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Protein

Lysophospholipase-like protein 1

Gene

LYPLAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.2 Publications

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124Charge relay systemBy similarity1
Active sitei179Charge relay systemBy similarity1
Active sitei211Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-LYPLAL1. LYsophospholipase_carboxylesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase-like protein 1 (EC:3.1.2.-)
Gene namesi
Name:LYPLAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20440. LYPLAL1.

Subcellular locationi

Isoform 1 :
Isoform 2 :

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi127018.
OpenTargetsiENSG00000143353.
PharmGKBiPA134986975.

Chemistry databases

ChEMBLiCHEMBL2189133.

Polymorphism and mutation databases

BioMutaiLYPLAL1.
DMDMi74762275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002275572 – 237Lysophospholipase-like protein 1Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5VWZ2.
MaxQBiQ5VWZ2.
PaxDbiQ5VWZ2.
PeptideAtlasiQ5VWZ2.
PRIDEiQ5VWZ2.

PTM databases

iPTMnetiQ5VWZ2.
PhosphoSitePlusiQ5VWZ2.

Expressioni

Gene expression databases

BgeeiENSG00000143353.
CleanExiHS_LYPLAL1.
GenevisibleiQ5VWZ2. HS.

Organism-specific databases

HPAiHPA045806.

Interactioni

Protein-protein interaction databases

BioGridi126031. 1 interactor.
IntActiQ5VWZ2. 3 interactors.
STRINGi9606.ENSP00000355895.

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 14Combined sources4
Beta strandi22 – 27Combined sources6
Helixi34 – 45Combined sources12
Beta strandi52 – 59Combined sources8
Beta strandi63 – 65Combined sources3
Helixi67 – 69Combined sources3
Beta strandi73 – 75Combined sources3
Beta strandi81 – 87Combined sources7
Helixi91 – 110Combined sources20
Helixi115 – 117Combined sources3
Beta strandi118 – 123Combined sources6
Helixi125 – 137Combined sources13
Beta strandi141 – 148Combined sources8
Helixi156 – 163Combined sources8
Beta strandi171 – 176Combined sources6
Beta strandi180 – 182Combined sources3
Helixi184 – 196Combined sources13
Beta strandi201 – 206Combined sources6
Helixi215 – 228Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U0VX-ray1.72A1-237[»]
5KREX-ray2.00A1-237[»]
ProteinModelPortaliQ5VWZ2.
SMRiQ5VWZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG105375.
InParanoidiQ5VWZ2.
KOiK06999.
OMAiLEYPHIK.
OrthoDBiEOG091G0G77.
PhylomeDBiQ5VWZ2.
TreeFamiTF314619.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VWZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAASGSVLQ RCIVSPAGRH SASLIFLHGS GDSGQGLRMW IKQVLNQDLT
60 70 80 90 100
FQHIKIIYPT APPRSYTPMK GGISNVWFDR FKITNDCPEH LESIDVMCQV
110 120 130 140 150
LTDLIDEEVK SGIKKNRILI GGFSMGGCMA IHLAYRNHQD VAGVFALSSF
160 170 180 190 200
LNKASAVYQA LQKSNGVLPE LFQCHGTADE LVLHSWAEET NSMLKSLGVT
210 220 230
TKFHSFPNVY HELSKTELDI LKLWILTKLP GEMEKQK
Length:237
Mass (Da):26,316
Last modified:January 23, 2007 - v3
Checksum:iA813A55DADDAF55E
GO
Isoform 2 (identifier: Q5VWZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-80: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:221
Mass (Da):24,476
Checksum:iFD2558A6BB7B1017
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32D → G in BAF84231 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025607131I → M.3 PublicationsCorresponds to variant rs940570dbSNPEnsembl.1
Natural variantiVAR_060992197L → V.Corresponds to variant rs34201999dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01755665 – 80Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341430 mRNA. Translation: AAQ17077.1.
AK291542 mRNA. Translation: BAF84231.1.
AL360093 Genomic DNA. Translation: CAH70459.1.
AL360093 Genomic DNA. Translation: CAH70460.1.
BC016711 mRNA. Translation: AAH16711.1.
CCDSiCCDS1522.1. [Q5VWZ2-1]
CCDS73032.1. [Q5VWZ2-2]
RefSeqiNP_001287698.1. NM_001300769.1.
NP_001287699.1. NM_001300770.1. [Q5VWZ2-2]
NP_001287700.1. NM_001300771.1.
NP_001287701.1. NM_001300772.1.
NP_620149.2. NM_138794.4. [Q5VWZ2-1]
UniGeneiHs.657617.

