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Q5VY80

- RET1L_HUMAN

UniProt

Q5VY80 - RET1L_HUMAN

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Protein
Retinoic acid early transcript 1L protein
Gene
RAET1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: RefGenome
  2. natural killer cell lectin-like receptor binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. antigen processing and presentation Source: RefGenome
  2. natural killer cell mediated cytotoxicity Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid early transcript 1L protein
Gene namesi
Name:RAET1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:16798. RAET1L.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 218193Retinoic acid early transcript 1L protein
PRO_0000320324Add
BLAST
Propeptidei219 – 24628Removed in mature form By similarity
PRO_0000320325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66 By similarity
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi127 ↔ 190 By similarity
Lipidationi218 – 2181GPI-anchor amidated glycine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ5VY80.

Expressioni

Tissue specificityi

Widely expressed in non-hemopoietic and non-intestinal tissues.1 Publication

Gene expression databases

ArrayExpressiQ5VY80.
BgeeiQ5VY80.
CleanExiHS_RAET1L.
GenevestigatoriQ5VY80.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000286380.

Structurei

3D structure databases

ProteinModelPortaliQ5VY80.
SMRiQ5VY80. Positions 29-206.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 11789MHC class I alpha-1 like By similarity
Add
BLAST
Regioni118 – 21093MHC class I alpha-2 like By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000070028.
HOVERGENiHBG052564.
InParanoidiQ5VY80.
KOiK07987.
OMAiAMSFHYI.
OrthoDBiEOG7HB59Z.
PhylomeDBiQ5VY80.
TreeFamiTF341724.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VY80-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC    50
AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI 100
LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL 150
FDSEKRMWTT VHPGARKMKE KWENDKDVAM SFHYISMGDC IGWLEDFLMG 200
MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI 246
Length:246
Mass (Da):27,509
Last modified:December 7, 2004 - v1
Checksum:i5FBBEA2289E32690
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261R → G.
Corresponds to variant rs1543547 [ dbSNP | Ensembl ].
VAR_039183
Natural varianti85 – 851M → T.2 Publications
Corresponds to variant rs912565 [ dbSNP | Ensembl ].
VAR_039184
Natural varianti106 – 1061L → R.
Corresponds to variant rs1555696 [ dbSNP | Ensembl ].
VAR_039185

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY039682 mRNA. Translation: AAK91503.1.
AL355497 Genomic DNA. Translation: CAH74125.1.
BC131600 mRNA. Translation: AAI31601.1.
CCDSiCCDS5224.1.
RefSeqiNP_570970.2. NM_130900.2.
UniGeneiHs.558659.

Genome annotation databases

EnsembliENST00000286380; ENSP00000286380; ENSG00000155918.
ENST00000367341; ENSP00000356310; ENSG00000155918.
GeneIDi154064.
KEGGihsa:154064.
UCSCiuc011eei.2. human.

Polymorphism databases

DMDMi74747619.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY039682 mRNA. Translation: AAK91503.1 .
AL355497 Genomic DNA. Translation: CAH74125.1 .
BC131600 mRNA. Translation: AAI31601.1 .
CCDSi CCDS5224.1.
RefSeqi NP_570970.2. NM_130900.2.
UniGenei Hs.558659.

3D structure databases

ProteinModelPortali Q5VY80.
SMRi Q5VY80. Positions 29-206.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000286380.

Polymorphism databases

DMDMi 74747619.

Proteomic databases

PRIDEi Q5VY80.

Protocols and materials databases

DNASUi 154064.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286380 ; ENSP00000286380 ; ENSG00000155918 .
ENST00000367341 ; ENSP00000356310 ; ENSG00000155918 .
GeneIDi 154064.
KEGGi hsa:154064.
UCSCi uc011eei.2. human.

Organism-specific databases

CTDi 154064.
GeneCardsi GC06M150339.
H-InvDBi HIX0032851.
HGNCi HGNC:16798. RAET1L.
MIMi 611047. gene.
neXtProti NX_Q5VY80.
PharmGKBi PA134918665.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000070028.
HOVERGENi HBG052564.
InParanoidi Q5VY80.
KOi K07987.
OMAi AMSFHYI.
OrthoDBi EOG7HB59Z.
PhylomeDBi Q5VY80.
TreeFami TF341724.

Miscellaneous databases

GenomeRNAii 154064.
NextBioi 87220.
PROi Q5VY80.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5VY80.
Bgeei Q5VY80.
CleanExi HS_RAET1L.
Genevestigatori Q5VY80.

Family and domain databases

Gene3Di 3.30.500.10. 1 hit.
InterProi IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF00129. MHC_I. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3."
    Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., Gilfillan S., Beck S., Trowsdale J., Bahram S.
    Genomics 79:114-123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-85.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-246, VARIANT THR-85.

Entry informationi

Entry nameiRET1L_HUMAN
AccessioniPrimary (citable) accession number: Q5VY80
Secondary accession number(s): A3KME4, Q8TE74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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