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Protein

UL16-binding protein 6

Gene

RAET1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.2 Publications

Miscellaneous

UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
UL16-binding protein 61 Publication
Alternative name(s):
Retinoic acid early transcript 1L protein
Gene namesi
Name:RAET1L
Synonyms:ULBP61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000155918.7
HGNCiHGNC:16798 RAET1L
MIMi611047 gene
neXtProtiNX_Q5VY80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi154064
OpenTargetsiENSG00000155918
PharmGKBiPA134918665

Polymorphism and mutation databases

BioMutaiRAET1L
DMDMi74747619

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000032032426 – 218UL16-binding protein 6Add BLAST193
PropeptideiPRO_0000320325219 – 246Removed in mature formBy similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66By similarity
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 190By similarity
Lipidationi218GPI-anchor amidated glycineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ5VY80
PaxDbiQ5VY80
PeptideAtlasiQ5VY80
PRIDEiQ5VY80

PTM databases

iPTMnetiQ5VY80
PhosphoSitePlusiQ5VY80

Expressioni

Tissue specificityi

Widely expressed (PubMed:11827464). Expressed in trachea (PubMed:19658097). Constitutively expressed in peripheral blood mononuclear cells, including B-cells and natural killer cells, as well as CD4+ and CD8+ T-cells and monocytes. Tends to be up-regulated in various lymphoid malignancies, including chronic lymphocytic leukemia (PubMed:28559451).3 Publications

Gene expression databases

BgeeiENSG00000155918
CleanExiHS_RAET1L

Interactioni

Subunit structurei

Interacts with KLRK1/NKG2D.2 Publications
(Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes relocalization from the cell surface to the cytoplasm and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267184EBI-16364752,EBI-458344

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127532, 1 interactor
IntActiQ5VY80, 2 interactors
STRINGi9606.ENSP00000286380

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 39Combined sources9
Helixi41 – 43Combined sources3
Helixi47 – 49Combined sources3
Beta strandi50 – 56Combined sources7
Beta strandi59 – 65Combined sources7
Helixi77 – 81Combined sources5
Helixi86 – 106Combined sources21
Beta strandi121 – 129Combined sources9
Beta strandi131 – 133Combined sources3
Beta strandi135 – 143Combined sources9
Beta strandi146 – 152Combined sources7
Turni153 – 156Combined sources4
Beta strandi157 – 163Combined sources7
Helixi166 – 174Combined sources9
Helixi176 – 187Combined sources12
Helixi189 – 202Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4S0UX-ray2.35C29-203[»]
ProteinModelPortaliQ5VY80
SMRiQ5VY80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 117MHC class I alpha-1 likeBy similarityAdd BLAST89
Regioni118 – 210MHC class I alpha-2 likeBy similarityAdd BLAST93

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
HOVERGENiHBG052564
InParanoidiQ5VY80
KOiK07987
OMAiFLVHWEE
OrthoDBiEOG091G0I62
PhylomeDBiQ5VY80
TreeFamiTF341724

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VY80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC
60 70 80 90 100
AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI
110 120 130 140 150
LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL
160 170 180 190 200
FDSEKRMWTT VHPGARKMKE KWENDKDVAM SFHYISMGDC IGWLEDFLMG
210 220 230 240
MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI
Length:246
Mass (Da):27,509
Last modified:December 7, 2004 - v1
Checksum:i5FBBEA2289E32690
GO

Polymorphismi

4 alleles have been identified in 32 Caucasian individuals: ULBP6*01 (frequency 0.483), ULBP6*02 (frequency 0.424), ULBP6*03 (frequency 0.069) and ULBP6*04 (frequency 0.024). The sequence shown is that of ULBP6*03 (PubMed:19658097). Allele ULBP6*02 has a much higher affinity for KLRK1/NKG2D than allele ULBP6*01, but elicits less-efficient cytotoxicity. This high binding affinity and limited functional potency may depend upon the presence of the Leu residue at position 106 (PubMed:28559451).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03918326R → G in allele ULBP6*01 and allele ULBP6*04. 2 PublicationsCorresponds to variant dbSNP:rs1543547Ensembl.1
Natural variantiVAR_03918485M → T in allele ULBP6*01, allele ULBP6*02 and allele ULBP6*04. 4 PublicationsCorresponds to variant dbSNP:rs912565Ensembl.1
Natural variantiVAR_039185106L → R in allele ULBP6*01; affects KLRK1-binding affinity and KLRK1-mediated cytotoxic response. 2 PublicationsCorresponds to variant dbSNP:rs1555696Ensembl.1
Natural variantiVAR_079132147T → I in allele ULBP6*01; no effect on KLRK1-binding affinity. 2 PublicationsCorresponds to variant dbSNP:rs61730071Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039682 mRNA Translation: AAK91503.1
AL355497 Genomic DNA No translation available.
BC131600 mRNA Translation: AAI31601.1
CCDSiCCDS5224.1
RefSeqiNP_570970.2, NM_130900.2
XP_011533788.1, XM_011535486.2
UniGeneiHs.558659

Genome annotation databases

EnsembliENST00000286380; ENSP00000286380; ENSG00000155918
ENST00000367341; ENSP00000356310; ENSG00000155918
GeneIDi154064
KEGGihsa:154064
UCSCiuc011eei.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiULBP6_HUMAN
AccessioniPrimary (citable) accession number: Q5VY80
Secondary accession number(s): A3KME4, Q8TE74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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