Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5VYV7 (SLX4I_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SLX4IP
Alternative name(s):
SLX4-interacting protein
Gene names
Name:SLX4IP
Synonyms:C20orf94
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases. Ref.4

Sequence similarities

Belongs to the SLX4IP family.

Sequence caution

The sequence AAH20787.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH26094.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SLX4Q8IY924EBI-2370881,EBI-2370740

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Protein SLX4IP
PRO_0000306119

Natural variations

Natural variant3171R → Q.
Corresponds to variant rs6077853 [ dbSNP | Ensembl ].
VAR_035277

Sequences

Sequence LengthMass (Da)Tools
Q5VYV7 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 4CBC9DF90E3B14E9

FASTA40845,552
        10         20         30         40         50         60 
MASKKFAVKC GNFAVLVDLH ILPQGSNKDT SWFSEQKKEE VCLLLKETID SRVQEYLEVR 

        70         80         90        100        110        120 
KQHRPSNAEF TRSNPLSLKG YGFQITAYFL KRGIRLRCIR STQNAELCVF PDRFVVCVSQ 

       130        140        150        160        170        180 
LAFSRDLLAS QNEDLTERVL HGVSDYFAEC AESSLPPSAK LRRNALKEIV KRTETKSSVT 

       190        200        210        220        230        240 
SKSQTRRDTV ETSSDSVIAE IARRRNDGQA SSSPPSESMG QAKDSIKAAE SHWGLPVQKL 

       250        260        270        280        290        300 
EKVNQTQPED TSGQQKPHPG ERLKTGLLSR SPVCSCESAS PCPKQSPRVA KTQQKRRNCS 

       310        320        330        340        350        360 
SAEDFDHHGR VSLGSDRLVP REIIVEKSKA VRVLPASELS DPGLLLKQDL AKTTSKEELH 

       370        380        390        400 
VLESLSSRHL MKNNPGQAQQ TGLATNTERL STIQNSPTKK RKKYERGH 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[3]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."
Svendsen J.M., Smogorzewska A., Sowa M.E., O'Connell B.C., Gygi S.P., Elledge S.J., Harper J.W.
Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SLX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL133340, AL035456, AL353599 Genomic DNA. Translation: CAH71244.1.
AL353599, AL035456, AL133340 Genomic DNA. Translation: CAH71745.1.
AL035456, AL133340, AL353599 Genomic DNA. Translation: CAI42184.1.
BC020787 mRNA. Translation: AAH20787.1. Sequence problems.
BC026094 mRNA. Translation: AAH26094.1. Sequence problems.
RefSeqNP_001009608.1. NM_001009608.1.
UniGeneHs.668782.

3D structure databases

ProteinModelPortalQ5VYV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126147. 15 interactions.
IntActQ5VYV7. 19 interactions.
STRING9606.ENSP00000335557.

PTM databases

PhosphoSiteQ5VYV7.

Polymorphism databases

DMDM74747720.

Proteomic databases

PaxDbQ5VYV7.
PRIDEQ5VYV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334534; ENSP00000335557; ENSG00000149346.
GeneID128710.
KEGGhsa:128710.
UCSCuc010zre.2. human.

Organism-specific databases

CTD128710.
GeneCardsGC20P010415.
H-InvDBHIX0027687.
HGNCHGNC:16225. SLX4IP.
HPAHPA046372.
neXtProtNX_Q5VYV7.
PharmGKBPA25801.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40225.
HOGENOMHOG000112024.
HOVERGENHBG094893.
InParanoidQ5VYV7.
OMAPGPKQSP.
OrthoDBEOG7B31MT.
PhylomeDBQ5VYV7.
TreeFamTF330769.

Gene expression databases

BgeeQ5VYV7.
CleanExHS_C20orf94.
GenevestigatorQ5VYV7.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSC20orf94. human.
GenomeRNAi128710.
NextBio82430.

Entry information

Entry nameSLX4I_HUMAN
AccessionPrimary (citable) accession number: Q5VYV7
Secondary accession number(s): Q05CG2, Q05CT9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM