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Protein

FYN-binding protein 2

Gene

FYB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501).1 Publication

GO - Biological processi

  • cell adhesion mediated by integrin Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
FYN-binding protein 2Combined sources
Alternative name(s):
Activation-dependent, raft-recruited ADAP-like phosphoprotein1 Publication
Gene namesi
Name:FYB2Combined sources
Synonyms:ARAP1 Publication, C1orf168
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187889.12
HGNCiHGNC:27295 FYB2
neXtProtiNX_Q5VWT5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi491Y → F: Decrease in phosphorylation and interaction with LCP2. Significant decrease in phosphorylation and loss of interaction with LCP2; when associated with F-587. 1 Publication1
Mutagenesisi587Y → F: Decrease in phosphorylation and interaction with LCP2. Significant decrease in phosphorylation and loss of interaction with LCP2; when associated with F-491. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000187889
PharmGKBiPA142672418

Polymorphism and mutation databases

BioMutaiC1orf168
DMDMi74747442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003045831 – 728FYN-binding protein 2Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei491Phosphotyrosine1 Publication1
Modified residuei587Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylation is required for its function in T-cell activation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VWT5
PaxDbiQ5VWT5
PeptideAtlasiQ5VWT5
PRIDEiQ5VWT5

PTM databases

iPTMnetiQ5VWT5
PhosphoSitePlusiQ5VWT5

Expressioni

Tissue specificityi

Expressed in T-cells (at protein level). Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000187889
CleanExiHS_C1orf168
GenevisibleiQ5VWT5 HS

Interactioni

Subunit structurei

Interacts with SKAP1, LCK and FYN. The phosphorylated form interacts with LCP2.1 Publication

Protein-protein interaction databases

BioGridi128284, 6 interactors
STRINGi9606.ENSP00000345972

Structurei

3D structure databases

ProteinModelPortaliQ5VWT5
SMRiQ5VWT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini664 – 724SH3PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi521 – 524SH2-binding; to LCP21 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi228 – 286Pro-richPROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IFNY Eukaryota
ENOG41116CN LUCA
GeneTreeiENSGT00730000111334
HOGENOMiHOG000111260
HOVERGENiHBG106641
InParanoidiQ5VWT5
OMAiFEEPHNY
OrthoDBiEOG091G04X1
PhylomeDBiQ5VWT5
TreeFamiTF337003

Family and domain databases

InterProiView protein in InterPro
IPR029294 hSH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF14603 hSH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VWT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGEGVRNFK ELRAKFQNLD APPLPGPIKF PAGVSPKGDI GGTQSTQILA
60 70 80 90 100
NGKPLSSNHK QRTPYCSSSE SQPLQPQKIK LAQKSEIPKC SNSPGPLGKS
110 120 130 140 150
TVCSATSSQK ASLLLEVTQS NVEIITKEKV MVANSFRNKL WNWEKVSSQK
160 170 180 190 200
SEMSSALLLA NYGSKAIHLE GQKGMGLTPE EPRKKLETKG AQTLPSQKHV
210 220 230 240 250
VAPKILHNVS EDPSFVISQH IRKSWENPPP ERSPASSPCQ PIYECELASQ
260 270 280 290 300
APEKQPDVRH HHLPKTKPLP SIDSLGPPPP KPSRPPIVNL QAFQRQPAAV
310 320 330 340 350
PKTQGEVTVE EGSLSPERLF NAEFEEPHNY EATISYLRHS GNSINLCTAK
360 370 380 390 400
EIADPTYEVG IEELQKPGKN FPYPEPSAKH EDKKMKEKQP CELKPKNTEK
410 420 430 440 450
EPYSNHVFKV DACEGTPEKI QMTNVHTGRR NMLAGKQEAM IDIIQTNPCP
460 470 480 490 500
EGPKLARHSQ GHCGHLEVLE STKETPDLGV SKTSSISEEI YDDVEYSRKE
510 520 530 540 550
VPKLNYSSSL ASSSEENREL YEDVYKTKNN YPKIDLDGKE ALKRLQQFFK
560 570 580 590 600
KEKDRFKIKK TKSKENLSAF SILLPDLELK SQEVIIYDDV DLSEKESKDE
610 620 630 640 650
DKLKMWKPKF LTPKEKKEKN GAEESESFSP RNFFKTKKQN LEKNRMKREE
660 670 680 690 700
KLFRERFKYD KEIIVINTAV ACSNNSRNGI FDLPISPGEE LEVIDTTEQN
710 720
LVICRNSKGK YGYVLIEHLD FKHQSWSP
Length:728
Mass (Da):82,070
Last modified:December 7, 2004 - v1
Checksum:iA98C37E6A0B7F2F9
GO
Isoform 2 (identifier: Q5VWT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-358: PTYE → RRCL
     359-728: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):39,236
Checksum:i6ED5A5844E7174C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103C → R in CAH56148 (PubMed:17974005).Curated1
Sequence conflicti400K → R in CAH56148 (PubMed:17974005).Curated1
Sequence conflicti718H → R in CAH56148 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035041125I → M. Corresponds to variant dbSNP:rs17114336Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028031355 – 358PTYE → RRCL in isoform 2. 1 Publication4
Alternative sequenceiVSP_028032359 – 728Missing in isoform 2. 1 PublicationAdd BLAST370

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125198 mRNA Translation: BAC86080.1
BX648439 mRNA Translation: CAH56148.1
AL035705 Genomic DNA No translation available.
AL360295 Genomic DNA No translation available.
CCDSiCCDS30729.1 [Q5VWT5-1]
RefSeqiNP_001004303.3, NM_001004303.4 [Q5VWT5-1]
UniGeneiHs.437655

Genome annotation databases

EnsembliENST00000343433; ENSP00000345972; ENSG00000187889 [Q5VWT5-1]
GeneIDi199920
KEGGihsa:199920
UCSCiuc001cym.5 human [Q5VWT5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFYB2_HUMAN
AccessioniPrimary (citable) accession number: Q5VWT5
Secondary accession number(s): Q63HM3, Q6ZUY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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