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Q5VY80 (RET1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinoic acid early transcript 1L protein
Gene names
Name:RAET1L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Tissue specificity

Widely expressed in non-hemopoietic and non-intestinal tissues. Ref.1

Sequence similarities

Belongs to the MHC class I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 218193Retinoic acid early transcript 1L protein
PRO_0000320324
Propeptide219 – 24628Removed in mature form By similarity
PRO_0000320325

Regions

Region29 – 11789MHC class I alpha-1 like By similarity
Region118 – 21093MHC class I alpha-2 like By similarity

Amino acid modifications

Lipidation2181GPI-anchor amidated glycine By similarity
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Disulfide bond50 ↔ 66 By similarity
Disulfide bond127 ↔ 190 By similarity

Natural variations

Natural variant261R → G.
Corresponds to variant rs1543547 [ dbSNP | Ensembl ].
VAR_039183
Natural variant851M → T. Ref.1 Ref.3
Corresponds to variant rs912565 [ dbSNP | Ensembl ].
VAR_039184
Natural variant1061L → R.
Corresponds to variant rs1555696 [ dbSNP | Ensembl ].
VAR_039185

Sequences

Sequence LengthMass (Da)Tools
Q5VY80 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 5FBBEA2289E32690

FASTA24627,509
        10         20         30         40         50         60 
MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT 

        70         80         90        100        110        120 
FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI LTEQLLDIQL ENYTPKEPLT 

       130        140        150        160        170        180 
LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL FDSEKRMWTT VHPGARKMKE KWENDKDVAM 

       190        200        210        220        230        240 
SFHYISMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC 


FILPGI 

« Hide

References

« Hide 'large scale' references
[1]"A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3."
Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., Gilfillan S., Beck S., Trowsdale J., Bahram S.
Genomics 79:114-123(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-85.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-246, VARIANT THR-85.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY039682 mRNA. Translation: AAK91503.1.
AL355497 Genomic DNA. Translation: CAH74125.1.
BC131600 mRNA. Translation: AAI31601.1.
CCDSCCDS5224.1.
RefSeqNP_570970.2. NM_130900.2.
UniGeneHs.558659.

3D structure databases

ProteinModelPortalQ5VY80.
SMRQ5VY80. Positions 29-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000286380.

Polymorphism databases

DMDM74747619.

Proteomic databases

PRIDEQ5VY80.

Protocols and materials databases

DNASU154064.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000286380; ENSP00000286380; ENSG00000155918.
ENST00000367341; ENSP00000356310; ENSG00000155918.
GeneID154064.
KEGGhsa:154064.
UCSCuc011eei.2. human.

Organism-specific databases

CTD154064.
GeneCardsGC06M150339.
H-InvDBHIX0032851.
HGNCHGNC:16798. RAET1L.
MIM611047. gene.
neXtProtNX_Q5VY80.
PharmGKBPA134918665.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000070028.
HOVERGENHBG052564.
InParanoidQ5VY80.
KOK07987.
OMAAMSFHYI.
OrthoDBEOG7HB59Z.
PhylomeDBQ5VY80.
TreeFamTF341724.

Gene expression databases

ArrayExpressQ5VY80.
BgeeQ5VY80.
CleanExHS_RAET1L.
GenevestigatorQ5VY80.

Family and domain databases

Gene3D3.30.500.10. 1 hit.
InterProIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi154064.
NextBio87220.
PROQ5VY80.
SOURCESearch...

Entry information

Entry nameRET1L_HUMAN
AccessionPrimary (citable) accession number: Q5VY80
Secondary accession number(s): A3KME4, Q8TE74
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM