Q5VXT5 (SYPL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptophysin-like protein 2

Gene names

Name:

SYPL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum By similarity.
Sequence similarities	Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle Inferred from electronic annotation. Source: InterPro
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VXT5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q5VXT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Synaptophysin-like protein 2		PRO_0000179166
Regions
	Topological domain	1 – 33	33	Cytoplasmic Potential
	Transmembrane	34 – 54	21	Helical; Potential
	Topological domain	55 – 116	62	Vesicular Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Topological domain	138 – 150	13	Cytoplasmic Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Topological domain	172 – 213	42	Vesicular Potential
	Transmembrane	214 – 234	21	Helical; Potential
	Topological domain	235 – 272	38	Cytoplasmic Potential
	Domain	30 – 238	209	MARVEL
Amino acid modifications
	Glycosylation	213	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	217 – 272	56	LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2.		VSP_014268
Experimental info
	Sequence conflict	99	1	E → G in BAD18604. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 0A5998BA30B35A75	FASTA	272	30,156
	10 20 30 40 50 60 MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET 70 80 90 100 110 120 GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES SSKTMHLMGD FSAPAEFFVT 130 140 150 160 170 180 LGIFSFFYTM AALVIYLRFH NLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG 190 200 210 220 230 240 ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH 250 260 270 GQGQGQDQDQ DQDQGQGPSQ ESAAEQGAVE KQ
	Isoform 2 [UniParc]. Checksum: 57B7CE8C9E3BC9F8	FASTA	236	25,696
	10 20 30 40 50 60 MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET 70 80 90 100 110 120 GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES SSKTMHLMGD FSAPAEFFVT 130 140 150 160 170 180 LGIFSFFYTM AALVIYLRFH NLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG 190 200 210 220 230 ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVVRPV ATAGSSTSPA AQACPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes." Satoh K., Akatsu H., Yamamoto T., Kosaka K., Yokota H., Yamada T. Brain Res. 1441:9-16(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cerebellum, Testis and Uterus.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB158472 mRNA. Translation: BAM08466.1. AK131459 mRNA. Translation: BAD18604.1. AK289513 mRNA. Translation: BAF82202.1. AK293082 mRNA. Translation: BAF85771.1. AL356735, AL355145 Genomic DNA. Translation: CAH70888.1. AL355145, AL356735 Genomic DNA. Translation: CAI22943.1. CH471122 Genomic DNA. Translation: EAW56384.1.
IPI	IPI00418582. IPI00477131.
RefSeq	NP_001035799.1. NM_001040709.1.
UniGene	Hs.528366.
3D structure databases
ProteinModelPortal	Q5VXT5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000358888.
Polymorphism databases
DMDM	68566071.
Proteomic databases
PRIDE	Q5VXT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369872; ENSP00000358888; ENSG00000143028.
GeneID	284612.
KEGG	hsa:284612.
UCSC	uc001dxo.2. human. uc001dxp.3. human.
Organism-specific databases
CTD	284612.
GeneCards	GC01P110010.
HGNC	HGNC:27638. SYPL2.
HPA	HPA018032.
neXtProt	NX_Q5VXT5.
PharmGKB	PA142670846.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82723.
HOGENOM	HOG000252913.
HOVERGEN	HBG006681.
InParanoid	Q5VXT5.
OMA	LYLRFHN.
OrthoDB	EOG4V438C.
PhylomeDB	Q5VXT5.
Gene expression databases
ArrayExpress	Q5VXT5.
Bgee	Q5VXT5.
CleanEx	HS_SYPL2.
Genevestigator	Q5VXT5.
GermOnline	ENSG00000143028. Homo sapiens.
Family and domain databases
InterPro	IPR008253. Marvel. IPR021128. MARVEL-like_dom. IPR001285. Synaptophysin/porin. [Graphical view]
PANTHER	PTHR10306. PTHR10306. 1 hit.
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PRINTS	PR00220. SYNAPTOPHYSN.
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284612.
NextBio	94995.

Entry information

Entry name

SYPL2_HUMAN

Accession

Primary (citable) accession number: Q5VXT5
Secondary accession number(s): A8K0E8 , A8KAL7, I0IT67, Q6ZMX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.