Genome annotation databases

EnsembliENST00000366927; ENSP00000355894; ENSG00000143353. [Q5VWZ2-2]
ENST00000366928; ENSP00000355895; ENSG00000143353. [Q5VWZ2-1]
GeneIDi127018.
KEGGihsa:127018.
UCSCiuc001hlq.5. human. [Q5VWZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341430 mRNA. Translation: AAQ17077.1.
AK291542 mRNA. Translation: BAF84231.1.
AL360093 Genomic DNA. Translation: CAH70459.1.
AL360093 Genomic DNA. Translation: CAH70460.1.
BC016711 mRNA. Translation: AAH16711.1.
CCDSiCCDS1522.1. [Q5VWZ2-1]
CCDS73032.1. [Q5VWZ2-2]
RefSeqiNP_001287698.1. NM_001300769.1.
NP_001287699.1. NM_001300770.1. [Q5VWZ2-2]
NP_001287700.1. NM_001300771.1.
NP_001287701.1. NM_001300772.1.
NP_620149.2. NM_138794.4. [Q5VWZ2-1]
UniGeneiHs.657617.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U0VX-ray1.72A1-237[»]
5KREX-ray2.00A1-237[»]
ProteinModelPortaliQ5VWZ2.
SMRiQ5VWZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126031. 1 interactor.
IntActiQ5VWZ2. 3 interactors.
STRINGi9606.ENSP00000355895.

Chemistry databases

ChEMBLiCHEMBL2189133.

Protein family/group databases

ESTHERihuman-LYPLAL1. LYsophospholipase_carboxylesterase.

PTM databases

iPTMnetiQ5VWZ2.
PhosphoSitePlusiQ5VWZ2.

Polymorphism and mutation databases

BioMutaiLYPLAL1.
DMDMi74762275.

Proteomic databases

EPDiQ5VWZ2.
MaxQBiQ5VWZ2.
PaxDbiQ5VWZ2.
PeptideAtlasiQ5VWZ2.
PRIDEiQ5VWZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366927; ENSP00000355894; ENSG00000143353. [Q5VWZ2-2]
ENST00000366928; ENSP00000355895; ENSG00000143353. [Q5VWZ2-1]
GeneIDi127018.
KEGGihsa:127018.
UCSCiuc001hlq.5. human. [Q5VWZ2-1]

Organism-specific databases

CTDi127018.
DisGeNETi127018.
GeneCardsiLYPLAL1.
H-InvDBHIX0001597.
HGNCiHGNC:20440. LYPLAL1.
HPAiHPA045806.
MIMi616548. gene.
neXtProtiNX_Q5VWZ2.
OpenTargetsiENSG00000143353.
PharmGKBiPA134986975.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG105375.
InParanoidiQ5VWZ2.
KOiK06999.
OMAiLEYPHIK.
OrthoDBiEOG091G0G77.
PhylomeDBiQ5VWZ2.
TreeFamiTF314619.

Miscellaneous databases

ChiTaRSiLYPLAL1. human.
GenomeRNAii127018.
PROiQ5VWZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143353.
CleanExiHS_LYPLAL1.
GenevisibleiQ5VWZ2. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLYPL1_HUMAN
AccessioniPrimary (citable) accession number: Q5VWZ2
Secondary accession number(s): A8K677
, Q5VWZ3, Q7Z4A3, Q96AV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.