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Protein

Renalase

Gene

RNLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.3 Publications

Catalytic activityi

1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.2 Publications
1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.2 Publications

Cofactori

FAD1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12FAD1
Binding sitei42FAD1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:G66-32717-MONOMER.
ZFISH:G66-32717-MONOMER.
BRENDAi1.6.3.5. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Renalase1 Publication (EC:1.6.3.52 Publications)
Alternative name(s):
Monoamine oxidase-C
Short name:
MAO-C
Gene namesi
Name:RNLS
Synonyms:C10orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25641. RNLS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55328.
OpenTargetsiENSG00000184719.
PharmGKBiPA165549084.

Polymorphism and mutation databases

BioMutaiRNLS.
DMDMi73914006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001958818 – 342RenalaseAdd BLAST325

Proteomic databases

PaxDbiQ5VYX0.
PeptideAtlasiQ5VYX0.
PRIDEiQ5VYX0.

PTM databases

iPTMnetiQ5VYX0.
PhosphoSitePlusiQ5VYX0.

Expressioni

Tissue specificityi

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.1 Publication

Gene expression databases

BgeeiENSG00000184719.
CleanExiHS_C10orf59.
ExpressionAtlasiQ5VYX0. baseline and differential.
GenevisibleiQ5VYX0. HS.

Interactioni

Protein-protein interaction databases

BioGridi120609. 1 interactor.
IntActiQ5VYX0. 1 interactor.
STRINGi9606.ENSP00000332530.

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi11 – 21Combined sources11
Beta strandi28 – 33Combined sources6
Beta strandi35 – 39Combined sources5
Helixi41 – 43Combined sources3
Beta strandi45 – 47Combined sources3
Beta strandi55 – 59Combined sources5
Beta strandi63 – 65Combined sources3
Helixi69 – 72Combined sources4
Helixi74 – 82Combined sources9
Beta strandi103 – 106Combined sources4
Helixi113 – 122Combined sources10
Beta strandi125 – 129Combined sources5
Beta strandi132 – 137Combined sources6
Beta strandi139 – 149Combined sources11
Beta strandi152 – 159Combined sources8
Helixi163 – 166Combined sources4
Helixi173 – 176Combined sources4
Helixi179 – 186Combined sources8
Beta strandi193 – 199Combined sources7
Beta strandi211 – 214Combined sources4
Beta strandi219 – 226Combined sources8
Helixi227 – 230Combined sources4
Beta strandi241 – 246Combined sources6
Helixi248 – 253Combined sources6
Turni254 – 256Combined sources3
Helixi259 – 273Combined sources15
Beta strandi281 – 288Combined sources8
Beta strandi292 – 295Combined sources4
Beta strandi298 – 300Combined sources3
Beta strandi304 – 307Combined sources4
Turni308 – 310Combined sources3
Beta strandi311 – 314Combined sources4
Helixi317 – 319Combined sources3
Helixi324 – 338Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QJ4X-ray2.50A/B1-342[»]
ProteinModelPortaliQ5VYX0.
SMRiQ5VYX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 62FAD-binding2

Sequence similaritiesi

Belongs to the renalase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE15. Eukaryota.
ENOG410XV8B. LUCA.
GeneTreeiENSGT00390000016052.
HOGENOMiHOG000007721.
InParanoidiQ5VYX0.
KOiK18208.
OMAiTGSLCAC.
OrthoDBiEOG091G0AJR.
PhylomeDBiQ5VYX0.
TreeFamiTF332799.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VYX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVLIVGAG MTGSLCAALL RRQTSGPLYL AVWDKAEDSG GRMTTACSPH
60 70 80 90 100
NPQCTADLGA QYITCTPHYA KKHQRFYDEL LAYGVLRPLS SPIEGMVMKE
110 120 130 140 150
GDCNFVAPQG ISSIIKHYLK ESGAEVYFRH RVTQINLRDD KWEVSKQTGS
160 170 180 190 200
PEQFDLIVLT MPVPEILQLQ GDITTLISEC QRQQLEAVSY SSRYALGLFY
210 220 230 240 250
EAGTKIDVPW AGQYITSNPC IRFVSIDNKK RNIESSEIGP SLVIHTTVPF
260 270 280 290 300
GVTYLEHSIE DVQELVFQQL ENILPGLPQP IATKCQKWRH SQVTNAAANC
310 320 330 340
PGQMTLHHKP FLACGGDGFT QSNFDGCITS ALCVLEALKN YI
Length:342
Mass (Da):37,847
Last modified:December 7, 2004 - v1
Checksum:i952827FF7926AF48
GO
Isoform 2 (identifier: Q5VYX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-315: TNAAANCPGQMTLHHKPFLACG → PSAGVILGCAKSPWMMAIGFPI
     316-342: Missing.

