Q5VXD3 (SAM13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sterile alpha motif domain-containing protein 13
Short name=SAM domain-containing protein 13

Gene names

Name:	SAMD13
ORF Names:	HSD42, HSD-42

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	122 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VXD3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VXD3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MANSLLEGVF → MRGV

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5VXD3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MANSLLEGVF...FEEQASAFQE → MRSCLMPGNE...GGGTMHSQDS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 122	122	Sterile alpha motif domain-containing protein 13		PRO_0000279505
Regions
	Domain	51 – 119	69	SAM
Natural variations
	Alternative sequence	1 – 74	74	MANSL…SAFQE → MRSCLMPGNEMSMTSPEGTE PKGKQRRWQRQKTFGGGTMH SQDS in isoform 3.		VSP_023464
	Alternative sequence	1 – 10	10	MANSLLEGVF → MRGV in isoform 2.		VSP_023463

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: CF36A3DC07CE1644	FASTA	122	13,570
	10 20 30 40 50 60 MANSLLEGVF AEVKEPCSLP MLSVDMENKE NGSVGVKNSM ENGRPPDPAD WAVMDVVNYF 70 80 90 100 110 120 RTVGFEEQAS AFQEQEIDGK SLLLMTRNDV LTGLQLKLGP ALKIYEYHVK PLQTKHLKNN SS
	Isoform 2 [UniParc]. Checksum: 79963CDA850C0F34	FASTA	116	12,952
	10 20 30 40 50 60 MRGVAEVKEP CSLPMLSVDM ENKENGSVGV KNSMENGRPP DPADWAVMDV VNYFRTVGFE 70 80 90 100 110 EQASAFQEQE IDGKSLLLMT RNDVLTGLQL KLGPALKIYE YHVKPLQTKH LKNNSS
	Isoform 3 [UniParc]. Checksum: D78325431269A611	FASTA	92	10,402
	10 20 30 40 50 60 MRSCLMPGNE MSMTSPEGTE PKGKQRRWQR QKTFGGGTMH SQDSQEIDGK SLLLMTRNDV 70 80 90 LTGLQLKLGP ALKIYEYHVK PLQTKHLKNN SS

References

[1]	"A new spermatogenesis-related gene." Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Salivary gland.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY604570 mRNA. Translation: AAU14234.1. AK056937 mRNA. Translation: BAG51830.1. AL359273 Genomic DNA. Translation: CAH73121.1. AL359273 Genomic DNA. Translation: CAH73122.1. AL359273 Genomic DNA. Translation: CAH73123.1. CH471097 Genomic DNA. Translation: EAW73240.1.
IPI	IPI00182967. IPI00604752. IPI00646930.
RefSeq	NP_001010971.1. NM_001010971.2. NP_001128135.1. NM_001134663.1. NP_001128136.1. NM_001134664.1.
UniGene	Hs.591445.
3D structure databases
HSSP	HSSP built from PDB template 1PK1 based on UniProtKB P39769.
ProteinModelPortal	Q5VXD3.
SMR	Q5VXD3. Positions 46-113.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5VXD3.
Polymorphism databases
DMDM	74747524.
Proteomic databases
PRIDE	Q5VXD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370671; ENSP00000359705; ENSG00000203943.
GeneID	148418.
KEGG	hsa:148418.
UCSC	uc001djr.1. human.
Organism-specific databases
CTD	148418.
GeneCards	GC01P084764.
HGNC	HGNC:24582. SAMD13.
neXtProt	NX_Q5VXD3.
PharmGKB	PA142670952.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20813.
GeneTree	ENSGT00530000063936.
HOGENOM	HBG714667.
HOVERGEN	HBG082495.
OMA	ADVVNYF.
Gene expression databases
ArrayExpress	Q5VXD3.
Bgee	Q5VXD3.
CleanEx	HS_SAMD13.
Genevestigator	Q5VXD3.
Family and domain databases
InterPro	IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. [Graphical view]
Gene3D	G3DSA:1.10.150.50. SAM_type. 1 hit.
Pfam	PF00536. SAM_1. 1 hit. [Graphical view]
SMART	SM00454. SAM. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAM13_HUMAN

Accession

Primary (citable) accession number: Q5VXD3
Secondary accession number(s): B3KPW8 , Q53AI4, Q5VXD2, Q5VXD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	December 7, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.