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Q5VXT5

- SYPL2_HUMAN

UniProt

Q5VXT5 - SYPL2_HUMAN

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Protein

Synaptophysin-like protein 2

Gene

SYPL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
  2. substantia nigra development Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Gene namesi
Name:SYPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27638. SYPL2.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity
Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.By similarity

GO - Cellular componenti

  1. integral component of synaptic vesicle membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Synaptophysin-like protein 2PRO_0000179166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5VXT5.
PRIDEiQ5VXT5.

Expressioni

Gene expression databases

BgeeiQ5VXT5.
CleanExiHS_SYPL2.
ExpressionAtlasiQ5VXT5. baseline and differential.
GenevestigatoriQ5VXT5.

Organism-specific databases

HPAiHPA018032.

Interactioni

Protein-protein interaction databases

BioGridi129915. 1 interaction.
STRINGi9606.ENSP00000358888.

Structurei

3D structure databases

ProteinModelPortaliQ5VXT5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini55 – 11662VesicularSequence AnalysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini172 – 21342VesicularSequence AnalysisAdd
BLAST
Topological domaini235 – 27238CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 238209MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82723.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ5VXT5.
OMAiYTMAALI.
OrthoDBiEOG7WT43S.
PhylomeDBiQ5VXT5.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VXT5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES
110 120 130 140 150
SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH NLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQGQDQDQ
260 270
DQDQGQGPSQ ESAAEQGAVE KQ

Note: No experimental confirmation available.

Length:272
Mass (Da):30,156
Last modified:December 7, 2004 - v1
Checksum:i0A5998BA30B35A75
GO
Isoform 2 (identifier: Q5VXT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-272: LFGFINFFLW...AAEQGAVEKQ → VRPVATAGSSTSPAAQACPS

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):25,696
Checksum:i57B7CE8C9E3BC9F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991E → G in BAD18604. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei217 – 27256LFGFI…AVEKQ → VRPVATAGSSTSPAAQACPS in isoform 2. 1 PublicationVSP_014268Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB158472 mRNA. Translation: BAM08466.1.
AK131459 mRNA. Translation: BAD18604.1.
AK289513 mRNA. Translation: BAF82202.1.
AK293082 mRNA. Translation: BAF85771.1.
AL356735, AL355145 Genomic DNA. Translation: CAH70888.1.
AL355145, AL356735 Genomic DNA. Translation: CAI22943.1.
CH471122 Genomic DNA. Translation: EAW56384.1.
CCDSiCCDS41365.1. [Q5VXT5-1]
RefSeqiNP_001035799.1. NM_001040709.1. [Q5VXT5-1]
XP_005270830.1. XM_005270773.2. [Q5VXT5-2]
UniGeneiHs.528366.

Genome annotation databases

EnsembliENST00000369872; ENSP00000358888; ENSG00000143028. [Q5VXT5-1]
GeneIDi284612.
KEGGihsa:284612.
UCSCiuc001dxo.2. human. [Q5VXT5-2]
uc001dxp.3. human. [Q5VXT5-1]

Polymorphism databases

DMDMi68566071.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB158472 mRNA. Translation: BAM08466.1 .
AK131459 mRNA. Translation: BAD18604.1 .
AK289513 mRNA. Translation: BAF82202.1 .
AK293082 mRNA. Translation: BAF85771.1 .
AL356735 , AL355145 Genomic DNA. Translation: CAH70888.1 .
AL355145 , AL356735 Genomic DNA. Translation: CAI22943.1 .
CH471122 Genomic DNA. Translation: EAW56384.1 .
CCDSi CCDS41365.1. [Q5VXT5-1 ]
RefSeqi NP_001035799.1. NM_001040709.1. [Q5VXT5-1 ]
XP_005270830.1. XM_005270773.2. [Q5VXT5-2 ]
UniGenei Hs.528366.

3D structure databases

ProteinModelPortali Q5VXT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129915. 1 interaction.
STRINGi 9606.ENSP00000358888.

Polymorphism databases

DMDMi 68566071.

Proteomic databases

MaxQBi Q5VXT5.
PRIDEi Q5VXT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369872 ; ENSP00000358888 ; ENSG00000143028 . [Q5VXT5-1 ]
GeneIDi 284612.
KEGGi hsa:284612.
UCSCi uc001dxo.2. human. [Q5VXT5-2 ]
uc001dxp.3. human. [Q5VXT5-1 ]

Organism-specific databases

CTDi 284612.
GeneCardsi GC01P110010.
HGNCi HGNC:27638. SYPL2.
HPAi HPA018032.
neXtProti NX_Q5VXT5.
PharmGKBi PA142670846.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82723.
GeneTreei ENSGT00390000010039.
HOGENOMi HOG000252913.
HOVERGENi HBG006681.
InParanoidi Q5VXT5.
OMAi YTMAALI.
OrthoDBi EOG7WT43S.
PhylomeDBi Q5VXT5.
TreeFami TF315804.

Miscellaneous databases

GenomeRNAii 284612.
NextBioi 94995.
PROi Q5VXT5.

Gene expression databases

Bgeei Q5VXT5.
CleanExi HS_SYPL2.
ExpressionAtlasi Q5VXT5. baseline and differential.
Genevestigatori Q5VXT5.

Family and domain databases

InterProi IPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view ]
PANTHERi PTHR10306. PTHR10306. 1 hit.
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PRINTSi PR00220. SYNAPTOPHYSN.
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes."
    Satoh K., Akatsu H., Yamamoto T., Kosaka K., Yokota H., Yamada T.
    Brain Res. 1441:9-16(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum, Testis and Uterus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYPL2_HUMAN
AccessioniPrimary (citable) accession number: Q5VXT5
Secondary accession number(s): A8K0E8
, A8KAL7, I0IT67, Q6ZMX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3