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Q5VYV0

- FOXB2_HUMAN

UniProt

Q5VYV0 - FOXB2_HUMAN

Protein

Forkhead box protein B2

Gene

FOXB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Transcription factor.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi13 – 10795Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein B2
    Gene namesi
    Name:FOXB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23315. FOXB2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148830.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Forkhead box protein B2PRO_0000263091Add
    BLAST

    Proteomic databases

    PaxDbiQ5VYV0.
    PRIDEiQ5VYV0.

    Expressioni

    Gene expression databases

    CleanExiHS_FOXB2.
    GenevestigatoriQ5VYV0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VYV0.
    SMRiQ5VYV0. Positions 13-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi135 – 15117Poly-HisAdd
    BLAST
    Compositional biasi155 – 1617Poly-His
    Compositional biasi162 – 17413Poly-ProAdd
    BLAST
    Compositional biasi220 – 23415Poly-AlaAdd
    BLAST
    Compositional biasi252 – 26110Poly-Ala
    Compositional biasi324 – 33310Poly-Ala
    Compositional biasi400 – 4034Poly-Ala

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000007545.
    HOVERGENiHBG102104.
    InParanoidiQ5VYV0.
    KOiK09395.
    OMAiCHSASQS.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ5VYV0.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VYV0-1 [UniParc]FASTAAdd to Basket

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    MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY    50
    REHTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG 100
    SFLRRRKRFK VLRADHTHLH AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH 150
    HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF HQQPPTAPQP PPHLPSQPPQ 200
    QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR LSQFPPYGLG 250
    SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY 300
    PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS 350
    LCHSASQSLP AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA 400
    AAASPVASLL EPTAPTSAES KGGSLHSVLV HS 432
    Length:432
    Mass (Da):45,581
    Last modified:December 7, 2004 - v1
    Checksum:i9A832ACDD9A765EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353637 Genomic DNA. Translation: CAH70683.1.
    CCDSiCCDS35045.1.
    RefSeqiNP_001013757.1. NM_001013735.1.
    UniGeneiHs.553843.

    Genome annotation databases

    EnsembliENST00000376708; ENSP00000365898; ENSG00000204612.
    GeneIDi442425.
    KEGGihsa:442425.
    UCSCiuc004ako.1. human.

    Polymorphism databases

    DMDMi74747718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353637 Genomic DNA. Translation: CAH70683.1 .
    CCDSi CCDS35045.1.
    RefSeqi NP_001013757.1. NM_001013735.1.
    UniGenei Hs.553843.

    3D structure databases

    ProteinModelPortali Q5VYV0.
    SMRi Q5VYV0. Positions 13-111.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74747718.

    Proteomic databases

    PaxDbi Q5VYV0.
    PRIDEi Q5VYV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376708 ; ENSP00000365898 ; ENSG00000204612 .
    GeneIDi 442425.
    KEGGi hsa:442425.
    UCSCi uc004ako.1. human.

    Organism-specific databases

    CTDi 442425.
    GeneCardsi GC09P079634.
    HGNCi HGNC:23315. FOXB2.
    neXtProti NX_Q5VYV0.
    PharmGKBi PA145148830.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000007545.
    HOVERGENi HBG102104.
    InParanoidi Q5VYV0.
    KOi K09395.
    OMAi CHSASQS.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q5VYV0.
    TreeFami TF316127.

    Miscellaneous databases

    NextBioi 111077.
    PROi Q5VYV0.

    Gene expression databases

    CleanExi HS_FOXB2.
    Genevestigatori Q5VYV0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFOXB2_HUMAN
    AccessioniPrimary (citable) accession number: Q5VYV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3