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Q5VYP0

- S31A3_HUMAN

UniProt

Q5VYP0 - S31A3_HUMAN

Protein

Spermatogenesis-associated protein 31A3

Gene

SPATA31A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    May play a role in spermatogenesis.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. spermatogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spermatogenesis-associated protein 31A3
    Alternative name(s):
    Protein FAM75A3
    Gene namesi
    Name:SPATA31A3
    Synonyms:FAM75A3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:32003. SPATA31A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162387867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13471347Spermatogenesis-associated protein 31A3PRO_0000313018Add
    BLAST

    Proteomic databases

    PaxDbiQ5VYP0.
    PRIDEiQ5VYP0.

    PTM databases

    PhosphoSiteiQ5VYP0.

    Expressioni

    Gene expression databases

    BgeeiQ5VYP0.
    CleanExiHS_FAM75A3.
    GenevestigatoriQ5VYP0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VYP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi120 – 228109Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SPATA31 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45889.
    HOGENOMiHOG000015250.
    HOVERGENiHBG107892.
    InParanoidiQ5VYP0.
    OMAiWISERSS.
    OrthoDBiEOG7SFHVW.
    PhylomeDBiQ5VYP0.
    TreeFamiTF338531.

    Family and domain databases

    InterProiIPR027970. DUF4599.
    [Graphical view]
    PfamiPF15371. DUF4599. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VYP0-1 [UniParc]FASTAAdd to Basket

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    MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR     50
    CDDPPSPSPG KRKCPVGRRR RPRGRMKNHS LRAGRECRRG LEETSDLLSQ 100
    LQSLLGPHLD KGDFGQLSGP DPPGEVGERA PDGASQSSHE PMEDAAPILS 150
    LLASPDPQAK HPQDLASTPS PGPMTTSVSS LSASQPPEPS LPLEHPSPEP 200
    PALFPHPPHT PDPLACSLPP PKGFTAPPLR DSTLITPSHC DSVALPLGTV 250
    PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD 300
    HLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF 350
    TNRMTPEKHL NSLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD 400
    PRLWQESFWK NYSQLFWGLP SLHSESLVAN AWVTDRSYTL QSPPFLFNEM 450
    SNVCPIQRET TMSPLLFQAQ PLSHLGPECQ PFISSTPQFR PTPMAQAEAQ 500
    AHLQSSFPVL SPAFPSLIQN TGVACPASQN KVQALSLPET QHPEWPLLRR 550
    QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE 600
    QHIKKWIIQH WGNLGRIQES LDLMQLQDES PGTSQAKGKP SPWQSSMSTG 650
    ESSKEAQKVK FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE 700
    LERNLRKPLR SDSGSDLLRC TERTHIENIL KAHMGRNLGQ TNEGLIPVRV 750
    RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK ACVNTAQVLS FLEPCTQQGL 800
    GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA GPSSATCESG 850
    AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR 900
    GIPSWNDHEP LKPPPAGQEG RWPSKPLTYS LTGSTQQSRS LGAQSSKAGE 950
    TREAVPQCRV PLETCMLANL QATSEDVHGF EAPGTSKSSL HPRVSVSQDP 1000
    RKLCLMEEVV SEFEPGMATK SETQPQVCAA VVLLPDGQAS VVPHASENLV 1050
    SQVPQGHLQS MPTGNMRASQ ELHDLMAARR SKLVHEEPRK PNCQGSCKSQ 1100
    RPMFPPIHKS EKFRKPNLEK HEERLEGLRT PQLTPVRKTE DTHQDEGVQL 1150
    LPSKKQPPSV SPFGENIKQI FQWIFSKKKS KPAPVTAESQ KTVKNRSCVY 1200
    SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH 1250
    RHLFYSEHGR ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ 1300
    WGLRHPQILH PKKAVSPVSP PQHWPKTSGA SSHHHHCPRH CLLWEGI 1347
    Length:1,347
    Mass (Da):148,706
    Last modified:December 7, 2004 - v1
    Checksum:i5C5457992FA6FE8E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1152 – 11521P → Q in CAB45741. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353770 Genomic DNA. Translation: CAH73359.1.
    AL080148 mRNA. Translation: CAB45741.1.
    CCDSiCCDS47969.1.
    PIRiT12532.
    RefSeqiNP_001076593.1. NM_001083124.1.
    UniGeneiHs.632078.

    Genome annotation databases

    GeneIDi727830.
    KEGGihsa:727830.
    UCSCiuc010mmj.3. human.

    Polymorphism databases

    DMDMi74747695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353770 Genomic DNA. Translation: CAH73359.1 .
    AL080148 mRNA. Translation: CAB45741.1 .
    CCDSi CCDS47969.1.
    PIRi T12532.
    RefSeqi NP_001076593.1. NM_001083124.1.
    UniGenei Hs.632078.

    3D structure databases

    ProteinModelPortali Q5VYP0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5VYP0.

    Polymorphism databases

    DMDMi 74747695.

    Proteomic databases

    PaxDbi Q5VYP0.
    PRIDEi Q5VYP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 727830.
    KEGGi hsa:727830.
    UCSCi uc010mmj.3. human.

    Organism-specific databases

    CTDi 727830.
    GeneCardsi GC09P040700.
    H-InvDB HIX0008058.
    HIX0025865.
    HIX0058660.
    HIX0058661.
    HIX0201371.
    HGNCi HGNC:32003. SPATA31A3.
    neXtProti NX_Q5VYP0.
    PharmGKBi PA162387867.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45889.
    HOGENOMi HOG000015250.
    HOVERGENi HBG107892.
    InParanoidi Q5VYP0.
    OMAi WISERSS.
    OrthoDBi EOG7SFHVW.
    PhylomeDBi Q5VYP0.
    TreeFami TF338531.

    Miscellaneous databases

    GenomeRNAii 727830.
    NextBioi 125249.
    PROi Q5VYP0.

    Gene expression databases

    Bgeei Q5VYP0.
    CleanExi HS_FAM75A3.
    Genevestigatori Q5VYP0.

    Family and domain databases

    InterProi IPR027970. DUF4599.
    [Graphical view ]
    Pfami PF15371. DUF4599. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-1347.
      Tissue: Testis.

    Entry informationi

    Entry nameiS31A3_HUMAN
    AccessioniPrimary (citable) accession number: Q5VYP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3