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Q5VWW1

- C1QL3_HUMAN

UniProt

Q5VWW1 - C1QL3_HUMAN

Protein

Complement C1q-like protein 3

Gene

C1QL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production By similarity.By similarity

    GO - Biological processi

    1. regulation of synapse organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q-like protein 3
    Alternative name(s):
    C1q and tumor necrosis factor-related protein 13
    Short name:
    C1q/TNF-related protein 13
    Gene namesi
    Name:C1QL3
    Synonyms:CTRP13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:19359. C1QL3.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 255235Complement C1q-like protein 3PRO_0000274337Add
    BLAST

    Proteomic databases

    PaxDbiQ5VWW1.
    PRIDEiQ5VWW1.

    PTM databases

    PhosphoSiteiQ5VWW1.

    Expressioni

    Tissue specificityi

    Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney.1 Publication

    Gene expression databases

    BgeeiQ5VWW1.
    CleanExiHS_C1QL3.
    GenevestigatoriQ5VWW1.

    Interactioni

    Subunit structurei

    Forms homooligomers. Interacts with BAI3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000298943.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VWW1.
    SMRiQ5VWW1. Positions 143-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 11151Collagen-likeAdd
    BLAST
    Domaini122 – 255134C1qPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi69 – 10840Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG45834.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiQ5VWW1.
    OMAiDPYGTKS.
    OrthoDBiEOG757CZJ.
    PhylomeDBiQ5VWW1.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VWW1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG    50
    LMQSLPTFIQ GPKGEAGRPG KAGPRGPPGE PGPPGPMGPP GEKGEPGRQG 100
    LPGPPGAPGL NAAGAISAAT YSTVPKIAFY AGLKRQHEGY EVLKFDDVVT 150
    NLGNHYDPTT GKFTCSIPGI YFFTYHVLMR GGDGTSMWAD LCKNNQVRAS 200
    AIAQDADQNY DYASNSVVLH LEPGDEVYIK LDGGKAHGGN NNKYSTFSGF 250
    IIYAD 255
    Length:255
    Mass (Da):26,719
    Last modified:December 7, 2004 - v1
    Checksum:iAEF2004E14DE07AC
    GO
    Isoform 2 (identifier: Q5VWW1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         63-86: Missing.

    Show »
    Length:231
    Mass (Da):24,517
    Checksum:iDA3414DB56F49522
    GO
    Isoform 3 (identifier: Q5VWW1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         63-86: Missing.
         87-104: Missing.

    Show »
    Length:213
    Mass (Da):22,774
    Checksum:iBA7784F72DB0E5D2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei63 – 8624Missing in isoform 2 and isoform 3. 1 PublicationVSP_027130Add
    BLAST
    Alternative sequencei87 – 10418Missing in isoform 3. 1 PublicationVSP_027131Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353576, AL360230 Genomic DNA. Translation: CAH72610.1.
    AL360230, AL353576 Genomic DNA. Translation: CAH73145.1.
    BC127716 mRNA. Translation: AAI27717.1.
    BC127717 mRNA. Translation: AAI27718.1.
    CCDSiCCDS31156.1. [Q5VWW1-1]
    RefSeqiNP_001010908.1. NM_001010908.1. [Q5VWW1-1]
    UniGeneiHs.676792.
    Hs.745101.

    Genome annotation databases

    EnsembliENST00000298943; ENSP00000298943; ENSG00000165985. [Q5VWW1-1]
    GeneIDi389941.
    KEGGihsa:389941.
    UCSCiuc001ioj.1. human. [Q5VWW1-1]

    Polymorphism databases

    DMDMi74747449.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353576 , AL360230 Genomic DNA. Translation: CAH72610.1 .
    AL360230 , AL353576 Genomic DNA. Translation: CAH73145.1 .
    BC127716 mRNA. Translation: AAI27717.1 .
    BC127717 mRNA. Translation: AAI27718.1 .
    CCDSi CCDS31156.1. [Q5VWW1-1 ]
    RefSeqi NP_001010908.1. NM_001010908.1. [Q5VWW1-1 ]
    UniGenei Hs.676792.
    Hs.745101.

    3D structure databases

    ProteinModelPortali Q5VWW1.
    SMRi Q5VWW1. Positions 143-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000298943.

    PTM databases

    PhosphoSitei Q5VWW1.

    Polymorphism databases

    DMDMi 74747449.

    Proteomic databases

    PaxDbi Q5VWW1.
    PRIDEi Q5VWW1.

    Protocols and materials databases

    DNASUi 389941.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298943 ; ENSP00000298943 ; ENSG00000165985 . [Q5VWW1-1 ]
    GeneIDi 389941.
    KEGGi hsa:389941.
    UCSCi uc001ioj.1. human. [Q5VWW1-1 ]

    Organism-specific databases

    CTDi 389941.
    GeneCardsi GC10M016594.
    HGNCi HGNC:19359. C1QL3.
    MIMi 615227. gene.
    neXtProti NX_Q5VWW1.
    PharmGKBi PA134891919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45834.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi Q5VWW1.
    OMAi DPYGTKS.
    OrthoDBi EOG757CZJ.
    PhylomeDBi Q5VWW1.
    TreeFami TF329591.

    Miscellaneous databases

    GenomeRNAii 389941.
    NextBioi 103227.
    PROi Q5VWW1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VWW1.
    CleanExi HS_C1QL3.
    Genevestigatori Q5VWW1.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    3. "Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling."
      Wei Z., Peterson J.M., Wong G.W.
      J. Biol. Chem. 286:15652-15665(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiC1QL3_HUMAN
    AccessioniPrimary (citable) accession number: Q5VWW1
    Secondary accession number(s): A0PJY4, A0PJY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3