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Protein

PRAME family member 7

Gene

PRAMEF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 7Imported
Gene namesi
Name:PRAMEF7Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000204510.5
HGNCiHGNC:28415 PRAMEF7
neXtProtiNX_Q5VXH5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204510
PharmGKBiPA142671144

Polymorphism and mutation databases

BioMutaiPRAMEF7
DMDMi74757002

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569811 – 474PRAME family member 7Add BLAST474

Proteomic databases

PeptideAtlasiQ5VXH5
PRIDEiQ5VXH5

PTM databases

iPTMnetiQ5VXH5
PhosphoSitePlusiQ5VXH5

Expressioni

Gene expression databases

CleanExiHS_PRAMEF7

Organism-specific databases

HPAiHPA049887
HPA051704

Structurei

3D structure databases

ProteinModelPortaliQ5VXH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 122LRR 1; degenerateBy similarityAdd BLAST26
Repeati177 – 201LRR 2; degenerateBy similarityAdd BLAST25
Repeati202 – 228LRR 3; degenerateBy similarityAdd BLAST27
Repeati229 – 264LRR 4; degenerateBy similarityAdd BLAST36
Repeati265 – 290LRR 5By similarityAdd BLAST26
Repeati291 – 322LRR 6By similarityAdd BLAST32
Repeati323 – 341LRR 7By similarityAdd BLAST19
Repeati347 – 374LRR 8By similarityAdd BLAST28
Repeati375 – 399LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KFA8 Eukaryota
ENOG411141V LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VXH5
OMAiASTHRCT
OrthoDBiEOG091G05PP
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VXH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE
60 70 80 90 100
TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL
110 120 130 140 150
QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID
160 170 180 190 200
LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC KELQVFGMPI HSIIEVLNMV
210 220 230 240 250
ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN
260 270 280 290 300
KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT
310 320 330 340 350
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQAVATL
360 370 380 390 400
QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT
410 420 430 440 450
VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMNTL RDLRQPKIIV
460 470
FCTVPCPRCG IRASYDLEPS HCLC
Length:474
Mass (Da):53,627
Last modified:January 20, 2016 - v2
Checksum:i7E6E3C0BC6EB2439
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346A → V in AAI40756 (PubMed:15489334).Curated1
Sequence conflicti438N → K in AAI40756 (PubMed:15489334).Curated1
Sequence conflicti440L → P in AAI40756 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA No translation available.
AL358783 Genomic DNA No translation available.
BC140755 mRNA Translation: AAI40756.1
CCDSiCCDS30593.1
RefSeqiNP_001012277.2, NM_001012277.4
UniGeneiHs.553832

Genome annotation databases

EnsembliENST00000330881; ENSP00000328915; ENSG00000204510
ENST00000355096; ENSP00000347211; ENSG00000279195
ENST00000616979; ENSP00000484237; ENSG00000204510
ENST00000633146; ENSP00000488446; ENSG00000279195
GeneIDi441871
KEGGihsa:441871
UCSCiuc031tpm.1 human
uc057ckj.1 human

Similar proteinsi

Entry informationi

Entry nameiPRAM7_HUMAN
AccessioniPrimary (citable) accession number: Q5VXH5
Secondary accession number(s): A0A087X1I7, A0A0A6YYA1, B9EIP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 20, 2016
Last modified: February 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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