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Q5VXT5 (SYPL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptophysin-like protein 2
Gene names
Name:SYPL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum By similarity.

Sequence similarities

Belongs to the synaptophysin/synaptobrevin family.

Contains 1 MARVEL domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VXT5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q5VXT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Synaptophysin-like protein 2
PRO_0000179166

Regions

Topological domain1 – 3333Cytoplasmic Potential
Transmembrane34 – 5421Helical; Potential
Topological domain55 – 11662Vesicular Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 15013Cytoplasmic Potential
Transmembrane151 – 17121Helical; Potential
Topological domain172 – 21342Vesicular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 27238Cytoplasmic Potential
Domain30 – 238209MARVEL

Amino acid modifications

Glycosylation2131N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence217 – 27256LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2.
VSP_014268

Experimental info

Sequence conflict991E → G in BAD18604. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 0A5998BA30B35A75

FASTA27230,156
        10         20         30         40         50         60 
MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET 

        70         80         90        100        110        120 
GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES SSKTMHLMGD FSAPAEFFVT 

       130        140        150        160        170        180 
LGIFSFFYTM AALVIYLRFH NLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG 

       190        200        210        220        230        240 
ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH 

       250        260        270 
GQGQGQDQDQ DQDQGQGPSQ ESAAEQGAVE KQ 

« Hide

Isoform 2 [UniParc].

Checksum: 57B7CE8C9E3BC9F8
Show »

FASTA23625,696

References

« Hide 'large scale' references
[1]"Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes."
Satoh K., Akatsu H., Yamamoto T., Kosaka K., Yokota H., Yamada T.
Brain Res. 1441:9-16(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cerebellum, Testis and Uterus.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB158472 mRNA. Translation: BAM08466.1.
AK131459 mRNA. Translation: BAD18604.1.
AK289513 mRNA. Translation: BAF82202.1.
AK293082 mRNA. Translation: BAF85771.1.
AL356735, AL355145 Genomic DNA. Translation: CAH70888.1.
AL355145, AL356735 Genomic DNA. Translation: CAI22943.1.
CH471122 Genomic DNA. Translation: EAW56384.1.
CCDSCCDS41365.1. [Q5VXT5-1]
RefSeqNP_001035799.1. NM_001040709.1. [Q5VXT5-1]
XP_005270830.1. XM_005270773.2. [Q5VXT5-2]
UniGeneHs.528366.

3D structure databases

ProteinModelPortalQ5VXT5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129915. 1 interaction.
STRING9606.ENSP00000358888.

Polymorphism databases

DMDM68566071.

Proteomic databases

MaxQBQ5VXT5.
PRIDEQ5VXT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369872; ENSP00000358888; ENSG00000143028. [Q5VXT5-1]
GeneID284612.
KEGGhsa:284612.
UCSCuc001dxo.2. human. [Q5VXT5-2]
uc001dxp.3. human. [Q5VXT5-1]

Organism-specific databases

CTD284612.
GeneCardsGC01P110010.
HGNCHGNC:27638. SYPL2.
HPAHPA018032.
neXtProtNX_Q5VXT5.
PharmGKBPA142670846.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82723.
HOGENOMHOG000252913.
HOVERGENHBG006681.
InParanoidQ5VXT5.
OMAYTMAALI.
OrthoDBEOG7WT43S.
PhylomeDBQ5VXT5.
TreeFamTF315804.

Gene expression databases

ArrayExpressQ5VXT5.
BgeeQ5VXT5.
CleanExHS_SYPL2.
GenevestigatorQ5VXT5.

Family and domain databases

InterProIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERPTHR10306. PTHR10306. 1 hit.
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR00220. SYNAPTOPHYSN.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284612.
NextBio94995.
PROQ5VXT5.

Entry information

Entry nameSYPL2_HUMAN
AccessionPrimary (citable) accession number: Q5VXT5
Secondary accession number(s): A8K0E8 expand/collapse secondary AC list , A8KAL7, I0IT67, Q6ZMX1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM