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Q5VYV0 (FOXB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein B2
Gene names
Name:FOXB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor Probable.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processembryo development

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ development

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Forkhead box protein B2
PRO_0000263091

Regions

DNA binding13 – 10795Fork-head
Compositional bias135 – 15117Poly-His
Compositional bias155 – 1617Poly-His
Compositional bias162 – 17413Poly-Pro
Compositional bias220 – 23415Poly-Ala
Compositional bias252 – 26110Poly-Ala
Compositional bias324 – 33310Poly-Ala
Compositional bias400 – 4034Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q5VYV0 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 9A832ACDD9A765EF

FASTA43245,581
        10         20         30         40         50         60 
MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY REHTQRWQNS 

        70         80         90        100        110        120 
LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG SFLRRRKRFK VLRADHTHLH 

       130        140        150        160        170        180 
AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF 

       190        200        210        220        230        240 
HQQPPTAPQP PPHLPSQPPQ QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR 

       250        260        270        280        290        300 
LSQFPPYGLG SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY 

       310        320        330        340        350        360 
PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS LCHSASQSLP 

       370        380        390        400        410        420 
AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA AAASPVASLL EPTAPTSAES 

       430 
KGGSLHSVLV HS 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL353637 Genomic DNA. Translation: CAH70683.1.
RefSeqNP_001013757.1. NM_001013735.1.
UniGeneHs.553843.

3D structure databases

ProteinModelPortalQ5VYV0.
SMRQ5VYV0. Positions 13-111.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74747718.

Proteomic databases

PaxDbQ5VYV0.
PRIDEQ5VYV0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376708; ENSP00000365898; ENSG00000204612.
GeneID442425.
KEGGhsa:442425.
UCSCuc004ako.1. human.

Organism-specific databases

CTD442425.
GeneCardsGC09P079634.
HGNCHGNC:23315. FOXB2.
neXtProtNX_Q5VYV0.
PharmGKBPA145148830.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000007545.
HOVERGENHBG102104.
InParanoidQ5VYV0.
KOK09395.
OMACHSASQS.
OrthoDBEOG7C8GHD.
TreeFamTF316127.

Gene expression databases

CleanExHS_FOXB2.
GenevestigatorQ5VYV0.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio111077.
PROQ5VYV0.

Entry information

Entry nameFOXB2_HUMAN
AccessionPrimary (citable) accession number: Q5VYV0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 7, 2004
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM