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Protein

SH2 domain-containing adapter protein E

Gene

SHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ5VZ18.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing adapter protein E
Gene namesi
Name:SHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27004. SHE.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670919.

Polymorphism and mutation databases

BioMutaiSHE.
DMDMi74747744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495SH2 domain-containing adapter protein EPRO_0000246775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5VZ18.
PeptideAtlasiQ5VZ18.
PRIDEiQ5VZ18.

PTM databases

iPTMnetiQ5VZ18.
PhosphoSiteiQ5VZ18.

Expressioni

Gene expression databases

BgeeiENSG00000169291.
CleanExiHS_SHE.
ExpressionAtlasiQ5VZ18. baseline and differential.
GenevisibleiQ5VZ18. HS.

Organism-specific databases

HPAiHPA037417.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102753EBI-3956977,EBI-608057

Protein-protein interaction databases

BioGridi126009. 3 interactions.
IntActiQ5VZ18. 4 interactions.
STRINGi9606.ENSP00000307369.

Structurei

3D structure databases

ProteinModelPortaliQ5VZ18.
SMRiQ5VZ18. Positions 333-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini395 – 49096SH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi159 – 18123Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGWI. Eukaryota.
ENOG410XQJ2. LUCA.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiQ5VZ18.
OMAiWFKEFPL.
OrthoDBiEOG091G0I06.
PhylomeDBiQ5VZ18.
TreeFamiTF325799.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VZ18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWSPTPGAS ACLGWASSLA CSTAPTLLGR AGRGPLMAAK WFKEFPLNLK
60 70 80 90 100
TVSERAKPGG GGGKLRKNSE AGGAGPGPGK GRKNSAAELG SGRAGVGPKD
110 120 130 140 150
SRLSRDSLQG LIQAAAGKGR KNSRATEEEP HRGATKSSGC STYINRLIKV
160 170 180 190 200
DTQEKNGKSN YPSSSSSSSS SSSSASSSPS SLGPELDKGK IIKQQETVII
210 220 230 240 250
LEDYADPYDA KRTKGQRDAE RVGENDGYME PYDAQQMITE IRRRGSKDPL
260 270 280 290 300
VKALQLLDSP CEPADGGLKS ETLAKRRSSK DLLGKPPQLY DTPYEPAEGG
310 320 330 340 350
PRAEGKARPP DSRLPENDER PAAEYEQPWE WKKEQIVRAL SVQFEGAERP
360 370 380 390 400
SFREETVRQH HRQKSWTQKI LKPALSDHSE GEKVDPGLPL EKQPWYHGAI
410 420 430 440 450
SRAEAESRLQ PCKEAGYLVR NSESGNSRYS IALKTSQGCV HIIVAQTKDN
460 470 480 490
KYTLNQTSAV FDSIPEVVHY YSNEKLPFKG AEHMTLLYPV HSKLH
Length:495
Mass (Da):53,950
Last modified:December 7, 2004 - v1
Checksum:i7E1E3D9645B00536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162591 Genomic DNA. Translation: CAH72851.1.
BC117210 mRNA. Translation: AAI17211.1.
AK074067 mRNA. Translation: BAB84893.1.
CCDSiCCDS30877.1.
RefSeqiNP_001010846.1. NM_001010846.2.
XP_011507465.1. XM_011509163.2.
UniGeneiHs.591481.

Genome annotation databases

EnsembliENST00000304760; ENSP00000307369; ENSG00000169291.
GeneIDi126669.
KEGGihsa:126669.
UCSCiuc001ffb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162591 Genomic DNA. Translation: CAH72851.1.
BC117210 mRNA. Translation: AAI17211.1.
AK074067 mRNA. Translation: BAB84893.1.
CCDSiCCDS30877.1.
RefSeqiNP_001010846.1. NM_001010846.2.
XP_011507465.1. XM_011509163.2.
UniGeneiHs.591481.

3D structure databases

ProteinModelPortaliQ5VZ18.
SMRiQ5VZ18. Positions 333-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126009. 3 interactions.
IntActiQ5VZ18. 4 interactions.
STRINGi9606.ENSP00000307369.

PTM databases

iPTMnetiQ5VZ18.
PhosphoSiteiQ5VZ18.

Polymorphism and mutation databases

BioMutaiSHE.
DMDMi74747744.

Proteomic databases

PaxDbiQ5VZ18.
PeptideAtlasiQ5VZ18.
PRIDEiQ5VZ18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304760; ENSP00000307369; ENSG00000169291.
GeneIDi126669.
KEGGihsa:126669.
UCSCiuc001ffb.4. human.

Organism-specific databases

CTDi126669.
GeneCardsiSHE.
HGNCiHGNC:27004. SHE.
HPAiHPA037417.
MIMi610482. gene.
neXtProtiNX_Q5VZ18.
PharmGKBiPA142670919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWI. Eukaryota.
ENOG410XQJ2. LUCA.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiQ5VZ18.
OMAiWFKEFPL.
OrthoDBiEOG091G0I06.
PhylomeDBiQ5VZ18.
TreeFamiTF325799.

Enzyme and pathway databases

SignaLinkiQ5VZ18.

Miscellaneous databases

GenomeRNAii126669.
PROiQ5VZ18.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169291.
CleanExiHS_SHE.
ExpressionAtlasiQ5VZ18. baseline and differential.
GenevisibleiQ5VZ18. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHE_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ18
Secondary accession number(s): Q8TEQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.