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Protein

Immediate early response gene 5 protein

Gene

IER5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).5 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • cellular response to heat Source: UniProtKB
  • positive regulation of cellular response to heat Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Repressor
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 5 protein
Gene namesi
Name:IER5
ORF Names:PP4583, SBBI48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162783.10.
HGNCiHGNC:5393. IER5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51278.
OpenTargetsiENSG00000162783.
PharmGKBiPA29640.

Polymorphism and mutation databases

BioMutaiIER5.
DMDMi116242521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904381 – 327Immediate early response gene 5 proteinAdd BLAST327

Proteomic databases

MaxQBiQ5VY09.
PaxDbiQ5VY09.
PeptideAtlasiQ5VY09.
PRIDEiQ5VY09.

PTM databases

iPTMnetiQ5VY09.
PhosphoSitePlusiQ5VY09.

Expressioni

Tissue specificityi

Expressed in acute myeloid leukemia (AML) cells.1 Publication

Inductioni

Up-regulated by heat shock in a heat shock HSF1-dependent manner (PubMed:25355627). Up-regulated by ionizing radiation (PubMed:19238419).2 Publications

Gene expression databases

BgeeiENSG00000162783.
CleanExiHS_IER5.
GenevisibleiQ5VY09. HS.

Organism-specific databases

HPAiHPA029894.

Interactioni

Subunit structurei

Monomer (PubMed:26496226). Homodimer (PubMed:26496226). Associates with the catalytic subunit of protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Interacts (via N- and C-terminal regions) with PPP2R2B (PubMed:25816751, PubMed:26496226). Interacts with PPP2R2A, PPP2R2C and PPP2R2D (PubMed:25816751). Interacts (via N-terminus) with RPS6KB1 (PubMed:26496226). Interacts (via central region) with HSF1; this interaction promotes PPP2CA-induced HSF1 dephosphorylation, leading to enhanced HSF1 transcriptional activity (PubMed:25816751, PubMed:26496226, PubMed:26754925).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119430. 5 interactors.
IntActiQ5VY09. 10 interactors.
STRINGi9606.ENSP00000356549.

Structurei

3D structure databases

ProteinModelPortaliQ5VY09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410J10V. Eukaryota.
ENOG4111NZJ. LUCA.
GeneTreeiENSGT00900000141021.
HOGENOMiHOG000112999.
HOVERGENiHBG105469.
InParanoidiQ5VY09.
OMAiMNPWSTA.
OrthoDBiEOG091G0HLK.
PhylomeDBiQ5VY09.
TreeFamiTF331376.

Family and domain databases

InterProiView protein in InterPro
IPR008653. IER.
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiView protein in Pfam
PF05760. IER. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5VY09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD
60 70 80 90 100
PCPGLYLAGP AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP
110 120 130 140 150
QPERSSVSDA PRVGDEVPVA TVTGVGDVFQ GGEADATEAA WSRVEGPRQA
160 170 180 190 200
AAREAEGTAG GWGVFPEVSR AARRPCGCPL GGEDPPGTPA ATPRAACCCA
210 220 230 240 250
PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK KPRRNLEQPP
260 270 280 290 300
SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE
310 320
AAEPGQICCD KPVLRDMNPW STAIVAF
Length:327
Mass (Da):33,704
Last modified:October 17, 2006 - v3
Checksum:iE841C5FAF6520A12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161G → A in CAB91983 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02840492R → H1 PublicationCorresponds to variant dbSNP:rs3747955Ensembl.1
Natural variantiVAR_028405168V → I. Corresponds to variant dbSNP:rs3747954Ensembl.1
Natural variantiVAR_028406194R → G1 PublicationCorresponds to variant dbSNP:rs1416829Ensembl.1
Natural variantiVAR_028407202Q → R5 PublicationsCorresponds to variant dbSNP:rs1361365Ensembl.1
Natural variantiVAR_028408285P → S. Corresponds to variant dbSNP:rs3747951Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA. Translation: AAF44348.1.
AJ251089 mRNA. Translation: CAB91983.1.
AF258581 mRNA. Translation: AAG23784.1.
AK314830 mRNA. Translation: BAG37350.1.
AL356267 Genomic DNA. No translation available.
BC000128 mRNA. Translation: AAH00128.1.
CCDSiCCDS1343.1.
RefSeqiNP_057629.2. NM_016545.4.
UniGeneiHs.15725.

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783.
GeneIDi51278.
KEGGihsa:51278.
UCSCiuc001got.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIER5_HUMAN
AccessioniPrimary (citable) accession number: Q5VY09
Secondary accession number(s): B2RBV3
, Q8WY68, Q9NY49, Q9NZP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: October 25, 2017
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families