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Protein
Submitted name:

Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)

Gene

GAD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)Imported
Submitted name:
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_bImported
Gene namesi
Name:GAD2Imported
ORF Names:hCG_23434Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28508.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei396N6-(pyridoxal phosphate)lysineUniRule annotation1

Expressioni

Gene expression databases

BgeeiENSG00000136750.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259271.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
HOVERGENiHBG004980.
KOiK01580.
OMAiWRAKGTT.
OrthoDBiEOG091G07ZU.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VZ30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGSGFWS FGSEDGSGDS ENPGTARAWC QVAQKFTGGI GNKLCALLYG
60 70 80 90 100
DAEKPAESGG SQPPRAAARK AACACDQKPC SCSKVDVNYA FLHATDLLPA
110 120 130 140 150
CDGERPTLAF LQDVMNILLQ YVVKSFDRST KVIDFHYPNE LLQEYNWELA
160 170 180 190 200
DQPQNLEEIL MHCQTTLKYA IKTGHPRYFN QLSTGLDMVG LAADWLTSTA
210 220 230 240 250
NTNMFTYEIA PVFVLLEYVT LKKMREIIGW PGGSGDGIFS PGGAISNMYA
260 270 280 290 300
MMIARFKMFP EVKEKGMAAL PRLIAFTSEH SHFSLKKGAA ALGIGTDSVI
310 320 330 340 350
LIKCDERGKM IPSDLERRIL EAKQKGFVPF LVSATAGTTV YGAFDPLLAV
360 370 380 390 400
ADICKKYKIW MHVDAAWGGG LLMSRKHKWK LSGVERANSV TWNPHKMMGV
410 420 430 440 450
PLQCSALLVR EEGLMQNCNQ MHASYLFQQD KHYDLSYDTG DKALQCGRHV
460 470 480 490 500
DVFKLWLMWR AKGTTGFEAH VDKCLELAEY LYNIIKNREG YEMVFDGKPQ
510 520 530 540 550
HTNVCFWYIP PSLRTLEDNE ERMSRLSKVA PVIKARMMEY GTTMVSYQPL
560 570 580
GDKVNFFRMV ISNPAATHQD IDFLIEEIER LGQDL
Length:585
Mass (Da):65,411
Last modified:May 10, 2005 - v1
Checksum:i0322509F0E2C32EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126327 mRNA. Translation: AAI26328.1.
BC126329 mRNA. Translation: AAI26330.1.
CH471072 Genomic DNA. Translation: EAW86102.1.
CH471072 Genomic DNA. Translation: EAW86103.1.
RefSeqiNP_000809.1. NM_000818.2.
NP_001127838.1. NM_001134366.1.
UniGeneiHs.231829.

Genome annotation databases

GeneIDi2572.
KEGGihsa:2572.
UCSCiuc001isp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126327 mRNA. Translation: AAI26328.1.
BC126329 mRNA. Translation: AAI26330.1.
CH471072 Genomic DNA. Translation: EAW86102.1.
CH471072 Genomic DNA. Translation: EAW86103.1.
RefSeqiNP_000809.1. NM_000818.2.
NP_001127838.1. NM_001134366.1.
UniGeneiHs.231829.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000259271.

Protocols and materials databases

DNASUi2572.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2572.
KEGGihsa:2572.
UCSCiuc001isp.3. human.

Organism-specific databases

CTDi2572.
PharmGKBiPA28508.

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
HOVERGENiHBG004980.
KOiK01580.
OMAiWRAKGTT.
OrthoDBiEOG091G07ZU.

Miscellaneous databases

GenomeRNAii2572.

Gene expression databases

BgeeiENSG00000136750.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5VZ30_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ30
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.