR18935. PTHR18935. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	JAKMIP3. human.
GenomeRNAi	282973.
SOURCE	Search...

Entry information

Entry name

JKIP3_HUMAN

Accession

Primary (citable) accession number: Q5VZ66
Secondary accession number(s): A6PW00, Q69YM6, Q6ZT29

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 21, 2007
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.