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Q5VWX1

- KHDR2_HUMAN

UniProt

Q5VWX1 - KHDR2_HUMAN

Protein

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Gene

KHDRBS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability By similarity.By similarity

    GO - Molecular functioni

    1. poly(A) binding Source: Ensembl
    2. poly(U) RNA binding Source: Ensembl
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Alternative name(s):
    Sam68-like mammalian protein 1
    Short name:
    SLM-1
    Short name:
    hSLM-1
    Gene namesi
    Name:KHDRBS2
    Synonyms:SLM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18114. KHDRBS2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30093.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349KH domain-containing, RNA-binding, signal transduction-associated protein 2PRO_0000308953Add
    BLAST

    Post-translational modificationi

    Methylated.1 Publication
    Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis By similarity.By similarity

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ5VWX1.
    PaxDbiQ5VWX1.
    PRIDEiQ5VWX1.

    PTM databases

    PhosphoSiteiQ5VWX1.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.1 Publication

    Gene expression databases

    BgeeiQ5VWX1.
    CleanExiHS_KHDRBS2.
    GenevestigatoriQ5VWX1.

    Organism-specific databases

    HPAiHPA029392.

    Interactioni

    Subunit structurei

    Self-associates to form homooligomers. Interacts with SAFB, SFRS9 and YTHDC1. Found in a complex with KHDRBS1, KHDRBS2 and KHDRBS3. Interacts with the SH3 domains of FYN and PLCG1. Interacts with the SH2 domains of FYN, GRAP2, PLCG1 and RASA1 By similarity. Interacts with RBMX.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RBMXP381592EBI-742808,EBI-743526

    Protein-protein interaction databases

    BioGridi128436. 50 interactions.
    IntActiQ5VWX1. 7 interactions.
    MINTiMINT-1449914.
    STRINGi9606.ENSP00000281156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VWX1.
    SMRiQ5VWX1. Positions 3-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 13571KHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi211 – 26252Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KHDRBS family.Curated
    Contains 1 KH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    eggNOGiCOG5176.
    HOGENOMiHOG000230771.
    HOVERGENiHBG079164.
    InParanoidiQ5VWX1.
    KOiK17843.
    OMAiKFQGSEG.
    OrthoDBiEOG75MVX3.
    PhylomeDBiQ5VWX1.
    TreeFamiTF314878.

    Family and domain databases

    Gene3Di3.30.1370.10. 1 hit.
    InterProiIPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF00013. KH_1. 1 hit.
    [Graphical view]
    SMARTiSM00322. KH. 1 hit.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VWX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEEKYLPEL MAEKDSLDPS FVHASRLLAE EIEKFQGSDG KKEDEEKKYL    50
    DVISNKNIKL SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS 100
    ILGKGSMRDK AKEEELRKSG EAKYAHLSDE LHVLIEVFAP PGEAYSRMSH 150
    ALEEIKKFLV PDYNDEIRQE QLRELSYLNG SEDSGRGRGI RGRGIRIAPT 200
    APSRGRGGAI PPPPPPGRGV LTPRGSTVTR GALPVPPVAR GVPTPRARGA 250
    PTVPGYRAPP PPAHEAYEEY GYDDGYGGEY DDQTYETYDN SYATQTQSVP 300
    EYYDYGHGVS EDAYDSYAPE EWATTRSSLK APPQRSARGG YREHPYGRY 349
    Length:349
    Mass (Da):38,927
    Last modified:December 7, 2004 - v1
    Checksum:iEF16E301D8A12164
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651L → P in AAL77219. (PubMed:12549823)Curated
    Sequence conflicti232 – 2321A → V in AAL77219. (PubMed:12549823)Curated
    Sequence conflicti326 – 3261R → S in AAH34043. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti308 – 3081G → A.
    Corresponds to variant rs7449840 [ dbSNP | Ensembl ].
    VAR_036885

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY077838 mRNA. Translation: AAL77219.1.
    AK292043 mRNA. Translation: BAF84732.1.
    AL360220
    , AL049544, AL138882, AL355347, AL391644, Z93021 Genomic DNA. Translation: CAH70882.1.
    AL355347
    , AL049544, AL138882, AL360220, AL391644, Z93021 Genomic DNA. Translation: CAI14907.1.
    AL391644
    , AL049544, AL138882, AL355347, AL360220, Z93021 Genomic DNA. Translation: CAI15262.1.
    AL138882
    , AL049544, AL355347, AL360220, AL391644, Z93021 Genomic DNA. Translation: CAI19748.1.
    AL049544
    , AL138882, AL355347, AL360220, AL391644, Z93021 Genomic DNA. Translation: CAI19918.1.
    Z93021
    , AL049544, AL138882, AL355347, AL360220, AL391644 Genomic DNA. Translation: CAI21649.1.
    CH471143 Genomic DNA. Translation: EAW88490.1.
    BC034043 mRNA. Translation: AAH34043.1.
    CCDSiCCDS4963.1.
    RefSeqiNP_689901.2. NM_152688.2.
    UniGeneiHs.519794.

