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Q5VY80

- RET1L_HUMAN

UniProt

Q5VY80 - RET1L_HUMAN

Protein

Retinoic acid early transcript 1L protein

Gene

RAET1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. antigen processing and presentation Source: InterPro
    2. immune response Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinoic acid early transcript 1L protein
    Gene namesi
    Name:RAET1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16798. RAET1L.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134918665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 218193Retinoic acid early transcript 1L proteinPRO_0000320324Add
    BLAST
    Propeptidei219 – 24628Removed in mature formBy similarityPRO_0000320325Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 66By similarity
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 190By similarity
    Lipidationi218 – 2181GPI-anchor amidated glycineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ5VY80.

    Expressioni

    Tissue specificityi

    Widely expressed in non-hemopoietic and non-intestinal tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ5VY80.
    BgeeiQ5VY80.
    CleanExiHS_RAET1L.
    GenevestigatoriQ5VY80.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000286380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VY80.
    SMRiQ5VY80. Positions 29-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 11789MHC class I alpha-1 likeBy similarityAdd
    BLAST
    Regioni118 – 21093MHC class I alpha-2 likeBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000070028.
    HOVERGENiHBG052564.
    InParanoidiQ5VY80.
    KOiK07987.
    OMAiAMSFHYI.
    OrthoDBiEOG7HB59Z.
    PhylomeDBiQ5VY80.
    TreeFamiTF341724.

    Family and domain databases

    Gene3Di3.30.500.10. 1 hit.
    InterProiIPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF00129. MHC_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5VY80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC    50
    AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI 100
    LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL 150
    FDSEKRMWTT VHPGARKMKE KWENDKDVAM SFHYISMGDC IGWLEDFLMG 200
    MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI 246
    Length:246
    Mass (Da):27,509
    Last modified:December 7, 2004 - v1
    Checksum:i5FBBEA2289E32690
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261R → G.
    Corresponds to variant rs1543547 [ dbSNP | Ensembl ].
    VAR_039183
    Natural varianti85 – 851M → T.2 Publications
    Corresponds to variant rs912565 [ dbSNP | Ensembl ].
    VAR_039184
    Natural varianti106 – 1061L → R.
    Corresponds to variant rs1555696 [ dbSNP | Ensembl ].
    VAR_039185

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY039682 mRNA. Translation: AAK91503.1.
    AL355497 Genomic DNA. Translation: CAH74125.1.
    BC131600 mRNA. Translation: AAI31601.1.
    CCDSiCCDS5224.1.
    RefSeqiNP_570970.2. NM_130900.2.
    UniGeneiHs.558659.

    Genome annotation databases

    EnsembliENST00000286380; ENSP00000286380; ENSG00000155918.
    ENST00000367341; ENSP00000356310; ENSG00000155918.
    GeneIDi154064.
    KEGGihsa:154064.
    UCSCiuc011eei.2. human.

    Polymorphism databases

    DMDMi74747619.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY039682 mRNA. Translation: AAK91503.1 .
    AL355497 Genomic DNA. Translation: CAH74125.1 .
    BC131600 mRNA. Translation: AAI31601.1 .
    CCDSi CCDS5224.1.
    RefSeqi NP_570970.2. NM_130900.2.
    UniGenei Hs.558659.

    3D structure databases

    ProteinModelPortali Q5VY80.
    SMRi Q5VY80. Positions 29-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000286380.

    Polymorphism databases

    DMDMi 74747619.

    Proteomic databases

    PRIDEi Q5VY80.

    Protocols and materials databases

    DNASUi 154064.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286380 ; ENSP00000286380 ; ENSG00000155918 .
    ENST00000367341 ; ENSP00000356310 ; ENSG00000155918 .
    GeneIDi 154064.
    KEGGi hsa:154064.
    UCSCi uc011eei.2. human.

    Organism-specific databases

    CTDi 154064.
    GeneCardsi GC06M150339.
    H-InvDB HIX0032851.
    HGNCi HGNC:16798. RAET1L.
    MIMi 611047. gene.
    neXtProti NX_Q5VY80.
    PharmGKBi PA134918665.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000070028.
    HOVERGENi HBG052564.
    InParanoidi Q5VY80.
    KOi K07987.
    OMAi AMSFHYI.
    OrthoDBi EOG7HB59Z.
    PhylomeDBi Q5VY80.
    TreeFami TF341724.

    Miscellaneous databases

    GenomeRNAii 154064.
    NextBioi 87220.
    PROi Q5VY80.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5VY80.
    Bgeei Q5VY80.
    CleanExi HS_RAET1L.
    Genevestigatori Q5VY80.

    Family and domain databases

    Gene3Di 3.30.500.10. 1 hit.
    InterProi IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF00129. MHC_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3."
      Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., Gilfillan S., Beck S., Trowsdale J., Bahram S.
      Genomics 79:114-123(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-85.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-246, VARIANT THR-85.

    Entry informationi

    Entry nameiRET1L_HUMAN
    AccessioniPrimary (citable) accession number: Q5VY80
    Secondary accession number(s): A3KME4, Q8TE74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3