Q5VWW1 (C1QL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement C1q-like protein 3

Gene names

Name:

C1QL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.
Subunit structure	Interacts with BAI3 By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Collagen Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of synapse organization Inferred from electronic annotation. Source: Compara
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VWW1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VWW1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     63-86: Missing.

Isoform 3 (identifier: Q5VWW1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     63-86: Missing.
     87-104: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 255	235	Complement C1q-like protein 3		PRO_0000274337
Regions
	Domain	61 – 111	51	Collagen-like
	Domain	122 – 255	134	C1q
	Compositional bias	69 – 108	40	Pro-rich
Natural variations
	Alternative sequence	63 – 86	24	Missing in isoform 2 and isoform 3.		VSP_027130
	Alternative sequence	87 – 104	18	Missing in isoform 3.		VSP_027131

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: AEF2004E14DE07AC	FASTA	255	26,719
	10 20 30 40 50 60 MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG LMQSLPTFIQ 70 80 90 100 110 120 GPKGEAGRPG KAGPRGPPGE PGPPGPMGPP GEKGEPGRQG LPGPPGAPGL NAAGAISAAT 130 140 150 160 170 180 YSTVPKIAFY AGLKRQHEGY EVLKFDDVVT NLGNHYDPTT GKFTCSIPGI YFFTYHVLMR 190 200 210 220 230 240 GGDGTSMWAD LCKNNQVRAS AIAQDADQNY DYASNSVVLH LEPGDEVYIK LDGGKAHGGN 250 NNKYSTFSGF IIYAD
	Isoform 2 [UniParc]. Checksum: DA3414DB56F49522	FASTA	231	24,517
	10 20 30 40 50 60 MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG LMQSLPTFIQ 70 80 90 100 110 120 GPMGPPGEKG EPGRQGLPGP PGAPGLNAAG AISAATYSTV PKIAFYAGLK RQHEGYEVLK 130 140 150 160 170 180 FDDVVTNLGN HYDPTTGKFT CSIPGIYFFT YHVLMRGGDG TSMWADLCKN NQVRASAIAQ 190 200 210 220 230 DADQNYDYAS NSVVLHLEPG DEVYIKLDGG KAHGGNNNKY STFSGFIIYA D
	Isoform 3 [UniParc]. Checksum: BA7784F72DB0E5D2	FASTA	213	22,774
	10 20 30 40 50 60 MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG LMQSLPTFIQ 70 80 90 100 110 120 GPPGAPGLNA AGAISAATYS TVPKIAFYAG LKRQHEGYEV LKFDDVVTNL GNHYDPTTGK 130 140 150 160 170 180 FTCSIPGIYF FTYHVLMRGG DGTSMWADLC KNNQVRASAI AQDADQNYDY ASNSVVLHLE 190 200 210 PGDEVYIKLD GGKAHGGNNN KYSTFSGFII YAD

References

[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353576, AL360230 Genomic DNA. Translation: CAH72610.1. AL360230, AL353576 Genomic DNA. Translation: CAH73145.1. BC127716 mRNA. Translation: AAI27717.1. BC127717 mRNA. Translation: AAI27718.1.
IPI	IPI00552939. IPI00816155. IPI00854882.
RefSeq	NP_001010908.1. NM_001010908.1.
UniGene	Hs.676792. Hs.741515.
3D structure databases
HSSP	HSSP built from PDB template 1Q7D based on UniProtKB Q15201.
ProteinModelPortal	Q5VWW1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298943.
PTM databases
PhosphoSite	Q5VWW1.
Polymorphism databases
DMDM	74747449.
Proteomic databases
PaxDb	Q5VWW1.
PRIDE	Q5VWW1.
Protocols and materials databases
DNASU	389941.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298943; ENSP00000298943; ENSG00000165985.
GeneID	389941.
KEGG	hsa:389941.
UCSC	uc001ioj.1. human.
Organism-specific databases
CTD	389941.
GeneCards	GC10M016594.
HGNC	HGNC:19359. C1QL3.
neXtProt	NX_Q5VWW1.
PharmGKB	PA134891919.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45834.
HOGENOM	HOG000085653.
HOVERGEN	HBG108220.
InParanoid	Q5VWW1.
OMA	QHEGYEL.
OrthoDB	EOG4R23VZ.
PhylomeDB	Q5VWW1.
Gene expression databases
ArrayExpress	Q5VWW1.
Bgee	Q5VWW1.
CleanEx	HS_C1QL3.
Genevestigator	Q5VWW1.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389941.
NextBio	103227.

Entry information

Entry name

C1QL3_HUMAN

Accession

Primary (citable) accession number: Q5VWW1
Secondary accession number(s): A0PJY4, A0PJY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.