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Protein

Ankyrin repeat domain-containing protein 22

Gene

ANKRD22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 22
Gene namesi
Name:ANKRD22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28321. ANKRD22.

Pathology & Biotechi

Organism-specific databases

DisGeNETi118932.
OpenTargetsiENSG00000152766.
PharmGKBiPA134954600.

Polymorphism and mutation databases

BioMutaiANKRD22.
DMDMi74747727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408381 – 191Ankyrin repeat domain-containing protein 22Add BLAST191

Proteomic databases

EPDiQ5VYY1.
MaxQBiQ5VYY1.
PaxDbiQ5VYY1.
PeptideAtlasiQ5VYY1.
PRIDEiQ5VYY1.

Expressioni

Gene expression databases

BgeeiENSG00000152766.
CleanExiHS_ANKRD22.
GenevisibleiQ5VYY1. HS.

Organism-specific databases

HPAiHPA012922.

Interactioni

Protein-protein interaction databases

BioGridi125627. 2 interactors.
STRINGi9606.ENSP00000360998.

Structurei

3D structure databases

ProteinModelPortaliQ5VYY1.
SMRiQ5VYY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 68ANK 1Add BLAST30
Repeati72 – 100ANK 2Add BLAST29
Repeati101 – 130ANK 3Add BLAST30
Repeati134 – 163ANK 4Add BLAST30

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000009005.
HOGENOMiHOG000033955.
HOVERGENiHBG059313.
InParanoidiQ5VYY1.
OMAiRFTFFDY.
OrthoDBiEOG091G0N93.
PhylomeDBiQ5VYY1.
TreeFamiTF332383.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VYY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILYSEPIC QAAYQNDFGQ VWRWVKEDSS YANVQDGFNG DTPLICACRR
60 70 80 90 100
GHVRIVSFLL RRNANVNLKN QKERTCLHYA VKKKFTFIDY LLIILLMPVL
110 120 130 140 150
LIGYFLMVSK TKQNEALVRM LLDAGVEVNA TDCYGCTALH YACEMKNQSL
160 170 180 190
IPLLLEARAD PTIKNKHGES SLDIARRLKF SQIELMLRKA L
Length:191
Mass (Da):21,849
Last modified:December 7, 2004 - v1
Checksum:i6F997DAEDB97161D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02762873E → G.1 PublicationCorresponds to variant rs17113412dbSNPEnsembl.1
Natural variantiVAR_02762979Y → H.1 PublicationCorresponds to variant rs17851907dbSNPEnsembl.1
Natural variantiVAR_027630148Q → P.1 PublicationCorresponds to variant rs2304804dbSNPEnsembl.1
Natural variantiVAR_027631177R → I.1 PublicationCorresponds to variant rs7912706dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313969 mRNA. Translation: BAG36684.1.
AL353113, AL157394 Genomic DNA. Translation: CAH72239.1.
AL157394, AL353113 Genomic DNA. Translation: CAI13859.1.
CH471066 Genomic DNA. Translation: EAW50159.1.
BC021671 mRNA. Translation: AAH21671.1.
CCDSiCCDS7390.1.
RefSeqiNP_653191.2. NM_144590.2.
UniGeneiHs.217484.

Genome annotation databases

EnsembliENST00000371930; ENSP00000360998; ENSG00000152766.
GeneIDi118932.
KEGGihsa:118932.
UCSCiuc001kfj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313969 mRNA. Translation: BAG36684.1.
AL353113, AL157394 Genomic DNA. Translation: CAH72239.1.
AL157394, AL353113 Genomic DNA. Translation: CAI13859.1.
CH471066 Genomic DNA. Translation: EAW50159.1.
BC021671 mRNA. Translation: AAH21671.1.
CCDSiCCDS7390.1.
RefSeqiNP_653191.2. NM_144590.2.
UniGeneiHs.217484.

3D structure databases

ProteinModelPortaliQ5VYY1.
SMRiQ5VYY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125627. 2 interactors.
STRINGi9606.ENSP00000360998.

Polymorphism and mutation databases

BioMutaiANKRD22.
DMDMi74747727.

Proteomic databases

EPDiQ5VYY1.
MaxQBiQ5VYY1.
PaxDbiQ5VYY1.
PeptideAtlasiQ5VYY1.
PRIDEiQ5VYY1.

Protocols and materials databases

DNASUi118932.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371930; ENSP00000360998; ENSG00000152766.
GeneIDi118932.
KEGGihsa:118932.
UCSCiuc001kfj.5. human.

Organism-specific databases

CTDi118932.
DisGeNETi118932.
GeneCardsiANKRD22.
HGNCiHGNC:28321. ANKRD22.
HPAiHPA012922.
neXtProtiNX_Q5VYY1.
OpenTargetsiENSG00000152766.
PharmGKBiPA134954600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000009005.
HOGENOMiHOG000033955.
HOVERGENiHBG059313.
InParanoidiQ5VYY1.
OMAiRFTFFDY.
OrthoDBiEOG091G0N93.
PhylomeDBiQ5VYY1.
TreeFamiTF332383.

Miscellaneous databases

GenomeRNAii118932.
PROiQ5VYY1.

Gene expression databases

BgeeiENSG00000152766.
CleanExiHS_ANKRD22.
GenevisibleiQ5VYY1. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR22_HUMAN
AccessioniPrimary (citable) accession number: Q5VYY1
Secondary accession number(s): B2R9Y7, Q8WU06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.