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Q5VWW1 (C1QL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q-like protein 3
Alternative name(s):
C1q and tumor necrosis factor-related protein 13
Short name=C1q/TNF-related protein 13
Gene names
Name:C1QL3
Synonyms:CTRP13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production By similarity.

Subunit structure

Forms homooligomers By similarity. Interacts with BAI3 By similarity. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney. Ref.3

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainCollagen
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of synapse organization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VWW1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VWW1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     63-86: Missing.
Isoform 3 (identifier: Q5VWW1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     63-86: Missing.
     87-104: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 255235Complement C1q-like protein 3
PRO_0000274337

Regions

Domain61 – 11151Collagen-like
Domain122 – 255134C1q
Compositional bias69 – 10840Pro-rich

Natural variations

Alternative sequence63 – 8624Missing in isoform 2 and isoform 3.
VSP_027130
Alternative sequence87 – 10418Missing in isoform 3.
VSP_027131

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: AEF2004E14DE07AC

FASTA25526,719
        10         20         30         40         50         60 
MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG LMQSLPTFIQ 

        70         80         90        100        110        120 
GPKGEAGRPG KAGPRGPPGE PGPPGPMGPP GEKGEPGRQG LPGPPGAPGL NAAGAISAAT 

       130        140        150        160        170        180 
YSTVPKIAFY AGLKRQHEGY EVLKFDDVVT NLGNHYDPTT GKFTCSIPGI YFFTYHVLMR 

       190        200        210        220        230        240 
GGDGTSMWAD LCKNNQVRAS AIAQDADQNY DYASNSVVLH LEPGDEVYIK LDGGKAHGGN 

       250 
NNKYSTFSGF IIYAD 

« Hide

Isoform 2 [UniParc].

Checksum: DA3414DB56F49522
Show »

FASTA23124,517
Isoform 3 [UniParc].

Checksum: BA7784F72DB0E5D2
Show »

FASTA21322,774

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
[3]"Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling."
Wei Z., Peterson J.M., Wong G.W.
J. Biol. Chem. 286:15652-15665(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL353576, AL360230 Genomic DNA. Translation: CAH72610.1.
AL360230, AL353576 Genomic DNA. Translation: CAH73145.1.
BC127716 mRNA. Translation: AAI27717.1.
BC127717 mRNA. Translation: AAI27718.1.
RefSeqNP_001010908.1. NM_001010908.1.
UniGeneHs.676792.
Hs.745101.

3D structure databases

ProteinModelPortalQ5VWW1.
SMRQ5VWW1. Positions 56-106, 143-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298943.

PTM databases

PhosphoSiteQ5VWW1.

Polymorphism databases

DMDM74747449.

Proteomic databases

PaxDbQ5VWW1.
PRIDEQ5VWW1.

Protocols and materials databases

DNASU389941.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298943; ENSP00000298943; ENSG00000165985. [Q5VWW1-1]
GeneID389941.
KEGGhsa:389941.
UCSCuc001ioj.1. human. [Q5VWW1-1]

Organism-specific databases

CTD389941.
GeneCardsGC10M016594.
HGNCHGNC:19359. C1QL3.
MIM615227. gene.
neXtProtNX_Q5VWW1.
PharmGKBPA134891919.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45834.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidQ5VWW1.
OMADPYGTKS.
OrthoDBEOG757CZJ.
PhylomeDBQ5VWW1.
TreeFamTF329591.

Gene expression databases

BgeeQ5VWW1.
CleanExHS_C1QL3.
GenevestigatorQ5VWW1.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi389941.
NextBio103227.
PROQ5VWW1.
SOURCESearch...

Entry information

Entry nameC1QL3_HUMAN
AccessionPrimary (citable) accession number: Q5VWW1
Secondary accession number(s): A0PJY4, A0PJY5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 7, 2004
Last modified: March 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM