Q5VXH4 (PRAM6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PRAME family member 6

Gene names

Name:

PRAMEF6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PRAME family. Contains 6 LRR (leucine-rich) repeats.

Ontologies

Keywords
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of apoptotic process Inferred from electronic annotation. Source: InterPro negative regulation of cell differentiation Inferred from electronic annotation. Source: InterPro negative regulation of retinoic acid receptor signaling pathway Inferred from electronic annotation. Source: InterPro negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	PRAME family member 6		PRO_0000156980
Regions
	Repeat	233 – 254	22	LRR 1
	Repeat	266 – 288	23	LRR 2
	Repeat	295 – 315	21	LRR 3
	Repeat	322 – 345	24	LRR 4
	Repeat	351 – 372	22	LRR 5
	Repeat	379 – 399	21	LRR 6
Experimental info
	Sequence conflict	16	1	S → N in AAI01343. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5VXH4 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 3A2FD8A09C6AC205	FASTA	476	54,852
	10 20 30 40 50 60 MSIRTPPRLL ELAGRSLLRD QALAMSTLEE LPTELFPPLF MEAFSRRRCE ALKLMVQAWP 70 80 90 100 110 120 FRRLPLRPLI KMPCLEAFQA VLDGLDALLT QGVHPRRWKL QVLDLQDVCE NFWMVWSEAM 130 140 150 160 170 180 ARGCFLNAKR NKTPVQDCPR MRGQQPLTVF VELWLKNRTL DEYLTCLLLW VKQRKDLLHL 190 200 210 220 230 240 CCKKLKILGM PFRNIRSILK MVNLDCIQEV EVNCKWVLPI LTQFTPYLGH MRNLQKLVLS 250 260 270 280 290 300 HMDVSRYVSP EQKKEIVTQF TTQFLKLCCL QKLSMNSVSF LEGHLDQLLS CLKTSLKVLT 310 320 330 340 350 360 ITNCVLLESD LKHLSQCPSI SQLKTLDLSG IRLTNYSLVP LQILLEKVAA TLEYLDLDDC 370 380 390 400 410 420 GIIDSQVNAI LPALSRCFEL NTFSFCGNPI SMATLENLLS HTIILKNLCV ELYPAPRESY 430 440 450 460 470 DADGTLCWSR FAQIRAELMK RVRDLRHPKR ILFCTDCCPD CGNRSFYDLE ADQCCC

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL358783 Genomic DNA. Translation: CAH73924.1. BC101342 mRNA. Translation: AAI01343.1.
IPI	IPI00554641.
RefSeq	NP_001010889.1. NM_001010889.2.
UniGene	Hs.567864.
3D structure databases
ProteinModelPortal	Q5VXH4.
ModBase	Search...
PTM databases
PhosphoSite	Q5VXH4.
Polymorphism databases
DMDM	74757001.
Proteomic databases
PaxDb	Q5VXH4.
PRIDE	Q5VXH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355096; ENSP00000347211; ENSG00000232423. ENST00000376189; ENSP00000365360; ENSG00000232423. ENST00000415464; ENSP00000401281; ENSG00000232423.
GeneID	440561.
KEGG	hsa:440561.
UCSC	uc001auq.2. human.
Organism-specific databases
CTD	440561.
GeneCards	GC01M012998.
HGNC	HGNC:30583. PRAMEF6.
neXtProt	NX_Q5VXH4.
PharmGKB	PA142671143.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242471.
HOGENOM	HOG000231112.
HOVERGEN	HBG006326.
InParanoid	Q5VXH4.
OMA	QNEASAW.
OrthoDB	EOG4HMJ96.
Gene expression databases
ArrayExpress	Q5VXH4.
CleanEx	HS_PRAMEF6.
Genevestigator	Q5VXH4.
GermOnline	ENSG00000204509. Homo sapiens.
Family and domain databases
InterPro	IPR026292. PRAME/Leu_rich_rep-con_p14. IPR026271. PRAME_family. [Graphical view]
PANTHER	PTHR14224. PTHR14224. 1 hit.
PIRSF	PIRSF038286. PRAME. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	440561.
NextBio	109354.

Entry information

Entry name

PRAM6_HUMAN

Accession

Primary (citable) accession number: Q5VXH4
Secondary accession number(s): A0AUJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.