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Q5VWT5

- CA168_HUMAN

UniProt

Q5VWT5 - CA168_HUMAN

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Protein
Uncharacterized protein C1orf168
Gene
C1orf168
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf168
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27295. C1orf168.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Uncharacterized protein C1orf168
PRO_0000304583Add
BLAST

Proteomic databases

PaxDbiQ5VWT5.
PRIDEiQ5VWT5.

PTM databases

PhosphoSiteiQ5VWT5.

Expressioni

Gene expression databases

BgeeiQ5VWT5.
CleanExiHS_C1orf168.
GenevestigatoriQ5VWT5.

Organism-specific databases

HPAiHPA030089.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345972.

Structurei

3D structure databases

ProteinModelPortaliQ5VWT5.
SMRiQ5VWT5. Positions 647-719.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70333.
HOGENOMiHOG000111260.
HOVERGENiHBG106641.
InParanoidiQ5VWT5.
OMAiFEEPHNY.
OrthoDBiEOG70W3CP.
PhylomeDBiQ5VWT5.
TreeFamiTF337003.

Family and domain databases

InterProiIPR029294. hSH3.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14603. hSH3. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VWT5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGEGVRNFK ELRAKFQNLD APPLPGPIKF PAGVSPKGDI GGTQSTQILA    50
NGKPLSSNHK QRTPYCSSSE SQPLQPQKIK LAQKSEIPKC SNSPGPLGKS 100
TVCSATSSQK ASLLLEVTQS NVEIITKEKV MVANSFRNKL WNWEKVSSQK 150
SEMSSALLLA NYGSKAIHLE GQKGMGLTPE EPRKKLETKG AQTLPSQKHV 200
VAPKILHNVS EDPSFVISQH IRKSWENPPP ERSPASSPCQ PIYECELASQ 250
APEKQPDVRH HHLPKTKPLP SIDSLGPPPP KPSRPPIVNL QAFQRQPAAV 300
PKTQGEVTVE EGSLSPERLF NAEFEEPHNY EATISYLRHS GNSINLCTAK 350
EIADPTYEVG IEELQKPGKN FPYPEPSAKH EDKKMKEKQP CELKPKNTEK 400
EPYSNHVFKV DACEGTPEKI QMTNVHTGRR NMLAGKQEAM IDIIQTNPCP 450
EGPKLARHSQ GHCGHLEVLE STKETPDLGV SKTSSISEEI YDDVEYSRKE 500
VPKLNYSSSL ASSSEENREL YEDVYKTKNN YPKIDLDGKE ALKRLQQFFK 550
KEKDRFKIKK TKSKENLSAF SILLPDLELK SQEVIIYDDV DLSEKESKDE 600
DKLKMWKPKF LTPKEKKEKN GAEESESFSP RNFFKTKKQN LEKNRMKREE 650
KLFRERFKYD KEIIVINTAV ACSNNSRNGI FDLPISPGEE LEVIDTTEQN 700
LVICRNSKGK YGYVLIEHLD FKHQSWSP 728
Length:728
Mass (Da):82,070
Last modified:December 7, 2004 - v1
Checksum:iA98C37E6A0B7F2F9
GO
Isoform 2 (identifier: Q5VWT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-358: PTYE → RRCL
     359-728: Missing.

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):39,236
Checksum:i6ED5A5844E7174C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251I → M.
Corresponds to variant rs17114336 [ dbSNP | Ensembl ].
VAR_035041

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei355 – 3584PTYE → RRCL in isoform 2.
VSP_028031
Alternative sequencei359 – 728370Missing in isoform 2.
VSP_028032Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031C → R in CAH56148. 1 Publication
Sequence conflicti400 – 4001K → R in CAH56148. 1 Publication
Sequence conflicti718 – 7181H → R in CAH56148. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK125198 mRNA. Translation: BAC86080.1.
BX648439 mRNA. Translation: CAH56148.1.
AL360295, AL035705 Genomic DNA. Translation: CAH73130.1.
AL035705, AL360295 Genomic DNA. Translation: CAI22671.1.
CCDSiCCDS30729.1. [Q5VWT5-1]
RefSeqiNP_001004303.3. NM_001004303.4. [Q5VWT5-1]
UniGeneiHs.437655.

Genome annotation databases

EnsembliENST00000343433; ENSP00000345972; ENSG00000187889. [Q5VWT5-1]
GeneIDi199920.
KEGGihsa:199920.
UCSCiuc001cym.4. human. [Q5VWT5-1]
uc009vzv.1. human. [Q5VWT5-2]

Polymorphism databases

DMDMi74747442.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK125198 mRNA. Translation: BAC86080.1 .
BX648439 mRNA. Translation: CAH56148.1 .
AL360295 , AL035705 Genomic DNA. Translation: CAH73130.1 .
AL035705 , AL360295 Genomic DNA. Translation: CAI22671.1 .
CCDSi CCDS30729.1. [Q5VWT5-1 ]
RefSeqi NP_001004303.3. NM_001004303.4. [Q5VWT5-1 ]
UniGenei Hs.437655.

3D structure databases

ProteinModelPortali Q5VWT5.
SMRi Q5VWT5. Positions 647-719.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000345972.

PTM databases

PhosphoSitei Q5VWT5.

Polymorphism databases

DMDMi 74747442.

Proteomic databases

PaxDbi Q5VWT5.
PRIDEi Q5VWT5.

Protocols and materials databases

DNASUi 199920.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343433 ; ENSP00000345972 ; ENSG00000187889 . [Q5VWT5-1 ]
GeneIDi 199920.
KEGGi hsa:199920.
UCSCi uc001cym.4. human. [Q5VWT5-1 ]
uc009vzv.1. human. [Q5VWT5-2 ]

Organism-specific databases

CTDi 199920.
GeneCardsi GC01M057184.
H-InvDB HIX0000629.
HGNCi HGNC:27295. C1orf168.
HPAi HPA030089.
neXtProti NX_Q5VWT5.
PharmGKBi PA142672418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70333.
HOGENOMi HOG000111260.
HOVERGENi HBG106641.
InParanoidi Q5VWT5.
OMAi FEEPHNY.
OrthoDBi EOG70W3CP.
PhylomeDBi Q5VWT5.
TreeFami TF337003.

Miscellaneous databases

GenomeRNAii 199920.
NextBioi 89775.

Gene expression databases

Bgeei Q5VWT5.
CleanExi HS_C1orf168.
Genevestigatori Q5VWT5.

Family and domain databases

InterProi IPR029294. hSH3.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF14603. hSH3. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Salivary gland.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCA168_HUMAN
AccessioniPrimary (citable) accession number: Q5VWT5
Secondary accession number(s): Q63HM3, Q6ZUY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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