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Protein

Lipase member K

Gene

LIPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei172 – 1721NucleophileBy similarity
Active sitei343 – 3431Charge relay systemPROSITE-ProRule annotation
Active sitei372 – 3721Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-LIPK. Acidic_Lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member K (EC:3.1.1.-)
Alternative name(s):
Lipase-like abhydrolase domain-containing protein 2
Gene namesi
Name:LIPK
Synonyms:LIPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23444. LIPK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394100.

Polymorphism and mutation databases

BioMutaiLIPK.
DMDMi147647699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 399380Lipase member KPRO_0000286699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi246 ↔ 255By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5VXJ0.
PRIDEiQ5VXJ0.

PTM databases

iPTMnetiQ5VXJ0.
PhosphoSiteiQ5VXJ0.

Expressioni

Tissue specificityi

Exclusively expressed in the epidermis within the granular keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000204021.
CleanExiHS_LIPK.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383900.

Structurei

3D structure databases

ProteinModelPortaliQ5VXJ0.
SMRiQ5VXJ0. Positions 28-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiQ5VXJ0.
OMAiLYNITKM.
OrthoDBiEOG091G09AX.
PhylomeDBiQ5VXJ0.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VXJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQLLAAACW MLLLGSMYGY DKKGNNANPE ANMNISQIIS YWGYPYEEYD
60 70 80 90 100
VTTKDGYILG IYRIPHGRGC PGRTAPKPAV YLQHGLIASA SNWICNLPNN
110 120 130 140 150
SLAFLLADSG YDVWLGNSRG NTWSRKHLKL SPKSPEYWAF SLDEMAKYDL
160 170 180 190 200
PATINFIIEK TGQKRLYYVG HSQGTTIAFI AFSTNPELAK KIKIFFALAP
210 220 230 240 250
VVTVKYTQSP MKKLTTLSRR VVKVLFGDKM FHPHTLFDQF IATKVCNRKL
260 270 280 290 300
FRRICSNFLF TLSGFDPQNL NMSRLDVYLS HNPAGTSVQN MLHWAQAVNS
310 320 330 340 350
GQLQAFDWGN SDQNMMHFHQ LTPPLYNITK MEVPTAIWNG GQDIVADPKD
360 370 380 390
VENLLPQIAN LIYYKLIPHY NHVDFYLGED APQEIYQDLI ILMEEYLQN
Length:399
Mass (Da):45,563
Last modified:May 15, 2007 - v2
Checksum:iC12D8DFC294B176E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti331 – 3311M → I.
Corresponds to variant rs1214464 [ dbSNP | Ensembl ].
VAR_032160
Natural varianti391 – 3911I → T.
Corresponds to variant rs17112457 [ dbSNP | Ensembl ].
VAR_032161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF426482 mRNA. Translation: ABR08387.1.
AL358532 Genomic DNA. Translation: CAH71058.2.
CCDSiCCDS44455.1.
RefSeqiNP_001073987.1. NM_001080518.1.
XP_011538379.1. XM_011540077.1.
UniGeneiHs.632092.

Genome annotation databases

EnsembliENST00000404190; ENSP00000383900; ENSG00000204021.
GeneIDi643414.
KEGGihsa:643414.
UCSCiuc010qmv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF426482 mRNA. Translation: ABR08387.1.
AL358532 Genomic DNA. Translation: CAH71058.2.
CCDSiCCDS44455.1.
RefSeqiNP_001073987.1. NM_001080518.1.
XP_011538379.1. XM_011540077.1.
UniGeneiHs.632092.

3D structure databases

ProteinModelPortaliQ5VXJ0.
SMRiQ5VXJ0. Positions 28-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383900.

Protein family/group databases

ESTHERihuman-LIPK. Acidic_Lipase.

PTM databases

iPTMnetiQ5VXJ0.
PhosphoSiteiQ5VXJ0.

Polymorphism and mutation databases

BioMutaiLIPK.
DMDMi147647699.

Proteomic databases

PaxDbiQ5VXJ0.
PRIDEiQ5VXJ0.

Protocols and materials databases

DNASUi643414.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404190; ENSP00000383900; ENSG00000204021.
GeneIDi643414.
KEGGihsa:643414.
UCSCiuc010qmv.3. human.

Organism-specific databases

CTDi643414.
GeneCardsiLIPK.
HGNCiHGNC:23444. LIPK.
MIMi613922. gene.
neXtProtiNX_Q5VXJ0.
PharmGKBiPA162394100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiQ5VXJ0.
OMAiLYNITKM.
OrthoDBiEOG091G09AX.
PhylomeDBiQ5VXJ0.
TreeFamiTF315485.

Enzyme and pathway databases

ReactomeiR-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

GenomeRNAii643414.
PROiQ5VXJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204021.
CleanExiHS_LIPK.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPK_HUMAN
AccessioniPrimary (citable) accession number: Q5VXJ0
Secondary accession number(s): A7KIH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.