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Protein

MORN repeat-containing protein 5

Gene

MORN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 5
Gene namesi
Name:MORN5
Synonyms:C9orf113, C9orf18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17841. MORN5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25975.

Polymorphism and mutation databases

BioMutaiMORN5.
DMDMi74747757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161MORN repeat-containing protein 5PRO_0000292840Add
BLAST

Proteomic databases

PaxDbiQ5VZ52.
PRIDEiQ5VZ52.

PTM databases

PhosphoSiteiQ5VZ52.

Expressioni

Gene expression databases

BgeeiQ5VZ52.
CleanExiHS_MORN5.
ExpressionAtlasiQ5VZ52. baseline and differential.
GenevisibleiQ5VZ52. HS.

Organism-specific databases

HPAiHPA020930.

Interactioni

Protein-protein interaction databases

BioGridi129063. 3 interactions.
STRINGi9606.ENSP00000362869.

Structurei

3D structure databases

ProteinModelPortaliQ5VZ52.
SMRiQ5VZ52. Positions 4-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 3023MORN 1Add
BLAST
Repeati31 – 5323MORN 2Add
BLAST
Repeati54 – 7522MORN 3Add
BLAST

Sequence similaritiesi

Contains 3 MORN repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00390000018089.
HOGENOMiHOG000007133.
HOVERGENiHBG059322.
InParanoidiQ5VZ52.
OMAiFYTEICH.
OrthoDBiEOG75B86R.
PhylomeDBiQ5VZ52.
TreeFamiTF327409.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 3 hits.
[Graphical view]
SMARTiSM00698. MORN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VZ52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEYTGSKYIG EYVDGRMEGK AKYILPTETI YVGEMKDGMF HGEGTLYFPS
60 70 80 90 100
GSQYDAIWEN GLAIKGTYTF SDGLHYDEKN WHYCDGYDRR FYTEILNGLK
110 120 130 140 150
PAGMAQLTNM DPPRKIPKGY YDCGDGFYNP VTRVVKDYRN RFLRNADDDE
160
HEWITRTCRK G
Length:161
Mass (Da):18,731
Last modified:December 7, 2004 - v1
Checksum:iC0DA34ED1D015866
GO
Isoform 2 (identifier: Q5VZ52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-161: DDDEHEWITRTCRKG → GRFLPTLQHVFSSPTYEYVHLYVQMYAHT

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):20,356
Checksum:i1AE8178BAD0B6C65
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451T → A in BAC87653 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei147 – 16115DDDEH…TCRKG → GRFLPTLQHVFSSPTYEYVH LYVQMYAHT in isoform 2. 1 PublicationVSP_055496Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128877 mRNA. Translation: BAC87653.1.
AK302081 mRNA. Translation: BAH13621.1.
AL162423, AL162424 Genomic DNA. Translation: CAH73981.1.
AL162424, AL162423 Genomic DNA. Translation: CAI14705.1.
CH471090 Genomic DNA. Translation: EAW87512.1.
BC133690 mRNA. Translation: AAI33691.1.
CCDSiCCDS6836.1. [Q5VZ52-1]
RefSeqiNP_001273757.1. NM_001286828.1.
NP_940871.2. NM_198469.3. [Q5VZ52-1]
XP_005251934.1. XM_005251877.3. [Q5VZ52-2]
UniGeneiHs.71428.

Genome annotation databases

EnsembliENST00000373764; ENSP00000362869; ENSG00000185681. [Q5VZ52-1]
GeneIDi254956.
KEGGihsa:254956.
UCSCiuc004blw.4. human. [Q5VZ52-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128877 mRNA. Translation: BAC87653.1.
AK302081 mRNA. Translation: BAH13621.1.
AL162423, AL162424 Genomic DNA. Translation: CAH73981.1.
AL162424, AL162423 Genomic DNA. Translation: CAI14705.1.
CH471090 Genomic DNA. Translation: EAW87512.1.
BC133690 mRNA. Translation: AAI33691.1.
CCDSiCCDS6836.1. [Q5VZ52-1]
RefSeqiNP_001273757.1. NM_001286828.1.
NP_940871.2. NM_198469.3. [Q5VZ52-1]
XP_005251934.1. XM_005251877.3. [Q5VZ52-2]
UniGeneiHs.71428.

3D structure databases

ProteinModelPortaliQ5VZ52.
SMRiQ5VZ52. Positions 4-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129063. 3 interactions.
STRINGi9606.ENSP00000362869.

PTM databases

PhosphoSiteiQ5VZ52.

Polymorphism and mutation databases

BioMutaiMORN5.
DMDMi74747757.

Proteomic databases

PaxDbiQ5VZ52.
PRIDEiQ5VZ52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373764; ENSP00000362869; ENSG00000185681. [Q5VZ52-1]
GeneIDi254956.
KEGGihsa:254956.
UCSCiuc004blw.4. human. [Q5VZ52-1]

Organism-specific databases

CTDi254956.
GeneCardsiMORN5.
HGNCiHGNC:17841. MORN5.
HPAiHPA020930.
neXtProtiNX_Q5VZ52.
PharmGKBiPA25975.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00390000018089.
HOGENOMiHOG000007133.
HOVERGENiHBG059322.
InParanoidiQ5VZ52.
OMAiFYTEICH.
OrthoDBiEOG75B86R.
PhylomeDBiQ5VZ52.
TreeFamiTF327409.

Miscellaneous databases

GenomeRNAii254956.
NextBioi35480238.
PROiQ5VZ52.

Gene expression databases

BgeeiQ5VZ52.
CleanExiHS_MORN5.
ExpressionAtlasiQ5VZ52. baseline and differential.
GenevisibleiQ5VZ52. HS.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 3 hits.
[Graphical view]
SMARTiSM00698. MORN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma and Testis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiMORN5_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ52
Secondary accession number(s): B7Z7I5, Q6ZQN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 7, 2004
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.