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Protein
Submitted name:

Partitioning defective 3 homolog

Gene

PARD3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Partitioning defective 3 homologImported
Gene namesi
Name:PARD3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16051. PARD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148498.

PTM / Processingi

Proteomic databases

MaxQBiQ5VWV2.
PaxDbiQ5VWV2.
PeptideAtlasiQ5VWV2.
PRIDEiQ5VWV2.

Expressioni

Gene expression databases

BgeeiENSG00000148498.
ExpressionAtlasiQ5VWV2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363921.

Structurei

3D structure databases

ProteinModelPortaliQ5VWV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 303PDZ (DHR)InterPro annotationAdd BLAST77
Domaini417 – 502PDZ (DHR)InterPro annotationAdd BLAST86
Domaini533 – 608PDZ (DHR)InterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili989 – 1016Sequence analysisAdd BLAST28
Coiled coili1220 – 1241Sequence analysisAdd BLAST22

Sequence similaritiesi

Contains 3 PDZ (DHR) domains.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410ITAJ. Eukaryota.
ENOG410ZDVK. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000232109.
HOVERGENiHBG053508.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VWV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR
60 70 80 90 100
LEHGDGGILD LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS
110 120 130 140 150
PEIFGSELGT NNVSAFQPYQ ATSEIEVTPS VLRANMPLHV RRSSDPALIG
160 170 180 190 200
LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL KQNTAGSPKT CDRKDEDGTE
210 220 230 240 250
EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL GIHVVPFSAR
260 270 280 290 300
GGRTLGLLVK RLEKGGKAEH ENLFRENDCI VRINDGDLRN RRFEQAQHMF
310 320 330 340 350
RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV
360 370 380 390 400
NSAGLHTVQR APRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS
410 420 430 440 450
TTVSSGYNTK KIGKRLNIQL KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL
460 470 480 490 500
PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ EEVVSLLRST KMEGTVSLLV
510 520 530 540 550
FRQEDAFHPR ELKAEDEDIV LTPDGTREFL TFEVPLNDSG SAGLGVSVKG
560 570 580 590 600
NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD
610 620 630 640 650
AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL
660 670 680 690 700
DDRERRISHS LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI
710 720 730 740 750
IEDDRLPVLP PHLSDQSSSS SHDDVGFVTA DAGTWAKAAI SDSADCSLSP
760 770 780 790 800
DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS QLDFVKTRKS KSMDLGIADE
810 820 830 840 850
TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV TLNGDIPFHR
860 870 880 890 900
PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR
910 920 930 940 950
ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM
960 970 980 990 1000
KAKKGMLKGL GDMFRFGKHR KDDKIEKTGK IKIQESFTSE EERIRMKQEQ
1010 1020 1030 1040 1050
ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELMYGG VSSYEGSMAL
1060 1070 1080 1090 1100
NARPQSPREG HMMDALYAQV KKPRNSKPSP VDSNRSTPSN HDRIQRLRQE
1110 1120 1130 1140 1150
FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE VQMQRQRQEE
1160 1170 1180 1190 1200
RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF QSAKENPRYS
1210 1220 1230 1240 1250
SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK QPPSEGPSNY
1260 1270 1280 1290
DSYKKVQDPS YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
Length:1,296
Mass (Da):144,491
Last modified:December 7, 2004 - v1
Checksum:i83E025EE59F78319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138768 Genomic DNA. No translation available.
AL160409 Genomic DNA. No translation available.
AL360233 Genomic DNA. No translation available.
AL390766 Genomic DNA. No translation available.
AL392123 Genomic DNA. No translation available.
AL450337 Genomic DNA. No translation available.
AL590039 Genomic DNA. No translation available.
AL603963 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000374790; ENSP00000363922; ENSG00000148498.
UCSCiuc057srn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138768 Genomic DNA. No translation available.
AL160409 Genomic DNA. No translation available.
AL360233 Genomic DNA. No translation available.
AL390766 Genomic DNA. No translation available.
AL392123 Genomic DNA. No translation available.
AL450337 Genomic DNA. No translation available.
AL590039 Genomic DNA. No translation available.
AL603963 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5VWV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363921.

Proteomic databases

MaxQBiQ5VWV2.
PaxDbiQ5VWV2.
PeptideAtlasiQ5VWV2.
PRIDEiQ5VWV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374790; ENSP00000363922; ENSG00000148498.
UCSCiuc057srn.1. human.

Organism-specific databases

HGNCiHGNC:16051. PARD3.
OpenTargetsiENSG00000148498.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITAJ. Eukaryota.
ENOG410ZDVK. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000232109.
HOVERGENiHBG053508.

Miscellaneous databases

ChiTaRSiPARD3. human.

Gene expression databases

BgeeiENSG00000148498.
ExpressionAtlasiQ5VWV2. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR021922. DUF3534.
IPR001478. PDZ.
[Graphical view]
PfamiPF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5VWV2_HUMAN
AccessioniPrimary (citable) accession number: Q5VWV2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.