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Q5VXT5

- SYPL2_HUMAN

UniProt

Q5VXT5 - SYPL2_HUMAN

Protein

Synaptophysin-like protein 2

Gene

SYPL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: Ensembl
    2. substantia nigra development Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptophysin-like protein 2
    Gene namesi
    Name:SYPL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27638. SYPL2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity
    Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. integral component of synaptic vesicle membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670846.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Synaptophysin-like protein 2PRO_0000179166Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ5VXT5.
    PRIDEiQ5VXT5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VXT5.
    BgeeiQ5VXT5.
    CleanExiHS_SYPL2.
    GenevestigatoriQ5VXT5.

    Organism-specific databases

    HPAiHPA018032.

    Interactioni

    Protein-protein interaction databases

    BioGridi129915. 1 interaction.
    STRINGi9606.ENSP00000358888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VXT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 11662VesicularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 21342VesicularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 27238CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 238209MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptophysin/synaptobrevin family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82723.
    HOGENOMiHOG000252913.
    HOVERGENiHBG006681.
    InParanoidiQ5VXT5.
    OMAiYTMAALI.
    OrthoDBiEOG7WT43S.
    PhylomeDBiQ5VXT5.
    TreeFamiTF315804.

    Family and domain databases

    InterProiIPR008253. Marvel.
    IPR001285. Synaptophysin/porin.
    [Graphical view]
    PANTHERiPTHR10306. PTHR10306. 1 hit.
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PRINTSiPR00220. SYNAPTOPHYSN.
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VXT5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF    50
    GSCGSYSGET GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES 100
    SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH NLYTENKRFP 150
    LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV 200
    CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQGQDQDQ 250
    DQDQGQGPSQ ESAAEQGAVE KQ 272

    Note: No experimental confirmation available.

    Length:272
    Mass (Da):30,156
    Last modified:December 7, 2004 - v1
    Checksum:i0A5998BA30B35A75
    GO
    Isoform 2 (identifier: Q5VXT5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):25,696
    Checksum:i57B7CE8C9E3BC9F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991E → G in BAD18604. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei217 – 27256LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2. 1 PublicationVSP_014268Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB158472 mRNA. Translation: BAM08466.1.
    AK131459 mRNA. Translation: BAD18604.1.
    AK289513 mRNA. Translation: BAF82202.1.
    AK293082 mRNA. Translation: BAF85771.1.
    AL356735, AL355145 Genomic DNA. Translation: CAH70888.1.
    AL355145, AL356735 Genomic DNA. Translation: CAI22943.1.
    CH471122 Genomic DNA. Translation: EAW56384.1.
    CCDSiCCDS41365.1. [Q5VXT5-1]
    RefSeqiNP_001035799.1. NM_001040709.1. [Q5VXT5-1]
    XP_005270830.1. XM_005270773.2. [Q5VXT5-2]
    UniGeneiHs.528366.

    Genome annotation databases

    EnsembliENST00000369872; ENSP00000358888; ENSG00000143028. [Q5VXT5-1]
    GeneIDi284612.
    KEGGihsa:284612.
    UCSCiuc001dxo.2. human. [Q5VXT5-2]
    uc001dxp.3. human. [Q5VXT5-1]

    Polymorphism databases

    DMDMi68566071.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB158472 mRNA. Translation: BAM08466.1 .
    AK131459 mRNA. Translation: BAD18604.1 .
    AK289513 mRNA. Translation: BAF82202.1 .
    AK293082 mRNA. Translation: BAF85771.1 .
    AL356735 , AL355145 Genomic DNA. Translation: CAH70888.1 .
    AL355145 , AL356735 Genomic DNA. Translation: CAI22943.1 .
    CH471122 Genomic DNA. Translation: EAW56384.1 .
    CCDSi CCDS41365.1. [Q5VXT5-1 ]
    RefSeqi NP_001035799.1. NM_001040709.1. [Q5VXT5-1 ]
    XP_005270830.1. XM_005270773.2. [Q5VXT5-2 ]
    UniGenei Hs.528366.

    3D structure databases

    ProteinModelPortali Q5VXT5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129915. 1 interaction.
    STRINGi 9606.ENSP00000358888.

    Polymorphism databases

    DMDMi 68566071.

    Proteomic databases

    MaxQBi Q5VXT5.
    PRIDEi Q5VXT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369872 ; ENSP00000358888 ; ENSG00000143028 . [Q5VXT5-1 ]
    GeneIDi 284612.
    KEGGi hsa:284612.
    UCSCi uc001dxo.2. human. [Q5VXT5-2 ]
    uc001dxp.3. human. [Q5VXT5-1 ]

    Organism-specific databases

    CTDi 284612.
    GeneCardsi GC01P110010.
    HGNCi HGNC:27638. SYPL2.
    HPAi HPA018032.
    neXtProti NX_Q5VXT5.
    PharmGKBi PA142670846.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82723.
    HOGENOMi HOG000252913.
    HOVERGENi HBG006681.
    InParanoidi Q5VXT5.
    OMAi YTMAALI.
    OrthoDBi EOG7WT43S.
    PhylomeDBi Q5VXT5.
    TreeFami TF315804.

    Miscellaneous databases

    GenomeRNAii 284612.
    NextBioi 94995.
    PROi Q5VXT5.

    Gene expression databases

    ArrayExpressi Q5VXT5.
    Bgeei Q5VXT5.
    CleanExi HS_SYPL2.
    Genevestigatori Q5VXT5.

    Family and domain databases

    InterProi IPR008253. Marvel.
    IPR001285. Synaptophysin/porin.
    [Graphical view ]
    PANTHERi PTHR10306. PTHR10306. 1 hit.
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PRINTSi PR00220. SYNAPTOPHYSN.
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes."
      Satoh K., Akatsu H., Yamamoto T., Kosaka K., Yokota H., Yamada T.
      Brain Res. 1441:9-16(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum, Testis and Uterus.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYPL2_HUMAN
    AccessioniPrimary (citable) accession number: Q5VXT5
    Secondary accession number(s): A8K0E8
    , A8KAL7, I0IT67, Q6ZMX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3