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Protein

Sushi domain-containing protein 4

Gene

SUSD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 4
Gene namesi
Name:SUSD4
ORF Names:UNQ196/PRO222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25470. SUSD4.

Subcellular locationi

Isoform 3 :
  • Secreted 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 319278ExtracellularSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Topological domaini341 – 490150CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670855.

Polymorphism and mutation databases

BioMutaiSUSD4.
DMDMi74747494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 490449Sushi domain-containing protein 4PRO_0000251975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 99PROSITE-ProRule annotation
Disulfide bondi85 ↔ 117PROSITE-ProRule annotation
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi122 ↔ 165PROSITE-ProRule annotation
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi147 ↔ 177PROSITE-ProRule annotation
Disulfide bondi180 ↔ 224PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi210 ↔ 237PROSITE-ProRule annotation
Disulfide bondi243 ↔ 289PROSITE-ProRule annotation
Disulfide bondi274 ↔ 302PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5VX71.
PeptideAtlasiQ5VX71.
PRIDEiQ5VX71.

PTM databases

iPTMnetiQ5VX71.
PhosphoSiteiQ5VX71.

Expressioni

Tissue specificityi

Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain.1 Publication

Gene expression databases

BgeeiENSG00000143502.
CleanExiHS_SUSD4.
ExpressionAtlasiQ5VX71. baseline and differential.
GenevisibleiQ5VX71. HS.

Organism-specific databases

HPAiHPA058296.

Interactioni

Protein-protein interaction databases

BioGridi120379. 45 interactions.
IntActiQ5VX71. 1 interaction.
MINTiMINT-8247631.

Structurei

3D structure databases

ProteinModelPortaliQ5VX71.
SMRiQ5VX71. Positions 71-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 11965Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 17960Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini178 – 23962Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 30464Sushi 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEVB. Eukaryota.
ENOG410ZTUX. LUCA.
GeneTreeiENSGT00530000063768.
HOGENOMiHOG000154450.
HOVERGENiHBG057231.
InParanoidiQ5VX71.
OMAiECMYNLI.
OrthoDBiEOG091G0E24.
PhylomeDBiQ5VX71.
TreeFamiTF332459.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VX71-1) [UniParc]FASTAAdd to basket
Also known as: SUSD4a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYHGMNPSNG DGFLEQQQQQ QQPQSPQRLL AVILWFQLAL CFGPAQLTGG
60 70 80 90 100
FDDLQVCADP GIPENGFRTP SGGVFFEGSV ARFHCQDGFK LKGATKRLCL
110 120 130 140 150
KHFNGTLGWI PSDNSICVQE DCRIPQIEDA EIHNKTYRHG EKLIITCHEG
160 170 180 190 200
FKIRYPDLHN MVSLCRDDGT WNNLPICQGC LRPLASSNGY VNISELQTSF
210 220 230 240 250
PVGTVISYRC FPGFKLDGSA YLECLQNLIW SSSPPRCLAL EVCPLPPMVS
260 270 280 290 300
HGDFVCHPRP CERYNHGTVV EFYCDPGYSL TSDYKYITCQ YGEWFPSYQV
310 320 330 340 350
YCIKSEQTWP STHETLLTTW KIVAFTATSV LLVLLLVILA RMFQTKFKAH
360 370 380 390 400
FPPRGPPRSS SSDPDFVVVD GVPVMLPSYD EAVSGGLSAL GPGYMASVGQ
410 420 430 440 450
GCPLPVDDQS PPAYPGSGDT DTGPGESETC DSVSGSSELL QSLYSPPRCQ
460 470 480 490
ESTHPASDNP DIIASTAEEV ASTSPGIDIA DEIPLMEEDP
Length:490
Mass (Da):53,778
Last modified:December 7, 2004 - v1
Checksum:i15392C2774BEFF22
GO
Isoform 2 (identifier: Q5VX71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-241: E → EAQ
     478-490: DIADEIPLMEEDP → HHAHWVLFLRN

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):53,920
Checksum:i950254448E4267D1
GO
Isoform 3 (identifier: Q5VX71-3) [UniParc]FASTAAdd to basket
Also known as: SUSD4b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     242-290: VCPLPPMVSH...TSDYKYITCQ → GGRPEHLFPV...SSTSTTTSLF
     291-490: Missing.

