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Protein

Proteasome adapter and scaffold protein ECM29

Gene

ECPAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • proteasome assembly Source: InterPro
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome adapter and scaffold protein ECM29Curated
Alternative name(s):
Ecm29 proteasome adapter and scaffoldImported
Proteasome-associated protein ECM29 homolog
Gene namesi
Name:ECPASImported
Synonyms:ECM29, KIAA0368
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136813.14
HGNCiHGNC:29020 ECPAS
MIMi616694 gene
neXtProtiNX_Q5VYK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Nucleus, Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23392

Polymorphism and mutation databases

DMDMi61212960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002125592 – 1845Proteasome adapter and scaffold protein ECM29Add BLAST1844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei830PhosphoserineCombined sources1
Modified residuei836PhosphothreonineCombined sources1
Cross-linki1039Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VYK3
MaxQBiQ5VYK3
PaxDbiQ5VYK3
PeptideAtlasiQ5VYK3
PRIDEiQ5VYK3

PTM databases

iPTMnetiQ5VYK3
PhosphoSitePlusiQ5VYK3
SwissPalmiQ5VYK3

Expressioni

Gene expression databases

BgeeiENSG00000136813
CleanExiHS_KIAA0368
ExpressionAtlasiQ5VYK3 baseline and differential
GenevisibleiQ5VYK3 HS

Organism-specific databases

HPAiHPA021646
HPA059795

Interactioni

Subunit structurei

Non-stoichiometric component of the proteasome; associates with the 26S proteasome. Interacts (via N-terminus) with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1. Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10, MYO10 and ARF6.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116966, 158 interactors
IntActiQ5VYK3, 36 interactors
MINTiQ5VYK3
STRINGi9606.ENSP00000259335

Structurei

3D structure databases

ProteinModelPortaliQ5VYK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 71HEAT 1Add BLAST38
Repeati113 – 150HEAT 2Add BLAST38
Repeati168 – 211HEAT 3Add BLAST44
Repeati332 – 368HEAT 4Add BLAST37
Repeati393 – 432HEAT 5Add BLAST40
Repeati435 – 472HEAT 6Add BLAST38
Repeati475 – 513HEAT 7Add BLAST39
Repeati689 – 726HEAT 8Add BLAST38
Repeati727 – 765HEAT 9Add BLAST39
Repeati789 – 826HEAT 10Add BLAST38
Repeati835 – 874HEAT 11Add BLAST40
Repeati876 – 913HEAT 12Add BLAST38
Repeati937 – 975HEAT 13Add BLAST39
Repeati981 – 1018HEAT 14Add BLAST38
Repeati1019 – 1056HEAT 15Add BLAST38
Repeati1118 – 1155HEAT 16Add BLAST38
Repeati1158 – 1195HEAT 17Add BLAST38
Repeati1200 – 1237HEAT 18Add BLAST38
Repeati1249 – 1287HEAT 19Add BLAST39
Repeati1291 – 1329HEAT 20Add BLAST39
Repeati1354 – 1392HEAT 21Add BLAST39
Repeati1396 – 1433HEAT 22Add BLAST38
Repeati1523 – 1560HEAT 23Add BLAST38
Repeati1564 – 1601HEAT 24Add BLAST38
Repeati1611 – 1648HEAT 25Add BLAST38
Repeati1652 – 1689HEAT 26Add BLAST38
Repeati1785 – 1828HEAT 27Add BLAST44

Sequence similaritiesi

Belongs to the ECM29 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0915 Eukaryota
ENOG410XPYT LUCA
HOGENOMiHOG000231642
HOVERGENiHBG051438
InParanoidiQ5VYK3
PhylomeDBiQ5VYK3

