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Protein

Forkhead box protein B2

Gene

FOXB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi13 – 10795Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: GO_Central
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B2
Gene namesi
Name:FOXB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23315. FOXB2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Forkhead box protein B2PRO_0000263091Add
BLAST

Proteomic databases

PaxDbiQ5VYV0.
PRIDEiQ5VYV0.

Expressioni

Gene expression databases

CleanExiHS_FOXB2.
GenevestigatoriQ5VYV0.

Structurei

3D structure databases

ProteinModelPortaliQ5VYV0.
SMRiQ5VYV0. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 15117Poly-HisAdd
BLAST
Compositional biasi155 – 1617Poly-His
Compositional biasi162 – 17413Poly-ProAdd
BLAST
Compositional biasi220 – 23415Poly-AlaAdd
BLAST
Compositional biasi252 – 26110Poly-Ala
Compositional biasi324 – 33310Poly-Ala
Compositional biasi400 – 4034Poly-Ala

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ5VYV0.
KOiK09395.
OMAiCHSASQS.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ5VYV0.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VYV0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY
60 70 80 90 100
REHTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLRADHTHLH AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH
160 170 180 190 200
HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF HQQPPTAPQP PPHLPSQPPQ
210 220 230 240 250
QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR LSQFPPYGLG
260 270 280 290 300
SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY
310 320 330 340 350
PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS
360 370 380 390 400
LCHSASQSLP AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA
410 420 430
AAASPVASLL EPTAPTSAES KGGSLHSVLV HS
Length:432
Mass (Da):45,581
Last modified:December 7, 2004 - v1
Checksum:i9A832ACDD9A765EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353637 Genomic DNA. Translation: CAH70683.1.
CCDSiCCDS35045.1.
RefSeqiNP_001013757.1. NM_001013735.1.
UniGeneiHs.553843.

Genome annotation databases

EnsembliENST00000376708; ENSP00000365898; ENSG00000204612.
GeneIDi442425.
KEGGihsa:442425.
UCSCiuc004ako.1. human.

Polymorphism databases

DMDMi74747718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353637 Genomic DNA. Translation: CAH70683.1.
CCDSiCCDS35045.1.
RefSeqiNP_001013757.1. NM_001013735.1.
UniGeneiHs.553843.

3D structure databases

ProteinModelPortaliQ5VYV0.
SMRiQ5VYV0. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi74747718.

Proteomic databases

PaxDbiQ5VYV0.
PRIDEiQ5VYV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376708; ENSP00000365898; ENSG00000204612.
GeneIDi442425.
KEGGihsa:442425.
UCSCiuc004ako.1. human.

Organism-specific databases

CTDi442425.
GeneCardsiGC09P079634.
HGNCiHGNC:23315. FOXB2.
neXtProtiNX_Q5VYV0.
PharmGKBiPA145148830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ5VYV0.
KOiK09395.
OMAiCHSASQS.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ5VYV0.
TreeFamiTF316127.

Miscellaneous databases

GenomeRNAii442425.
NextBioi111077.
PROiQ5VYV0.

Gene expression databases

CleanExiHS_FOXB2.
GenevestigatoriQ5VYV0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFOXB2_HUMAN
AccessioniPrimary (citable) accession number: Q5VYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 7, 2004
Last modified: February 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.