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Q5VWT5

- CA168_HUMAN

UniProt

Q5VWT5 - CA168_HUMAN

Protein

Uncharacterized protein C1orf168

Gene

C1orf168

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C1orf168
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27295. C1orf168.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672418.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 728728Uncharacterized protein C1orf168PRO_0000304583Add
    BLAST

    Proteomic databases

    PaxDbiQ5VWT5.
    PRIDEiQ5VWT5.

    PTM databases

    PhosphoSiteiQ5VWT5.

    Expressioni

    Gene expression databases

    BgeeiQ5VWT5.
    CleanExiHS_C1orf168.
    GenevestigatoriQ5VWT5.

    Organism-specific databases

    HPAiHPA030089.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000345972.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VWT5.
    SMRiQ5VWT5. Positions 647-719.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG70333.
    HOGENOMiHOG000111260.
    HOVERGENiHBG106641.
    InParanoidiQ5VWT5.
    OMAiFEEPHNY.
    OrthoDBiEOG70W3CP.
    PhylomeDBiQ5VWT5.
    TreeFamiTF337003.

    Family and domain databases

    InterProiIPR029294. hSH3.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF14603. hSH3. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VWT5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGEGVRNFK ELRAKFQNLD APPLPGPIKF PAGVSPKGDI GGTQSTQILA    50
    NGKPLSSNHK QRTPYCSSSE SQPLQPQKIK LAQKSEIPKC SNSPGPLGKS 100
    TVCSATSSQK ASLLLEVTQS NVEIITKEKV MVANSFRNKL WNWEKVSSQK 150
    SEMSSALLLA NYGSKAIHLE GQKGMGLTPE EPRKKLETKG AQTLPSQKHV 200
    VAPKILHNVS EDPSFVISQH IRKSWENPPP ERSPASSPCQ PIYECELASQ 250
    APEKQPDVRH HHLPKTKPLP SIDSLGPPPP KPSRPPIVNL QAFQRQPAAV 300
    PKTQGEVTVE EGSLSPERLF NAEFEEPHNY EATISYLRHS GNSINLCTAK 350
    EIADPTYEVG IEELQKPGKN FPYPEPSAKH EDKKMKEKQP CELKPKNTEK 400
    EPYSNHVFKV DACEGTPEKI QMTNVHTGRR NMLAGKQEAM IDIIQTNPCP 450
    EGPKLARHSQ GHCGHLEVLE STKETPDLGV SKTSSISEEI YDDVEYSRKE 500
    VPKLNYSSSL ASSSEENREL YEDVYKTKNN YPKIDLDGKE ALKRLQQFFK 550
    KEKDRFKIKK TKSKENLSAF SILLPDLELK SQEVIIYDDV DLSEKESKDE 600
    DKLKMWKPKF LTPKEKKEKN GAEESESFSP RNFFKTKKQN LEKNRMKREE 650
    KLFRERFKYD KEIIVINTAV ACSNNSRNGI FDLPISPGEE LEVIDTTEQN 700
    LVICRNSKGK YGYVLIEHLD FKHQSWSP 728
    Length:728
    Mass (Da):82,070
    Last modified:December 7, 2004 - v1
    Checksum:iA98C37E6A0B7F2F9
    GO
    Isoform 2 (identifier: Q5VWT5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         355-358: PTYE → RRCL
         359-728: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:358
    Mass (Da):39,236
    Checksum:i6ED5A5844E7174C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031C → R in CAH56148. (PubMed:17974005)Curated
    Sequence conflicti400 – 4001K → R in CAH56148. (PubMed:17974005)Curated
    Sequence conflicti718 – 7181H → R in CAH56148. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251I → M.
    Corresponds to variant rs17114336 [ dbSNP | Ensembl ].
    VAR_035041

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei355 – 3584PTYE → RRCL in isoform 2. 1 PublicationVSP_028031
    Alternative sequencei359 – 728370Missing in isoform 2. 1 PublicationVSP_028032Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125198 mRNA. Translation: BAC86080.1.
    BX648439 mRNA. Translation: CAH56148.1.
    AL360295, AL035705 Genomic DNA. Translation: CAH73130.1.
    AL035705, AL360295 Genomic DNA. Translation: CAI22671.1.
    CCDSiCCDS30729.1. [Q5VWT5-1]
    RefSeqiNP_001004303.3. NM_001004303.4. [Q5VWT5-1]
    UniGeneiHs.437655.

    Genome annotation databases

    EnsembliENST00000343433; ENSP00000345972; ENSG00000187889. [Q5VWT5-1]
    GeneIDi199920.
    KEGGihsa:199920.
    UCSCiuc001cym.4. human. [Q5VWT5-1]
    uc009vzv.1. human. [Q5VWT5-2]

    Polymorphism databases

    DMDMi74747442.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125198 mRNA. Translation: BAC86080.1 .
    BX648439 mRNA. Translation: CAH56148.1 .
    AL360295 , AL035705 Genomic DNA. Translation: CAH73130.1 .
    AL035705 , AL360295 Genomic DNA. Translation: CAI22671.1 .
    CCDSi CCDS30729.1. [Q5VWT5-1 ]
    RefSeqi NP_001004303.3. NM_001004303.4. [Q5VWT5-1 ]
    UniGenei Hs.437655.

    3D structure databases

    ProteinModelPortali Q5VWT5.
    SMRi Q5VWT5. Positions 647-719.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000345972.

    PTM databases

    PhosphoSitei Q5VWT5.

    Polymorphism databases

    DMDMi 74747442.

    Proteomic databases

    PaxDbi Q5VWT5.
    PRIDEi Q5VWT5.

    Protocols and materials databases

    DNASUi 199920.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343433 ; ENSP00000345972 ; ENSG00000187889 . [Q5VWT5-1 ]
    GeneIDi 199920.
    KEGGi hsa:199920.
    UCSCi uc001cym.4. human. [Q5VWT5-1 ]
    uc009vzv.1. human. [Q5VWT5-2 ]

    Organism-specific databases

    CTDi 199920.
    GeneCardsi GC01M057184.
    H-InvDB HIX0000629.
    HGNCi HGNC:27295. C1orf168.
    HPAi HPA030089.
    neXtProti NX_Q5VWT5.
    PharmGKBi PA142672418.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70333.
    HOGENOMi HOG000111260.
    HOVERGENi HBG106641.
    InParanoidi Q5VWT5.
    OMAi FEEPHNY.
    OrthoDBi EOG70W3CP.
    PhylomeDBi Q5VWT5.
    TreeFami TF337003.

    Miscellaneous databases

    GenomeRNAii 199920.
    NextBioi 89775.

    Gene expression databases

    Bgeei Q5VWT5.
    CleanExi HS_C1orf168.
    Genevestigatori Q5VWT5.

    Family and domain databases

    InterProi IPR029294. hSH3.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF14603. hSH3. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Salivary gland.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCA168_HUMAN
    AccessioniPrimary (citable) accession number: Q5VWT5
    Secondary accession number(s): Q63HM3, Q6ZUY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3