Q5VYV0 (FOXB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein B2

Gene names

Name:

FOXB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor Probable.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from Biological aspect of Ancestor. Source: RefGenome embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Forkhead box protein B2		PRO_0000263091
Regions
	DNA binding	13 – 107	95	Fork-head
	Compositional bias	135 – 151	17	Poly-His
	Compositional bias	155 – 161	7	Poly-His
	Compositional bias	162 – 174	13	Poly-Pro
	Compositional bias	220 – 234	15	Poly-Ala
	Compositional bias	252 – 261	10	Poly-Ala
	Compositional bias	324 – 333	10	Poly-Ala
	Compositional bias	400 – 403	4	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q5VYV0 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 9A832ACDD9A765EF	FASTA	432	45,581
	10 20 30 40 50 60 MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY REHTQRWQNS 70 80 90 100 110 120 LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG SFLRRRKRFK VLRADHTHLH 130 140 150 160 170 180 AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF 190 200 210 220 230 240 HQQPPTAPQP PPHLPSQPPQ QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR 250 260 270 280 290 300 LSQFPPYGLG SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY 310 320 330 340 350 360 PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS LCHSASQSLP 370 380 390 400 410 420 AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA AAASPVASLL EPTAPTSAES 430 KGGSLHSVLV HS

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353637 Genomic DNA. Translation: CAH70683.1.
IPI	IPI00455929.
RefSeq	NP_001013757.1. NM_001013735.1.
UniGene	Hs.553843.
3D structure databases
HSSP	HSSP built from PDB template 2HDC based on UniProtKB Q63245.
ProteinModelPortal	Q5VYV0.
ModBase	Search...
Polymorphism databases
DMDM	74747718.
Proteomic databases
PaxDb	Q5VYV0.
PRIDE	Q5VYV0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376708; ENSP00000365898; ENSG00000204612.
GeneID	442425.
KEGG	hsa:442425.
UCSC	uc004ako.1. human.
Organism-specific databases
CTD	442425.
GeneCards	GC09P079634.
HGNC	HGNC:23315. FOXB2.
neXtProt	NX_Q5VYV0.
PharmGKB	PA145148830.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000007545.
HOVERGEN	HBG102104.
InParanoid	Q5VYV0.
KO	K09395.
OMA	CHSASQS.
OrthoDB	EOG40GCRF.
Gene expression databases
CleanEx	HS_FOXB2.
Genevestigator	Q5VYV0.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	111077.

Entry information

Entry name

FOXB2_HUMAN

Accession

Primary (citable) accession number: Q5VYV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.