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Protein

Tudor domain-containing protein 10

Gene

TDRD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 10
Gene namesi
Name:TDRD10
ORF Names:UNQ9380/PRO34205
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25316. TDRD10.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670823.

Polymorphism and mutation databases

BioMutaiTDRD10.
DMDMi239938838.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Tudor domain-containing protein 10PRO_0000270754Add
BLAST

Proteomic databases

EPDiQ5VZ19.
PaxDbiQ5VZ19.
PRIDEiQ5VZ19.

PTM databases

iPTMnetiQ5VZ19.

Expressioni

Gene expression databases

BgeeiQ5VZ19.
CleanExiHS_TDRD10.
GenevisibleiQ5VZ19. HS.

Organism-specific databases

HPAiHPA028390.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357465.

Structurei

3D structure databases

ProteinModelPortaliQ5VZ19.
SMRiQ5VZ19. Positions 33-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10774RRMPROSITE-ProRule annotationAdd
BLAST
Domaini210 – 317108TudorAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili216 – 23722Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 Tudor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKPU. Eukaryota.
ENOG4111FQ7. LUCA.
GeneTreeiENSGT00390000006620.
InParanoidiQ5VZ19.
OMAiCFAFVDL.
OrthoDBiEOG7PCJH2.
PhylomeDBiQ5VZ19.
TreeFamiTF343710.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VZ19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWNISHPQL SDKLFGKNGV LEEQKSPGFK KRETEVYVGN LPLDISKEEI
60 70 80 90 100
LYLLKDFNPL DVHKIQNGCK CFAFVDLGSM QKVTLAIQEL NGKLFHKRKL
110 120 130 140 150
FVNTSKRPPK RTPDMIQQPR APLVLEKASG EGFGKTAAII QLAPKAPVDL
160 170 180 190 200
CETEKLRAAF FAVPLEMRGS FLVLLLRECF RDLSWLALIH SVRGEAGLLV
210 220 230 240 250
TSIVPKTPFF WAMHVTEALH QNMQALFSTL AQAEEQQPYL EGSTVMRGTR
260 270 280 290 300
CLAEYHLGDY GHAWNRCWVL DRVDTWAVVM FIDFGQLATI PVQSLRSLDS
310 320 330 340 350
DDFWTIPPLT QPFMLEKDIL SSYEVVHRIL KGKITGALNS AVTAPASNLA
360
VVPPLLPLGC LQQAAA
Length:366
Mass (Da):40,941
Last modified:June 16, 2009 - v3
Checksum:i0CA48444B9FF6F49
GO
Isoform 2 (identifier: Q5VZ19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-366: VTAPASNLAVVPPLLPLGCLQQAAA → LHILKFEESK

Show »
Length:351
Mass (Da):39,769
Checksum:iEB931A94349AFB8B
GO

Sequence cautioni

The sequence AAH44864.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI00896.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI00897.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI00898.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI00899.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAQ88562.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD28538.1 differs from that shown. Reason: Frameshift at positions 93 and 242. Curated
The sequence CAH72850.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI16182.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI16188.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAQ08365.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAQ10669.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931K → N in CAD28538 (PubMed:17974005).Curated
Sequence conflicti297 – 2971S → Q in CAD28538 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811R → Q.
Corresponds to variant rs12750774 [ dbSNP | Ensembl ].
VAR_029817
Natural varianti215 – 2151V → I.3 Publications
Corresponds to variant rs3811448 [ dbSNP | Ensembl ].
VAR_029818

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei342 – 36625VTAPA…QQAAA → LHILKFEESK in isoform 2. 1 PublicationVSP_022216Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302144 mRNA. Translation: BAG63516.1.
AL162591, AL592078 Genomic DNA. Translation: CAH72850.1. Sequence problems.
AL162591, AL592078 Genomic DNA. Translation: CAQ10669.1. Sequence problems.
AL592078, AL162591 Genomic DNA. Translation: CAI16182.1. Sequence problems.
AL592078 Genomic DNA. Translation: CAI16188.1. Sequence problems.
AL592078, AL162591 Genomic DNA. Translation: CAQ08365.1. Sequence problems.
BC044864 mRNA. Translation: AAH44864.1. Different initiation.
BC100895 mRNA. Translation: AAI00896.1. Different initiation.
BC100896 mRNA. Translation: AAI00897.1. Different initiation.
BC100897 mRNA. Translation: AAI00898.1. Different initiation.
BC100898 mRNA. Translation: AAI00899.1. Different initiation.
AL713777 mRNA. Translation: CAD28538.1. Frameshift.
AY358195 mRNA. Translation: AAQ88562.1. Different initiation.
CCDSiCCDS30878.2. [Q5VZ19-2]
CCDS41406.1. [Q5VZ19-1]
RefSeqiNP_001091945.1. NM_001098475.1. [Q5VZ19-1]
NP_872305.3. NM_182499.3. [Q5VZ19-2]
XP_006711219.1. XM_006711156.2.
XP_011507462.1. XM_011509160.1.
XP_011507463.1. XM_011509161.1.
UniGeneiHs.387671.

