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Q5VWW1

- C1QL3_HUMAN

UniProt

Q5VWW1 - C1QL3_HUMAN

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Protein

Complement C1q-like protein 3

Gene

C1QL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).By similarity

GO - Biological processi

  1. regulation of synapse organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q-like protein 3
Alternative name(s):
C1q and tumor necrosis factor-related protein 13
Short name:
C1q/TNF-related protein 13
Gene namesi
Name:C1QL3
Synonyms:CTRP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:19359. C1QL3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 255235Complement C1q-like protein 3PRO_0000274337Add
BLAST

Proteomic databases

PaxDbiQ5VWW1.
PRIDEiQ5VWW1.

PTM databases

PhosphoSiteiQ5VWW1.

Expressioni

Tissue specificityi

Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney.1 Publication

Gene expression databases

BgeeiQ5VWW1.
CleanExiHS_C1QL3.
GenevestigatoriQ5VWW1.

Interactioni

Subunit structurei

Forms homooligomers. Interacts with BAI3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000298943.

Structurei

3D structure databases

ProteinModelPortaliQ5VWW1.
SMRiQ5VWW1. Positions 143-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 11151Collagen-likeAdd
BLAST
Domaini122 – 255134C1qPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 10840Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG45834.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ5VWW1.
OMAiDPYGTKS.
OrthoDBiEOG757CZJ.
PhylomeDBiQ5VWW1.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VWW1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG
60 70 80 90 100
LMQSLPTFIQ GPKGEAGRPG KAGPRGPPGE PGPPGPMGPP GEKGEPGRQG
110 120 130 140 150
LPGPPGAPGL NAAGAISAAT YSTVPKIAFY AGLKRQHEGY EVLKFDDVVT
160 170 180 190 200
NLGNHYDPTT GKFTCSIPGI YFFTYHVLMR GGDGTSMWAD LCKNNQVRAS
210 220 230 240 250
AIAQDADQNY DYASNSVVLH LEPGDEVYIK LDGGKAHGGN NNKYSTFSGF

IIYAD
Length:255
Mass (Da):26,719
Last modified:December 7, 2004 - v1
Checksum:iAEF2004E14DE07AC
GO
Isoform 2 (identifier: Q5VWW1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-86: Missing.

Show »
Length:231
Mass (Da):24,517
Checksum:iDA3414DB56F49522
GO
Isoform 3 (identifier: Q5VWW1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-86: Missing.
     87-104: Missing.

Show »
Length:213
Mass (Da):22,774
Checksum:iBA7784F72DB0E5D2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei63 – 8624Missing in isoform 2 and isoform 3. 1 PublicationVSP_027130Add
BLAST
Alternative sequencei87 – 10418Missing in isoform 3. 1 PublicationVSP_027131Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353576, AL360230 Genomic DNA. Translation: CAH72610.1.
AL360230, AL353576 Genomic DNA. Translation: CAH73145.1.
BC127716 mRNA. Translation: AAI27717.1.
BC127717 mRNA. Translation: AAI27718.1.
CCDSiCCDS31156.1. [Q5VWW1-1]
RefSeqiNP_001010908.1. NM_001010908.1. [Q5VWW1-1]
UniGeneiHs.676792.
Hs.745101.

Genome annotation databases

EnsembliENST00000298943; ENSP00000298943; ENSG00000165985. [Q5VWW1-1]
ENST00000619991; ENSP00000480149; ENSG00000165985. [Q5VWW1-3]
GeneIDi389941.
KEGGihsa:389941.
UCSCiuc001ioj.1. human. [Q5VWW1-1]

Polymorphism databases

DMDMi74747449.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353576 , AL360230 Genomic DNA. Translation: CAH72610.1 .
AL360230 , AL353576 Genomic DNA. Translation: CAH73145.1 .
BC127716 mRNA. Translation: AAI27717.1 .
BC127717 mRNA. Translation: AAI27718.1 .
CCDSi CCDS31156.1. [Q5VWW1-1 ]
RefSeqi NP_001010908.1. NM_001010908.1. [Q5VWW1-1 ]
UniGenei Hs.676792.
Hs.745101.

3D structure databases

ProteinModelPortali Q5VWW1.
SMRi Q5VWW1. Positions 143-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000298943.

PTM databases

PhosphoSitei Q5VWW1.

Polymorphism databases

DMDMi 74747449.

Proteomic databases

PaxDbi Q5VWW1.
PRIDEi Q5VWW1.

Protocols and materials databases

DNASUi 389941.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298943 ; ENSP00000298943 ; ENSG00000165985 . [Q5VWW1-1 ]
ENST00000619991 ; ENSP00000480149 ; ENSG00000165985 . [Q5VWW1-3 ]
GeneIDi 389941.
KEGGi hsa:389941.
UCSCi uc001ioj.1. human. [Q5VWW1-1 ]

Organism-specific databases

CTDi 389941.
GeneCardsi GC10M016561.
HGNCi HGNC:19359. C1QL3.
MIMi 615227. gene.
neXtProti NX_Q5VWW1.
PharmGKBi PA134891919.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45834.
GeneTreei ENSGT00760000119052.
HOGENOMi HOG000085653.
HOVERGENi HBG108220.
InParanoidi Q5VWW1.
OMAi DPYGTKS.
OrthoDBi EOG757CZJ.
PhylomeDBi Q5VWW1.
TreeFami TF329591.

Miscellaneous databases

GenomeRNAii 389941.
NextBioi 103227.
PROi Q5VWW1.
SOURCEi Search...

Gene expression databases

Bgeei Q5VWW1.
CleanExi HS_C1QL3.
Genevestigatori Q5VWW1.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  3. "Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling."
    Wei Z., Peterson J.M., Wong G.W.
    J. Biol. Chem. 286:15652-15665(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiC1QL3_HUMAN
AccessioniPrimary (citable) accession number: Q5VWW1
Secondary accession number(s): A0PJY4, A0PJY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3