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Protein

Platelet endothelial aggregation receptor 1

Gene

PEAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet endothelial aggregation receptor 1
Short name:
hPEAR1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 12
Short name:
Multiple EGF-like domains protein 12
Gene namesi
Name:PEAR1
Synonyms:MEGF12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33631. PEAR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 755735ExtracellularSequence analysisAdd
BLAST
Transmembranei756 – 77621HelicalSequence analysisAdd
BLAST
Topological domaini777 – 1037261CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399233.

Polymorphism and mutation databases

BioMutaiPEAR1.
DMDMi74757035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 10371017Platelet endothelial aggregation receptor 1PRO_0000309737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 91Sequence analysis
Disulfide bondi55 ↔ 65Sequence analysis
Disulfide bondi90 ↔ 101Sequence analysis
Disulfide bondi105 ↔ 114By similarity
Disulfide bondi109 ↔ 120By similarity
Disulfide bondi122 ↔ 131By similarity
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi235 ↔ 248By similarity
Disulfide bondi250 ↔ 259By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi272 ↔ 284By similarity
Disulfide bondi278 ↔ 291By similarity
Disulfide bondi293 ↔ 302By similarity
Disulfide bondi315 ↔ 327By similarity
Disulfide bondi321 ↔ 334By similarity
Disulfide bondi336 ↔ 345By similarity
Disulfide bondi404 ↔ 416By similarity
Disulfide bondi410 ↔ 423By similarity
Disulfide bondi425 ↔ 434By similarity
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi490 ↔ 502By similarity
Disulfide bondi496 ↔ 509By similarity
Disulfide bondi511 ↔ 520By similarity
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi580 ↔ 588By similarity
Disulfide bondi582 ↔ 595By similarity
Disulfide bondi597 ↔ 606By similarity
Disulfide bondi619 ↔ 630By similarity
Disulfide bondi624 ↔ 637By similarity
Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi639 ↔ 648By similarity
Disulfide bondi661 ↔ 673By similarity
Disulfide bondi667 ↔ 680By similarity
Disulfide bondi682 ↔ 691By similarity
Modified residuei925 – 9251Phosphotyrosine1 Publication
Modified residuei953 – 9531Phosphoserine1 Publication
Modified residuei1029 – 10291Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5VY43.
PRIDEiQ5VY43.

PTM databases

iPTMnetiQ5VY43.
PhosphoSiteiQ5VY43.

Expressioni

Tissue specificityi

Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.

Gene expression databases

BgeeiQ5VY43.
CleanExiHS_PEAR1.
ExpressionAtlasiQ5VY43. baseline and differential.
GenevisibleiQ5VY43. HS.

Organism-specific databases

HPAiHPA035217.

Interactioni

Subunit structurei

Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.1 Publication

Protein-protein interaction databases

BioGridi131950. 2 interactions.
IntActiQ5VY43. 1 interaction.
STRINGi9606.ENSP00000292357.

Structurei

3D structure databases

ProteinModelPortaliQ5VY43.
SMRiQ5VY43. Positions 101-734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10379EMIPROSITE-ProRule annotationAdd
BLAST
Domaini102 – 13231EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini225 – 26036EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini268 – 30336EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 34636EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini400 – 43536EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini486 – 52136EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini577 – 60731EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini615 – 64935EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini657 – 69236EGF-like 9PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi807 – 1031225Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the MEGF family.Curated
Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00730000110380.
HOGENOMiHOG000294130.
HOVERGENiHBG108333.
InParanoidiQ5VY43.
OMAiCNESCPQ.
OrthoDBiEOG72C50D.
PhylomeDBiQ5VY43.
TreeFamiTF332598.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011489. EMI_domain.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF12661. hEGF. 5 hits.
PF00053. Laminin_EGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 15 hits.
SM00180. EGF_Lam. 12 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 13 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 9 hits.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VY43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPLCPLLL LAVGLRLAGT LNPSDPNTCS FWESFTTTTK ESHSRPFSLL
60 70 80 90 100
PSEPCERPWE GPHTCPQPTV VYRTVYRQVV KTDHRQRLQC CHGFYESRGF
110 120 130 140 150
CVPLCAQECV HGRCVAPNQC QCVPGWRGDD CSSECAPGMW GPQCDKPCSC
160 170 180 190 200
GNNSSCDPKS GVCSCPSGLQ PPNCLQPCTP GYYGPACQFR CQCHGAPCDP
210 220 230 240 250
QTGACFCPAE RTGPSCDVSC SQGTSGFFCP STHSCQNGGV FQTPQGSCSC
260 270 280 290 300
PPGWMGTICS LPCPEGFHGP NCSQECRCHN GGLCDRFTGQ CRCAPGYTGD
310 320 330 340 350
RCREECPVGR FGQDCAETCD CAPDARCFPA NGACLCEHGF TGDRCTDRLC
360 370 380 390 400
PDGFYGLSCQ APCTCDREHS LSCHPMNGEC SCLPGWAGLH CNESCPQDTH
410 420 430 440 450
GPGCQEHCLC LHGGVCQATS GLCQCAPGYT GPHCASLCPP DTYGVNCSAR
460 470 480 490 500
CSCENAIACS PIDGECVCKE GWQRGNCSVP CPPGTWGFSC NASCQCAHEA
510 520 530 540 550
VCSPQTGACT CTPGWHGAHC QLPCPKGQFG EGCASRCDCD HSDGCDPVHG
560 570 580 590 600
RCQCQAGWMG ARCHLSCPEG LWGVNCSNTC TCKNGGTCLP ENGNCVCAPG
610 620 630 640 650
FRGPSCQRSC QPGRYGKRCV PCKCANHSFC HPSNGTCYCL AGWTGPDCSQ
660 670 680 690 700
PCPPGHWGEN CAQTCQCHHG GTCHPQDGSC ICPLGWTGHH CLEGCPLGTF
710 720 730 740 750
GANCSQPCQC GPGEKCHPET GACVCPPGHS GAPCRIGIQE PFTVMPTTPV
760 770 780 790 800
AYNSLGAVIG IAVLGSLVVA LVALFIGYRH WQKGKEHHHL AVAYSSGRLD
810 820 830 840 850
GSEYVMPDVP PSYSHYYSNP SYHTLSQCSP NPPPPNKVPG PLFASLQNPE
860 870 880 890 900
RPGGAQGHDN HTTLPADWKH RREPPPGPLD RGSSRLDRSY SYSYSNGPGP
910 920 930 940 950
FYNKGLISEE ELGASVASLS SENPYATIRD LPSLPGGPRE SSYMEMKGPP
960 970 980 990 1000
SGSPPRQPPQ FWDSQRRRQP QPQRDSGTYE QPSPLIHDRD SVGSQPPLPP
1010 1020 1030
GLPPGHYDSP KNSHIPGHYD LPPVRHPPSP PLRRQDR
Length:1,037
Mass (Da):110,666
Last modified:December 7, 2004 - v1
Checksum:iD0DBB323D5F8C7E3
GO