Genome annotation databases

EnsembliENST00000368480; ENSP00000357465; ENSG00000163239. [Q5VZ19-1]
ENST00000368482; ENSP00000357467; ENSG00000163239. [Q5VZ19-2]
GeneIDi126668.
KEGGihsa:126668.
UCSCiuc001ffd.3. human. [Q5VZ19-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302144 mRNA. Translation: BAG63516.1.
AL162591, AL592078 Genomic DNA. Translation: CAH72850.1. Sequence problems.
AL162591, AL592078 Genomic DNA. Translation: CAQ10669.1. Sequence problems.
AL592078, AL162591 Genomic DNA. Translation: CAI16182.1. Sequence problems.
AL592078 Genomic DNA. Translation: CAI16188.1. Sequence problems.
AL592078, AL162591 Genomic DNA. Translation: CAQ08365.1. Sequence problems.
BC044864 mRNA. Translation: AAH44864.1. Different initiation.
BC100895 mRNA. Translation: AAI00896.1. Different initiation.
BC100896 mRNA. Translation: AAI00897.1. Different initiation.
BC100897 mRNA. Translation: AAI00898.1. Different initiation.
BC100898 mRNA. Translation: AAI00899.1. Different initiation.
AL713777 mRNA. Translation: CAD28538.1. Frameshift.
AY358195 mRNA. Translation: AAQ88562.1. Different initiation.
CCDSiCCDS30878.2. [Q5VZ19-2]
CCDS41406.1. [Q5VZ19-1]
RefSeqiNP_001091945.1. NM_001098475.1. [Q5VZ19-1]
NP_872305.3. NM_182499.3. [Q5VZ19-2]
XP_006711219.1. XM_006711156.2.
XP_011507462.1. XM_011509160.1.
XP_011507463.1. XM_011509161.1.
UniGeneiHs.387671.

3D structure databases

ProteinModelPortaliQ5VZ19.
SMRiQ5VZ19. Positions 33-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357465.

PTM databases

iPTMnetiQ5VZ19.

Polymorphism and mutation databases

BioMutaiTDRD10.
DMDMi239938838.

Proteomic databases

EPDiQ5VZ19.
PaxDbiQ5VZ19.
PRIDEiQ5VZ19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368480; ENSP00000357465; ENSG00000163239. [Q5VZ19-1]
ENST00000368482; ENSP00000357467; ENSG00000163239. [Q5VZ19-2]
GeneIDi126668.
KEGGihsa:126668.
UCSCiuc001ffd.3. human. [Q5VZ19-1]

Organism-specific databases

CTDi126668.
GeneCardsiTDRD10.
H-InvDBHIX0001105.
HGNCiHGNC:25316. TDRD10.
HPAiHPA028390.
neXtProtiNX_Q5VZ19.
PharmGKBiPA142670823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKPU. Eukaryota.
ENOG4111FQ7. LUCA.
GeneTreeiENSGT00390000006620.
InParanoidiQ5VZ19.
OMAiCFAFVDL.
OrthoDBiEOG7PCJH2.
PhylomeDBiQ5VZ19.
TreeFamiTF343710.

Miscellaneous databases

GenomeRNAii126668.
PROiQ5VZ19.

Gene expression databases

BgeeiQ5VZ19.
CleanExiHS_TDRD10.
GenevisibleiQ5VZ19. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-215.
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-357 (ISOFORM 1), VARIANT ILE-215.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 86-366 (ISOFORM 1), VARIANT ILE-215.
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-366 (ISOFORM 1).

Entry informationi

Entry nameiTDR10_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ19
Secondary accession number(s): A4FU09
, B0QZ53, B4DXV4, Q3ZCP1, Q3ZCS7, Q5SXY7, Q6UXV2, Q8TCN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 16, 2009
Last modified: June 8, 2016
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.