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Q5VXT5

- SYPL2_HUMAN

UniProt

Q5VXT5 - SYPL2_HUMAN

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Protein
Synaptophysin-like protein 2
Gene
SYPL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes By similarity.

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
  2. substantia nigra development Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Gene namesi
Name:SYPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27638. SYPL2.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity
Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei34 – 5421Helical; Reviewed prediction
Add
BLAST
Topological domaini55 – 11662Vesicular Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 15013Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Reviewed prediction
Add
BLAST
Topological domaini172 – 21342Vesicular Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Topological domaini235 – 27238Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of synaptic vesicle membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Synaptophysin-like protein 2
PRO_0000179166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5VXT5.
PRIDEiQ5VXT5.

Expressioni

Gene expression databases

ArrayExpressiQ5VXT5.
BgeeiQ5VXT5.
CleanExiHS_SYPL2.
GenevestigatoriQ5VXT5.

Organism-specific databases

HPAiHPA018032.

Interactioni

Protein-protein interaction databases

BioGridi129915. 1 interaction.
STRINGi9606.ENSP00000358888.

Structurei

3D structure databases

ProteinModelPortaliQ5VXT5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 238209MARVEL
Add
BLAST

Sequence similaritiesi

Contains 1 MARVEL domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82723.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ5VXT5.
OMAiYTMAALI.
OrthoDBiEOG7WT43S.
PhylomeDBiQ5VXT5.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VXT5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF    50
GSCGSYSGET GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES 100
SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH NLYTENKRFP 150
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV 200
CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQGQDQDQ 250
DQDQGQGPSQ ESAAEQGAVE KQ 272

Note: No experimental confirmation available.

Length:272
Mass (Da):30,156
Last modified:December 7, 2004 - v1
Checksum:i0A5998BA30B35A75
GO
Isoform 2 (identifier: Q5VXT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):25,696
Checksum:i57B7CE8C9E3BC9F8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei217 – 27256LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2.
VSP_014268Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991E → G in BAD18604. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB158472 mRNA. Translation: BAM08466.1.
AK131459 mRNA. Translation: BAD18604.1.
AK289513 mRNA. Translation: BAF82202.1.
AK293082 mRNA. Translation: BAF85771.1.
AL356735, AL355145 Genomic DNA. Translation: CAH70888.1.
AL355145, AL356735 Genomic DNA. Translation: CAI22943.1.
CH471122 Genomic DNA. Translation: EAW56384.1.
CCDSiCCDS41365.1. [Q5VXT5-1]
RefSeqiNP_001035799.1. NM_001040709.1. [Q5VXT5-1]
XP_005270830.1. XM_005270773.2. [Q5VXT5-2]
UniGeneiHs.528366.

Genome annotation databases

EnsembliENST00000369872; ENSP00000358888; ENSG00000143028. [Q5VXT5-1]
GeneIDi284612.
KEGGihsa:284612.
UCSCiuc001dxo.2. human. [Q5VXT5-2]
uc001dxp.3. human. [Q5VXT5-1]

Polymorphism databases

DMDMi68566071.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB158472 mRNA. Translation: BAM08466.1 .
AK131459 mRNA. Translation: BAD18604.1 .
AK289513 mRNA. Translation: BAF82202.1 .
AK293082 mRNA. Translation: BAF85771.1 .
AL356735 , AL355145 Genomic DNA. Translation: CAH70888.1 .
AL355145 , AL356735 Genomic DNA. Translation: CAI22943.1 .
CH471122 Genomic DNA. Translation: EAW56384.1 .
CCDSi CCDS41365.1. [Q5VXT5-1 ]
RefSeqi NP_001035799.1. NM_001040709.1. [Q5VXT5-1 ]
XP_005270830.1. XM_005270773.2. [Q5VXT5-2 ]
UniGenei Hs.528366.

3D structure databases

ProteinModelPortali Q5VXT5.
ModBasei Search...

Protein-protein interaction databases

BioGridi 129915. 1 interaction.
STRINGi 9606.ENSP00000358888.

Polymorphism databases

DMDMi 68566071.

Proteomic databases

MaxQBi Q5VXT5.
PRIDEi Q5VXT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369872 ; ENSP00000358888 ; ENSG00000143028 . [Q5VXT5-1 ]
GeneIDi 284612.
KEGGi hsa:284612.
UCSCi uc001dxo.2. human. [Q5VXT5-2 ]
uc001dxp.3. human. [Q5VXT5-1 ]

Organism-specific databases

CTDi 284612.
GeneCardsi GC01P110010.
HGNCi HGNC:27638. SYPL2.
HPAi HPA018032.
neXtProti NX_Q5VXT5.
PharmGKBi PA142670846.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82723.
HOGENOMi HOG000252913.
HOVERGENi HBG006681.
InParanoidi Q5VXT5.
OMAi YTMAALI.
OrthoDBi EOG7WT43S.
PhylomeDBi Q5VXT5.
TreeFami TF315804.

Miscellaneous databases

GenomeRNAii 284612.
NextBioi 94995.
PROi Q5VXT5.

Gene expression databases

ArrayExpressi Q5VXT5.
Bgeei Q5VXT5.
CleanExi HS_SYPL2.
Genevestigatori Q5VXT5.

Family and domain databases

InterProi IPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view ]
PANTHERi PTHR10306. PTHR10306. 1 hit.
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PRINTSi PR00220. SYNAPTOPHYSN.
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes."
    Satoh K., Akatsu H., Yamamoto T., Kosaka K., Yokota H., Yamada T.
    Brain Res. 1441:9-16(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum, Testis and Uterus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYPL2_HUMAN
AccessioniPrimary (citable) accession number: Q5VXT5
Secondary accession number(s): A8K0E8
, A8KAL7, I0IT67, Q6ZMX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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