Note: No experimental confirmation available.
Show »
Length:290
Mass (Da):32,165
Checksum:i58181E7BA44EE4CD
GO
Isoform 4 (identifier: Q5VX71-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-236: SSNGYVNISE...NLIWSSSPPR → PQHTPAQGTR...APTLLRTTLT
     237-490: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):26,094
Checksum:i9417D03CAEA973BA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei186 – 23651SSNGY…SSPPR → PQHTPAQGTRTQAQGSQKPV TASQALLSCSKVCIHLPGAK RAPTLLRTTLT in isoform 4. 1 PublicationVSP_020838Add
BLAST
Alternative sequencei237 – 490254Missing in isoform 4. 1 PublicationVSP_020839Add
BLAST
Alternative sequencei241 – 2411E → EAQ in isoform 2. 1 PublicationVSP_020840
Alternative sequencei242 – 29049VCPLP…YITCQ → GGRPEHLFPVLYFPHIRLAA AVLYFCPVLKSSPTPAPTCS STSTTTSLF in isoform 3. 1 PublicationVSP_020841Add
BLAST
Alternative sequencei291 – 490200Missing in isoform 3. 1 PublicationVSP_020842Add
BLAST
Alternative sequencei478 – 49013DIADE…MEEDP → HHAHWVLFLRN in isoform 2. 1 PublicationVSP_020843Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358495 mRNA. Translation: AAQ88859.1.
AK000914 mRNA. Translation: BAA91421.1.
AL359733, AL359979 Genomic DNA. Translation: CAH73991.1.
AL359733, AL359979 Genomic DNA. Translation: CAH73992.1.
AL359979, AL359733 Genomic DNA. Translation: CAI12801.1.
AL359979, AL359733 Genomic DNA. Translation: CAI12802.1.
CH471100 Genomic DNA. Translation: EAW93260.1.
CH471100 Genomic DNA. Translation: EAW93261.1.
BC004888 mRNA. Translation: AAH04888.1.
CCDSiCCDS31034.1. [Q5VX71-3]
CCDS41471.1. [Q5VX71-1]
RefSeqiNP_001032252.1. NM_001037175.2. [Q5VX71-3]
NP_060452.3. NM_017982.3. [Q5VX71-1]
UniGeneiHs.497841.

Genome annotation databases

EnsembliENST00000343846; ENSP00000344219; ENSG00000143502. [Q5VX71-1]
ENST00000344029; ENSP00000339926; ENSG00000143502. [Q5VX71-3]
ENST00000366878; ENSP00000355843; ENSG00000143502. [Q5VX71-1]
GeneIDi55061.
KEGGihsa:55061.
UCSCiuc001hnx.3. human. [Q5VX71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358495 mRNA. Translation: AAQ88859.1.
AK000914 mRNA. Translation: BAA91421.1.
AL359733, AL359979 Genomic DNA. Translation: CAH73991.1.
AL359733, AL359979 Genomic DNA. Translation: CAH73992.1.
AL359979, AL359733 Genomic DNA. Translation: CAI12801.1.
AL359979, AL359733 Genomic DNA. Translation: CAI12802.1.
CH471100 Genomic DNA. Translation: EAW93260.1.
CH471100 Genomic DNA. Translation: EAW93261.1.
BC004888 mRNA. Translation: AAH04888.1.
CCDSiCCDS31034.1. [Q5VX71-3]
CCDS41471.1. [Q5VX71-1]
RefSeqiNP_001032252.1. NM_001037175.2. [Q5VX71-3]
NP_060452.3. NM_017982.3. [Q5VX71-1]
UniGeneiHs.497841.

3D structure databases

ProteinModelPortaliQ5VX71.
SMRiQ5VX71. Positions 71-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120379. 45 interactions.
IntActiQ5VX71. 1 interaction.
MINTiMINT-8247631.

PTM databases

iPTMnetiQ5VX71.
PhosphoSiteiQ5VX71.

Polymorphism and mutation databases

BioMutaiSUSD4.
DMDMi74747494.

Proteomic databases

PaxDbiQ5VX71.
PeptideAtlasiQ5VX71.
PRIDEiQ5VX71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343846; ENSP00000344219; ENSG00000143502. [Q5VX71-1]
ENST00000344029; ENSP00000339926; ENSG00000143502. [Q5VX71-3]
ENST00000366878; ENSP00000355843; ENSG00000143502. [Q5VX71-1]
GeneIDi55061.
KEGGihsa:55061.
UCSCiuc001hnx.3. human. [Q5VX71-1]

Organism-specific databases

CTDi55061.
GeneCardsiSUSD4.
H-InvDBHIX0022277.
HGNCiHGNC:25470. SUSD4.
HPAiHPA058296.
MIMi615827. gene.
neXtProtiNX_Q5VX71.
PharmGKBiPA142670855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVB. Eukaryota.
ENOG410ZTUX. LUCA.
GeneTreeiENSGT00530000063768.
HOGENOMiHOG000154450.
HOVERGENiHBG057231.
InParanoidiQ5VX71.
OMAiECMYNLI.
OrthoDBiEOG091G0E24.
PhylomeDBiQ5VX71.
TreeFamiTF332459.

Miscellaneous databases

ChiTaRSiSUSD4. human.
GenomeRNAii55061.
PROiQ5VX71.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143502.
CleanExiHS_SUSD4.
ExpressionAtlasiQ5VX71. baseline and differential.
GenevisibleiQ5VX71. HS.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUSD4_HUMAN
AccessioniPrimary (citable) accession number: Q5VX71
Secondary accession number(s): D3DTB9
, Q6UX62, Q9BSR0, Q9NWG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.