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):34,949
Checksum:i8C1EBF93073E4690
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02331037E → D.1 PublicationCorresponds to variant rs2296545dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015211294 – 315TNAAA…FLACG → PSAGVILGCAKSPWMMAIGF PI in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_015212316 – 342Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002080 mRNA. Translation: BAA92073.1.
AL353149, AL365185, AL139406 Genomic DNA. Translation: CAH70340.1.
AL353149, AL139406, AL365185 Genomic DNA. Translation: CAH70341.1.
AL365185, AL353149, AL139406 Genomic DNA. Translation: CAH73628.1.
AL365185, AL139406, AL353149 Genomic DNA. Translation: CAH73629.1.
AL139406, AL353149, AL365185 Genomic DNA. Translation: CAH73711.1.
AL139406, AL353149, AL365185 Genomic DNA. Translation: CAH73712.1.
BC005364 mRNA. Translation: AAH05364.1.
CCDSiCCDS31239.1. [Q5VYX0-1]
CCDS7388.1. [Q5VYX0-2]
RefSeqiNP_001026879.2. NM_001031709.2. [Q5VYX0-1]
NP_060833.1. NM_018363.3. [Q5VYX0-2]
XP_011538226.1. XM_011539924.2. [Q5VYX0-2]
XP_016871869.1. XM_017016380.1. [Q5VYX0-2]
UniGeneiHs.149849.

Genome annotation databases

EnsembliENST00000331772; ENSP00000332530; ENSG00000184719. [Q5VYX0-1]
ENST00000371947; ENSP00000361015; ENSG00000184719. [Q5VYX0-2]
GeneIDi55328.
KEGGihsa:55328.
UCSCiuc001kfd.3. human. [Q5VYX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002080 mRNA. Translation: BAA92073.1.
AL353149, AL365185, AL139406 Genomic DNA. Translation: CAH70340.1.
AL353149, AL139406, AL365185 Genomic DNA. Translation: CAH70341.1.
AL365185, AL353149, AL139406 Genomic DNA. Translation: CAH73628.1.
AL365185, AL139406, AL353149 Genomic DNA. Translation: CAH73629.1.
AL139406, AL353149, AL365185 Genomic DNA. Translation: CAH73711.1.
AL139406, AL353149, AL365185 Genomic DNA. Translation: CAH73712.1.
BC005364 mRNA. Translation: AAH05364.1.
CCDSiCCDS31239.1. [Q5VYX0-1]
CCDS7388.1. [Q5VYX0-2]
RefSeqiNP_001026879.2. NM_001031709.2. [Q5VYX0-1]
NP_060833.1. NM_018363.3. [Q5VYX0-2]
XP_011538226.1. XM_011539924.2. [Q5VYX0-2]
XP_016871869.1. XM_017016380.1. [Q5VYX0-2]
UniGeneiHs.149849.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QJ4X-ray2.50A/B1-342[»]
ProteinModelPortaliQ5VYX0.
SMRiQ5VYX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120609. 1 interactor.
IntActiQ5VYX0. 1 interactor.
STRINGi9606.ENSP00000332530.

PTM databases

iPTMnetiQ5VYX0.
PhosphoSitePlusiQ5VYX0.

Polymorphism and mutation databases

BioMutaiRNLS.
DMDMi73914006.

Proteomic databases

PaxDbiQ5VYX0.
PeptideAtlasiQ5VYX0.
PRIDEiQ5VYX0.

Protocols and materials databases

DNASUi55328.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331772; ENSP00000332530; ENSG00000184719. [Q5VYX0-1]
ENST00000371947; ENSP00000361015; ENSG00000184719. [Q5VYX0-2]
GeneIDi55328.
KEGGihsa:55328.
UCSCiuc001kfd.3. human. [Q5VYX0-1]

Organism-specific databases

CTDi55328.
DisGeNETi55328.
GeneCardsiRNLS.
HGNCiHGNC:25641. RNLS.
MIMi609360. gene.
neXtProtiNX_Q5VYX0.
OpenTargetsiENSG00000184719.
PharmGKBiPA165549084.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE15. Eukaryota.
ENOG410XV8B. LUCA.
GeneTreeiENSGT00390000016052.
HOGENOMiHOG000007721.
InParanoidiQ5VYX0.
KOiK18208.
OMAiTGSLCAC.
OrthoDBiEOG091G0AJR.
PhylomeDBiQ5VYX0.
TreeFamiTF332799.

Enzyme and pathway databases

BioCyciMetaCyc:G66-32717-MONOMER.
ZFISH:G66-32717-MONOMER.
BRENDAi1.6.3.5. 2681.

Miscellaneous databases

GeneWikiiRenalase.
GenomeRNAii55328.
PROiQ5VYX0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184719.
CleanExiHS_C10orf59.
ExpressionAtlasiQ5VYX0. baseline and differential.
GenevisibleiQ5VYX0. HS.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRNLS_HUMAN
AccessioniPrimary (citable) accession number: Q5VYX0
Secondary accession number(s): Q9BS33, Q9NUP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.