Q5VZ19 (TDR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tudor domain-containing protein 10

Gene names

Name:	TDRD10
ORF Names:	UNQ9380/PRO34205

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RRM (RNA recognition motif) domain. Contains 1 Tudor domain.

Sequence caution

The sequence AAH44864.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI00896.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI00897.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI00898.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI00899.1 differs from that shown. Reason: Erroneous initiation. The sequence AAQ88562.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD28538.1 differs from that shown. Reason: Frameshift at positions 93 and 242. The sequence CAH72850.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16182.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16188.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ08365.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ10669.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VZ19-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VZ19-2)

The sequence of this isoform differs from the canonical sequence as follows:
     342-366: VTAPASNLAVVPPLLPLGCLQQAAA → LHILKFEESK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Tudor domain-containing protein 10		PRO_0000270754
Regions
	Domain	34 – 107	74	RRM
	Domain	210 – 317	108	Tudor
	Coiled coil	216 – 237	22	Potential
Natural variations
	Alternative sequence	342 – 366	25	VTAPA…QQAAA → LHILKFEESK in isoform 2.		VSP_022216
	Natural variant	181	1	R → Q. Corresponds to variant rs12750774 [ dbSNP | Ensembl ].		VAR_029817
	Natural variant	215	1	V → I. Ref.1 Ref.3 Ref.4 Corresponds to variant rs3811448 [ dbSNP | Ensembl ].		VAR_029818
Experimental info
	Sequence conflict	93	1	K → N in CAD28538. Ref.4
	Sequence conflict	297	1	S → Q in CAD28538. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 16, 2009. Version 3. Checksum: 0CA48444B9FF6F49	FASTA	366	40,941
	10 20 30 40 50 60 MSWNISHPQL SDKLFGKNGV LEEQKSPGFK KRETEVYVGN LPLDISKEEI LYLLKDFNPL 70 80 90 100 110 120 DVHKIQNGCK CFAFVDLGSM QKVTLAIQEL NGKLFHKRKL FVNTSKRPPK RTPDMIQQPR 130 140 150 160 170 180 APLVLEKASG EGFGKTAAII QLAPKAPVDL CETEKLRAAF FAVPLEMRGS FLVLLLRECF 190 200 210 220 230 240 RDLSWLALIH SVRGEAGLLV TSIVPKTPFF WAMHVTEALH QNMQALFSTL AQAEEQQPYL 250 260 270 280 290 300 EGSTVMRGTR CLAEYHLGDY GHAWNRCWVL DRVDTWAVVM FIDFGQLATI PVQSLRSLDS 310 320 330 340 350 360 DDFWTIPPLT QPFMLEKDIL SSYEVVHRIL KGKITGALNS AVTAPASNLA VVPPLLPLGC LQQAAA
	Isoform 2 [UniParc]. Checksum: EB931A94349AFB8B	FASTA	351	39,769
	10 20 30 40 50 60 MSWNISHPQL SDKLFGKNGV LEEQKSPGFK KRETEVYVGN LPLDISKEEI LYLLKDFNPL 70 80 90 100 110 120 DVHKIQNGCK CFAFVDLGSM QKVTLAIQEL NGKLFHKRKL FVNTSKRPPK RTPDMIQQPR 130 140 150 160 170 180 APLVLEKASG EGFGKTAAII QLAPKAPVDL CETEKLRAAF FAVPLEMRGS FLVLLLRECF 190 200 210 220 230 240 RDLSWLALIH SVRGEAGLLV TSIVPKTPFF WAMHVTEALH QNMQALFSTL AQAEEQQPYL 250 260 270 280 290 300 EGSTVMRGTR CLAEYHLGDY GHAWNRCWVL DRVDTWAVVM FIDFGQLATI PVQSLRSLDS 310 320 330 340 350 DDFWTIPPLT QPFMLEKDIL SSYEVVHRIL KGKITGALNS ALHILKFEES K

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-215. Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-357 (ISOFORM 1), VARIANT ILE-215. Tissue: Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 86-366 (ISOFORM 1), VARIANT ILE-215. Tissue: Testis.
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-366 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK302144 mRNA. Translation: BAG63516.1. AL162591, AL592078 Genomic DNA. Translation: CAH72850.1. Sequence problems. AL162591, AL592078 Genomic DNA. Translation: CAQ10669.1. Sequence problems. AL592078, AL162591 Genomic DNA. Translation: CAI16182.1. Sequence problems. AL592078 Genomic DNA. Translation: CAI16188.1. Sequence problems. AL592078, AL162591 Genomic DNA. Translation: CAQ08365.1. Sequence problems. BC044864 mRNA. Translation: AAH44864.1. Different initiation. BC100895 mRNA. Translation: AAI00896.1. Different initiation. BC100896 mRNA. Translation: AAI00897.1. Different initiation. BC100897 mRNA. Translation: AAI00898.1. Different initiation. BC100898 mRNA. Translation: AAI00899.1. Different initiation. AL713777 mRNA. Translation: CAD28538.1. Frameshift. AY358195 mRNA. Translation: AAQ88562.1. Different initiation.
IPI	IPI00432733. IPI00514618.
RefSeq	NP_001091945.1. NM_001098475.1. NP_872305.3. NM_182499.3.
UniGene	Hs.387671.
3D structure databases
ProteinModelPortal	Q5VZ19.
ModBase	Search...
Polymorphism databases
DMDM	239938838.
Proteomic databases
PaxDb	Q5VZ19.
PRIDE	Q5VZ19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368480; ENSP00000357465; ENSG00000163239. ENST00000368482; ENSP00000357467; ENSG00000163239.
GeneID	126668.
KEGG	hsa:126668.
UCSC	uc001ffd.3. human. uc001ffe.3. human.
Organism-specific databases
CTD	126668.
GeneCards	GC01P154474.
H-InvDB	HIX0001105.
HGNC	HGNC:25316. TDRD10.
HPA	HPA028390.
neXtProt	NX_Q5VZ19.
PharmGKB	PA142670823.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG76688.
InParanoid	Q5VZ19.
OMA	KCFAFVD.
Gene expression databases
Bgee	Q5VZ19.
CleanEx	HS_TDRD10.
Genevestigator	Q5VZ19.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. IPR002999. Tudor. [Graphical view]
Pfam	PF00567. TUDOR. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. PS50304. TUDOR. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	126668.
NextBio	81882.

Entry information

Entry name

TDR10_HUMAN

Accession

Primary (citable) accession number: Q5VZ19
Secondary accession number(s): A4FU09 , B0QZ53, B4DXV4, Q3ZCP1, Q3ZCS7, Q5SXY7, Q6UXV2, Q8TCN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.