Q5VYV7 (SLX4I_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SLX4IP

Alternative name(s):
SLX4-interacting protein

Gene names

Name:	SLX4IP
Synonyms:	C20orf94

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases. Ref.4
Sequence similarities	Belongs to the SLX4IP family.
Sequence caution	The sequence AAH20787.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH26094.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SLX4	Q8IY92	4	EBI-2370881,EBI-2370740

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Protein SLX4IP		PRO_0000306119
Natural variations
	Natural variant	317	1	R → Q. Corresponds to variant rs6077853 [ dbSNP | Ensembl ].		VAR_035277

Sequences

	Sequence		Length	Mass (Da)
	Q5VYV7 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 4CBC9DF90E3B14E9	FASTA	408	45,552
	10 20 30 40 50 60 MASKKFAVKC GNFAVLVDLH ILPQGSNKDT SWFSEQKKEE VCLLLKETID SRVQEYLEVR 70 80 90 100 110 120 KQHRPSNAEF TRSNPLSLKG YGFQITAYFL KRGIRLRCIR STQNAELCVF PDRFVVCVSQ 130 140 150 160 170 180 LAFSRDLLAS QNEDLTERVL HGVSDYFAEC AESSLPPSAK LRRNALKEIV KRTETKSSVT 190 200 210 220 230 240 SKSQTRRDTV ETSSDSVIAE IARRRNDGQA SSSPPSESMG QAKDSIKAAE SHWGLPVQKL 250 260 270 280 290 300 EKVNQTQPED TSGQQKPHPG ERLKTGLLSR SPVCSCESAS PCPKQSPRVA KTQQKRRNCS 310 320 330 340 350 360 SAEDFDHHGR VSLGSDRLVP REIIVEKSKA VRVLPASELS DPGLLLKQDL AKTTSKEELH 370 380 390 400 VLESLSSRHL MKNNPGQAQQ TGLATNTERL STIQNSPTKK RKKYERGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[4]	"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair." Svendsen J.M., Smogorzewska A., Sowa M.E., O'Connell B.C., Gygi S.P., Elledge S.J., Harper J.W. Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SLX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL133340, AL035456, AL353599 Genomic DNA. Translation: CAH71244.1. AL353599, AL035456, AL133340 Genomic DNA. Translation: CAH71745.1. AL035456, AL133340, AL353599 Genomic DNA. Translation: CAI42184.1. BC020787 mRNA. Translation: AAH20787.1. Sequence problems. BC026094 mRNA. Translation: AAH26094.1. Sequence problems.
IPI	IPI00046188.
RefSeq	NP_001009608.1. NM_001009608.1.
UniGene	Hs.668782.
3D structure databases
ProteinModelPortal	Q5VYV7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5VYV7. 18 interactions.
STRING	9606.ENSP00000335557.
PTM databases
PhosphoSite	Q5VYV7.
Polymorphism databases
DMDM	74747720.
Proteomic databases
PaxDb	Q5VYV7.
PRIDE	Q5VYV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334534; ENSP00000335557; ENSG00000149346.
GeneID	128710.
KEGG	hsa:128710.
UCSC	uc010zre.2. human.
Organism-specific databases
CTD	128710.
GeneCards	GC20P010410.
H-InvDB	HIX0027687.
HGNC	HGNC:16225. SLX4IP.
HPA	HPA046372.
neXtProt	NX_Q5VYV7.
PharmGKB	PA25801.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40225.
HOGENOM	HOG000112024.
HOVERGEN	HBG094893.
InParanoid	Q5VYV7.
OMA	PGPKQSP.
OrthoDB	EOG4548ZN.
PhylomeDB	Q5VYV7.
Gene expression databases
Bgee	Q5VYV7.
CleanEx	HS_C20orf94.
Genevestigator	Q5VYV7.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	C20orf94. human.
GenomeRNAi	128710.
NextBio	82430.

Entry information

Entry name

SLX4I_HUMAN

Accession

Primary (citable) accession number: Q5VYV7
Secondary accession number(s): Q05CG2, Q05CT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.