Q5VY80 (RET1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinoic acid early transcript 1L protein

Gene names

Name:

RAET1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Tissue specificity	Widely expressed in non-hemopoietic and non-intestinal tissues. Ref.1
Sequence similarities	Belongs to the MHC class I family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: InterPro anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 218	193	Retinoic acid early transcript 1L protein		PRO_0000320324
	Propeptide	219 – 246	28	Removed in mature form By similarity		PRO_0000320325
Regions
	Region	29 – 117	89	MHC class I alpha-1 like By similarity
	Region	118 – 210	93	MHC class I alpha-2 like By similarity
Amino acid modifications
	Lipidation	218	1	GPI-anchor amidated glycine By similarity
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
	Disulfide bond	50 ↔ 66		By similarity
	Disulfide bond	127 ↔ 190		By similarity
Natural variations
	Natural variant	26	1	R → G. Corresponds to variant rs1543547 [ dbSNP | Ensembl ].		VAR_039183
	Natural variant	85	1	M → T. Ref.1 Ref.3 Corresponds to variant rs912565 [ dbSNP | Ensembl ].		VAR_039184
	Natural variant	106	1	L → R. Corresponds to variant rs1555696 [ dbSNP | Ensembl ].		VAR_039185

Sequences

	Sequence		Length	Mass (Da)
	Q5VY80 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 5FBBEA2289E32690	FASTA	246	27,509
	10 20 30 40 50 60 MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT 70 80 90 100 110 120 FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI LTEQLLDIQL ENYTPKEPLT 130 140 150 160 170 180 LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL FDSEKRMWTT VHPGARKMKE KWENDKDVAM 190 200 210 220 230 240 SFHYISMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC FILPGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3." Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., Gilfillan S., Beck S., Trowsdale J., Bahram S. Genomics 79:114-123(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-85.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-246, VARIANT THR-85.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY039682 mRNA. Translation: AAK91503.1. AL355497 Genomic DNA. Translation: CAH74125.1. BC131600 mRNA. Translation: AAI31601.1.
IPI	IPI00152655.
RefSeq	NP_570970.2. NM_130900.2.
UniGene	Hs.558659.
3D structure databases
HSSP	HSSP built from PDB template 1KCG based on UniProtKB Q9BZM4.
ProteinModelPortal	Q5VY80.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000286380.
Polymorphism databases
DMDM	74747619.
Proteomic databases
PRIDE	Q5VY80.
Protocols and materials databases
DNASU	154064.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286380; ENSP00000286380; ENSG00000155918. ENST00000367341; ENSP00000356310; ENSG00000155918.
GeneID	154064.
KEGG	hsa:154064.
UCSC	uc011eei.2. human.
Organism-specific databases
CTD	154064.
GeneCards	GC06M150339.
H-InvDB	HIX0032851.
HGNC	HGNC:16798. RAET1L.
MIM	611047. gene.
neXtProt	NX_Q5VY80.
PharmGKB	PA134918665.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000070028.
HOVERGEN	HBG052564.
InParanoid	Q5VY80.
KO	K07987.
OMA	AMSFHYI.
OrthoDB	EOG42FSJH.
PhylomeDB	Q5VY80.
Gene expression databases
Bgee	Q5VY80.
CleanEx	HS_RAET1L.
Genevestigator	Q5VY80.
Family and domain databases
Gene3D	3.30.500.10. 1 hit.
InterPro	IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. [Graphical view]
Pfam	PF00129. MHC_I. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS00290. IG_MHC. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	154064.
NextBio	87220.
SOURCE	Search...

Entry information

Entry name

RET1L_HUMAN

Accession

Primary (citable) accession number: Q5VY80
Secondary accession number(s): A3KME4, Q8TE74

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.