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Protein

Immediate early response gene 5 protein

Gene

IER5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 5 protein
Gene namesi
Name:IER5
ORF Names:PP4583, SBBI48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:5393. IER5.

Pathology & Biotechi

Organism-specific databases

DisGeNETi51278.
OpenTargetsiENSG00000162783.
PharmGKBiPA29640.

Polymorphism and mutation databases

BioMutaiIER5.
DMDMi116242521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904381 – 327Immediate early response gene 5 proteinAdd BLAST327

Proteomic databases

MaxQBiQ5VY09.
PaxDbiQ5VY09.
PeptideAtlasiQ5VY09.
PRIDEiQ5VY09.

PTM databases

iPTMnetiQ5VY09.
PhosphoSitePlusiQ5VY09.

Expressioni

Gene expression databases

BgeeiENSG00000162783.
CleanExiHS_IER5.
GenevisibleiQ5VY09. HS.

Organism-specific databases

HPAiHPA029894.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1774000,EBI-1774000
HSF1Q006133EBI-1774000,EBI-719620
MINK1Q8N4C8-42EBI-1774000,EBI-11475194
RPS6KB1P234432EBI-1774000,EBI-1775921

Protein-protein interaction databases

BioGridi119430. 5 interactors.
IntActiQ5VY09. 6 interactors.
STRINGi9606.ENSP00000356549.

Structurei

3D structure databases

ProteinModelPortaliQ5VY09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410J10V. Eukaryota.
ENOG4111NZJ. LUCA.
GeneTreeiENSGT00730000111126.
HOGENOMiHOG000112999.
HOVERGENiHBG105469.
InParanoidiQ5VY09.
OMAiDMNPWST.
OrthoDBiEOG091G0HLK.
PhylomeDBiQ5VY09.
TreeFamiTF331376.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VY09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD
60 70 80 90 100
PCPGLYLAGP AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP
110 120 130 140 150
QPERSSVSDA PRVGDEVPVA TVTGVGDVFQ GGEADATEAA WSRVEGPRQA
160 170 180 190 200
AAREAEGTAG GWGVFPEVSR AARRPCGCPL GGEDPPGTPA ATPRAACCCA
210 220 230 240 250
PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK KPRRNLEQPP
260 270 280 290 300
SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE
310 320
AAEPGQICCD KPVLRDMNPW STAIVAF
Length:327
Mass (Da):33,704
Last modified:October 17, 2006 - v3
Checksum:iE841C5FAF6520A12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161G → A in CAB91983 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02840492R → H.1 PublicationCorresponds to variant rs3747955dbSNPEnsembl.1
Natural variantiVAR_028405168V → I.Corresponds to variant rs3747954dbSNPEnsembl.1
Natural variantiVAR_028406194R → G.1 PublicationCorresponds to variant rs1416829dbSNPEnsembl.1
Natural variantiVAR_028407202Q → R.5 PublicationsCorresponds to variant rs1361365dbSNPEnsembl.1
Natural variantiVAR_028408285P → S.Corresponds to variant rs3747951dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA. Translation: AAF44348.1.
AJ251089 mRNA. Translation: CAB91983.1.
AF258581 mRNA. Translation: AAG23784.1.
AK314830 mRNA. Translation: BAG37350.1.
AL356267 Genomic DNA. Translation: CAH72306.1.
BC000128 mRNA. Translation: AAH00128.1.
CCDSiCCDS1343.1.
RefSeqiNP_057629.2. NM_016545.4.
UniGeneiHs.15725.

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783.
GeneIDi51278.
KEGGihsa:51278.
UCSCiuc001got.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA. Translation: AAF44348.1.
AJ251089 mRNA. Translation: CAB91983.1.
AF258581 mRNA. Translation: AAG23784.1.
AK314830 mRNA. Translation: BAG37350.1.
AL356267 Genomic DNA. Translation: CAH72306.1.
BC000128 mRNA. Translation: AAH00128.1.
CCDSiCCDS1343.1.
RefSeqiNP_057629.2. NM_016545.4.
UniGeneiHs.15725.

3D structure databases

ProteinModelPortaliQ5VY09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119430. 5 interactors.
IntActiQ5VY09. 6 interactors.
STRINGi9606.ENSP00000356549.

PTM databases

iPTMnetiQ5VY09.
PhosphoSitePlusiQ5VY09.

Polymorphism and mutation databases

BioMutaiIER5.
DMDMi116242521.

Proteomic databases

MaxQBiQ5VY09.
PaxDbiQ5VY09.
PeptideAtlasiQ5VY09.
PRIDEiQ5VY09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783.
GeneIDi51278.
KEGGihsa:51278.
UCSCiuc001got.5. human.

Organism-specific databases

CTDi51278.
DisGeNETi51278.
GeneCardsiIER5.
HGNCiHGNC:5393. IER5.
HPAiHPA029894.
MIMi607177. gene.
neXtProtiNX_Q5VY09.
OpenTargetsiENSG00000162783.
PharmGKBiPA29640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J10V. Eukaryota.
ENOG4111NZJ. LUCA.
GeneTreeiENSGT00730000111126.
HOGENOMiHOG000112999.
HOVERGENiHBG105469.
InParanoidiQ5VY09.
OMAiDMNPWST.
OrthoDBiEOG091G0HLK.
PhylomeDBiQ5VY09.
TreeFamiTF331376.

Miscellaneous databases

GenomeRNAii51278.
PROiQ5VY09.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162783.
CleanExiHS_IER5.
GenevisibleiQ5VY09. HS.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIER5_HUMAN
AccessioniPrimary (citable) accession number: Q5VY09
Secondary accession number(s): B2RBV3
, Q8WY68, Q9NY49, Q9NZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.