Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Immediate early response gene 5 protein

Gene

IER5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 5 protein
Gene namesi
Name:IER5
ORF Names:PP4583, SBBI48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:5393. IER5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29640.

Polymorphism and mutation databases

BioMutaiIER5.
DMDMi116242521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Immediate early response gene 5 proteinPRO_0000190438Add
BLAST

Proteomic databases

MaxQBiQ5VY09.
PaxDbiQ5VY09.
PRIDEiQ5VY09.

PTM databases

PhosphoSiteiQ5VY09.

Expressioni

Gene expression databases

BgeeiQ5VY09.
CleanExiHS_IER5.
GenevisibleiQ5VY09. HS.

Organism-specific databases

HPAiHPA029894.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1774000,EBI-1774000
HSF1Q006133EBI-1774000,EBI-719620
MINK1Q8N4C8-42EBI-1774000,EBI-11475194
RPS6KB1P234432EBI-1774000,EBI-1775921

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi119430. 5 interactions.
IntActiQ5VY09. 6 interactions.
STRINGi9606.ENSP00000356549.

Structurei

3D structure databases

ProteinModelPortaliQ5VY09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410J10V. Eukaryota.
ENOG4111NZJ. LUCA.
GeneTreeiENSGT00730000111126.
HOGENOMiHOG000112999.
HOVERGENiHBG105469.
InParanoidiQ5VY09.
OMAiDMNPWST.
OrthoDBiEOG7XH6R3.
PhylomeDBiQ5VY09.
TreeFamiTF331376.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VY09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD
60 70 80 90 100
PCPGLYLAGP AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP
110 120 130 140 150
QPERSSVSDA PRVGDEVPVA TVTGVGDVFQ GGEADATEAA WSRVEGPRQA
160 170 180 190 200
AAREAEGTAG GWGVFPEVSR AARRPCGCPL GGEDPPGTPA ATPRAACCCA
210 220 230 240 250
PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK KPRRNLEQPP
260 270 280 290 300
SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE
310 320
AAEPGQICCD KPVLRDMNPW STAIVAF
Length:327
Mass (Da):33,704
Last modified:October 17, 2006 - v3
Checksum:iE841C5FAF6520A12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611G → A in CAB91983 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921R → H.1 Publication
Corresponds to variant rs3747955 [ dbSNP | Ensembl ].
VAR_028404
Natural varianti168 – 1681V → I.
Corresponds to variant rs3747954 [ dbSNP | Ensembl ].
VAR_028405
Natural varianti194 – 1941R → G.1 Publication
Corresponds to variant rs1416829 [ dbSNP | Ensembl ].
VAR_028406
Natural varianti202 – 2021Q → R.5 Publications
Corresponds to variant rs1361365 [ dbSNP | Ensembl ].
VAR_028407
Natural varianti285 – 2851P → S.
Corresponds to variant rs3747951 [ dbSNP | Ensembl ].
VAR_028408

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA. Translation: AAF44348.1.
AJ251089 mRNA. Translation: CAB91983.1.
AF258581 mRNA. Translation: AAG23784.1.
AK314830 mRNA. Translation: BAG37350.1.
AL356267 Genomic DNA. Translation: CAH72306.1.
BC000128 mRNA. Translation: AAH00128.1.
CCDSiCCDS1343.1.
RefSeqiNP_057629.2. NM_016545.4.
UniGeneiHs.15725.

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783.
GeneIDi51278.
KEGGihsa:51278.
UCSCiuc001got.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA. Translation: AAF44348.1.
AJ251089 mRNA. Translation: CAB91983.1.
AF258581 mRNA. Translation: AAG23784.1.
AK314830 mRNA. Translation: BAG37350.1.
AL356267 Genomic DNA. Translation: CAH72306.1.
BC000128 mRNA. Translation: AAH00128.1.
CCDSiCCDS1343.1.
RefSeqiNP_057629.2. NM_016545.4.
UniGeneiHs.15725.

3D structure databases

ProteinModelPortaliQ5VY09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119430. 5 interactions.
IntActiQ5VY09. 6 interactions.
STRINGi9606.ENSP00000356549.

PTM databases

PhosphoSiteiQ5VY09.

Polymorphism and mutation databases

BioMutaiIER5.
DMDMi116242521.

Proteomic databases

MaxQBiQ5VY09.
PaxDbiQ5VY09.
PRIDEiQ5VY09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783.
GeneIDi51278.
KEGGihsa:51278.
UCSCiuc001got.5. human.

Organism-specific databases

CTDi51278.
GeneCardsiIER5.
HGNCiHGNC:5393. IER5.
HPAiHPA029894.
MIMi607177. gene.
neXtProtiNX_Q5VY09.
PharmGKBiPA29640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J10V. Eukaryota.
ENOG4111NZJ. LUCA.
GeneTreeiENSGT00730000111126.
HOGENOMiHOG000112999.
HOVERGENiHBG105469.
InParanoidiQ5VY09.
OMAiDMNPWST.
OrthoDBiEOG7XH6R3.
PhylomeDBiQ5VY09.
TreeFamiTF331376.

Miscellaneous databases

GenomeRNAii51278.
NextBioi54497.
PROiQ5VY09.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VY09.
CleanExiHS_IER5.
GenevisibleiQ5VY09. HS.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcript profile of dendritic cells: insights into dendritic cell biology and identification of novel genes."
    Zhang W., Wan T., Yuan Z., He L., Li N., Cao X.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-202.
    Tissue: Dendritic cell.
  2. "Isolation and characterisation of a 34 kDa protein associated with the lysosomal/autophagic compartment."
    Biederbick A., Lenz H.J., Elsaesser H.P.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-202.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-92; GLY-194 AND ARG-202.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-202.
    Tissue: Testis.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-202.
    Tissue: Cervix.

Entry informationi

Entry nameiIER5_HUMAN
AccessioniPrimary (citable) accession number: Q5VY09
Secondary accession number(s): B2RBV3
, Q8WY68, Q9NY49, Q9NZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: May 11, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.