Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5VWT5 (CA168_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C1orf168
Gene names
Name:C1orf168
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length728 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VWT5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VWT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     355-358: PTYE → RRCL
     359-728: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 728728Uncharacterized protein C1orf168
PRO_0000304583

Natural variations

Alternative sequence355 – 3584PTYE → RRCL in isoform 2.
VSP_028031
Alternative sequence359 – 728370Missing in isoform 2.
VSP_028032
Natural variant1251I → M.
Corresponds to variant rs17114336 [ dbSNP | Ensembl ].
VAR_035041

Experimental info

Sequence conflict1031C → R in CAH56148. Ref.2
Sequence conflict4001K → R in CAH56148. Ref.2
Sequence conflict7181H → R in CAH56148. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: A98C37E6A0B7F2F9

FASTA72882,070
        10         20         30         40         50         60 
MEGEGVRNFK ELRAKFQNLD APPLPGPIKF PAGVSPKGDI GGTQSTQILA NGKPLSSNHK 

        70         80         90        100        110        120 
QRTPYCSSSE SQPLQPQKIK LAQKSEIPKC SNSPGPLGKS TVCSATSSQK ASLLLEVTQS 

       130        140        150        160        170        180 
NVEIITKEKV MVANSFRNKL WNWEKVSSQK SEMSSALLLA NYGSKAIHLE GQKGMGLTPE 

       190        200        210        220        230        240 
EPRKKLETKG AQTLPSQKHV VAPKILHNVS EDPSFVISQH IRKSWENPPP ERSPASSPCQ 

       250        260        270        280        290        300 
PIYECELASQ APEKQPDVRH HHLPKTKPLP SIDSLGPPPP KPSRPPIVNL QAFQRQPAAV 

       310        320        330        340        350        360 
PKTQGEVTVE EGSLSPERLF NAEFEEPHNY EATISYLRHS GNSINLCTAK EIADPTYEVG 

       370        380        390        400        410        420 
IEELQKPGKN FPYPEPSAKH EDKKMKEKQP CELKPKNTEK EPYSNHVFKV DACEGTPEKI 

       430        440        450        460        470        480 
QMTNVHTGRR NMLAGKQEAM IDIIQTNPCP EGPKLARHSQ GHCGHLEVLE STKETPDLGV 

       490        500        510        520        530        540 
SKTSSISEEI YDDVEYSRKE VPKLNYSSSL ASSSEENREL YEDVYKTKNN YPKIDLDGKE 

       550        560        570        580        590        600 
ALKRLQQFFK KEKDRFKIKK TKSKENLSAF SILLPDLELK SQEVIIYDDV DLSEKESKDE 

       610        620        630        640        650        660 
DKLKMWKPKF LTPKEKKEKN GAEESESFSP RNFFKTKKQN LEKNRMKREE KLFRERFKYD 

       670        680        690        700        710        720 
KEIIVINTAV ACSNNSRNGI FDLPISPGEE LEVIDTTEQN LVICRNSKGK YGYVLIEHLD 


FKHQSWSP 

« Hide

Isoform 2 [UniParc].

Checksum: 6ED5A5844E7174C5
Show »

FASTA35839,236

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Salivary gland.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK125198 mRNA. Translation: BAC86080.1.
BX648439 mRNA. Translation: CAH56148.1.
AL360295, AL035705 Genomic DNA. Translation: CAH73130.1.
AL035705, AL360295 Genomic DNA. Translation: CAI22671.1.
CCDSCCDS30729.1. [Q5VWT5-1]
RefSeqNP_001004303.3. NM_001004303.4. [Q5VWT5-1]
UniGeneHs.437655.

3D structure databases

ProteinModelPortalQ5VWT5.
SMRQ5VWT5. Positions 647-719.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000345972.

PTM databases

PhosphoSiteQ5VWT5.

Polymorphism databases

DMDM74747442.

Proteomic databases

PaxDbQ5VWT5.
PRIDEQ5VWT5.

Protocols and materials databases

DNASU199920.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343433; ENSP00000345972; ENSG00000187889. [Q5VWT5-1]
GeneID199920.
KEGGhsa:199920.
UCSCuc001cym.4. human. [Q5VWT5-1]
uc009vzv.1. human. [Q5VWT5-2]

Organism-specific databases

CTD199920.
GeneCardsGC01M057184.
H-InvDBHIX0000629.
HGNCHGNC:27295. C1orf168.
HPAHPA030089.
neXtProtNX_Q5VWT5.
PharmGKBPA142672418.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70333.
HOGENOMHOG000111260.
HOVERGENHBG106641.
InParanoidQ5VWT5.
OMAFEEPHNY.
OrthoDBEOG70W3CP.
PhylomeDBQ5VWT5.
TreeFamTF337003.

Gene expression databases

BgeeQ5VWT5.
CleanExHS_C1orf168.
GenevestigatorQ5VWT5.

Family and domain databases

InterProIPR029294. hSH3.
IPR001452. SH3_domain.
[Graphical view]
PfamPF14603. hSH3. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi199920.
NextBio89775.

Entry information

Entry nameCA168_HUMAN
AccessionPrimary (citable) accession number: Q5VWT5
Secondary accession number(s): Q63HM3, Q6ZUY6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM