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Protein

Uncharacterized protein KIAA1614

Gene

KIAA1614

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1614
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29327. KIAA1614.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671595.

Polymorphism and mutation databases

BioMutaiKIAA1614.
DMDMi296439321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11901190Uncharacterized protein KIAA1614PRO_0000313645Add
BLAST

Proteomic databases

EPDiQ5VZ46.
PaxDbiQ5VZ46.
PeptideAtlasiQ5VZ46.
PRIDEiQ5VZ46.

PTM databases

iPTMnetiQ5VZ46.
PhosphoSiteiQ5VZ46.

Expressioni

Gene expression databases

BgeeiENSG00000135835.
CleanExiHS_KIAA1614.
GenevisibleiQ5VZ46. HS.

Organism-specific databases

HPAiHPA028227.
HPA061684.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356560.

Structurei

3D structure databases

ProteinModelPortaliQ5VZ46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi943 – 1081139Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IEUQ. Eukaryota.
ENOG411288M. LUCA.
GeneTreeiENSGT00390000013003.
HOGENOMiHOG000168960.
HOVERGENiHBG108039.
InParanoidiQ5VZ46.
OMAiRETHIGD.
OrthoDBiEOG091G07GI.
PhylomeDBiQ5VZ46.
TreeFamiTF332517.

Family and domain databases

InterProiIPR032756. DUF4685.
[Graphical view]
PfamiPF15737. DUF4685. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VZ46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGTEAAAAK PAGGSPQGPK TGSGTASPVE GTSAVEWSGP EPQLDNGHPP
60 70 80 90 100
RPWPCPQENR TSSLMAPQPP RVWGVQLQGP SVLESKVRAL KEKMTVAKQG
110 120 130 140 150
VSPCSASQEW SSPKKPQCRR GKAGRAGTPS EGSFLPGAVV APRTQNLPDG
160 170 180 190 200
QLDGSINEEQ PARDGGPRLP RPPAPGREYC NRGSPWPPEA EWTLPDHDRG
210 220 230 240 250
PLLGPSSLQQ SPIHGVTPGR PGGPGHCNKI IHIPSPRTGR SYPFPDGVVT
260 270 280 290 300
EADLDSTSLT SEEVFVPRTA LLGERWRAGD LEALGAGSSV LSLSDRVERN
310 320 330 340 350
RLLLQEMLNV SGQSPRKVGT PAWTPSWDTA APERPVGDVD WASGTSLQDS
360 370 380 390 400
GQNRTVGPNP EPVLSPRHEE ATHLLQRARM KARTRPLRAS HDIVPTITQG
410 420 430 440 450
SRDGHRSPAR DPRTTPACRD SLQNGHTSDS SSGESSGGHR PRRGPSPSHV
460 470 480 490 500
RFEDESAREA EFRHLERLQQ RQRQVLSTVL QAADQGPLRS KPDLADYING
510 520 530 540 550
APRLRDAGQG TFHRLVGSLD RRGHPAPPAP GSERRCQACG SCIDDPRPAQ
560 570 580 590 600
GKAPPVPRTL QELQAACGME RVLGGLSSPL RLLPAEPRLH MEWIRETHIG
610 620 630 640 650
DTVCPAEVDS ALDSTDNSDN CRTDSEEAGT SQAGWACGRT QGSSPRLRLR
660 670 680 690 700
GSRPRGHRWS KKAEAELPWG LQAQQHLPRA DDVEVENEVK EGRGHTPEGT
710 720 730 740 750
LFLREDAKPP DLELKRVSLG PQWQPGPGLG SHQPHPLDSR TPCRTAYATT
760 770 780 790 800
APMTPESSGP GGQAQVTESH ESLEIVSPSS LQQSHAEPSA PHQAWQPTAS
810 820 830 840 850
LCPEGWAPTP PPSRKTTSPV SHRKAALAGL LRLGDQTEPV GIPRPPSRSA
860 870 880 890 900
VLRTCELPPS QTQPSRPQVR HPLLALSTNN CNNSAPRGLQ EPYGGAVHEG
910 920 930 940 950
RVERGPCSRE PEPPLENSRD GGPQGFLGSA DVATINSTGI TLSLSSEESE
960 970 980 990 1000
SSKESEGSLQ RTGSGSGGHV LSRASAGAGT GPGSPSAAPL DQNKKRSSSI
1010 1020 1030 1040 1050
ASTLGLKKLF SALGQSSRPK LGKSRSYSVE QLQPAPPGLT SQSRAPSLQS
1060 1070 1080 1090 1100
LHPVSPSHQR RKAASFQNLH SLLSSKGNRS SLYLVAGPGD HSAAGRPAKT
1110 1120 1130 1140 1150
SPRRALSVED VGAPSLARTV GRLVEVFPDG TSQLQLQRSP GGTFGFCVAS
1160 1170 1180 1190
GNGRPDSGMP SPLPQPHGWG GLSKQGRAFW LWSEAFLVFG
Length:1,190
Mass (Da):126,604
Last modified:May 18, 2010 - v3
Checksum:i7C76CC6A2C181E77
GO
Isoform 2 (identifier: Q5VZ46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-379: Missing.

