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Q5VYV7

- SLX4I_HUMAN

UniProt

Q5VYV7 - SLX4I_HUMAN

Protein

Protein SLX4IP

Gene

SLX4IP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SLX4IP
    Alternative name(s):
    SLX4-interacting protein
    Gene namesi
    Name:SLX4IP
    Synonyms:C20orf94
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16225. SLX4IP.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25801.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Protein SLX4IPPRO_0000306119Add
    BLAST

    Proteomic databases

    MaxQBiQ5VYV7.
    PaxDbiQ5VYV7.
    PRIDEiQ5VYV7.

    PTM databases

    PhosphoSiteiQ5VYV7.

    Expressioni

    Gene expression databases

    BgeeiQ5VYV7.
    CleanExiHS_C20orf94.
    GenevestigatoriQ5VYV7.

    Organism-specific databases

    HPAiHPA046372.

    Interactioni

    Subunit structurei

    Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SLX4Q8IY924EBI-2370881,EBI-2370740

    Protein-protein interaction databases

    BioGridi126147. 15 interactions.
    IntActiQ5VYV7. 19 interactions.
    STRINGi9606.ENSP00000335557.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VYV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLX4IP family.Curated

    Phylogenomic databases

    eggNOGiNOG40225.
    HOGENOMiHOG000112024.
    HOVERGENiHBG094893.
    InParanoidiQ5VYV7.
    OMAiPGPKQSP.
    OrthoDBiEOG7B31MT.
    PhylomeDBiQ5VYV7.
    TreeFamiTF330769.

    Sequencei

    Sequence statusi: Complete.

    Q5VYV7-1 [UniParc]FASTAAdd to Basket

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    MASKKFAVKC GNFAVLVDLH ILPQGSNKDT SWFSEQKKEE VCLLLKETID    50
    SRVQEYLEVR KQHRPSNAEF TRSNPLSLKG YGFQITAYFL KRGIRLRCIR 100
    STQNAELCVF PDRFVVCVSQ LAFSRDLLAS QNEDLTERVL HGVSDYFAEC 150
    AESSLPPSAK LRRNALKEIV KRTETKSSVT SKSQTRRDTV ETSSDSVIAE 200
    IARRRNDGQA SSSPPSESMG QAKDSIKAAE SHWGLPVQKL EKVNQTQPED 250
    TSGQQKPHPG ERLKTGLLSR SPVCSCESAS PCPKQSPRVA KTQQKRRNCS 300
    SAEDFDHHGR VSLGSDRLVP REIIVEKSKA VRVLPASELS DPGLLLKQDL 350
    AKTTSKEELH VLESLSSRHL MKNNPGQAQQ TGLATNTERL STIQNSPTKK 400
    RKKYERGH 408
    Length:408
    Mass (Da):45,552
    Last modified:December 7, 2004 - v1
    Checksum:i4CBC9DF90E3B14E9
    GO

    Sequence cautioni

    The sequence AAH20787.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH26094.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti317 – 3171R → Q.
    Corresponds to variant rs6077853 [ dbSNP | Ensembl ].
    VAR_035277

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133340, AL035456, AL353599 Genomic DNA. Translation: CAH71244.1.
    AL353599, AL035456, AL133340 Genomic DNA. Translation: CAH71745.1.
    AL035456, AL133340, AL353599 Genomic DNA. Translation: CAI42184.1.
    BC020787 mRNA. Translation: AAH20787.1. Sequence problems.
    BC026094 mRNA. Translation: AAH26094.1. Sequence problems.
    CCDSiCCDS33439.1.
    RefSeqiNP_001009608.1. NM_001009608.1.
    UniGeneiHs.668782.

    Genome annotation databases

    EnsembliENST00000334534; ENSP00000335557; ENSG00000149346.
    GeneIDi128710.
    KEGGihsa:128710.
    UCSCiuc010zre.2. human.

    Polymorphism databases

    DMDMi74747720.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133340 , AL035456 , AL353599 Genomic DNA. Translation: CAH71244.1 .
    AL353599 , AL035456 , AL133340 Genomic DNA. Translation: CAH71745.1 .
    AL035456 , AL133340 , AL353599 Genomic DNA. Translation: CAI42184.1 .
    BC020787 mRNA. Translation: AAH20787.1 . Sequence problems.
    BC026094 mRNA. Translation: AAH26094.1 . Sequence problems.
    CCDSi CCDS33439.1.
    RefSeqi NP_001009608.1. NM_001009608.1.
    UniGenei Hs.668782.

    3D structure databases

    ProteinModelPortali Q5VYV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126147. 15 interactions.
    IntActi Q5VYV7. 19 interactions.
    STRINGi 9606.ENSP00000335557.

    PTM databases

    PhosphoSitei Q5VYV7.

    Polymorphism databases

    DMDMi 74747720.

    Proteomic databases

    MaxQBi Q5VYV7.
    PaxDbi Q5VYV7.
    PRIDEi Q5VYV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334534 ; ENSP00000335557 ; ENSG00000149346 .
    GeneIDi 128710.
    KEGGi hsa:128710.
    UCSCi uc010zre.2. human.

    Organism-specific databases

    CTDi 128710.
    GeneCardsi GC20P010415.
    H-InvDB HIX0027687.
    HGNCi HGNC:16225. SLX4IP.
    HPAi HPA046372.
    neXtProti NX_Q5VYV7.
    PharmGKBi PA25801.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40225.
    HOGENOMi HOG000112024.
    HOVERGENi HBG094893.
    InParanoidi Q5VYV7.
    OMAi PGPKQSP.
    OrthoDBi EOG7B31MT.
    PhylomeDBi Q5VYV7.
    TreeFami TF330769.

    Miscellaneous databases

    ChiTaRSi C20orf94. human.
    GenomeRNAii 128710.
    NextBioi 82430.

    Gene expression databases

    Bgeei Q5VYV7.
    CleanExi HS_C20orf94.
    Genevestigatori Q5VYV7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."
      Svendsen J.M., Smogorzewska A., Sowa M.E., O'Connell B.C., Gygi S.P., Elledge S.J., Harper J.W.
      Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLX4.

    Entry informationi

    Entry nameiSLX4I_HUMAN
    AccessioniPrimary (citable) accession number: Q5VYV7
    Secondary accession number(s): Q05CG2, Q05CT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3