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024372 Ecm29
IPR032878 Vac14_Fab1-bd
PANTHERiPTHR23346:SF19 PTHR23346:SF19, 1 hit
PfamiView protein in Pfam
PF13001 Ecm29, 1 hit
PF12755 Vac14_Fab1_bd, 1 hit
SUPFAMiSSF48371 SSF48371, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAASASQ DELNQLERVF LRLGHAETDE QLQNIISKFL PPVLLKLSST
60 70 80 90 100
QEGVRKKVME LLVHLNKRIK SRPKIQLPVE TLLVQYQDPA AVSFVTNFTI
110 120 130 140 150
IYVKMGYPRL PVEKQCELAP TLLTAMEGKP QPQQDSLMHL LIPTLFHMKY
160 170 180 190 200
PVESSKSASP FNLAEKPKTV QLLLDFMLDV LLMPYGYVLN ESQSRQNSSS
210 220 230 240 250
AQGSSSNSGG GSGIPQPPPG MSFYAAKRVI GDNPWTPEQL EQCKLGIVKF
260 270 280 290 300
IEAEQVPELE AVLHLVIASS DTRHSVATAA DLELKSKQSL IDWNNPAIIN
310 320 330 340 350
KMYKVYLGDI PLKTKEGAVL KPELKRDPVS TRVKLKIVPH LLRSRQAAET
360 370 380 390 400
FPANIQVVYD GLFGTNTNSK LRTLSLQFVH HICITCPEIK IKPLGPMLLN
410 420 430 440 450
GLTKLINEYK EDPKLLSMAY SAVGKLSSRM PHLFTKDIAL VQQLFEALCK
460 470 480 490 500
EEPETRLAIQ EALSMMVGAY STLEGAQRTL MEALVASYLI KPEVQVRQVA
510 520 530 540 550
VKFASTVFPS DHIPSRYLLL LAAGDPREEV HGEAQRVLRC LPGRNRKEST
560 570 580 590 600
SEQMPSFPEM VYYIQEKASH RMKTPVKYMT GTTVLPFNPA AFGEIVLYLR
610 620 630 640 650
MCLAHSAGVV PTSQSLADMQ DHAPAIGRYI RTLMSSGQMA PSSSNKSGET
660 670 680 690 700
NPVQIYIGLL QQLLAGVGGL PVMYCLLEAV SVYPEKLATK FVDKTEWIKS
710 720 730 740 750
LMNNSKEEMR ELAALFYSVV VSTVSGNELK SMIEQLIKTT KDNHSPEIQH
760 770 780 790 800
GSLLALGFTV GRYLAKKKMR MSEQQDLERN ADTLPDQEEL IQSATETIGS
810 820 830 840 850
FLDSTSPLLA IAACTALGEI GRNGPLPIPS EGSGFTKLHL VESLLSRIPS
860 870 880 890 900
SKETNKMKER AIQTLGYFPV GDGDFPHQKL LLQGLMDSVE AKQIELQFTI
910 920 930 940 950
GEAITSAAIG TSSVAARDAW QMTEEEYTPP AGAKVNDVVP WVLDVILNKH
960 970 980 990 1000
IISPNPHVRQ AACIWLLSLV RKLSTHKEVK SHLKEIQSAF VSVLSENDEL
1010 1020 1030 1040 1050
SQDVASKGLG LVYELGNEQD QQELVSTLVE TLMTGKRVKH EVSGETVVFQ
1060 1070 1080 1090 1100
GGALGKTPDG QGLSTYKELC SLASDLSQPD LVYKFMNLAN HHAMWNSRKG
1110 1120 1130 1140 1150
AAFGFNVIAT RAGEQLAPFL PQLVPRLYRY QFDPNLGIRQ AMTSIWNALV
1160 1170 1180 1190 1200
TDKSMVDKYL KEILQDLVKN LTSNMWRVRE SSCLALNDLL RGRPLDDIID
1210 1220 1230 1240 1250
KLPEIWETLF RVQDDIKESV RKAAELALKT LSKVCVKMCD PAKGAAGQRT
1260 1270 1280 1290 1300
IAALLPCLLD KGMMSTVTEV RALSINTLVK ISKSAGAMLK PHAPKLIPAL
1310 1320 1330 1340 1350
LESLSVLEPQ VLNYLSLRAT EQEKAAMDSA RLSAAKSSPM METINMCLQY
1360 1370 1380 1390 1400
LDVSVLGELV PRLCELIRSG VGLGTKGGCA SVIVSLTTQC PQDLTPYSGK
1410 1420 1430 1440 1450
LMSALLSGLT DRNSVIQKSC AFAMGHLVRT SRDSSTEKLL QKLNGWYMEK
1460 1470 1480 1490 1500
EEPIYKTSCA LTIHAIGRYS PDVLKNHAKE VLPLAFLGMH EIADEEKSEK
1510 1520 1530 1540 1550
EECNLWTEVW QENVPGSFGG IRLYLQELIT ITQKALQSQS WKMKAQGAIA
1560 1570 1580 1590 1600
MASIAKQTSS LVPPYLGMIL TALLQGLAGR TWAGKEELLK AIACVVTACS
1610 1620 1630 1640 1650
AELEKSVPNQ PSTNEILQAV LKECSKENVK YKIVAISCAA DILKATKEDR
1660 1670 1680 1690 1700
FQEFSNIVIP LIKKNSLESS GVRTTKNEEE NEKEKELQLE YLLGAFESLG
1710 1720 1730 1740 1750
KAWPRNAETQ RCYRQELCKL MCERLKLSTW KVQLGVLQSM NAFFQGLMLL
1760 1770 1780 1790 1800
EEEHADPEAL AEILLETCKS ITYSLENKTY SSVRTEALSV IELLLKKLEE
1810 1820 1830 1840
SKQWECLTSE CRVLLIESLA TMEPDSRPEL QEKAALLKKT LENLE
Length:1,845
Mass (Da):204,291
Last modified:March 15, 2005 - v2
Checksum:i5809A9208F5B4441
GO

Sequence cautioni

The sequence AAH21127 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101I → N in AI916718 (Ref. 2) Curated1
Sequence conflicti101I → N in AK127247 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055702472T → S. Corresponds to variant dbSNP:rs16916091Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354661 Genomic DNA No translation available.
AL159168 Genomic DNA No translation available.
AI916718 mRNA No translation available.
AK127247 mRNA No translation available.
AB002366 mRNA Translation: BAA20823.1
BC021127 mRNA Translation: AAH21127.1 Different initiation.
RefSeqiXP_005251907.1, XM_005251850.3
UniGeneiHs.368255

Genome annotation databases

EnsembliENST00000338205; ENSP00000339889; ENSG00000136813
GeneIDi23392
UCSCiuc064vau.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiECM29_HUMAN
AccessioniPrimary (citable) accession number: Q5VYK3
Secondary accession number(s): O15074, Q8WU82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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