Sequence cautioni

The sequence BAB84947.1 differs from that shown. Reason: Frameshift at position 557. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341S → P.
Corresponds to variant rs1952294 [ dbSNP | Ensembl ].
VAR_048978
Natural varianti848 – 8481N → K.
Corresponds to variant rs822442 [ dbSNP | Ensembl ].
VAR_061158
Natural varianti885 – 8851R → H.
Corresponds to variant rs11264581 [ dbSNP | Ensembl ].
VAR_048979
Natural varianti903 – 9031N → D.
Corresponds to variant rs12137505 [ dbSNP | Ensembl ].
VAR_048980

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158169, AL356104 Genomic DNA. Translation: CAH70011.1.
AL356104, AL158169 Genomic DNA. Translation: CAH72941.1.
AK074121 mRNA. Translation: BAB84947.1. Frameshift.
CCDSiCCDS30892.1.
RefSeqiNP_001073940.1. NM_001080471.1.
XP_005245198.1. XM_005245141.2.
XP_011507812.1. XM_011509510.1.
UniGeneiHs.142003.

Genome annotation databases

EnsembliENST00000292357; ENSP00000292357; ENSG00000187800.
ENST00000338302; ENSP00000344465; ENSG00000187800.
GeneIDi375033.
KEGGihsa:375033.
UCSCiuc001fqj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158169, AL356104 Genomic DNA. Translation: CAH70011.1.
AL356104, AL158169 Genomic DNA. Translation: CAH72941.1.
AK074121 mRNA. Translation: BAB84947.1. Frameshift.
CCDSiCCDS30892.1.
RefSeqiNP_001073940.1. NM_001080471.1.
XP_005245198.1. XM_005245141.2.
XP_011507812.1. XM_011509510.1.
UniGeneiHs.142003.

3D structure databases

ProteinModelPortaliQ5VY43.
SMRiQ5VY43. Positions 101-734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131950. 2 interactions.
IntActiQ5VY43. 1 interaction.
STRINGi9606.ENSP00000292357.

PTM databases

iPTMnetiQ5VY43.
PhosphoSiteiQ5VY43.

Polymorphism and mutation databases

BioMutaiPEAR1.
DMDMi74757035.

Proteomic databases

PaxDbiQ5VY43.
PRIDEiQ5VY43.

Protocols and materials databases

DNASUi375033.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292357; ENSP00000292357; ENSG00000187800.
ENST00000338302; ENSP00000344465; ENSG00000187800.
GeneIDi375033.
KEGGihsa:375033.
UCSCiuc001fqj.1. human.

Organism-specific databases

CTDi375033.
GeneCardsiPEAR1.
H-InvDBHIX0001178.
HGNCiHGNC:33631. PEAR1.
HPAiHPA035217.
MIMi610278. gene.
neXtProtiNX_Q5VY43.
PharmGKBiPA162399233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00730000110380.
HOGENOMiHOG000294130.
HOVERGENiHBG108333.
InParanoidiQ5VY43.
OMAiCNESCPQ.
OrthoDBiEOG72C50D.
PhylomeDBiQ5VY43.
TreeFamiTF332598.

Miscellaneous databases

GenomeRNAii375033.
NextBioi100378.
PROiQ5VY43.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VY43.
CleanExiHS_PEAR1.
ExpressionAtlasiQ5VY43. baseline and differential.
GenevisibleiQ5VY43. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011489. EMI_domain.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF12661. hEGF. 5 hits.
PF00053. Laminin_EGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 15 hits.
SM00180. EGF_Lam. 12 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 13 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 9 hits.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation."
    Nanda N., Bao M., Lin H., Clauser K., Komuves L., Quertermous T., Conley P.B., Phillips D.R., Hart M.J.
    J. Biol. Chem. 280:24680-24689(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 873-881; 905-928; 930-938; 948-966; 990-1011 AND 1026-1034, PHOSPHORYLATION AT TYR-925; SER-953 AND SER-1029, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH SHC2, SUBCELLULAR LOCATION.
    Tissue: Platelet.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-1037.
    Tissue: Spleen.

Entry informationi

Entry nameiPEAR1_HUMAN
AccessioniPrimary (citable) accession number: Q5VY43
Secondary accession number(s): Q8TEK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 7, 2004
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.