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Protein

Synaptophysin-like protein 2

Gene

SYPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Gene namesi
Name:SYPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143028.8
HGNCiHGNC:27638 SYPL2
neXtProtiNX_Q5VXT5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 116VesicularSequence analysisAdd BLAST62
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 213VesicularSequence analysisAdd BLAST42
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 272CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi284612
OpenTargetsiENSG00000143028
PharmGKBiPA142670846

Polymorphism and mutation databases

BioMutaiSYPL2
DMDMi68566071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791661 – 272Synaptophysin-like protein 2Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5VXT5
PaxDbiQ5VXT5
PeptideAtlasiQ5VXT5
PRIDEiQ5VXT5

PTM databases

PhosphoSitePlusiQ5VXT5

Expressioni

Gene expression databases

BgeeiENSG00000143028
CleanExiHS_SYPL2
GenevisibleiQ5VXT5 HS

Organism-specific databases

HPAiHPA018032

Interactioni

Protein-protein interaction databases

BioGridi129915, 12 interactors
IntActiQ5VXT5, 1 interactor
MINTiQ5VXT5

Structurei

3D structure databases

ProteinModelPortaliQ5VXT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 238MARVELPROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF8N Eukaryota
ENOG4111ZDM LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ5VXT5
OMAiNRVQYEM
OrthoDBiEOG091G0ZEI
PhylomeDBiQ5VXT5
TreeFamiTF315804

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VXT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES
110 120 130 140 150
SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH NLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQGQDQDQ
260 270
DQDQGQGPSQ ESAAEQGAVE KQ
Note: No experimental confirmation available.
Length:272
Mass (Da):30,156
Last modified:December 7, 2004 - v1
Checksum:i0A5998BA30B35A75
GO
Isoform 2 (identifier: Q5VXT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):25,696
Checksum:i57B7CE8C9E3BC9F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99E → G in BAD18604 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014268217 – 272LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158472 mRNA Translation: BAM08466.1
AK131459 mRNA Translation: BAD18604.1
AK289513 mRNA Translation: BAF82202.1
AK293082 mRNA Translation: BAF85771.1
AL355145 Genomic DNA No translation available.
AL356735 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56384.1
CCDSiCCDS41365.1 [Q5VXT5-1]
RefSeqiNP_001035799.1, NM_001040709.1 [Q5VXT5-1]
UniGeneiHs.528366

Genome annotation databases

EnsembliENST00000369872; ENSP00000358888; ENSG00000143028 [Q5VXT5-1]
GeneIDi284612
KEGGihsa:284612
UCSCiuc001dxp.4 human [Q5VXT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYPL2_HUMAN
AccessioniPrimary (citable) accession number: Q5VXT5
Secondary accession number(s): A8K0E8
, A8KAL7, I0IT67, Q6ZMX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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