    Genome annotation databases

    EnsembliENST00000281156; ENSP00000281156; ENSG00000112232.
    GeneIDi202559.
    KEGGihsa:202559.
    UCSCiuc003peg.2. human.

    Polymorphism databases

    DMDMi74762274.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY077838 mRNA. Translation: AAL77219.1 .
    AK292043 mRNA. Translation: BAF84732.1 .
    AL360220
    , AL049544 , AL138882 , AL355347 , AL391644 , Z93021 Genomic DNA. Translation: CAH70882.1 .
    AL355347
    , AL049544 , AL138882 , AL360220 , AL391644 , Z93021 Genomic DNA. Translation: CAI14907.1 .
    AL391644
    , AL049544 , AL138882 , AL355347 , AL360220 , Z93021 Genomic DNA. Translation: CAI15262.1 .
    AL138882
    , AL049544 , AL355347 , AL360220 , AL391644 , Z93021 Genomic DNA. Translation: CAI19748.1 .
    AL049544
    , AL138882 , AL355347 , AL360220 , AL391644 , Z93021 Genomic DNA. Translation: CAI19918.1 .
    Z93021
    , AL049544 , AL138882 , AL355347 , AL360220 , AL391644 Genomic DNA. Translation: CAI21649.1 .
    CH471143 Genomic DNA. Translation: EAW88490.1 .
    BC034043 mRNA. Translation: AAH34043.1 .
    CCDSi CCDS4963.1.
    RefSeqi NP_689901.2. NM_152688.2.
    UniGenei Hs.519794.

    3D structure databases

    ProteinModelPortali Q5VWX1.
    SMRi Q5VWX1. Positions 3-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128436. 50 interactions.
    IntActi Q5VWX1. 7 interactions.
    MINTi MINT-1449914.
    STRINGi 9606.ENSP00000281156.

    PTM databases

    PhosphoSitei Q5VWX1.

    Polymorphism databases

    DMDMi 74762274.

    Proteomic databases

    MaxQBi Q5VWX1.
    PaxDbi Q5VWX1.
    PRIDEi Q5VWX1.

    Protocols and materials databases

    DNASUi 202559.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281156 ; ENSP00000281156 ; ENSG00000112232 .
    GeneIDi 202559.
    KEGGi hsa:202559.
    UCSCi uc003peg.2. human.

    Organism-specific databases

    CTDi 202559.
    GeneCardsi GC06M062447.
    H-InvDB HIX0005989.
    HGNCi HGNC:18114. KHDRBS2.
    HPAi HPA029392.
    MIMi 610487. gene.
    neXtProti NX_Q5VWX1.
    PharmGKBi PA30093.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5176.
    HOGENOMi HOG000230771.
    HOVERGENi HBG079164.
    InParanoidi Q5VWX1.
    KOi K17843.
    OMAi KFQGSEG.
    OrthoDBi EOG75MVX3.
    PhylomeDBi Q5VWX1.
    TreeFami TF314878.

    Miscellaneous databases

    GenomeRNAii 202559.
    NextBioi 90301.
    PROi Q5VWX1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VWX1.
    CleanExi HS_KHDRBS2.
    Genevestigatori Q5VWX1.

    Family and domain databases

    Gene3Di 3.30.1370.10. 1 hit.
    InterProi IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF00013. KH_1. 1 hit.
    [Graphical view ]
    SMARTi SM00322. KH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2."
      Wang L., Xu J., Zeng L., Ye X., Wu Q., Dai J., Ji C., Gu S., Zhao C., Xie Y., Mao Y.
      Mol. Biol. Rep. 29:369-375(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1."
      Cote J., Boisvert F.-M., Boulanger M.-C., Bedford M.T., Richard S.
      Mol. Biol. Cell 14:274-287(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: METHYLATION.
    7. "Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA."
      Heinrich B., Zhang Z., Raitskin O., Hiller M., Benderska N., Hartmann A.M., Bracco L., Elliott D., Ben-Ari S., Soreq H., Sperling J., Sperling R., Stamm S.
      J. Biol. Chem. 284:14303-14315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RBMX.

    Entry informationi

    Entry nameiKHDR2_HUMAN
    AccessioniPrimary (citable) accession number: Q5VWX1
    Secondary accession number(s): A8K7M8, Q8N4I4, Q8TCZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3