Q5VY09 (IER5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immediate early response gene 5 protein

Gene names

Name:	IER5
ORF Names:	PP4583, SBBI48

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the IER family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Immediate early response gene 5 protein		PRO_0000190438
Natural variations
	Natural variant	92	1	R → H. Ref.3 Corresponds to variant rs3747955 [ dbSNP | Ensembl ].		VAR_028404
	Natural variant	168	1	V → I. Corresponds to variant rs3747954 [ dbSNP | Ensembl ].		VAR_028405
	Natural variant	194	1	R → G. Ref.3 Corresponds to variant rs1416829 [ dbSNP | Ensembl ].		VAR_028406
	Natural variant	202	1	Q → R. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Corresponds to variant rs1361365 [ dbSNP | Ensembl ].		VAR_028407
	Natural variant	285	1	P → S. Corresponds to variant rs3747951 [ dbSNP | Ensembl ].		VAR_028408
Experimental info
	Sequence conflict	161	1	G → A in CAB91983. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5VY09 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: E841C5FAF6520A12	FASTA	327	33,704
	10 20 30 40 50 60 MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD PCPGLYLAGP 70 80 90 100 110 120 AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP QPERSSVSDA PRVGDEVPVA 130 140 150 160 170 180 TVTGVGDVFQ GGEADATEAA WSRVEGPRQA AAREAEGTAG GWGVFPEVSR AARRPCGCPL 190 200 210 220 230 240 GGEDPPGTPA ATPRAACCCA PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK 250 260 270 280 290 300 KPRRNLEQPP SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE 310 320 AAEPGQICCD KPVLRDMNPW STAIVAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcript profile of dendritic cells: insights into dendritic cell biology and identification of novel genes." Zhang W., Wan T., Yuan Z., He L., Li N., Cao X. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-202. Tissue: Dendritic cell.
[2]	"Isolation and characterisation of a 34 kDa protein associated with the lysosomal/autophagic compartment." Biederbick A., Lenz H.J., Elsaesser H.P. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-202.
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-92; GLY-194 AND ARG-202.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-202. Tissue: Testis.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-202. Tissue: Cervix.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF178984 mRNA. Translation: AAF44348.1. AJ251089 mRNA. Translation: CAB91983.1. AF258581 mRNA. Translation: AAG23784.1. AK314830 mRNA. Translation: BAG37350.1. AL356267 Genomic DNA. Translation: CAH72306.1. BC000128 mRNA. Translation: AAH00128.1.
IPI	IPI00292208.
RefSeq	NP_057629.2. NM_016545.4.
UniGene	Hs.15725.
3D structure databases
ProteinModelPortal	Q5VY09.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5VY09. 1 interaction.
STRING	Q5VY09.
Polymorphism databases
DMDM	116242521.
Proteomic databases
PRIDE	Q5VY09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367577; ENSP00000356549; ENSG00000162783.
GeneID	51278.
KEGG	hsa:51278.
NMPDR	fig|9606.3.peg.2722.
UCSC	uc001got.2. human.
Organism-specific databases
CTD	51278.
GeneCards	GC01P181057.
H-InvDB	HIX0001396.
HGNC	HGNC:5393. IER5.
HPA	HPA029894.
MIM	607177. gene.
neXtProt	NX_Q5VY09.
PharmGKB	PA29640.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08966.
GeneTree	ENSGT00530000064009.
HOGENOM	HBG268105.
HOVERGEN	HBG105469.
InParanoid	Q5VY09.
OMA	CDKPVLR.
OrthoDB	EOG40P47J.
PhylomeDB	Q5VY09.
Gene expression databases
ArrayExpress	Q5VY09.
Bgee	Q5VY09.
CleanEx	HS_IER5.
Genevestigator	Q5VY09.
GermOnline	ENSG00000162783. Homo sapiens.
Family and domain databases
InterPro	IPR008653. IER. [Graphical view]
PANTHER	PTHR15895. IER. 1 hit.
Pfam	PF05760. IER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	54497.
SOURCE	Search...

Entry information

Entry name

IER5_HUMAN

Accession

Primary (citable) accession number: Q5VY09
Secondary accession number(s): B2RBV3 , Q8WY68, Q9NY49, Q9NZP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.