Q5VYP0 (S31A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermatogenesis-associated protein 31A3

Alternative name(s):
Protein FAM75A3

Gene names

Name:	SPATA31A3
Synonyms:	FAM75A3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1347 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in spermatogenesis By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the SPATA31 family.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1347	1347	Spermatogenesis-associated protein 31A3		PRO_0000313018
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Compositional bias	120 – 228	109	Pro-rich
Experimental info
	Sequence conflict	1152	1	P → Q in CAB45741. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5VYP0 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 5C5457992FA6FE8E	FASTA	1,347	148,706
	10 20 30 40 50 60 MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG 70 80 90 100 110 120 KRKCPVGRRR RPRGRMKNHS LRAGRECRRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP 130 140 150 160 170 180 DPPGEVGERA PDGASQSSHE PMEDAAPILS LLASPDPQAK HPQDLASTPS PGPMTTSVSS 190 200 210 220 230 240 LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSLPP PKGFTAPPLR DSTLITPSHC 250 260 270 280 290 300 DSVALPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD 310 320 330 340 350 360 HLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNRMTPEKHL 370 380 390 400 410 420 NSLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP 430 440 450 460 470 480 SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHLGPECQ 490 500 510 520 530 540 PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIQN TGVACPASQN KVQALSLPET 550 560 570 580 590 600 QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE 610 620 630 640 650 660 QHIKKWIIQH WGNLGRIQES LDLMQLQDES PGTSQAKGKP SPWQSSMSTG ESSKEAQKVK 670 680 690 700 710 720 FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE LERNLRKPLR SDSGSDLLRC 730 740 750 760 770 780 TERTHIENIL KAHMGRNLGQ TNEGLIPVRV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK 790 800 810 820 830 840 ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA 850 860 870 880 890 900 GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR 910 920 930 940 950 960 GIPSWNDHEP LKPPPAGQEG RWPSKPLTYS LTGSTQQSRS LGAQSSKAGE TREAVPQCRV 970 980 990 1000 1010 1020 PLETCMLANL QATSEDVHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV SEFEPGMATK 1030 1040 1050 1060 1070 1080 SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPTGNMRASQ ELHDLMAARR 1090 1100 1110 1120 1130 1140 SKLVHEEPRK PNCQGSCKSQ RPMFPPIHKS EKFRKPNLEK HEERLEGLRT PQLTPVRKTE 1150 1160 1170 1180 1190 1200 DTHQDEGVQL LPSKKQPPSV SPFGENIKQI FQWIFSKKKS KPAPVTAESQ KTVKNRSCVY 1210 1220 1230 1240 1250 1260 SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR 1270 1280 1290 1300 1310 1320 ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP 1330 1340 PQHWPKTSGA SSHHHHCPRH CLLWEGI

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-1347. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353770 Genomic DNA. Translation: CAH73359.1. AL080148 mRNA. Translation: CAB45741.1.
IPI	IPI00472874.
PIR	T12532.
RefSeq	NP_001076593.1. NM_001083124.1.
UniGene	Hs.632078.
3D structure databases
ProteinModelPortal	Q5VYP0.
ModBase	Search...
PTM databases
PhosphoSite	Q5VYP0.
Polymorphism databases
DMDM	74747695.
Proteomic databases
PaxDb	Q5VYP0.
PRIDE	Q5VYP0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356699; ENSP00000349132; ENSG00000147926.
GeneID	727830.
KEGG	hsa:727830.
UCSC	uc010mmj.3. human.
Organism-specific databases
CTD	727830.
GeneCards	GC09P040692.
H-InvDB	HIX0008058. HIX0025865. HIX0058660. HIX0058661. HIX0201371.
HGNC	HGNC:32003. SPATA31A3.
neXtProt	NX_Q5VYP0.
PharmGKB	PA162387867.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45889.
HOGENOM	HOG000015250.
HOVERGEN	HBG107892.
InParanoid	Q5VYP0.
OMA	ARINIPD.
OrthoDB	EOG4HHP1S.
Gene expression databases
Bgee	Q5VYP0.
CleanEx	HS_FAM75A3.
Genevestigator	Q5VYP0.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	727830.
NextBio	125249.

Entry information

Entry name

S31A3_HUMAN

Accession

Primary (citable) accession number: Q5VYP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.