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Protein

Uncharacterized protein C1orf168

Gene

C1orf168

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf168
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27295. C1orf168.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672418.

Polymorphism and mutation databases

BioMutaiC1orf168.
DMDMi74747442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Uncharacterized protein C1orf168PRO_0000304583Add
BLAST

Proteomic databases

PaxDbiQ5VWT5.
PRIDEiQ5VWT5.

PTM databases

PhosphoSiteiQ5VWT5.

Expressioni

Gene expression databases

BgeeiQ5VWT5.
CleanExiHS_C1orf168.
GenevestigatoriQ5VWT5.

Organism-specific databases

HPAiHPA030089.
HPA054923.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345972.

Structurei

3D structure databases

ProteinModelPortaliQ5VWT5.
SMRiQ5VWT5. Positions 647-719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70333.
GeneTreeiENSGT00730000111334.
HOGENOMiHOG000111260.
HOVERGENiHBG106641.
InParanoidiQ5VWT5.
OMAiFEEPHNY.
OrthoDBiEOG70W3CP.
PhylomeDBiQ5VWT5.
TreeFamiTF337003.

Family and domain databases

InterProiIPR029294. hSH3.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14603. hSH3. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VWT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGEGVRNFK ELRAKFQNLD APPLPGPIKF PAGVSPKGDI GGTQSTQILA
60 70 80 90 100
NGKPLSSNHK QRTPYCSSSE SQPLQPQKIK LAQKSEIPKC SNSPGPLGKS
110 120 130 140 150
TVCSATSSQK ASLLLEVTQS NVEIITKEKV MVANSFRNKL WNWEKVSSQK
160 170 180 190 200
SEMSSALLLA NYGSKAIHLE GQKGMGLTPE EPRKKLETKG AQTLPSQKHV
210 220 230 240 250
VAPKILHNVS EDPSFVISQH IRKSWENPPP ERSPASSPCQ PIYECELASQ
260 270 280 290 300
APEKQPDVRH HHLPKTKPLP SIDSLGPPPP KPSRPPIVNL QAFQRQPAAV
310 320 330 340 350
PKTQGEVTVE EGSLSPERLF NAEFEEPHNY EATISYLRHS GNSINLCTAK
360 370 380 390 400
EIADPTYEVG IEELQKPGKN FPYPEPSAKH EDKKMKEKQP CELKPKNTEK
410 420 430 440 450
EPYSNHVFKV DACEGTPEKI QMTNVHTGRR NMLAGKQEAM IDIIQTNPCP
460 470 480 490 500
EGPKLARHSQ GHCGHLEVLE STKETPDLGV SKTSSISEEI YDDVEYSRKE
510 520 530 540 550
VPKLNYSSSL ASSSEENREL YEDVYKTKNN YPKIDLDGKE ALKRLQQFFK
560 570 580 590 600
KEKDRFKIKK TKSKENLSAF SILLPDLELK SQEVIIYDDV DLSEKESKDE
610 620 630 640 650
DKLKMWKPKF LTPKEKKEKN GAEESESFSP RNFFKTKKQN LEKNRMKREE
660 670 680 690 700
KLFRERFKYD KEIIVINTAV ACSNNSRNGI FDLPISPGEE LEVIDTTEQN
710 720
LVICRNSKGK YGYVLIEHLD FKHQSWSP
Length:728
Mass (Da):82,070
Last modified:December 7, 2004 - v1
Checksum:iA98C37E6A0B7F2F9
GO
Isoform 2 (identifier: Q5VWT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-358: PTYE → RRCL
     359-728: Missing.

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):39,236
Checksum:i6ED5A5844E7174C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031C → R in CAH56148 (PubMed:17974005).Curated
Sequence conflicti400 – 4001K → R in CAH56148 (PubMed:17974005).Curated
Sequence conflicti718 – 7181H → R in CAH56148 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251I → M.
Corresponds to variant rs17114336 [ dbSNP | Ensembl ].
VAR_035041

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei355 – 3584PTYE → RRCL in isoform 2. 1 PublicationVSP_028031
Alternative sequencei359 – 728370Missing in isoform 2. 1 PublicationVSP_028032Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125198 mRNA. Translation: BAC86080.1.
BX648439 mRNA. Translation: CAH56148.1.
AL360295, AL035705 Genomic DNA. Translation: CAH73130.1.
AL035705, AL360295 Genomic DNA. Translation: CAI22671.1.
CCDSiCCDS30729.1. [Q5VWT5-1]
RefSeqiNP_001004303.3. NM_001004303.4. [Q5VWT5-1]
UniGeneiHs.437655.

Genome annotation databases

EnsembliENST00000343433; ENSP00000345972; ENSG00000187889. [Q5VWT5-1]
GeneIDi199920.
KEGGihsa:199920.
UCSCiuc001cym.4. human. [Q5VWT5-1]
uc009vzv.1. human. [Q5VWT5-2]

Polymorphism and mutation databases

BioMutaiC1orf168.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125198 mRNA. Translation: BAC86080.1.
BX648439 mRNA. Translation: CAH56148.1.
AL360295, AL035705 Genomic DNA. Translation: CAH73130.1.
AL035705, AL360295 Genomic DNA. Translation: CAI22671.1.
CCDSiCCDS30729.1. [Q5VWT5-1]
RefSeqiNP_001004303.3. NM_001004303.4. [Q5VWT5-1]
UniGeneiHs.437655.

3D structure databases

ProteinModelPortaliQ5VWT5.
SMRiQ5VWT5. Positions 647-719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345972.

PTM databases

PhosphoSiteiQ5VWT5.

Polymorphism and mutation databases

BioMutaiC1orf168.
DMDMi74747442.

Proteomic databases

PaxDbiQ5VWT5.
PRIDEiQ5VWT5.

Protocols and materials databases

DNASUi199920.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343433; ENSP00000345972; ENSG00000187889. [Q5VWT5-1]
GeneIDi199920.
KEGGihsa:199920.
UCSCiuc001cym.4. human. [Q5VWT5-1]
uc009vzv.1. human. [Q5VWT5-2]

Organism-specific databases

CTDi199920.
GeneCardsiGC01M057184.
H-InvDBHIX0000629.
HGNCiHGNC:27295. C1orf168.
HPAiHPA030089.
HPA054923.
neXtProtiNX_Q5VWT5.
PharmGKBiPA142672418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70333.
GeneTreeiENSGT00730000111334.
HOGENOMiHOG000111260.
HOVERGENiHBG106641.
InParanoidiQ5VWT5.
OMAiFEEPHNY.
OrthoDBiEOG70W3CP.
PhylomeDBiQ5VWT5.
TreeFamiTF337003.

Miscellaneous databases

GenomeRNAii199920.
NextBioi89775.
PROiQ5VWT5.

Gene expression databases

BgeeiQ5VWT5.
CleanExiHS_C1orf168.
GenevestigatoriQ5VWT5.

Family and domain databases

InterProiIPR029294. hSH3.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14603. hSH3. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Salivary gland.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCA168_HUMAN
AccessioniPrimary (citable) accession number: Q5VWT5
Secondary accession number(s): Q63HM3, Q6ZUY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.