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Protein

Synaptophysin-like protein 2

Gene

SYPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: Ensembl
  • substantia nigra development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Gene namesi
Name:SYPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27638. SYPL2.

Subcellular locationi

  • Membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 116VesicularSequence analysisAdd BLAST62
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 213VesicularSequence analysisAdd BLAST42
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 272CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi284612.
OpenTargetsiENSG00000143028.
PharmGKBiPA142670846.

Polymorphism and mutation databases

BioMutaiSYPL2.
DMDMi68566071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791661 – 272Synaptophysin-like protein 2Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5VXT5.
PaxDbiQ5VXT5.
PeptideAtlasiQ5VXT5.
PRIDEiQ5VXT5.

PTM databases

PhosphoSitePlusiQ5VXT5.

Expressioni

Gene expression databases

BgeeiENSG00000143028.
CleanExiHS_SYPL2.
GenevisibleiQ5VXT5. HS.

Organism-specific databases

HPAiHPA018032.

Interactioni

Protein-protein interaction databases

BioGridi129915. 12 interactors.
IntActiQ5VXT5. 1 interactor.
STRINGi9606.ENSP00000358888.

Structurei

3D structure databases

ProteinModelPortaliQ5VXT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 238MARVELPROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF8N. Eukaryota.
ENOG4111ZDM. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ5VXT5.
OMAiWHGQGQD.
OrthoDBiEOG091G0ZEI.
PhylomeDBiQ5VXT5.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VXT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES
110 120 130 140 150
SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH NLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQGQDQDQ
260 270
DQDQGQGPSQ ESAAEQGAVE KQ
Note: No experimental confirmation available.
Length:272
Mass (Da):30,156
Last modified:December 7, 2004 - v1
Checksum:i0A5998BA30B35A75
GO
Isoform 2 (identifier: Q5VXT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):25,696
Checksum:i57B7CE8C9E3BC9F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99E → G in BAD18604 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014268217 – 272LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158472 mRNA. Translation: BAM08466.1.
AK131459 mRNA. Translation: BAD18604.1.
AK289513 mRNA. Translation: BAF82202.1.
AK293082 mRNA. Translation: BAF85771.1.
AL356735, AL355145 Genomic DNA. Translation: CAH70888.1.
AL355145, AL356735 Genomic DNA. Translation: CAI22943.1.
CH471122 Genomic DNA. Translation: EAW56384.1.
CCDSiCCDS41365.1. [Q5VXT5-1]
RefSeqiNP_001035799.1. NM_001040709.1. [Q5VXT5-1]
UniGeneiHs.528366.

Genome annotation databases

EnsembliENST00000369872; ENSP00000358888; ENSG00000143028. [Q5VXT5-1]
GeneIDi284612.
KEGGihsa:284612.
UCSCiuc001dxp.4. human. [Q5VXT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158472 mRNA. Translation: BAM08466.1.
AK131459 mRNA. Translation: BAD18604.1.
AK289513 mRNA. Translation: BAF82202.1.
AK293082 mRNA. Translation: BAF85771.1.
AL356735, AL355145 Genomic DNA. Translation: CAH70888.1.
AL355145, AL356735 Genomic DNA. Translation: CAI22943.1.
CH471122 Genomic DNA. Translation: EAW56384.1.
CCDSiCCDS41365.1. [Q5VXT5-1]
RefSeqiNP_001035799.1. NM_001040709.1. [Q5VXT5-1]
UniGeneiHs.528366.

3D structure databases

ProteinModelPortaliQ5VXT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129915. 12 interactors.
IntActiQ5VXT5. 1 interactor.
STRINGi9606.ENSP00000358888.

PTM databases

PhosphoSitePlusiQ5VXT5.

Polymorphism and mutation databases

BioMutaiSYPL2.
DMDMi68566071.

Proteomic databases

MaxQBiQ5VXT5.
PaxDbiQ5VXT5.
PeptideAtlasiQ5VXT5.
PRIDEiQ5VXT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369872; ENSP00000358888; ENSG00000143028. [Q5VXT5-1]
GeneIDi284612.
KEGGihsa:284612.
UCSCiuc001dxp.4. human. [Q5VXT5-1]

Organism-specific databases

CTDi284612.
DisGeNETi284612.
GeneCardsiSYPL2.
HGNCiHGNC:27638. SYPL2.
HPAiHPA018032.
neXtProtiNX_Q5VXT5.
OpenTargetsiENSG00000143028.
PharmGKBiPA142670846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF8N. Eukaryota.
ENOG4111ZDM. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ5VXT5.
OMAiWHGQGQD.
OrthoDBiEOG091G0ZEI.
PhylomeDBiQ5VXT5.
TreeFamiTF315804.

Miscellaneous databases

GenomeRNAii284612.
PROiQ5VXT5.

Gene expression databases

BgeeiENSG00000143028.
CleanExiHS_SYPL2.
GenevisibleiQ5VXT5. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL2_HUMAN
AccessioniPrimary (citable) accession number: Q5VXT5
Secondary accession number(s): A8K0E8
, A8KAL7, I0IT67, Q6ZMX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.