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Protein
Submitted name:

Rho guanine nucleotide exchange factor 10-like protein

Gene

ARHGEF10L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: HGNC
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  • positive regulation of stress fiber assembly Source: HGNC
  • regulation of Rho protein signal transduction Source: InterPro
  • SREBP signaling pathway Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 10-like proteinImported
Gene namesi
Name:ARHGEF10LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25540. ARHGEF10L.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HGNC
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ5VXI4.
PaxDbiQ5VXI4.
PeptideAtlasiQ5VXI4.
PRIDEiQ5VXI4.

Expressioni

Gene expression databases

BgeeiQ5VXI4.
ExpressionAtlasiQ5VXI4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 281188DH (DBL-homology)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili261 – 29434Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
KOG3524. Eukaryota.
ENOG410ZJK1. LUCA.
GeneTreeiENSGT00670000097546.
HOGENOMiHOG000232060.
HOVERGENiHBG050570.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VXI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSSSWGKR KLRGRLGWVR SDARGVMWAR QEGLHHPHPH AVIRCPSSSS
60 70 80 90 100
SSVSCSGDSE EEDMGLLEVS VSDIKPPAPE LGPMPEGLSP QQVVRRHILG
110 120 130 140 150
SIVQSEGSYV ESLKRILQDY RNPLMEMEPK ALSARKCQVV FFRVKEILHC
160 170 180 190 200
HSMFQIALSS RVAEWDSTEK IGDLFVASFS KSMVLDVYSD YVNNFTSAMS
210 220 230 240 250
IIKKACLTKP AFLEFLKRRQ VCSPDRVTLY GLMVKPIQRF PQFILLLQDM
260 270 280 290 300
LKNTPRGHPD RLSLQLALTE LETLAEKLNE QKRLADQVAE IQQLTKSVSD
310 320 330 340 350
RSSLNKLLTS GQRQLLLCET LTETVYGDRG QLIKSKERRV FLLNDMLVCA
360 370 380 390 400
NINFKGQLEI SSLVPLGPKY VVKWNTALPQ VQVVEVGQDG GTYDKDNVLI
410 420 430 440 450
QHSGAKKASA SGQAQNKVYL GPPRLFQELQ DLQKDLAVVE QITLLISTLH
460 470 480 490 500
GTYQNLNMTV AQDWCLALQR LMRVKEEEIH SANKCRLRLL LPGKPDKSGR
510 520 530 540 550
PISFMVVFIT PNPLSKISWV NRLHLAKIGL REENQPGWLC PDEDKKSKAP
560 570 580 590 600
FWCPILACCI PAFSSRALSL QLGALVHSPV NCPLLGFSAV STSLPQGYLW
610 620 630 640 650
VGGGQEGAGG QVEIFSLNRP SPRTVKSFPL AAPVLCMEYI PELEEEAESR
660 670 680 690 700
DESPTVADPS ATVHPTICLG LQDGSILLYS SVDTGTQCLV SCRSPGLQPV
710 720 730 740 750
LCLRHSPFHL LAGLQDGTLA AYPRTSGGVL WDLESPPVCL TVGPGPVRTL
760 770 780 790 800
LSLEDAVWAS CGPRVTVLEA TTLQPQQSFE AHQDEAVSVT HMVKAGSGVW
810 820 830 840 850
MAFSSGTSIR LFHTETLEHL QEINIATRTT FLLPGQKHLC VTSLLICQGL
860 870 880 890 900
LWVGTDQGVI VLLPVPRLEG IPKITGKGMV SLNGHCGPVA FLAVATSILA
910 920 930 940 950
PDILRSDQEE AEGPRAEEDK PDGQAHEPMP DSHVGRELTR KKGILLQYRL
960 970 980 990 1000
RSTAHLPGPL LSMREPAPAD GAALEHSEED GSIYEMADDP DIWVRSRPCA
1010 1020 1030 1040 1050
RDAHRKEICS VAIISGGQGY RNFGSALGSS GRQAPCGETD STLLIWQVPL

ML
Length:1,052
Mass (Da):115,568
Last modified:October 29, 2014 - v2
Checksum:i38BF19D3CBD9B8B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139250 Genomic DNA. No translation available.
AL358593 Genomic DNA. No translation available.
AL390994 Genomic DNA. No translation available.
KF495877 Genomic DNA. No translation available.
RefSeqiXP_005245986.2. XM_005245929.2.
UniGeneiHs.443460.

Genome annotation databases

EnsembliENST00000375408; ENSP00000364557; ENSG00000074964.
GeneIDi55160.
UCSCiuc010ocs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139250 Genomic DNA. No translation available.
AL358593 Genomic DNA. No translation available.
AL390994 Genomic DNA. No translation available.
KF495877 Genomic DNA. No translation available.
RefSeqiXP_005245986.2. XM_005245929.2.
UniGeneiHs.443460.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355060.

Proteomic databases

EPDiQ5VXI4.
PaxDbiQ5VXI4.
PeptideAtlasiQ5VXI4.
PRIDEiQ5VXI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375408; ENSP00000364557; ENSG00000074964.
GeneIDi55160.
UCSCiuc010ocs.3. human.

Organism-specific databases

CTDi55160.
HGNCiHGNC:25540. ARHGEF10L.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
KOG3524. Eukaryota.
ENOG410ZJK1. LUCA.
GeneTreeiENSGT00670000097546.
HOGENOMiHOG000232060.
HOVERGENiHBG050570.

Miscellaneous databases

ChiTaRSiARHGEF10L. human.
GenomeRNAii55160.

Gene expression databases

BgeeiQ5VXI4.
ExpressionAtlasiQ5VXI4. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5VXI4_HUMAN
AccessioniPrimary (citable) accession number: Q5VXI4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: October 29, 2014
Last modified: July 6, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.