Show »
Length:811
Mass (Da):86,395
Checksum:i917DBA8F691DD549
GO

Sequence cautioni

The sequence BAB13440 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti574 – 5741G → D in AK090668 (PubMed:14702039).Curated
Sequence conflicti1157 – 11571S → L in AK090668 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641L → P.1 Publication
Corresponds to variant rs10732273 [ dbSNP | Ensembl ].
VAR_063118
Natural varianti214 – 2141H → Y.
Corresponds to variant rs3747959 [ dbSNP | Ensembl ].
VAR_037682
Natural varianti740 – 7401R → W.
Corresponds to variant rs17302207 [ dbSNP | Ensembl ].
VAR_037683
Natural varianti801 – 8011L → F.2 Publications
Corresponds to variant rs3795504 [ dbSNP | Ensembl ].
VAR_037684
Natural varianti1078 – 10781N → D.2 Publications
Corresponds to variant rs2331995 [ dbSNP | Ensembl ].
VAR_037685

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 379379Missing in isoform 2. 1 PublicationVSP_030081Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046834 mRNA. Translation: BAB13440.1. Different initiation.
AK090668 mRNA. No translation available.
AL162431 Genomic DNA. Translation: CAH74091.1.
AL162431 Genomic DNA. Translation: CAH74092.1.
CCDSiCCDS41442.1. [Q5VZ46-1]
RefSeqiNP_066001.1. NM_020950.1. [Q5VZ46-1]
UniGeneiHs.734816.

Genome annotation databases

EnsembliENST00000367587; ENSP00000356559; ENSG00000135835. [Q5VZ46-2]
ENST00000367588; ENSP00000356560; ENSG00000135835. [Q5VZ46-1]
GeneIDi57710.
KEGGihsa:57710.
UCSCiuc001gok.3. human. [Q5VZ46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046834 mRNA. Translation: BAB13440.1. Different initiation.
AK090668 mRNA. No translation available.
AL162431 Genomic DNA. Translation: CAH74091.1.
AL162431 Genomic DNA. Translation: CAH74092.1.
CCDSiCCDS41442.1. [Q5VZ46-1]
RefSeqiNP_066001.1. NM_020950.1. [Q5VZ46-1]
UniGeneiHs.734816.

3D structure databases

ProteinModelPortaliQ5VZ46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356560.

PTM databases

iPTMnetiQ5VZ46.
PhosphoSiteiQ5VZ46.

Polymorphism and mutation databases

BioMutaiKIAA1614.
DMDMi296439321.

Proteomic databases

EPDiQ5VZ46.
PaxDbiQ5VZ46.
PeptideAtlasiQ5VZ46.
PRIDEiQ5VZ46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367587; ENSP00000356559; ENSG00000135835. [Q5VZ46-2]
ENST00000367588; ENSP00000356560; ENSG00000135835. [Q5VZ46-1]
GeneIDi57710.
KEGGihsa:57710.
UCSCiuc001gok.3. human. [Q5VZ46-1]

Organism-specific databases

CTDi57710.
GeneCardsiKIAA1614.
HGNCiHGNC:29327. KIAA1614.
HPAiHPA028227.
HPA061684.
neXtProtiNX_Q5VZ46.
PharmGKBiPA142671595.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEUQ. Eukaryota.
ENOG411288M. LUCA.
GeneTreeiENSGT00390000013003.
HOGENOMiHOG000168960.
HOVERGENiHBG108039.
InParanoidiQ5VZ46.
OMAiRETHIGD.
OrthoDBiEOG091G07GI.
PhylomeDBiQ5VZ46.
TreeFamiTF332517.

Miscellaneous databases

ChiTaRSiKIAA1614. human.
GenomeRNAii57710.
PROiQ5VZ46.

Gene expression databases

BgeeiENSG00000135835.
CleanExiHS_KIAA1614.
GenevisibleiQ5VZ46. HS.

Family and domain databases

InterProiIPR032756. DUF4685.
[Graphical view]
PfamiPF15737. DUF4685. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1614_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ46
Secondary accession number(s): Q5VZ45, Q9HCF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.